JP4874969B2 - 新規な温度及びｐＨに感受性の両親媒性コポリマー、同コポリマーを含む組成物及び同コポリマーの医薬品の製造における使用方法 - Google Patents

新規な温度及びｐＨに感受性の両親媒性コポリマー、同コポリマーを含む組成物及び同コポリマーの医薬品の製造における使用方法 Download PDF

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JP4874969B2
JP4874969B2 JP2007527146A JP2007527146A JP4874969B2 JP 4874969 B2 JP4874969 B2 JP 4874969B2 JP 2007527146 A JP2007527146 A JP 2007527146A JP 2007527146 A JP2007527146 A JP 2007527146A JP 4874969 B2 JP4874969 B2 JP 4874969B2
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acid
copolymer
polymer
group
monomer units
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JP2008502785A (ja
JP2008502785A5 (enExample
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ヤン ヤン、イ
ソピマトゥ、クマレーシュ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/62—Monocarboxylic acids having ten or more carbon atoms; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/04—Homopolymers or copolymers of esters
    • C08L33/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
    • C08L33/08—Homopolymers or copolymers of acrylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/24—Homopolymers or copolymers of amides or imides
    • C08L33/26—Homopolymers or copolymers of acrylamide or methacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
JP2007527146A 2004-06-10 2005-05-24 新規な温度及びｐＨに感受性の両親媒性コポリマー、同コポリマーを含む組成物及び同コポリマーの医薬品の製造における使用方法 Expired - Fee Related JP4874969B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/865,681 US7316816B2 (en) 2004-06-10 2004-06-10 Temperature and pH sensitive copolymers
US10/865,681 2004-06-10
PCT/SG2005/000164 WO2005121196A1 (en) 2004-06-10 2005-05-24 Novel temperature and ph sensitive copolymers

Publications (3)

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JP2008502785A JP2008502785A (ja) 2008-01-31
JP2008502785A5 JP2008502785A5 (enExample) 2011-03-17
JP4874969B2 true JP4874969B2 (ja) 2012-02-15

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US (2) US7316816B2 (enExample)
EP (1) EP1765894B9 (enExample)
JP (1) JP4874969B2 (enExample)
CN (1) CN100582130C (enExample)
AT (1) ATE551371T1 (enExample)
WO (1) WO2005121196A1 (enExample)

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US7316816B2 (en) * 2004-06-10 2008-01-08 Agency For Science Technology And Research Temperature and pH sensitive copolymers
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US8021689B2 (en) * 2006-02-21 2011-09-20 Ecole Polytechnique Federale de Lausanne (“EPFL”) Nanoparticles for immunotherapy
EP2035488A4 (en) * 2006-07-05 2010-06-16 Agency Science Tech & Res MICELLES FOR DRUG DELIVERY
JP5260542B2 (ja) * 2006-12-12 2013-08-14 ユニリーバー・エヌ・ブイ ポリマー
KR100868724B1 (ko) 2007-05-30 2008-11-13 한국생산기술연구원 가역적 온도감응성을 가지는 자기집합성 나노운반체의제조방법
GB0712482D0 (en) * 2007-06-27 2007-08-08 Eastman Kodak Co Thermally-responsive dispersants for media formulations
KR101470679B1 (ko) * 2007-07-19 2014-12-08 올엑셀, 인크. 항암제로서의 자기 조립형 양친매성 중합체
US9987221B2 (en) * 2007-08-23 2018-06-05 Boston Scientific Scimed, Inc. Injectable hydrogel compositions
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US8703194B2 (en) * 2007-11-02 2014-04-22 Agency For Science, Technology And Research Stimulus-responsive biodegradable polymers and methods of preparation
US8597269B2 (en) * 2008-04-11 2013-12-03 Medtronic Minimed, Inc. Reservoir seal retainer systems and methods
FR2930444B1 (fr) * 2008-04-29 2010-06-04 Servier Lab Micelles polymerisees
JP5382567B2 (ja) * 2008-05-02 2014-01-08 公立大学法人大阪府立大学 温度感受性リポソーム
EP2128180A1 (en) 2008-05-29 2009-12-02 Unilever N.V. Amphiphilic branched polymers and their use as emulsifiers
US8318207B2 (en) * 2009-02-12 2012-11-27 University Of South Carolina Encapsulation and controlled release of small molecules for intracellular delivery using thermally responsive nanocapsules
CN101649034B (zh) * 2009-08-31 2011-05-25 苏州大学 pH/温度响应的双亲水性嵌段共聚物及其制备方法
JP5472072B2 (ja) * 2010-01-13 2014-04-16 信越化学工業株式会社 ネガ型レジスト組成物及びパターン形成方法
US8822550B2 (en) * 2010-03-23 2014-09-02 Kyushu University, National University Corporation Temperature-, pH- or salt concentration-sensitive separation material and use thereof
WO2012174287A1 (en) * 2011-06-15 2012-12-20 The Board Of Regents Of The University Of Texas System Luminescent nanoparticle compositions
TWI462753B (zh) * 2011-11-29 2014-12-01 Univ Nat Chiao Tung 雙乳化核殼奈米結構及其製備方法
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CN102964547B (zh) * 2012-12-05 2014-07-09 南通大学 一种嵌段结构pH响应型糖基智能水凝胶及其制备方法
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WO2015082656A1 (en) * 2013-12-04 2015-06-11 Nexdot Nanoparticles complexed with functionalizable enhanced affinity ligands and use thereof
US10953110B2 (en) 2014-04-25 2021-03-23 Board Of Regents, The University Of Texas System Dual emissive metal nanoparticles as ratiometric pH indicators
JP6254045B2 (ja) * 2014-05-20 2017-12-27 キリン株式会社 細胞内の温度を測定するためのレシオ型蛍光性プローブ
SG11201610433PA (en) * 2014-06-13 2017-01-27 Agency Science Tech & Res A copolymer and a micellar particle comprising the copolymer
CN104382851B (zh) * 2014-10-17 2018-12-28 南开大学 一种智能靶向载药复合胶束的制备方法
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JPH08311290A (ja) * 1995-05-23 1996-11-26 Showa Denko Kk 吸液材料用組成物、吸液材料成形体およびその製造方法
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US8541013B2 (en) 2013-09-24
EP1765894B1 (en) 2012-03-28
EP1765894B9 (en) 2012-08-01
JP2008502785A (ja) 2008-01-31
EP1765894A1 (en) 2007-03-28
WO2005121196A1 (en) 2005-12-22
EP1765894A4 (en) 2010-11-03
ATE551371T1 (de) 2012-04-15
US20050277739A1 (en) 2005-12-15
US20080182959A1 (en) 2008-07-31
US7316816B2 (en) 2008-01-08
CN100582130C (zh) 2010-01-20
CN1984935A (zh) 2007-06-20

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