BR112017018345A2 - copolímeros como excipientes para a solubilização eficaz de substâncias fracamente solúveis em água a partir de misturas sólidas - Google Patents

copolímeros como excipientes para a solubilização eficaz de substâncias fracamente solúveis em água a partir de misturas sólidas

Info

Publication number
BR112017018345A2
BR112017018345A2 BR112017018345A BR112017018345A BR112017018345A2 BR 112017018345 A2 BR112017018345 A2 BR 112017018345A2 BR 112017018345 A BR112017018345 A BR 112017018345A BR 112017018345 A BR112017018345 A BR 112017018345A BR 112017018345 A2 BR112017018345 A2 BR 112017018345A2
Authority
BR
Brazil
Prior art keywords
excipients
copolymers
soluble substances
poorly water
water soluble
Prior art date
Application number
BR112017018345A
Other languages
English (en)
Inventor
S Bates Frank
M Ting Jeffrey
Widanapathirana Lakmini
Guo Li
J Guillaudeu Steven
Tale Swapnil
M Reineke Theresa
Original Assignee
Dow Global Technologies Llc
Univ Minnesota
Rohm & Haas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Global Technologies Llc, Univ Minnesota, Rohm & Haas filed Critical Dow Global Technologies Llc
Publication of BR112017018345A2 publication Critical patent/BR112017018345A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/56—Acrylamide; Methacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F226/06—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
    • C08F226/10—N-Vinyl-pyrrolidone

Abstract

a presente invenção se refere ao uso de copolímeros não reticulados tendo uma cadeia principal compreendendo: i) uma pluralidade de unidades estruturais termorresponsivas derivadas de um ou mais de um monômero de (alquil) acrilamida substituída por nalquil ou n,n-dialquil e ii) uma pluralidade de unidades estruturais hidrofílicas derivadas de um ou mais de um segundo monômero etilenicamente insaturado como excipientes em misturas sólidas com substâncias fracamente solúveis em água para a solubilização eficaz desta última no meio aquoso. formas de dosagem sólidas compreendendo uma mistura sólida desse(s) copolímero(s) e substância(s) fracamente solúvel(is) em água também fazem parte do escopo da invenção.
BR112017018345A 2015-03-04 2016-02-24 copolímeros como excipientes para a solubilização eficaz de substâncias fracamente solúveis em água a partir de misturas sólidas BR112017018345A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562127874P 2015-03-04 2015-03-04
PCT/US2016/019342 WO2016140845A1 (en) 2015-03-04 2016-02-24 Copolymers as excipients for effective solubilization of poorly water-soluble substances from solid mixtures

Publications (1)

Publication Number Publication Date
BR112017018345A2 true BR112017018345A2 (pt) 2018-04-17

Family

ID=55861123

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017018345A BR112017018345A2 (pt) 2015-03-04 2016-02-24 copolímeros como excipientes para a solubilização eficaz de substâncias fracamente solúveis em água a partir de misturas sólidas

Country Status (7)

Country Link
US (1) US10717799B2 (pt)
EP (1) EP3265062B1 (pt)
JP (1) JP6721603B2 (pt)
KR (1) KR20170126936A (pt)
CN (1) CN107406556B (pt)
BR (1) BR112017018345A2 (pt)
WO (1) WO2016140845A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11667784B2 (en) 2017-07-24 2023-06-06 Regents Of The University Of Minnesota Copolymers including cinchona alkaloid components and one or more acrylamide or acrylate containing components, complexes containing the same, and methods of using the
CN108785260B (zh) * 2018-06-20 2020-06-02 华中科技大学 温敏性非甾体抗炎药固体分散体和速溶片及其制备方法
TW202203964A (zh) 2020-04-17 2022-02-01 小利蘭史丹佛大學董事會 用於生物醫藥調配物之聚合物賦形劑
WO2023230046A1 (en) * 2022-05-23 2023-11-30 Surf Bio, Inc. Polymer excipients comprising n,n-diethylacrylamide (dea) for biopharmaceutical formulations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6372251B2 (en) 1999-06-11 2002-04-16 Abbott Laboratories Formulations comprising lipid-regulating agents
EP1072617A1 (en) 1999-07-30 2001-01-31 Universiteit van Utrecht Temperature sensitive polymers
US7425581B2 (en) * 1999-07-30 2008-09-16 Universiteit Utrecht Temperature sensitive polymers
US20050158271A1 (en) * 2000-10-11 2005-07-21 Lee Sang C. Pharmaceutical applications of hydrotropic polymer micelles
CN1197888C (zh) * 2001-12-31 2005-04-20 财团法人工业技术研究院 热敏性水溶性高分子材料
US7316816B2 (en) * 2004-06-10 2008-01-08 Agency For Science Technology And Research Temperature and pH sensitive copolymers
US9987221B2 (en) * 2007-08-23 2018-06-05 Boston Scientific Scimed, Inc. Injectable hydrogel compositions
US20120183500A1 (en) * 2010-07-20 2012-07-19 Surmodics, Inc. Articles and methods including stable thermally-responsive polymers
EP2958557B1 (en) * 2013-02-25 2019-11-27 University Of Rochester Nanoparticles for controlled release of anti-biofilm agents

Also Published As

Publication number Publication date
US20180066091A1 (en) 2018-03-08
JP6721603B2 (ja) 2020-07-15
EP3265062A1 (en) 2018-01-10
CN107406556A (zh) 2017-11-28
KR20170126936A (ko) 2017-11-20
US10717799B2 (en) 2020-07-21
EP3265062B1 (en) 2019-05-22
WO2016140845A1 (en) 2016-09-09
JP2018510854A (ja) 2018-04-19
CN107406556B (zh) 2020-07-17

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B25A Requested transfer of rights approved

Owner name: ROHM AND HAAS COMPANY (US) ; REGENTS OF THE UNIVERSITY OF MINNESOTA (US) ; THE DOW CHEMICAL COMPANY (US)

B25A Requested transfer of rights approved

Owner name: ROHM AND HAAS COMPANY (US) ; REGENTS OF THE UNIVERSITY OF MINNESOTA (US) ; DDP SPECIALTY ELECTRONIC MATERIALS US, INC. (US)

B25D Requested change of name of applicant approved

Owner name: ROHM AND HAAS COMPANY (US) ; REGENTS OF THE UNIVERSITY OF MINNESOTA (US) ; DDP SPECIALTY ELECTRONIC MATERIALS US, LLC (US)

B25A Requested transfer of rights approved

Owner name: ROHM AND HAAS COMPANY (US) ; REGENTS OF THE UNIVERSITY OF MINNESOTA (US) ; NUTRITION AND BIOSCIENCES USA 1, LLC (US)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2711 DE 20-12-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.