RU2015153913A - Полимерная мицеллярная фармацевтическая композиция - Google Patents
Полимерная мицеллярная фармацевтическая композиция Download PDFInfo
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- RU2015153913A RU2015153913A RU2015153913A RU2015153913A RU2015153913A RU 2015153913 A RU2015153913 A RU 2015153913A RU 2015153913 A RU2015153913 A RU 2015153913A RU 2015153913 A RU2015153913 A RU 2015153913A RU 2015153913 A RU2015153913 A RU 2015153913A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyamides (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Claims (19)
1. Полимерная мицеллярная фармацевтическая композиция, включающая:
звено α блок-сополимера, которое имеет гидрофильный сегмент полимерной цепи и гидрофобный сегмент полимерной цепи;
звено β блок-сополимера, которое имеет гидрофильный сегмент полимерной цепи и гидрофобный сегмент полимерной цепи; и
звено γ блок-сополимера, которое имеет гидрофильный сегмент полимерной цепи, который имеет сайт связывания мишени, связанный с ним, и гидрофобный сегмент полимерной цепи,
где:
звено β блок-сополимера имеет лекарственное средство, связанное с ним;
звено α блок-сополимера не содержит сайт связывания мишени и лекарственное средство;
звено α блок-сополимера, звено β блок-сополимера и звено γ блок-сополимера расположены радиально в состоянии, в котором гидрофильные сегменты полимерной цепи направлены наружу и гидрофобные сегменты полимерной цепи направлены внутрь;
гидрофобный сегмент полимерной цепи звена α блок-сополимера образован из повторяющихся звеньев, которые имеют боковые цепи, по меньшей мере одна из боковых цепей имеет гидрофильную группу; и
содержание звена α блок-сополимера составляет 15% масс. или больше.
2. Полимерная мицеллярная фармацевтическая композиция по п. 1, где от 20% до 80% боковых цепей гидрофобного сегмента полимерной цепи звена α блок-сополимера имеют гидрофильную группу.
3. Полимерная мицеллярная фармацевтическая композиция по п. 1 или 2, где содержание звена α блок-сополимера составляет 80% масс. или меньше.
4. Полимерная мицеллярная фармацевтическая композиция по любому одному из пп. 1-3, где гидрофильный сегмент полимерной цепи каждого из звеньев α и β блок-сополимера содержит цепь полиэтиленгликоля и гидрофобный сегмент полимерной цепи каждого из звеньев α и β блок-сополимера содержит цепь полиаминокислоты.
5. Полимерная мицеллярная фармацевтическая композиция по любому одному из пп. 1-4, где звено α блок-сополимера имеет более низкую гидрофобность, чем звено β блок-сополимера, из-за гидрофильной группы(групп) боковых цепей гидрофобного сегмента полимерной цепи.
6. Полимерная мицеллярная фармацевтическая композиция по любому одному из пп. 1-5, где:
гидрофобный сегмент полимерной цепи звена β блок-сополимера образован из повторяющихся звеньев, которые имеют боковые цепи; и
число гидрофильных групп боковых цепей гидрофобного сегмента полимерной цепи звена α блок-сополимера больше, чем число гидрофильных групп боковых цепей гидрофобного сегмента полимерной цепи звена β блок-сополимера.
7. Полимерная мицеллярная фармацевтическая композиция по любому одному из пп. 1-6, где звено β блок-сополимера имеет более высокую гидрофобность, чем звено α блок-сополимера, из-за лекарственного средства.
8. Полимерная мицеллярная фармацевтическая композиция по любому одному из пп. 1-7, где звено β блок-сополимера, даже хотя и имеет больше гидрофильных групп, чем звено α блок-сополимера, имеет более высокую гидрофобность, чем звено α блок-сополимера, из-за лекарственного средства.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013-105465 | 2013-05-17 | ||
| JP2013105465 | 2013-05-17 | ||
| PCT/JP2014/063020 WO2014185504A1 (ja) | 2013-05-17 | 2014-05-16 | ポリマーミセル医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015153913A true RU2015153913A (ru) | 2017-06-22 |
| RU2015153913A3 RU2015153913A3 (ru) | 2018-04-25 |
Family
ID=51898479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015153913A RU2015153913A (ru) | 2013-05-17 | 2014-05-16 | Полимерная мицеллярная фармацевтическая композиция |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20160114058A1 (ru) |
| EP (1) | EP2997979A4 (ru) |
| JP (1) | JP5692887B1 (ru) |
| KR (1) | KR20160007529A (ru) |
| CN (1) | CN105377302B (ru) |
| AU (1) | AU2014266254B2 (ru) |
| BR (1) | BR112015028414A2 (ru) |
| CA (1) | CA2911495A1 (ru) |
| HK (2) | HK1217905A1 (ru) |
| MX (1) | MX2015015334A (ru) |
| RU (1) | RU2015153913A (ru) |
| SG (1) | SG11201509460UA (ru) |
| TW (1) | TWI632922B (ru) |
| WO (1) | WO2014185504A1 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012135831A1 (en) | 2011-04-01 | 2012-10-04 | Yale University | Cell-penetrating anti-dna antibodies and uses thereof inhibit dna repair |
| US10993960B1 (en) | 2014-05-08 | 2021-05-04 | Kawasaki Institute Of Industrial Promotion | Pharmaceutical composition |
| TW201737897A (zh) * | 2016-03-30 | 2017-11-01 | Nanocarrier Co Ltd | 高分子微胞醫藥組成物 |
| JP2019518040A (ja) | 2016-06-15 | 2019-06-27 | イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔｙ | 腫瘍に対して標的化されるナノキャリアの抗体媒介性自触反応的送達 |
| US20190330317A1 (en) | 2016-06-15 | 2019-10-31 | Yale University | Anti-guanosine antibody as a molecular delivery vehicle |
| WO2018025699A1 (ja) * | 2016-08-02 | 2018-02-08 | 日本化薬株式会社 | アクティブターゲティング型高分子誘導体、その高分子誘導体を含む組成物、及びそれらの用途 |
| EP4408457A1 (en) | 2021-09-30 | 2024-08-07 | Yale University | Compositions and methods for the treatment of autosomal dominant polycystic kidney disease and other diseases having upregulated mtor activity |
| WO2024050524A1 (en) | 2022-09-01 | 2024-03-07 | University Of Georgia Research Foundation, Inc. | Compositions and methods for directing apolipoprotein l1 to induce mammalian cell death |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5289096A (en) | 1995-04-14 | 1996-10-30 | Kazunori Kataoka | Polyethylene oxides having saccharide residue at one end and different functional group at another end, and process for producing the same |
| AU5346896A (en) | 1995-04-19 | 1996-11-07 | Kazunori Kataoka | Heterotelechelic block copolymers and process for producing the same |
| SI9620107A (sl) | 1995-08-10 | 1998-10-31 | Kazunori Kataoka | Blok polimer, ki ima funkcionalne skupine na obeh svojih koncih |
| ES2396134T3 (es) * | 2008-05-23 | 2013-02-19 | Nanocarrier Co., Ltd. | Derivado polimérico de docetaxel, método de preparación del mismo y sus usos |
| EP2133433A1 (en) * | 2008-06-09 | 2009-12-16 | Centre Georges François Leclerc | A method for predicting responsiveness to a treatment with an anti-HER2 antibody |
| EP2281576B1 (en) * | 2008-07-29 | 2013-07-24 | NanoCarrier Co., Ltd. | Active targeting type polymeric micelle carrying drug enclosed therein and medicinal composition |
| JP4829351B2 (ja) * | 2010-02-05 | 2011-12-07 | ナノキャリア株式会社 | 易崩壊型ポリマーミセル組成物 |
-
2014
- 2014-05-16 RU RU2015153913A patent/RU2015153913A/ru not_active Application Discontinuation
- 2014-05-16 EP EP14797011.5A patent/EP2997979A4/en not_active Withdrawn
- 2014-05-16 US US14/891,561 patent/US20160114058A1/en not_active Abandoned
- 2014-05-16 CN CN201480028651.XA patent/CN105377302B/zh not_active Expired - Fee Related
- 2014-05-16 MX MX2015015334A patent/MX2015015334A/es unknown
- 2014-05-16 CA CA2911495A patent/CA2911495A1/en not_active Abandoned
- 2014-05-16 AU AU2014266254A patent/AU2014266254B2/en not_active Expired - Fee Related
- 2014-05-16 BR BR112015028414A patent/BR112015028414A2/pt not_active IP Right Cessation
- 2014-05-16 TW TW103117309A patent/TWI632922B/zh not_active IP Right Cessation
- 2014-05-16 WO PCT/JP2014/063020 patent/WO2014185504A1/ja active Application Filing
- 2014-05-16 JP JP2014550568A patent/JP5692887B1/ja not_active Expired - Fee Related
- 2014-05-16 SG SG11201509460UA patent/SG11201509460UA/en unknown
- 2014-05-16 KR KR1020157032398A patent/KR20160007529A/ko not_active Application Discontinuation
-
2016
- 2016-05-24 HK HK16105898.4A patent/HK1217905A1/zh unknown
- 2016-07-28 HK HK16109033.2A patent/HK1220904A1/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1217905A1 (zh) | 2017-01-27 |
| WO2014185504A1 (ja) | 2014-11-20 |
| JP5692887B1 (ja) | 2015-04-01 |
| TW201524533A (zh) | 2015-07-01 |
| MX2015015334A (es) | 2016-03-04 |
| TWI632922B (zh) | 2018-08-21 |
| US20160114058A1 (en) | 2016-04-28 |
| RU2015153913A3 (ru) | 2018-04-25 |
| SG11201509460UA (en) | 2015-12-30 |
| AU2014266254A1 (en) | 2015-12-03 |
| EP2997979A1 (en) | 2016-03-23 |
| JPWO2014185504A1 (ja) | 2017-02-23 |
| BR112015028414A2 (pt) | 2017-07-25 |
| KR20160007529A (ko) | 2016-01-20 |
| WO2014185504A8 (ja) | 2015-01-22 |
| HK1220904A1 (zh) | 2017-05-19 |
| CN105377302B (zh) | 2018-05-11 |
| AU2014266254B2 (en) | 2018-12-13 |
| CN105377302A (zh) | 2016-03-02 |
| EP2997979A4 (en) | 2016-10-12 |
| CA2911495A1 (en) | 2014-11-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20190206 |