WO2014185504A8 - ポリマーミセル医薬組成物 - Google Patents

ポリマーミセル医薬組成物 Download PDF

Info

Publication number
WO2014185504A8
WO2014185504A8 PCT/JP2014/063020 JP2014063020W WO2014185504A8 WO 2014185504 A8 WO2014185504 A8 WO 2014185504A8 JP 2014063020 W JP2014063020 W JP 2014063020W WO 2014185504 A8 WO2014185504 A8 WO 2014185504A8
Authority
WO
WIPO (PCT)
Prior art keywords
polymer chain
pharmaceutical composition
chain segments
polymeric micelle
block copolymer
Prior art date
Application number
PCT/JP2014/063020
Other languages
English (en)
French (fr)
Other versions
WO2014185504A1 (ja
Inventor
加藤 泰己
充訓 原田
亮佑 田中
Original Assignee
ナノキャリア株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BR112015028414A priority Critical patent/BR112015028414A2/pt
Priority to RU2015153913A priority patent/RU2015153913A/ru
Priority to CN201480028651.XA priority patent/CN105377302B/zh
Priority to MX2015015334A priority patent/MX2015015334A/es
Application filed by ナノキャリア株式会社 filed Critical ナノキャリア株式会社
Priority to AU2014266254A priority patent/AU2014266254B2/en
Priority to SG11201509460UA priority patent/SG11201509460UA/en
Priority to JP2014550568A priority patent/JP5692887B1/ja
Priority to US14/891,561 priority patent/US20160114058A1/en
Priority to EP14797011.5A priority patent/EP2997979A4/en
Priority to CA2911495A priority patent/CA2911495A1/en
Priority to KR1020157032398A priority patent/KR20160007529A/ko
Publication of WO2014185504A1 publication Critical patent/WO2014185504A1/ja
Publication of WO2014185504A8 publication Critical patent/WO2014185504A8/ja
Priority to HK16105898.4A priority patent/HK1217905A1/zh
Priority to HK16109033.2A priority patent/HK1220904A1/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Polyamides (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

 親水性ポリマー鎖セグメントと疎水性ポリマー鎖セグメントとを有するブロックコポリマーユニットαおよびブロックコポリマーユニットβとを含むポリマーミセル医薬組成物であって、ブロックコポリマーユニットαおよびブロックコポリマーユニットβが、親水性ポリマー鎖セグメントを外側に向けるとともに疎水性ポリマー鎖セグメントを内側に向けた状態で放射状に配列しており、ブロックコポリマーユニットαの疎水性ポリマー鎖セグメントが側鎖を有する繰り返し単位で構成されており、側鎖の少なくとも1つが親水性基を有する、ポリマーミセル医薬組成物を提供する。
PCT/JP2014/063020 2013-05-17 2014-05-16 ポリマーミセル医薬組成物 WO2014185504A1 (ja)

Priority Applications (13)

Application Number Priority Date Filing Date Title
SG11201509460UA SG11201509460UA (en) 2013-05-17 2014-05-16 Polymeric micelle pharmaceutical composition
CN201480028651.XA CN105377302B (zh) 2013-05-17 2014-05-16 聚合物胶束医药组合物
MX2015015334A MX2015015334A (es) 2013-05-17 2014-05-16 Composicion farmaceutica de micela polimerica.
US14/891,561 US20160114058A1 (en) 2013-05-17 2014-05-16 Polymer micelle pharmaceutical composition
AU2014266254A AU2014266254B2 (en) 2013-05-17 2014-05-16 Polymeric micelle pharmaceutical composition
RU2015153913A RU2015153913A (ru) 2013-05-17 2014-05-16 Полимерная мицеллярная фармацевтическая композиция
JP2014550568A JP5692887B1 (ja) 2013-05-17 2014-05-16 ポリマーミセル医薬組成物
BR112015028414A BR112015028414A2 (pt) 2013-05-17 2014-05-16 composição farmacêutica de micela de polímero
EP14797011.5A EP2997979A4 (en) 2013-05-17 2014-05-16 PHARMACEUTICAL COMPOSITION BASED ON POLYMER MICELLES
CA2911495A CA2911495A1 (en) 2013-05-17 2014-05-16 Polymeric micelle pharmaceutical composition
KR1020157032398A KR20160007529A (ko) 2013-05-17 2014-05-16 중합체 미셀 의약 조성물
HK16105898.4A HK1217905A1 (zh) 2013-05-17 2016-05-24 聚合物膠束醫藥組合物
HK16109033.2A HK1220904A1 (zh) 2013-05-17 2016-07-28 聚合物膠束醫藥組合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013-105465 2013-05-17
JP2013105465 2013-05-17

Publications (2)

Publication Number Publication Date
WO2014185504A1 WO2014185504A1 (ja) 2014-11-20
WO2014185504A8 true WO2014185504A8 (ja) 2015-01-22

Family

ID=51898479

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2014/063020 WO2014185504A1 (ja) 2013-05-17 2014-05-16 ポリマーミセル医薬組成物

Country Status (14)

Country Link
US (1) US20160114058A1 (ja)
EP (1) EP2997979A4 (ja)
JP (1) JP5692887B1 (ja)
KR (1) KR20160007529A (ja)
CN (1) CN105377302B (ja)
AU (1) AU2014266254B2 (ja)
BR (1) BR112015028414A2 (ja)
CA (1) CA2911495A1 (ja)
HK (2) HK1217905A1 (ja)
MX (1) MX2015015334A (ja)
RU (1) RU2015153913A (ja)
SG (1) SG11201509460UA (ja)
TW (1) TWI632922B (ja)
WO (1) WO2014185504A1 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6178785B2 (ja) 2011-04-01 2017-08-09 イェール ユニバーシティーYale University 細胞浸透性抗dna抗体およびdna修復を阻害するためのその使用
US10993960B1 (en) 2014-05-08 2021-05-04 Kawasaki Institute Of Industrial Promotion Pharmaceutical composition
WO2017170846A1 (ja) * 2016-03-30 2017-10-05 ナノキャリア株式会社 ポリマーミセル医薬組成物
WO2017218825A1 (en) 2016-06-15 2017-12-21 Yale University Antibody-mediated autocatalytic, targeted delivery of nanocarriers to tumors
WO2017218824A1 (en) 2016-06-15 2017-12-21 Yale University Anti-guanosine antibody as a molecular delivery vehicle
EP3495406A4 (en) 2016-08-02 2020-04-01 Nippon Kayaku Kabushiki Kaisha ACTIVE TARGETING TYPE POLYMER DERIVATIVE, COMPOSITION CONTAINING SAID POLYMER DERIVATIVE, AND USES OF SAID POLYMER DERIVATIVE AND COMPOSITION THEREOF
WO2023056450A1 (en) 2021-09-30 2023-04-06 Yale University Compositions and methods for the treatment of autosomal dominant polycystic kidney disease and other diseases having upregulated mtor activity
WO2024050524A1 (en) 2022-09-01 2024-03-07 University Of Georgia Research Foundation, Inc. Compositions and methods for directing apolipoprotein l1 to induce mammalian cell death

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9620064A (sl) 1995-04-14 1998-06-30 Kazunori Kataoka Polioksietilen s sladkorjem na enem koncu in različno funkcionalno skupino na drugem koncu ter postopek za njegovo pripravo
RU2169742C2 (ru) 1995-04-19 2001-06-27 Катаока Казунори Гетеротелехелатный блок-сополимер и способ его получения
AU726749B2 (en) 1995-08-10 2000-11-16 Kazunori Kataoka Block polymer having functional groups on its both ends
CN102037058B (zh) * 2008-05-23 2013-08-07 那野伽利阿株式会社 多西紫杉醇高分子衍生物、及其制造方法及其用途
EP2133433A1 (en) * 2008-06-09 2009-12-16 Centre Georges François Leclerc A method for predicting responsiveness to a treatment with an anti-HER2 antibody
EP2281576B1 (en) * 2008-07-29 2013-07-24 NanoCarrier Co., Ltd. Active targeting type polymeric micelle carrying drug enclosed therein and medicinal composition
JP4829351B2 (ja) * 2010-02-05 2011-12-07 ナノキャリア株式会社 易崩壊型ポリマーミセル組成物

Also Published As

Publication number Publication date
KR20160007529A (ko) 2016-01-20
AU2014266254A1 (en) 2015-12-03
MX2015015334A (es) 2016-03-04
RU2015153913A (ru) 2017-06-22
HK1217905A1 (zh) 2017-01-27
CA2911495A1 (en) 2014-11-20
JPWO2014185504A1 (ja) 2017-02-23
TWI632922B (zh) 2018-08-21
RU2015153913A3 (ja) 2018-04-25
EP2997979A4 (en) 2016-10-12
AU2014266254B2 (en) 2018-12-13
EP2997979A1 (en) 2016-03-23
CN105377302B (zh) 2018-05-11
BR112015028414A2 (pt) 2017-07-25
HK1220904A1 (zh) 2017-05-19
TW201524533A (zh) 2015-07-01
WO2014185504A1 (ja) 2014-11-20
CN105377302A (zh) 2016-03-02
JP5692887B1 (ja) 2015-04-01
US20160114058A1 (en) 2016-04-28
SG11201509460UA (en) 2015-12-30

Similar Documents

Publication Publication Date Title
WO2014185504A8 (ja) ポリマーミセル医薬組成物
EP3363824A4 (en) Multicomponent copolymer, rubber composition, cross-linked rubber composition, rubber product, and tire
EP3191530A4 (en) Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
MX2020000970A (es) Materiales forosos a partir de arquitecturas de copolímeros en bloque complejas.
MX355924B (es) Composicion hemostatica.
SG11201507465YA (en) Copolymer having amphiphilic blocks, and use thereof for manufacturing polymer filtration membranes
EP4245564A3 (en) Wheel for a vehicle
EP3241852A4 (en) Hyaluronic acid-based amphiphilic polymer, preparation method and application thereof
EP3313939A4 (en) LATEX PRODUCTS HAVING POLYMERIC POLYMERS AND ADDUCTS AS FAST-TAKING ADDITIVES
EP4257639A3 (en) Polyethylene polymers and articles made therefrom
EP3521324A4 (en) SOLID CATALYST COMPONENT FOR OLEFIN POLYMERIZATION, PROCESS FOR MANUFACTURING A SOLID CATALYST COMPONENT FOR OLEFIN POLYMERIZATION, CATALYST FOR OLEFIN POLYMERIZATION AND PROPERTY PROPERTY AND PROPERTY CYLINDER MANUFACTURING PROPERTY PROPERTY
EP3452426A4 (en) HIGH TO MEDIUM REDUCING WATER REDUCING POLYMER WITH MIXED POLYOXYALKYLENE SIDE CHAINS
EP3459546A4 (en) POLYMER TARGETING CONJUGATE WITH MULTIPLE ANTICANCER ARMS
EP3363839A4 (en) MULTICOMPONENT COPOLYMER, RUBBER COMPOSITION, NETWORKED RUBBER COMPOSITION, AND RUBBER ARTICLES
EP3445771A4 (en) BIOCOMPATIBLE POLYMERIC MEMBRANES
EP3680259A4 (en) POLYMERIZATION CATALYST COMPOSITION, POLYMER MANUFACTURING PROCESS, POLYMER, RUBBER COMPOSITION AND TIRES
EP3284474A4 (en) Polyion complex of poly(l-arginine) segment-containing block copolymer and polyanionic polymer
EP3517131A4 (en) MOLECULAR ASSEMBLY CONTAINING A MEDICINAL AGENT USING AN AMPHIPHILIC SEQUENCED POLYMER
EP3383524A4 (en) MIXTURE OF ZWITTERIONIC SULFONATED POLYMERS AND HOLLOW FIBER MEMBRANE
EP3567074A4 (en) MODIFIED POLYMER BASED ON CONJUGATED SERVES WITH MODIFIED POLYMERIZATION INITIATOR AND FUNCTIONAL GROUP DERIVED FROM THIS
EP3205688A4 (en) Amphiphilic polymer
EP3394024A4 (en) POLYMERIC BIOMATERIALS DERIVED FROM PHENOLIC MONOMERS AND THEIR MEDICAL USES
EP3674347A4 (en) ETHYLENEIMINE POLYMER SOLUTION AND ITS PRODUCTION PROCESS
EP3392277A4 (en) METHOD FOR PRODUCING A SOLID CATALYST COMPONENT FOR ALPHA OLEFINE POLYMERIZATION AND METHOD FOR PRODUCING AN ALPHA OLEFINE POLYMER THEREWITH
EP3431483A4 (en) METALLOCENE COMPOUND, OLEFIN POLYMERIZATION CATALYST COMPONENT AND OLEFIN POLYMERIZATION CATALYST COMPRISING EACH THEREOF, AND METHOD FOR PRODUCING OLEFIN POLYMER USING THE OLEFIN POLYMERIZATION CATALYST

Legal Events

Date Code Title Description
ENP Entry into the national phase

Ref document number: 2014550568

Country of ref document: JP

Kind code of ref document: A

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14797011

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: MX/A/2015/015334

Country of ref document: MX

ENP Entry into the national phase

Ref document number: 2911495

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2014797011

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 20157032398

Country of ref document: KR

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 14891561

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2014266254

Country of ref document: AU

Date of ref document: 20140516

Kind code of ref document: A

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112015028414

Country of ref document: BR

ENP Entry into the national phase

Ref document number: 2015153913

Country of ref document: RU

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 112015028414

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20151112