WO2014185504A8 - ポリマーミセル医薬組成物 - Google Patents

ポリマーミセル医薬組成物 Download PDF

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Publication number
WO2014185504A8
WO2014185504A8 PCT/JP2014/063020 JP2014063020W WO2014185504A8 WO 2014185504 A8 WO2014185504 A8 WO 2014185504A8 JP 2014063020 W JP2014063020 W JP 2014063020W WO 2014185504 A8 WO2014185504 A8 WO 2014185504A8
Authority
WO
WIPO (PCT)
Prior art keywords
polymer chain
pharmaceutical composition
chain segments
polymeric micelle
block copolymer
Prior art date
Application number
PCT/JP2014/063020
Other languages
English (en)
French (fr)
Other versions
WO2014185504A1 (ja
Inventor
加藤　泰己
充訓 原田
亮佑 田中
Original Assignee
ナノキャリア株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2014266254A priority Critical patent/AU2014266254B2/en
Priority to CN201480028651.XA priority patent/CN105377302B/zh
Priority to JP2014550568A priority patent/JP5692887B1/ja
Priority to MX2015015334A priority patent/MX2015015334A/es
Application filed by ナノキャリア株式会社 filed Critical ナノキャリア株式会社
Priority to RU2015153913A priority patent/RU2015153913A/ru
Priority to BR112015028414A priority patent/BR112015028414A2/pt
Priority to US14/891,561 priority patent/US20160114058A1/en
Priority to CA2911495A priority patent/CA2911495A1/en
Priority to SG11201509460UA priority patent/SG11201509460UA/en
Priority to KR1020157032398A priority patent/KR20160007529A/ko
Priority to EP14797011.5A priority patent/EP2997979A4/en
Publication of WO2014185504A1 publication Critical patent/WO2014185504A1/ja
Publication of WO2014185504A8 publication Critical patent/WO2014185504A8/ja
Priority to HK16105898.4A priority patent/HK1217905A1/zh
Priority to HK16109033.2A priority patent/HK1220904A1/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Polyamides (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

　親水性ポリマー鎖セグメントと疎水性ポリマー鎖セグメントとを有するブロックコポリマーユニットαおよびブロックコポリマーユニットβとを含むポリマーミセル医薬組成物であって、ブロックコポリマーユニットαおよびブロックコポリマーユニットβが、親水性ポリマー鎖セグメントを外側に向けるとともに疎水性ポリマー鎖セグメントを内側に向けた状態で放射状に配列しており、ブロックコポリマーユニットαの疎水性ポリマー鎖セグメントが側鎖を有する繰り返し単位で構成されており、側鎖の少なくとも１つが親水性基を有する、ポリマーミセル医薬組成物を提供する。
PCT/JP2014/063020 2013-05-17 2014-05-16 ポリマーミセル医薬組成物 WO2014185504A1 (ja)

Priority Applications (13)

Application Number Priority Date Filing Date Title
BR112015028414A BR112015028414A2 (pt) 2013-05-17 2014-05-16 composição farmacêutica de micela de polímero
JP2014550568A JP5692887B1 (ja) 2013-05-17 2014-05-16 ポリマーミセル医薬組成物
MX2015015334A MX2015015334A (es) 2013-05-17 2014-05-16 Composicion farmaceutica de micela polimerica.
CA2911495A CA2911495A1 (en) 2013-05-17 2014-05-16 Polymeric micelle pharmaceutical composition
RU2015153913A RU2015153913A (ru) 2013-05-17 2014-05-16 Полимерная мицеллярная фармацевтическая композиция
CN201480028651.XA CN105377302B (zh) 2013-05-17 2014-05-16 聚合物胶束医药组合物
US14/891,561 US20160114058A1 (en) 2013-05-17 2014-05-16 Polymer micelle pharmaceutical composition
AU2014266254A AU2014266254B2 (en) 2013-05-17 2014-05-16 Polymeric micelle pharmaceutical composition
SG11201509460UA SG11201509460UA (en) 2013-05-17 2014-05-16 Polymeric micelle pharmaceutical composition
KR1020157032398A KR20160007529A (ko) 2013-05-17 2014-05-16 중합체 미셀 의약 조성물
EP14797011.5A EP2997979A4 (en) 2013-05-17 2014-05-16 PHARMACEUTICAL COMPOSITION BASED ON POLYMER MICELLES
HK16105898.4A HK1217905A1 (zh) 2013-05-17 2016-05-24 聚合物膠束醫藥組合物
HK16109033.2A HK1220904A1 (zh) 2013-05-17 2016-07-28 聚合物膠束醫藥組合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013-105465 2013-05-17
JP2013105465 2013-05-17

Publications (2)

Publication Number Publication Date
WO2014185504A1 WO2014185504A1 (ja) 2014-11-20
WO2014185504A8 true WO2014185504A8 (ja) 2015-01-22

Family

ID=51898479

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2014/063020 WO2014185504A1 (ja) 2013-05-17 2014-05-16 ポリマーミセル医薬組成物

Country Status (14)

Country Link
US (1) US20160114058A1 (ja)
EP (1) EP2997979A4 (ja)
JP (1) JP5692887B1 (ja)
KR (1) KR20160007529A (ja)
CN (1) CN105377302B (ja)
AU (1) AU2014266254B2 (ja)
BR (1) BR112015028414A2 (ja)
CA (1) CA2911495A1 (ja)
HK (2) HK1217905A1 (ja)
MX (1) MX2015015334A (ja)
RU (1) RU2015153913A (ja)
SG (1) SG11201509460UA (ja)
TW (1) TWI632922B (ja)
WO (1) WO2014185504A1 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012135831A1 (en) 2011-04-01 2012-10-04 Yale University Cell-penetrating anti-dna antibodies and uses thereof inhibit dna repair
JP6566936B2 (ja) 2014-05-08 2019-08-28 国立大学法人 東京大学 医薬組成物
TW201737897A (zh) * 2016-03-30 2017-11-01 Nanocarrier Co Ltd 高分子微胞醫藥組成物
CN109803687B (zh) 2016-06-15 2022-11-15 耶鲁大学 纳米载体向肿瘤的抗体介导的自催化靶向递送
US20190330317A1 (en) 2016-06-15 2019-10-31 Yale University Anti-guanosine antibody as a molecular delivery vehicle
US10973762B2 (en) 2016-08-02 2021-04-13 Nippon Kayaku Kabushiki Kaisha Active-targeting-type polymer derivative, composition containing said polymer derivative, and uses of said polymer derivative and said composition
WO2023056450A1 (en) 2021-09-30 2023-04-06 Yale University Compositions and methods for the treatment of autosomal dominant polycystic kidney disease and other diseases having upregulated mtor activity
WO2024050524A1 (en) 2022-09-01 2024-03-07 University Of Georgia Research Foundation, Inc. Compositions and methods for directing apolipoprotein l1 to induce mammalian cell death

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE226966T1 (de) 1995-04-14 2002-11-15 Kazunori Kataoka Polyethylenoxide mit einer saccharidgruppe an einem ende und einer anderen funktionellen gruppe am anderem ende sowie verfahren zu deren herstellung
RU2169742C2 (ru) 1995-04-19 2001-06-27 Катаока Казунори Гетеротелехелатный блок-сополимер и способ его получения
NZ313769A (en) 1995-08-10 2000-02-28 Kazunori Kataoka block polymer having a functional group presented on each end
KR20110020779A (ko) 2008-05-23 2011-03-03 나노캐리어 가부시키가이샤 도세탁셀 고분자 유도체 및 그 제조 방법 및 그 용도
EP2133433A1 (en) * 2008-06-09 2009-12-16 Centre Georges François Leclerc A method for predicting responsiveness to a treatment with an anti-HER2 antibody
CN101808668B (zh) * 2008-07-29 2012-06-27 那野伽利阿株式会社 药物内包活性靶向型高分子微团、医药组合物
JP4829351B2 (ja) * 2010-02-05 2011-12-07 ナノキャリア株式会社 易崩壊型ポリマーミセル組成物

Also Published As

Publication number Publication date
HK1220904A1 (zh) 2017-05-19
EP2997979A4 (en) 2016-10-12
RU2015153913A (ru) 2017-06-22
EP2997979A1 (en) 2016-03-23
KR20160007529A (ko) 2016-01-20
WO2014185504A1 (ja) 2014-11-20
JPWO2014185504A1 (ja) 2017-02-23
BR112015028414A2 (pt) 2017-07-25
CA2911495A1 (en) 2014-11-20
AU2014266254A1 (en) 2015-12-03
MX2015015334A (es) 2016-03-04
RU2015153913A3 (ja) 2018-04-25
JP5692887B1 (ja) 2015-04-01
CN105377302B (zh) 2018-05-11
HK1217905A1 (zh) 2017-01-27
US20160114058A1 (en) 2016-04-28
SG11201509460UA (en) 2015-12-30
AU2014266254B2 (en) 2018-12-13
CN105377302A (zh) 2016-03-02
TW201524533A (zh) 2015-07-01
TWI632922B (zh) 2018-08-21

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