CN100582130C - 新的温度和pH敏感性共聚物 - Google Patents

新的温度和pH敏感性共聚物 Download PDF

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Publication number
CN100582130C
CN100582130C CN200580023278A CN200580023278A CN100582130C CN 100582130 C CN100582130 C CN 100582130C CN 200580023278 A CN200580023278 A CN 200580023278A CN 200580023278 A CN200580023278 A CN 200580023278A CN 100582130 C CN100582130 C CN 100582130C
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copolymer
acid
composition
polymer
temperature
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CN1984935A (zh
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杨义燕
库马列什·索皮马思
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Agency for Science Technology and Research Singapore
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/62—Monocarboxylic acids having ten or more carbon atoms; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/04—Homopolymers or copolymers of esters
    • C08L33/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
    • C08L33/08—Homopolymers or copolymers of acrylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/24—Homopolymers or copolymers of amides or imides
    • C08L33/26—Homopolymers or copolymers of acrylamide or methacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
CN200580023278A 2004-06-10 2005-05-24 新的温度和pH敏感性共聚物 Expired - Fee Related CN100582130C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/865,681 2004-06-10
US10/865,681 US7316816B2 (en) 2004-06-10 2004-06-10 Temperature and pH sensitive copolymers

Publications (2)

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CN1984935A CN1984935A (zh) 2007-06-20
CN100582130C true CN100582130C (zh) 2010-01-20

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US (2) US7316816B2 (enExample)
EP (1) EP1765894B9 (enExample)
JP (1) JP4874969B2 (enExample)
CN (1) CN100582130C (enExample)
AT (1) ATE551371T1 (enExample)
WO (1) WO2005121196A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
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CN107406556A (zh) * 2015-03-04 2017-11-28 陶氏环球技术有限责任公司 作为用于不良水溶性物质从固体混合物有效增溶的赋形剂的共聚物
CN107397959A (zh) * 2017-07-28 2017-11-28 国家纳米科学中心 一种表面具有超微结构的纳米拮抗剂的制备方法和应用
CN110382005A (zh) * 2016-10-07 2019-10-25 于利希研究中心有限公司 通过脂质膜的合成聚合物移位

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US7316816B2 (en) * 2004-06-10 2008-01-08 Agency For Science Technology And Research Temperature and pH sensitive copolymers
KR100665672B1 (ko) 2005-04-13 2007-01-09 성균관대학교산학협력단 새로운 온도 및 ｐＨ 민감성 블록 공중합체 및 이를 이용한고분자 하이드로겔
US8021689B2 (en) * 2006-02-21 2011-09-20 Ecole Polytechnique Federale de Lausanne (“EPFL”) Nanoparticles for immunotherapy
WO2008004978A1 (en) * 2006-07-05 2008-01-10 Agency For Science, Technology And Research Micelles for drug delivery
CN101605827B (zh) * 2006-12-12 2012-08-08 联合利华公司 聚合物
KR100868724B1 (ko) 2007-05-30 2008-11-13 한국생산기술연구원 가역적 온도감응성을 가지는 자기집합성 나노운반체의제조방법
GB0712482D0 (en) * 2007-06-27 2007-08-08 Eastman Kodak Co Thermally-responsive dispersants for media formulations
KR101470679B1 (ko) * 2007-07-19 2014-12-08 올엑셀, 인크. 항암제로서의 자기 조립형 양친매성 중합체
US9987221B2 (en) * 2007-08-23 2018-06-05 Boston Scientific Scimed, Inc. Injectable hydrogel compositions
WO2009036368A2 (en) * 2007-09-14 2009-03-19 Nitto Denko Corporation Drug carriers
US8703194B2 (en) * 2007-11-02 2014-04-22 Agency For Science, Technology And Research Stimulus-responsive biodegradable polymers and methods of preparation
US8597269B2 (en) * 2008-04-11 2013-12-03 Medtronic Minimed, Inc. Reservoir seal retainer systems and methods
FR2930444B1 (fr) * 2008-04-29 2010-06-04 Servier Lab Micelles polymerisees
JP5382567B2 (ja) * 2008-05-02 2014-01-08 公立大学法人大阪府立大学 温度感受性リポソーム
EP2128180A1 (en) * 2008-05-29 2009-12-02 Unilever N.V. Amphiphilic branched polymers and their use as emulsifiers
US8318207B2 (en) * 2009-02-12 2012-11-27 University Of South Carolina Encapsulation and controlled release of small molecules for intracellular delivery using thermally responsive nanocapsules
CN101649034B (zh) * 2009-08-31 2011-05-25 苏州大学 pH/温度响应的双亲水性嵌段共聚物及其制备方法
JP5472072B2 (ja) * 2010-01-13 2014-04-16 信越化学工業株式会社 ネガ型レジスト組成物及びパターン形成方法
US8822550B2 (en) * 2010-03-23 2014-09-02 Kyushu University, National University Corporation Temperature-, pH- or salt concentration-sensitive separation material and use thereof
WO2012174287A1 (en) * 2011-06-15 2012-12-20 The Board Of Regents Of The University Of Texas System Luminescent nanoparticle compositions
TWI462753B (zh) * 2011-11-29 2014-12-01 Univ Nat Chiao Tung 雙乳化核殼奈米結構及其製備方法
EP2859088A4 (en) 2012-06-07 2016-04-13 Univ Queensland RELEASE MEDIA
CN102964547B (zh) * 2012-12-05 2014-07-09 南通大学 一种嵌段结构pH响应型糖基智能水凝胶及其制备方法
CN103694426B (zh) * 2013-11-25 2015-10-21 同济大学 一种含碱基对的多重响应型聚合物的制备方法
US10465030B2 (en) 2013-12-04 2019-11-05 Nexdot Nanoparticles complexed with functionalizable enhanced affinity ligands and use thereof
US10953110B2 (en) 2014-04-25 2021-03-23 Board Of Regents, The University Of Texas System Dual emissive metal nanoparticles as ratiometric pH indicators
JP6254045B2 (ja) * 2014-05-20 2017-12-27 キリン株式会社 細胞内の温度を測定するためのレシオ型蛍光性プローブ
WO2015191009A1 (en) * 2014-06-13 2015-12-17 Agency For Science, Technology And Research A copolymer and a micellar particle comprising the copolymer
CN104382851B (zh) * 2014-10-17 2018-12-28 南开大学 一种智能靶向载药复合胶束的制备方法
CN105131199B (zh) * 2015-08-28 2018-01-23 吴奇 一种制剂及其制备方法与应用
JP6638706B2 (ja) * 2016-08-03 2020-01-29 東ソー株式会社 ブロック共重合体およびそれを用いた表面処理剤
US20190358341A1 (en) * 2016-12-23 2019-11-28 Commonwealth Scientific And Industrial Research Organisation Biocompatible and hydrophilic polymer conjugate for targeted delivery of an agent
CN106977674B (zh) * 2017-03-09 2018-12-21 浙江理工大学 一种pH响应型抗菌聚合物纳米颗粒及其制备方法
JP2018154752A (ja) * 2017-03-17 2018-10-04 東ソー株式会社 共重合体およびその製造方法
WO2018183624A1 (en) 2017-03-29 2018-10-04 The Regents Of The University Of Colorado, A Body Corporate Reverse thermal gels and their use as vascular embolic repair agents
CN107432934A (zh) * 2017-04-24 2017-12-05 合肥工业大学 一种嵌段型支化聚合物药物载体及其制备方法和应用
CN110538618B (zh) * 2018-05-28 2022-01-14 浙江工业大学 一种以核壳结构微凝胶作为开关的温度和pH双响应智能开关膜的制备方法
WO2020210533A1 (en) * 2019-04-12 2020-10-15 The Regents Of The University Of Michigan Tri-block copolymers and nano-fibrous gelling microspheres including the same
CN111269365B (zh) * 2019-04-15 2021-04-27 中国农业科学院农业质量标准与检测技术研究所 一种温敏Wulff型硼亲和纳米颗粒及其制备方法与用途
CN111595954B (zh) * 2019-11-18 2022-07-15 远大医药（中国）有限公司 吲达帕胺原料药中dcc和dcu含量的检测方法
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CN116178699B (zh) * 2022-09-09 2024-12-03 浙江大学医学院附属第一医院 一种可促进药物入胞的药物递送载体材料及其制备方法和应用
WO2025145010A1 (en) * 2023-12-29 2025-07-03 The University Of Chicago Amphiphilic block copolymers, polymersomes, and methods of use

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107406556A (zh) * 2015-03-04 2017-11-28 陶氏环球技术有限责任公司 作为用于不良水溶性物质从固体混合物有效增溶的赋形剂的共聚物
CN107406556B (zh) * 2015-03-04 2020-07-17 陶氏环球技术有限责任公司 作为用于不良水溶性物质从固体混合物有效增溶的赋形剂的共聚物
CN110382005A (zh) * 2016-10-07 2019-10-25 于利希研究中心有限公司 通过脂质膜的合成聚合物移位
CN110382005B (zh) * 2016-10-07 2022-12-13 于利希研究中心有限公司 穿过脂质膜移位的合成聚合物及其用途
CN107397959A (zh) * 2017-07-28 2017-11-28 国家纳米科学中心 一种表面具有超微结构的纳米拮抗剂的制备方法和应用
CN107397959B (zh) * 2017-07-28 2020-10-16 国家纳米科学中心 一种表面具有超微结构的纳米拮抗剂的制备方法和应用

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US7316816B2 (en) 2008-01-08
JP2008502785A (ja) 2008-01-31
EP1765894A1 (en) 2007-03-28
US20080182959A1 (en) 2008-07-31
WO2005121196A1 (en) 2005-12-22
EP1765894B9 (en) 2012-08-01
EP1765894A4 (en) 2010-11-03
ATE551371T1 (de) 2012-04-15
US20050277739A1 (en) 2005-12-15
CN1984935A (zh) 2007-06-20
US8541013B2 (en) 2013-09-24
JP4874969B2 (ja) 2012-02-15
EP1765894B1 (en) 2012-03-28

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