JP4837812B2 - 微粉砕粉末カロテノイド製剤の製造 - Google Patents

微粉砕粉末カロテノイド製剤の製造 Download PDF

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Publication number
JP4837812B2
JP4837812B2 JP04259499A JP4259499A JP4837812B2 JP 4837812 B2 JP4837812 B2 JP 4837812B2 JP 04259499 A JP04259499 A JP 04259499A JP 4259499 A JP4259499 A JP 4259499A JP 4837812 B2 JP4837812 B2 JP 4837812B2
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Japan
Prior art keywords
heat exchanger
suspension
solution
kettle
carotene
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Expired - Fee Related
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JP04259499A
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Japanese (ja)
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JP2000186224A (ja
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ヘルマン・シュタイン
クラウス・ヴィアドー
ビン・ヤング
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DSM IP Assets BV
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DSM IP Assets BV
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/24Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L5/00Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/40Colouring or decolouring of foods
    • A23L5/42Addition of dyes or pigments, e.g. in combination with optical brighteners
    • A23L5/43Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives
    • A23L5/44Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives using carotenoids or xanthophylls

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Fodder In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP04259499A 1998-02-23 1999-02-22 微粉砕粉末カロテノイド製剤の製造 Expired - Fee Related JP4837812B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98103113.1 1998-02-23
EP98103113 1998-02-23

Publications (2)

Publication Number Publication Date
JP2000186224A JP2000186224A (ja) 2000-07-04
JP4837812B2 true JP4837812B2 (ja) 2011-12-14

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JP04259499A Expired - Fee Related JP4837812B2 (ja) 1998-02-23 1999-02-22 微粉砕粉末カロテノイド製剤の製造

Country Status (16)

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US (1) US6406735B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0937412B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP4837812B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR100695589B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1173637C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU743535B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BR9900776A8 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2261456A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE69929641T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2257828T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ID (1) ID23623A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN1999CH00212A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX224632B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO315892B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH11999000351B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW565434B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE292455T1 (de) * 1999-12-09 2005-04-15 Dsm Ip Assets Bv Fettlösliche vitamine enthaltende zusammensetzungen
WO2002008182A1 (es) * 2000-07-13 2002-01-31 Vitatene, S.A. Procedimiento para la produccion de una formulacion dispersable en agua que contiene carotenoides
DK1213013T3 (da) * 2000-11-29 2007-07-02 Basf Ag Fremgangsmåde til fremstilling af faste præparater af vandoplöselige, tungt vandoplöselige eller vanduoplöselige aktive stoffer
US7105176B2 (en) 2000-11-29 2006-09-12 Basf Aktiengesellschaft Production of solid preparations of water-soluble, sparingly water-soluble or water-insoluble active compounds
DE10064387A1 (de) 2000-12-21 2002-06-27 Basf Ag Verfahren zur Herstellung von Trockenpulvern eines oder mehrerer Sauerstoff-haltiger Carotinoide
ATE269301T1 (de) 2001-01-24 2004-07-15 Kuraray Co Verfahren zur herstellung von carotinoid emulsionen
DE10104494A1 (de) * 2001-01-31 2002-08-01 Basf Ag Verfahren zur Herstellung von Trockenpulvern eines oder mehrerer Carotinoide
MXPA04001079A (es) * 2001-08-13 2004-05-20 Dsm Ip Assets Bv Composiciones que comprenden pectina de remolacha azucarera y carotenoides.
US6811801B2 (en) * 2001-12-12 2004-11-02 Abbott Laboratories Methods and compositions for brightening the color of thermally processed nutritionals
ES2189697B1 (es) * 2001-12-28 2005-02-01 Antibioticos, S.A.U. Procedimiento para obtener nuevas formulaciones a base de luteina.
ES2297125T5 (es) 2002-02-06 2013-07-03 Dsm Ip Assets B.V. Ésteres de astaxantina
US6936279B2 (en) * 2002-06-18 2005-08-30 Zeavision Llc Microcrystalline zeaxanthin with high bioavailability in oily carrier formulations
EP1405572A1 (en) * 2002-10-04 2004-04-07 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Modified lupin proteins for the preparation of water dispersible product forms of fat soluble compounds
WO2004087645A1 (ja) * 2003-03-28 2004-10-14 Kuraray Co., Ltd. カロテノイド乳化液の製造方法
KR20040098887A (ko) * 2003-05-16 2004-11-26 주식회사 마린프로덕트테크 지용성 아스타산틴 등의 수용화 조제 방법
CN100383194C (zh) * 2004-02-17 2008-04-23 章浩龙 一种液状分散染料的制造方法
DE102004030072A1 (de) * 2004-06-23 2006-01-19 Basf Ag Wässrige Dispersionen schwer wasserlöslicher oder wasserunlöslicher Wirkstoffe und daraus hergestellte Trockenpulver
US10463061B2 (en) 2004-11-19 2019-11-05 Dsm Ip Assets B.V. Modified plant gums for preparations of active ingredients
AU2006251391B2 (en) 2005-05-23 2011-10-06 Phares Pharmaceutical Research N.V. Direct dissolution
DE102005030952A1 (de) 2005-06-30 2007-01-18 Basf Ag Verfahren zur Herstellung einer wässrigen Suspension und einer pulverförmigen Zubereitung eines oder mehrerer Carotinoide
CN101312655B (zh) * 2005-07-20 2012-02-29 帝斯曼知识产权资产管理有限公司 新颖的稳定的类胡萝卜素组合物
ES2279695B1 (es) * 2005-08-01 2008-08-01 Jesus Antas Pharma, S.A. Nuevas formulaciones solidas de carotenoides y procedimiento para su obtencion.
CN101243032B (zh) * 2005-08-15 2012-10-10 法雷斯药品研究公司 虾青素的晶型
EP1886584A1 (en) * 2006-08-08 2008-02-13 Indena S.P.A. Stable and bioavailable compositions of isomers of lycopene for skin and hair
US7435846B2 (en) * 2006-08-18 2008-10-14 Industrial Organica, S.A. De C.V. Absorption and bioavailability of carotenoids, formulations and applications
EP2111125B2 (de) 2007-01-16 2016-11-16 Basf Se Flüssige formulierungen enthaltend carotinoide
EP1967081A1 (en) * 2007-03-05 2008-09-10 DSMIP Assets B.V. Process for the manufacture of a powder containing carotenoids
US9707185B2 (en) * 2007-05-07 2017-07-18 Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College Water-soluble nanoparticles containing water-insoluble compounds
ES2731881T3 (es) 2007-09-25 2019-11-19 Formulex Pharma Innovations Ltd Composiciones que comprenden compuestos activos lipófilos y método para su preparación
CN101396068B (zh) * 2007-09-27 2013-05-01 浙江医药股份有限公司新昌制药厂 类胡萝卜素制剂及其应用和包含该制剂的饲料及其制备方法
US11185093B2 (en) 2007-11-29 2021-11-30 Christian Köpsel Pulverulent carotenoid preparation for colouring drinks
KR20100097666A (ko) * 2007-12-05 2010-09-03 디에스엠 아이피 어셋츠 비.브이. 지용성 활성 성분의 분말 제형
JP2011505157A (ja) * 2007-12-05 2011-02-24 ディーエスエム アイピー アセッツ ビー.ブイ. 脂溶性活性成分の微粉砕状調合物
CN101297691B (zh) * 2008-06-06 2011-12-14 成都建福化学品有限公司 稳定的水溶性类胡萝卜素干粉的制备方法
JP5932334B2 (ja) 2008-10-07 2016-06-08 ビーエーエスエフ ソシエタス・ヨーロピアBasf Se すぐ使用できる安定なエマルション
EP2210593A3 (en) 2009-01-21 2011-05-18 DSM IP Assets B.V. Tablettable formulations of vitamin A and derivatives thereof
DK2403361T3 (da) * 2009-03-04 2013-04-08 Basf Se Fremgangsmåde til fremstilling af carotinoid-opløsninger
DK2403362T3 (da) * 2009-03-05 2013-04-15 Basf Se Pulverformede sammensætninger af astaxanthin-derivater II
WO2010111132A2 (en) 2009-03-27 2010-09-30 Bend Research, Inc. Spray-drying process
US20120039970A1 (en) 2009-03-30 2012-02-16 Basf Se Ready-to-use, stable suspension of partially amorphous carotenoid particles
PT2611529T (pt) 2010-09-03 2019-05-09 Bend Res Inc Método de secagem por pulverização
EP2611530B1 (en) 2010-09-03 2019-01-16 Bend Research, Inc. Spray-drying apparatus and methods of using the same
WO2012040502A1 (en) 2010-09-24 2012-03-29 Bend Research, Inc. High-temperature spray drying process and apparatus
US20130317098A1 (en) * 2010-11-26 2013-11-28 Christian Schaefer Protective hydrocolloid for active ingredients
US20120157547A1 (en) 2010-12-21 2012-06-21 Ricardo Montoya-Olvera Compositions and applications of carotenoids of improved absorption and bioavailability
US20140364512A9 (en) * 2012-04-19 2014-12-11 Epc (Beijing) Natural Products Co., Ltd. Compositions comprising a combination of at least one colorant and at least one polysaccharide
WO2015044212A1 (en) * 2013-09-24 2015-04-02 Dsm Ip Assets B.V. Stable red formulations for the coloration of beverages and food
WO2016044001A1 (en) * 2014-09-15 2016-03-24 Sustainable Aquatics, Inc. Method and apparatus for producing astaxanthin
JP6650933B2 (ja) 2014-10-31 2020-02-19 ベンド リサーチ, インコーポレイテッド マトリックス中に分散された活性薬剤ドメインを形成するためのプロセス
KR101700909B1 (ko) 2015-05-29 2017-02-14 주식회사 마크로케어 장쇄 레티닐 에스테르 제조를 위한 2상 반응 시스템 및 장쇄 레티닐 에스테르 제조방법
US10479906B2 (en) * 2015-09-18 2019-11-19 Oregon State University Use of fungal pigments from wood-staining fungi as colorants in wood finishes and paints
WO2018015346A1 (de) * 2016-07-19 2018-01-25 Basf Se Propylgallathaltige vitaminzubereitungen
CN106278976A (zh) * 2016-08-09 2017-01-04 嘉必优生物技术(武汉)股份有限公司 制备β‑胡萝卜素晶体的方法
CN106278977A (zh) * 2016-08-09 2017-01-04 嘉必优生物技术(武汉)股份有限公司 制备β‑胡萝卜素晶体的方法
CN106278978A (zh) * 2016-08-09 2017-01-04 嘉必优生物技术(武汉)股份有限公司 制备β‑胡萝卜素晶体的方法
WO2019068288A1 (de) 2017-10-04 2019-04-11 Berlimed International Research Gmbh Wirkstoff und wirkstoffmatrix enthaltendes produkt zur transdermalen wirkstoffabgabe sowie dessen herstellung und verwendung sowie die wirkstoffmatrix, ihre herstellung und verwendung
WO2019207083A1 (en) 2018-04-27 2019-10-31 Dsm Ip Assets B.V. Set-up for manufacturing spray-dried powders
TW201945474A (zh) 2018-04-27 2019-12-01 荷蘭商帝斯曼知識產權資產管理有限公司 噴霧乾燥粉末之連續製造技術
CN112040786A (zh) 2018-04-27 2020-12-04 帝斯曼知识产权资产管理有限公司 用于制造喷雾干燥粉末的方法
CN111471317B (zh) * 2020-03-26 2021-06-04 广东省农业科学院蚕业与农产品加工研究所 一种稳态化玉米黄色素及其制备方法
CN114287625B (zh) * 2021-12-28 2024-04-05 大连医诺生物股份有限公司 一种类胡萝卜素制剂及其应用
WO2024028398A1 (en) * 2022-08-05 2024-02-08 Dsm Ip Assets B.V. Solid formulations comprising beta-carotene

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2861891A (en) * 1956-12-13 1958-11-25 Hoffmann La Roche Water dispersible carotenoid compositions and process of making the same
US3110598A (en) * 1959-09-08 1963-11-12 Hoffmann La Roche Process of making a carotenoid preparation
DE1211911B (de) * 1959-09-08 1966-03-03 Hoffmann La Roche Verfahren zur Herstellung eines insbesondere zum Faerben von Lebens- und Futtermitteln geeigneten Carotinoidpraeparates
US3316101A (en) * 1965-08-03 1967-04-25 Hoffmann La Roche Stabilizing carotenoid compositions
CH522717A (de) * 1969-02-07 1972-06-30 Hoffmann La Roche Färbepräparat
US3790688A (en) * 1972-03-15 1974-02-05 Us Agriculture Water dispersible beta-carotene
US3998753A (en) * 1974-08-13 1976-12-21 Hoffmann-La Roche Inc. Water dispersible carotenoid preparations and processes thereof
DE3119383A1 (de) 1981-05-15 1982-12-02 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinodpraeparaten
DE3610191A1 (de) * 1986-03-26 1987-10-01 Basf Ag Verfahren zur herstellung von feinteiligen, wasserdispergierbaren carotinoid-praeparationen
DE3611229A1 (de) * 1986-04-04 1987-10-08 Basf Ag Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinoidpraeparaten
DK0410236T3 (da) * 1989-07-25 1993-12-13 Hoffmann La Roche Fremgangsmåde til fremstilling af caratenoidpræparater
DE19609538A1 (de) * 1996-03-11 1997-09-18 Basf Ag Feinverteilte Carotinoid- und Retinoidsuspensionen und Verfahren zu ihrer Herstellung
DE19838636A1 (de) * 1998-08-26 2000-03-02 Basf Ag Carotinoid-Formulierungen, enthaltend ein Gemisch aus beta-Carotin, Lycopin und Lutein

Also Published As

Publication number Publication date
NO315892B1 (no) 2003-11-10
CA2261456A1 (en) 1999-08-23
US6406735B2 (en) 2002-06-18
AU1836299A (en) 1999-09-09
BR9900776A (pt) 2000-03-28
EP0937412A1 (en) 1999-08-25
PH11999000351B1 (en) 2004-02-11
NO990852D0 (no) 1999-02-23
CN1231843A (zh) 1999-10-20
EP0937412B1 (en) 2006-02-01
DE69929641D1 (de) 2006-04-13
KR19990072792A (ko) 1999-09-27
US20010008644A1 (en) 2001-07-19
CN1173637C (zh) 2004-11-03
TW565434B (en) 2003-12-11
IN1999CH00212A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2007-05-18
BR9900776B1 (pt) 2011-05-31
JP2000186224A (ja) 2000-07-04
ES2257828T3 (es) 2006-08-01
KR100695589B1 (ko) 2007-03-14
DE69929641T2 (de) 2006-12-14
MX9901754A (es) 2000-02-28
AU743535B2 (en) 2002-01-31
ID23623A (id) 2000-05-04
NO990852L (no) 1999-08-24
MX224632B (es) 2004-12-03
BR9900776A8 (pt) 2018-03-20

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