JP4830075B2 - ケイ素含有化合物を含む抗ウィルス剤組成物、及び抗ウィルス剤固定化方法 - Google Patents
ケイ素含有化合物を含む抗ウィルス剤組成物、及び抗ウィルス剤固定化方法 Download PDFInfo
- Publication number
- JP4830075B2 JP4830075B2 JP2011008174A JP2011008174A JP4830075B2 JP 4830075 B2 JP4830075 B2 JP 4830075B2 JP 2011008174 A JP2011008174 A JP 2011008174A JP 2011008174 A JP2011008174 A JP 2011008174A JP 4830075 B2 JP4830075 B2 JP 4830075B2
- Authority
- JP
- Japan
- Prior art keywords
- antibacterial
- agent composition
- antiviral agent
- silicon
- antiviral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 161
- 239000002210 silicon-based material Substances 0.000 title claims abstract description 72
- 239000003443 antiviral agent Substances 0.000 title claims abstract description 44
- 238000000034 method Methods 0.000 title claims abstract description 33
- 230000003100 immobilizing effect Effects 0.000 title claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 151
- 241000700605 Viruses Species 0.000 claims abstract description 54
- -1 triethoxysilyl compound Chemical class 0.000 claims abstract description 44
- 238000004519 manufacturing process Methods 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 57
- 230000000840 anti-viral effect Effects 0.000 claims description 31
- 239000003093 cationic surfactant Substances 0.000 claims description 31
- 239000002888 zwitterionic surfactant Substances 0.000 claims description 18
- 125000004432 carbon atom Chemical group C* 0.000 claims description 15
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 11
- 229910052760 oxygen Inorganic materials 0.000 claims description 11
- 239000001301 oxygen Substances 0.000 claims description 11
- 125000000524 functional group Chemical group 0.000 claims description 10
- HRBYCVPFYWTROV-UHFFFAOYSA-M dimethyl-octadecyl-(3-triethoxysilylpropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCC[Si](OCC)(OCC)OCC HRBYCVPFYWTROV-UHFFFAOYSA-M 0.000 claims description 9
- 229910052736 halogen Inorganic materials 0.000 claims description 9
- 241001263478 Norovirus Species 0.000 claims description 8
- 241000282898 Sus scrofa Species 0.000 claims description 8
- 241000282414 Homo sapiens Species 0.000 claims description 7
- 241000712431 Influenza A virus Species 0.000 claims description 6
- 241000713196 Influenza B virus Species 0.000 claims description 4
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims description 4
- 125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 claims description 4
- 150000002500 ions Chemical class 0.000 claims description 4
- 241000271566 Aves Species 0.000 claims description 3
- 238000007598 dipping method Methods 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 100
- 239000003242 anti bacterial agent Substances 0.000 abstract description 75
- 238000004140 cleaning Methods 0.000 abstract description 33
- 239000002904 solvent Substances 0.000 abstract description 19
- 230000009849 deactivation Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 64
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 42
- 238000012360 testing method Methods 0.000 description 33
- 230000000249 desinfective effect Effects 0.000 description 24
- 238000011282 treatment Methods 0.000 description 24
- 239000004094 surface-active agent Substances 0.000 description 19
- 241000894006 Bacteria Species 0.000 description 16
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 16
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 16
- 241000712461 unidentified influenza virus Species 0.000 description 16
- 238000005406 washing Methods 0.000 description 16
- 230000015572 biosynthetic process Effects 0.000 description 14
- 238000004659 sterilization and disinfection Methods 0.000 description 14
- 238000003786 synthesis reaction Methods 0.000 description 14
- 208000015181 infectious disease Diseases 0.000 description 13
- 239000002280 amphoteric surfactant Substances 0.000 description 12
- 239000011521 glass Substances 0.000 description 12
- 239000002609 medium Substances 0.000 description 12
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 11
- 150000001412 amines Chemical class 0.000 description 11
- 210000004027 cell Anatomy 0.000 description 10
- 230000002779 inactivation Effects 0.000 description 10
- 239000007864 aqueous solution Substances 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 9
- 238000005507 spraying Methods 0.000 description 9
- 230000000087 stabilizing effect Effects 0.000 description 9
- 230000001580 bacterial effect Effects 0.000 description 8
- 210000000214 mouth Anatomy 0.000 description 8
- 230000002458 infectious effect Effects 0.000 description 7
- 239000005548 dental material Substances 0.000 description 6
- WSFMFXQNYPNYGG-UHFFFAOYSA-M dimethyl-octadecyl-(3-trimethoxysilylpropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCC[Si](OC)(OC)OC WSFMFXQNYPNYGG-UHFFFAOYSA-M 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000007794 irritation Effects 0.000 description 6
- 238000001556 precipitation Methods 0.000 description 6
- 230000001954 sterilising effect Effects 0.000 description 6
- 239000012085 test solution Substances 0.000 description 6
- 241000222122 Candida albicans Species 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 5
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 description 5
- 238000011081 inoculation Methods 0.000 description 5
- 230000001717 pathogenic effect Effects 0.000 description 5
- 231100000331 toxic Toxicity 0.000 description 5
- 230000002588 toxic effect Effects 0.000 description 5
- 239000008215 water for injection Substances 0.000 description 5
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 4
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 4
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 229960003237 betaine Drugs 0.000 description 4
- 239000012459 cleaning agent Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 230000007613 environmental effect Effects 0.000 description 4
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000004744 fabric Substances 0.000 description 4
- 230000009036 growth inhibition Effects 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- 238000007654 immersion Methods 0.000 description 4
- 206010022000 influenza Diseases 0.000 description 4
- 239000002324 mouth wash Substances 0.000 description 4
- 229940051866 mouthwash Drugs 0.000 description 4
- 239000002736 nonionic surfactant Substances 0.000 description 4
- 244000052769 pathogen Species 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 229910052710 silicon Inorganic materials 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 3
- 241000714201 Feline calicivirus Species 0.000 description 3
- 206010035669 Pneumonia aspiration Diseases 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 201000009807 aspiration pneumonia Diseases 0.000 description 3
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 3
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 239000000551 dentifrice Substances 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 238000001879 gelation Methods 0.000 description 3
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 3
- 125000001183 hydrocarbyl group Chemical group 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 210000003292 kidney cell Anatomy 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 230000002062 proliferating effect Effects 0.000 description 3
- 238000007086 side reaction Methods 0.000 description 3
- 239000011550 stock solution Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000004753 textile Substances 0.000 description 3
- LYAHJFZLDZDIOH-VURMDHGXSA-N (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide Chemical compound C=1C=COC=1/C(C(=O)N)=C/C1=CC=C([N+]([O-])=O)O1 LYAHJFZLDZDIOH-VURMDHGXSA-N 0.000 description 2
- XPALGXXLALUMLE-UHFFFAOYSA-N 2-(dimethylamino)tetradecanoic acid Chemical compound CCCCCCCCCCCCC(N(C)C)C(O)=O XPALGXXLALUMLE-UHFFFAOYSA-N 0.000 description 2
- KSCAZPYHLGGNPZ-UHFFFAOYSA-N 3-chloropropyl(triethoxy)silane Chemical compound CCO[Si](OCC)(OCC)CCCCl KSCAZPYHLGGNPZ-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 102000004142 Trypsin Human genes 0.000 description 2
- 108090000631 Trypsin Proteins 0.000 description 2
- 231100000460 acute oral toxicity Toxicity 0.000 description 2
- YCSBALJAGZKWFF-UHFFFAOYSA-N anthracen-2-amine Chemical compound C1=CC=CC2=CC3=CC(N)=CC=C3C=C21 YCSBALJAGZKWFF-UHFFFAOYSA-N 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 125000001204 arachidyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 description 2
- RLGQACBPNDBWTB-UHFFFAOYSA-N cetyltrimethylammonium ion Chemical compound CCCCCCCCCCCCCCCC[N+](C)(C)C RLGQACBPNDBWTB-UHFFFAOYSA-N 0.000 description 2
- 239000006059 cover glass Substances 0.000 description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- HXWGXXDEYMNGCT-UHFFFAOYSA-M decyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)C HXWGXXDEYMNGCT-UHFFFAOYSA-M 0.000 description 2
- 238000000432 density-gradient centrifugation Methods 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- GWKSUDBMSKFKQL-UHFFFAOYSA-M diethyl-hexadecyl-(3-triethoxysilylpropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](CC)(CC)CCC[Si](OCC)(OCC)OCC GWKSUDBMSKFKQL-UHFFFAOYSA-M 0.000 description 2
- PNCRJMNCFHMFJQ-UHFFFAOYSA-M diethyl-octadecyl-(3-triethoxysilylpropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](CC)(CC)CCC[Si](OCC)(OCC)OCC PNCRJMNCFHMFJQ-UHFFFAOYSA-M 0.000 description 2
- IETNFDXLTBTSFQ-UHFFFAOYSA-M diethyl-pentadecyl-(3-triethoxysilylpropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCC[N+](CC)(CC)CCC[Si](OCC)(OCC)OCC IETNFDXLTBTSFQ-UHFFFAOYSA-M 0.000 description 2
- UYHCOJRSVFXMFN-UHFFFAOYSA-M diethyl-tetradecyl-(3-triethoxysilylpropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](CC)(CC)CCC[Si](OCC)(OCC)OCC UYHCOJRSVFXMFN-UHFFFAOYSA-M 0.000 description 2
- NAPSCFZYZVSQHF-UHFFFAOYSA-N dimantine Chemical compound CCCCCCCCCCCCCCCCCCN(C)C NAPSCFZYZVSQHF-UHFFFAOYSA-N 0.000 description 2
- ADUSEOXLGLLZKO-UHFFFAOYSA-N dimethyl-octadecyl-(3-triethoxysilylpropyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CCC[Si](OCC)(OCC)OCC ADUSEOXLGLLZKO-UHFFFAOYSA-N 0.000 description 2
- NXUWOWMHSQNNOI-UHFFFAOYSA-M dimethyl-pentadecyl-(3-triethoxysilylpropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCC[N+](C)(C)CCC[Si](OCC)(OCC)OCC NXUWOWMHSQNNOI-UHFFFAOYSA-M 0.000 description 2
- HJHSNSJIXVUTGJ-UHFFFAOYSA-M dimethyl-tetradecyl-(3-triethoxysilylpropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](C)(C)CCC[Si](OCC)(OCC)OCC HJHSNSJIXVUTGJ-UHFFFAOYSA-M 0.000 description 2
- FODRJVFSMYJEPB-UHFFFAOYSA-M dipropyl-tetradecyl-(3-triethoxysilylpropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](CCC)(CCC)CCC[Si](OCC)(OCC)OCC FODRJVFSMYJEPB-UHFFFAOYSA-M 0.000 description 2
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- SNGNISHAHJKHLH-UHFFFAOYSA-M dodecyl-di(propan-2-yl)-(3-triethoxysilylpropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C(C)C)(C(C)C)CCC[Si](OCC)(OCC)OCC SNGNISHAHJKHLH-UHFFFAOYSA-M 0.000 description 2
- YWZQRISHIOLKIZ-UHFFFAOYSA-M dodecyl-dimethyl-(3-triethoxysilylpropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CCC[Si](OCC)(OCC)OCC YWZQRISHIOLKIZ-UHFFFAOYSA-M 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 238000010265 fast atom bombardment Methods 0.000 description 2
- RYJVNHWSPPNQPJ-UHFFFAOYSA-M hexadecyl-dimethyl-(3-triethoxysilylpropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)CCC[Si](OCC)(OCC)OCC RYJVNHWSPPNQPJ-UHFFFAOYSA-M 0.000 description 2
- JCTKINGATLUKIN-UHFFFAOYSA-M hexadecyl-dipropyl-(3-triethoxysilylpropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](CCC)(CCC)CCC[Si](OCC)(OCC)OCC JCTKINGATLUKIN-UHFFFAOYSA-M 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 125000002960 margaryl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
- DCVOWNNIQFCMDW-UHFFFAOYSA-N methoxysilicon Chemical compound CO[Si] DCVOWNNIQFCMDW-UHFFFAOYSA-N 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 238000004264 monolayer culture Methods 0.000 description 2
- 230000007886 mutagenicity Effects 0.000 description 2
- 231100000299 mutagenicity Toxicity 0.000 description 2
- 231100000150 mutagenicity / genotoxicity testing Toxicity 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000001196 nonadecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- MYKVCKVLZVWRIL-UHFFFAOYSA-M octadecyl-dipropyl-(3-triethoxysilylpropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](CCC)(CCC)CCC[Si](OCC)(OCC)OCC MYKVCKVLZVWRIL-UHFFFAOYSA-M 0.000 description 2
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000002958 pentadecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- WESQXPKKEJICNB-UHFFFAOYSA-M pentadecyl-dipropyl-(3-triethoxysilylpropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCC[N+](CCC)(CCC)CCC[Si](OCC)(OCC)OCC WESQXPKKEJICNB-UHFFFAOYSA-M 0.000 description 2
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 2
- 208000028169 periodontal disease Diseases 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 238000013207 serial dilution Methods 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 238000004381 surface treatment Methods 0.000 description 2
- 125000002889 tridecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 239000012588 trypsin Substances 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- QAQSNXHKHKONNS-UHFFFAOYSA-N 1-ethyl-2-hydroxy-4-methyl-6-oxopyridine-3-carboxamide Chemical compound CCN1C(O)=C(C(N)=O)C(C)=CC1=O QAQSNXHKHKONNS-UHFFFAOYSA-N 0.000 description 1
- XJGFWWJLMVZSIG-UHFFFAOYSA-N 9-aminoacridine Chemical compound C1=CC=C2C(N)=C(C=CC=C3)C3=NC2=C1 XJGFWWJLMVZSIG-UHFFFAOYSA-N 0.000 description 1
- FTGPOQQGJVJDCT-UHFFFAOYSA-N 9-aminoacridine hydrochloride Chemical compound Cl.C1=CC=C2C(N)=C(C=CC=C3)C3=NC2=C1 FTGPOQQGJVJDCT-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010015946 Eye irritation Diseases 0.000 description 1
- 241000282324 Felis Species 0.000 description 1
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- RAXXELZNTBOGNW-UHFFFAOYSA-O Imidazolium Chemical compound C1=C[NH+]=CN1 RAXXELZNTBOGNW-UHFFFAOYSA-O 0.000 description 1
- 208000002979 Influenza in Birds Diseases 0.000 description 1
- 241001500351 Influenzavirus A Species 0.000 description 1
- 241000712079 Measles morbillivirus Species 0.000 description 1
- 241000711386 Mumps virus Species 0.000 description 1
- 231100000694 OECD Guidelines for the Testing of Chemicals Toxicity 0.000 description 1
- RODZIAKMFCIGPL-UHFFFAOYSA-N P.I.I Chemical compound P.I.I RODZIAKMFCIGPL-UHFFFAOYSA-N 0.000 description 1
- 241000282320 Panthera leo Species 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 241000711798 Rabies lyssavirus Species 0.000 description 1
- 231100000645 Reed–Muench method Toxicity 0.000 description 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229960001441 aminoacridine Drugs 0.000 description 1
- 206010064097 avian influenza Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- YPTVWMKFECALOB-UHFFFAOYSA-M decyl(triethyl)azanium;acetate Chemical compound CC([O-])=O.CCCCCCCCCC[N+](CC)(CC)CC YPTVWMKFECALOB-UHFFFAOYSA-M 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- YZYMMOVPUXGRBQ-UHFFFAOYSA-M dimethyl-octadecyl-(3-triethoxysilylpropyl)azanium;ethanol;chloride Chemical compound [Cl-].CCO.CCCCCCCCCCCCCCCCCC[N+](C)(C)CCC[Si](OCC)(OCC)OCC YZYMMOVPUXGRBQ-UHFFFAOYSA-M 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- OIYJQMZNRJJLJX-UHFFFAOYSA-M dodecyl(trimethyl)azanium;acetate Chemical compound CC([O-])=O.CCCCCCCCCCCC[N+](C)(C)C OIYJQMZNRJJLJX-UHFFFAOYSA-M 0.000 description 1
- XLGBLPNKBBGIQB-UHFFFAOYSA-M dodecyl-tri(propan-2-yl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C(C)C)(C(C)C)C(C)C XLGBLPNKBBGIQB-UHFFFAOYSA-M 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- MTKPOFJUULWZNU-UHFFFAOYSA-N ethoxysilicon Chemical compound CCO[Si] MTKPOFJUULWZNU-UHFFFAOYSA-N 0.000 description 1
- 231100000013 eye irritation Toxicity 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- ATPUEECSGDZDJO-UHFFFAOYSA-M hexadecyl(tripropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](CCC)(CCC)CCC ATPUEECSGDZDJO-UHFFFAOYSA-M 0.000 description 1
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000002563 ionic surfactant Substances 0.000 description 1
- 238000000752 ionisation method Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- COCAUCFPFHUGAA-MGNBDDOMSA-N n-[3-[(1s,7s)-5-amino-4-thia-6-azabicyclo[5.1.0]oct-5-en-7-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide Chemical compound C=1C=C(F)C([C@@]23N=C(SCC[C@@H]2C3)N)=CC=1NC(=O)C1=CC=C(Cl)C=N1 COCAUCFPFHUGAA-MGNBDDOMSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- MWPGECNOSCRMII-UHFFFAOYSA-M octadecyl(tripropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](CCC)(CCC)CCC MWPGECNOSCRMII-UHFFFAOYSA-M 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- ZTXVWEKBRXHTRO-UHFFFAOYSA-M pentadecyl(tripropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCC[N+](CCC)(CCC)CCC ZTXVWEKBRXHTRO-UHFFFAOYSA-M 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 238000011012 sanitization Methods 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 231100000057 systemic toxicity Toxicity 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- WPPGURUIRLDHAB-UHFFFAOYSA-M triethyl(hexadecyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](CC)(CC)CC WPPGURUIRLDHAB-UHFFFAOYSA-M 0.000 description 1
- OWGHQYPQNSZTFQ-UHFFFAOYSA-M triethyl(octadecyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](CC)(CC)CC OWGHQYPQNSZTFQ-UHFFFAOYSA-M 0.000 description 1
- OPOYIRZGOYMLBV-UHFFFAOYSA-M triethyl(pentadecyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCC[N+](CC)(CC)CC OPOYIRZGOYMLBV-UHFFFAOYSA-M 0.000 description 1
- FGEMVHCDHVPYQX-UHFFFAOYSA-M triethyl(tetradecyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](CC)(CC)CC FGEMVHCDHVPYQX-UHFFFAOYSA-M 0.000 description 1
- QMFWEFZFXCTEOF-UHFFFAOYSA-M triethyl(tridecyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCCC[N+](CC)(CC)CC QMFWEFZFXCTEOF-UHFFFAOYSA-M 0.000 description 1
- OHCYZUDVCRJREC-UHFFFAOYSA-M trimethyl(pentadecyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCC[N+](C)(C)C OHCYZUDVCRJREC-UHFFFAOYSA-M 0.000 description 1
- CEYYIKYYFSTQRU-UHFFFAOYSA-M trimethyl(tetradecyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](C)(C)C CEYYIKYYFSTQRU-UHFFFAOYSA-M 0.000 description 1
- CWOBBUOEWRRVPD-UHFFFAOYSA-M tripropyl(tetradecyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](CCC)(CCC)CCC CWOBBUOEWRRVPD-UHFFFAOYSA-M 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N3/00—Preservation of plants or parts thereof, e.g. inhibiting evaporation, improvement of the appearance of leaves or protection against physical influences such as UV radiation using chemical compositions; Grafting wax
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/88—Ampholytes; Electroneutral compounds
- C11D1/94—Mixtures with anionic, cationic or non-ionic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2006—Monohydric alcohols
- C11D3/201—Monohydric alcohols linear
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/373—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds containing silicones
- C11D3/3742—Nitrogen containing silicones
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/38—Cationic compounds
- C11D1/62—Quaternary ammonium compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/72—Ethers of polyoxyalkylene glycols
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/88—Ampholytes; Electroneutral compounds
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Agronomy & Crop Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pest Control & Pesticides (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Detergent Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Description
加えて、こうした高性能な抗菌剤組成物や抗ウィルス剤組成物を物品の表面に堅固に固着できれば、さらに利用価値が高まることも予想される。
すなわち、本発明の抗ウィルス剤組成物は、下記一般式(1);
上記抗ウィルス剤組成物は、さらにエタノールを含んでもよく、さらに水を含んでもよく、さらに両イオン界面活性剤及び/又は陽イオン界面活性剤を含んでもよい。
本発明の抗ウィルス剤固定化方法は、表面に含酸素官能基を有する物品を用い、該物品の表面に上記抗ウィルス剤組成物を塗布又は噴霧することを特徴とする。
なお、本明細書において、「抗菌」とは、細菌及び真菌類の殺菌又は損傷、或いはこれらの増殖防止を意味し、「抗ウィルス」とは病原体ウィルスの不活化を意味する。
EtAC:オクタデシルジメチル(3−トリエトキシシリルプロピル)アンモニウムクロライド
Si−QAC:オクタデシルジメチル(3−トリメトキシシリルプロピル)アンモニウムクロライド
CPB:セチルピリジニウムブロミド
Aromox(登録商標):ラウリルジメチルアミンオキサイド(ライオン社製)
LAD:ラウロイルアミドプロピルジメチルアミンオキサイド(川研ファイン社製)
HD:ヘキサデシルトリメチルアンモニウムクロライド
CPC:セチルピリジニウムクロライド
PO:ポリオキシエチレンソルビタンモノラウレート
CDE:ココ脂肪酸ジエタノールアミド
消毒用エタノール(日本薬局方70%消毒用アルコール)
窒素パージした加圧反応器に、トリエトキシシリルプロピルクロライド(東京化成工業株式会社)41.5g(0.17moL)、N,N-ジメチルオクタデシルアミン(東京化成工業株式会社)44.6g (0.150moL)、エタノール40.5gを入れ、135℃に加熱した。20時間反応しジメチルオクタデシル[3-(トリエトキシシリル)プロピル]アンモニウムクロライド(EtAC)エタノール溶液121.4gを得た。
含量 63.8% 純分 77.5g 収率 95.9%
1)測定条件:
質量範囲 :22.0458 〜 711.451m/z
イオン化法 : FAB(高速原子衝撃)
モード : 正
2)スペクトルデータ:m/z=530
本発明のオクタデシルジメチル(3−トリエトキシシリルプロピル)アンモニウムクロライドを含む組成物の安全性を確認するため、変異原性試験、雌マウスを用いた急性経口毒性試験、及びウサギを用いた皮膚一次刺激性試験を行った。
検体として、合成例1で得られた60wt%EtACエタノール溶液(淡黄色透明液体)を用い、かかる検体の突然変異誘起性を調べる目的で、労働省告示第77号(昭和63年9月1日)に従い、Escherichia coli WP2uvrA及びSalmonella typhimurium TA系4菌株(TA100、TA1535、TA98及びTA1537)を用いて復帰突然変異試験を行った。試験に際し、ニュートリエントブロス培地[OXOID,Nutrient broth No.2]を15 mL分注したバッフル付三角フラスコに解凍した菌分注凍結保存液を接種して、37 ℃で10時間旋回培養したものを検定菌液とした。検体をひょう取して注射用水を加え、試験原液を調製し、注射用水を用いて試験原液を適宜希釈して試験液を調製した。陽性対照物質としては、2-(2-フリル)-3-(5-ニトロ-2-フリル)アクリルアミド、アジ化ナトリウム、9-アミノアクリジン・塩酸塩、2-アミノアントラセンを用いた。注射用水を陰性対照とし、0.610〜1250 μg/プレートの用量で試験を行った。
合成例1で得られた60wt%EtACエタノール溶液を注射溶液で希釈し、400、300、200及び100mg/mlの試験液を調整した。この溶液をマウスに8000、6000、4000及び2000mg/Kgの容量で、対照群には注射溶液水を雌マウスに単回経口投与し、14日間観察を行った。
合成例1で得られたEtACエタノール溶液を消毒用エタノール(80%エタノール)で希釈して3重量%EtACの80%エタノール溶液を調整し、これを綿100%のタオルに噴霧後、室温にて3分間放置し、流水下で水洗・乾燥してEtAC処理タオルを作製した。かかる処理タオルを検体として、OECD Guidelines for the Testing of Chemicals 404(2002)に準拠し、ウサギを用いた皮膚一次刺激性試験を行った。約2 cm×3 cmに裁断した検体を約0.5 mLの注射用水で湿潤させ、ウサギ3匹の無傷及び有傷皮膚の各1箇所ずつに24時間適用した。
上記合成例1で得られた60wt%EtACエタノール溶液と水と各種界面活性剤を混合し、安定性を比較した。使用した界面活性剤は、両イオン界面活性剤として、CPB、Aromox及びLAD、陽イオン界面活性剤として、HD及びCPC、非イオン界面活性剤として、PO及びCDEを用いた。EtACの最終濃度は3wt%になるように調整した。各界面活性剤の最終濃度は非イオン界面活性剤と両イオン界面活性剤は1wt%、陽イオン界面活性剤は0.1wt%になるように調整した。得られた溶液について、5日〜2週間後の沈殿の有無を確認した。結果を表1〜2に示す。
上記合成例1で得られた60wt%EtACエタノール溶液と陽イオン界面活性剤を混合し消毒用エタノールで20倍希釈してEtACの最終濃度が3wt%、界面活性剤の最終濃度が1wt%になるように調整した。陽イオン界面活性剤として、HD及びCPCを用いた。得られた溶液について、沈殿の有無を確認した。結果を表3に示す。
また、比較のため界面活性剤なしの場合についても同様の試験を行ったが、混合から数時間で沈殿が生じた(表3;Entry1)。
60wt%Si−QACメタノール溶液或いは上記合成例1で得られた60wt%EtACエタノール溶液と界面活性剤を混合し、水或いは消毒用エタノールで20倍希釈して、EtAC或いはSi−QACと界面活性剤の最終濃度がそれぞれ下記の濃度になるように調整した。
3%SiQAC+1%PO、3%EtAC+1%LAD、3%EtAC+1%LAD+0.1%CPCの水溶液3検体。
3%EtAC+0.1%HD、3%EtAC+0.1%CPCの消毒用エタノール溶液2検体
60wt%Si−QACメタノール溶液或いは上記合成例1で得られた60wt%EtACエタノール溶液と界面活性剤と水を混合しEtAC或いはSi−QACと界面活性剤の最終濃度がそれぞれ下記の濃度になるように調整した。
3%SiQAC+1%PO、3%SiQAC+1%PO+HD、3%SiQAC+1%LAD、3%EtAC+1%LAD、3%EtAC+1%LAD+0.1%CPCの各水溶液
上記合成例1で得られた60wt%EtACエタノール溶液と両イオン界面活性剤と水を混合しEtACと界面活性剤の最終濃度がEtACが3%、両イオン界面活性剤が1%になるように調整した。
両イオン界面活性剤にはCPBとAromox、LADを用いた。
上記合成例1で得られた60wt%EtACエタノール溶液と水と各種界面活性剤を混合し、安定性を比較した。使用した界面活性剤は、両イオン界面活性剤として、CPB、Aromox及びLAD、非イオン界面活性剤として、POを用いた。EtACの最終濃度は3wt%になるように調整し、各界面活性剤の最終濃度は1wt%になるように調整した。
上記合成例1で得られた60wt%EtACエタノール溶液とAromoxと水を混合し最終濃度3%EtAC、1%Aromoxになるように調整した。
本発明の洗浄剤組成物及び消毒・洗浄・洗口・除菌及び抗菌化用組成物がウィルスを不活性化する能力を有するか否か試験した。ウィルスは、インフルエンザウィルス、ネコカリシウィルス(ヒトのノロウィルスと同属で、ネコ腎臓細胞であるCRFK 細胞で増殖することが知られ、ヒトのノロウィルスの代替実験系として用いることができる)を用いた。ウィルス力価の測定は、50%Tissue Culture Infectious Dose(TCID50)法を用いて行った。
インフルエンザウィルスとしてトリ 無症状(弱毒株)であるオルソミクソウィルス科インフルエンザウィルスA属A/swan/Shimane/499/83(H5N3)及び新型(ブタ)インフルエンザウィルス(H1N1型)を用い、しょ糖密度勾配遠心で精製し、PBSに対して透析したウィルス液として用いた。さらにイヌ腎細胞のセルラインであるMDCK(+)細胞を用いた。
ウィルス(ウィルス液)及び細胞は実施例9と同様のものを用いた。
合成例1で得られたEtACエタノール溶液を消毒用エタノール(80%エタノール)で希釈して3重量%EtAC、0.3重量%EtAC、0.06重量%EtACの80%エタノール溶液を調整し、これを綿100%のタオルに噴霧後、室温にて3分間放置し、流水下で水洗・乾燥してEtAC処理タオルを作製した。
処理後のウィルス液から実施例9と同様にしてDMEMで10倍段階希釈列を調製し、96 穴プレートの単層培養細胞に接種し(50μL/well)、1時間ウィルス吸着を行った。
Claims (8)
- 上記一般式(1)で表されるケイ素含有化合物が、オクタデシルジメチル(3−トリエトキシシリルプロピル)アンモニウムクロライドであることを特徴とする請求項1記載の抗ウィルス剤組成物。
- さらに、エタノールを含むことを特徴とする請求項1又は2記載の抗ウィルス剤組成物。
- さらに、水を含むことを特徴とする請求項1〜3のいずれか1項に記載の抗ウィルス剤組成物。
- さらに、両イオン界面活性剤及び/又は陽イオン界面活性剤を含むことを特徴とする請求項1〜4のいずれか1項に記載の抗ウィルス剤組成物。
- 前記抗ウィルス剤組成物が、A型インフルエンザウィルス(ヒト、トリ、豚(新型))、B型インフルエンザウィルス、パラインフルエンザウィルス及びノロウィルスからなる群より選ばれる少なくとも1種のウィルスを不活性化する能力を有することを特徴とする請求項1〜5のいずれか1項に記載の抗ウィルス剤組成物。
- 表面に含酸素官能基を有する物品を用い、
該物品の表面に請求項1〜6のいずれかに記載の抗ウィルス剤組成物を塗布又は噴霧すること、或いは該物品を請求項1〜6のいずれかに記載の抗ウィルス剤組成物中に浸漬することを特徴とする抗ウィルス剤固定化方法。 - 表面に含酸素官能基を有する物品を用い、
該物品の表面に請求項1〜6のいずれかに記載の抗ウィルス剤組成物を塗布又は噴霧或いは、該物品を請求項1〜6のいずれかに記載の抗ウィルス剤組成物中に浸漬してなることを特徴とする抗ウィルス剤固定化物を製造する方法。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011008174A JP4830075B2 (ja) | 2008-12-25 | 2011-01-18 | ケイ素含有化合物を含む抗ウィルス剤組成物、及び抗ウィルス剤固定化方法 |
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008329036 | 2008-12-25 | ||
JP2008329036 | 2008-12-25 | ||
JP2009205296 | 2009-09-04 | ||
JP2009205296 | 2009-09-04 | ||
JP2009233013 | 2009-10-07 | ||
JP2009233013 | 2009-10-07 | ||
JP2011008174A JP4830075B2 (ja) | 2008-12-25 | 2011-01-18 | ケイ素含有化合物を含む抗ウィルス剤組成物、及び抗ウィルス剤固定化方法 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010543968A Division JP4848484B2 (ja) | 2008-12-25 | 2009-11-05 | ケイ素含有化合物を含む抗菌剤組成物、並びに抗菌化方法、洗浄・洗口方法及び抗菌剤固定化方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011098976A JP2011098976A (ja) | 2011-05-19 |
JP4830075B2 true JP4830075B2 (ja) | 2011-12-07 |
Family
ID=42287450
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010543968A Active JP4848484B2 (ja) | 2008-12-25 | 2009-11-05 | ケイ素含有化合物を含む抗菌剤組成物、並びに抗菌化方法、洗浄・洗口方法及び抗菌剤固定化方法 |
JP2011008174A Active JP4830075B2 (ja) | 2008-12-25 | 2011-01-18 | ケイ素含有化合物を含む抗ウィルス剤組成物、及び抗ウィルス剤固定化方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010543968A Active JP4848484B2 (ja) | 2008-12-25 | 2009-11-05 | ケイ素含有化合物を含む抗菌剤組成物、並びに抗菌化方法、洗浄・洗口方法及び抗菌剤固定化方法 |
Country Status (7)
Country | Link |
---|---|
US (2) | US9278107B2 (ja) |
EP (1) | EP2377400B1 (ja) |
JP (2) | JP4848484B2 (ja) |
KR (1) | KR101649387B1 (ja) |
CN (2) | CN107006510B (ja) |
ES (1) | ES2869252T3 (ja) |
WO (1) | WO2010073825A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022209202A1 (ja) | 2021-03-31 | 2022-10-06 | 株式会社ジーシー | 物品の被覆方法、物品の被覆のための使用、及び重合性組成物 |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9278107B2 (en) * | 2008-12-25 | 2016-03-08 | Hiroshima University | Antibacterial agent composition and antiviral agent composition comprising silicon-containing compound; antibacterializing method, cleaning/mouth rinsing method; method for fixing antibacterial agent and antiviral agent |
JP2014524980A (ja) * | 2011-07-08 | 2014-09-25 | スペシャルティ コーティング システムズ, インク. | 抗菌性パリレン・コーティング及び同コーティングを蒸着する方法 |
CN102391299A (zh) * | 2011-08-06 | 2012-03-28 | 江苏迅扬环保新材料有限公司 | 有机硅季铵盐组合物的制备方法及其应用 |
JP5864594B2 (ja) * | 2011-09-29 | 2016-02-17 | Tbカワシマ株式会社 | 抗菌性を有する剤が固定化された物品及びその製造方法 |
JP6395200B2 (ja) * | 2012-10-22 | 2018-09-26 | ジェクス株式会社 | ケイ素含有化合物水溶液及び該水溶液を含む抗菌・抗ウィルス剤 |
JP5916965B2 (ja) * | 2014-03-18 | 2016-05-11 | マナック株式会社 | オルガノシラン水溶液及びその保存方法 |
JP2019043848A (ja) * | 2015-12-25 | 2019-03-22 | ライオン株式会社 | 口腔用カンジダ菌殺菌剤及び義歯洗浄剤組成物 |
GB201607699D0 (en) | 2016-05-03 | 2016-06-15 | Surgical Ltd Q | Anti-microbial compositions |
JP6432892B2 (ja) * | 2017-05-15 | 2018-12-05 | ジェクス株式会社 | ケイ素含有化合物水溶液及び該水溶液を含む抗菌・抗ウィルス剤 |
US20200375190A1 (en) * | 2017-08-01 | 2020-12-03 | Nano Global | Alkyl Dimethyl Organosilane Quaternaries in Persistent Systems and Methods |
JP7032905B2 (ja) * | 2017-10-18 | 2022-03-09 | スターライト工業株式会社 | 積層体およびそれを用いたフィルター濾材 |
US10967082B2 (en) | 2017-11-08 | 2021-04-06 | Parasol Medical, Llc | Method of limiting the spread of norovirus within a cruise ship |
CN107970129A (zh) * | 2017-12-04 | 2018-05-01 | 广州市润研基因科技有限公司 | 一种新型漱口水及其制备方法 |
US20190230929A1 (en) * | 2018-01-30 | 2019-08-01 | W.M. Barr & Company, Inc. | Composition for residual sanitization |
US10864058B2 (en) | 2018-03-28 | 2020-12-15 | Parasol Medical, Llc | Antimicrobial treatment for a surgical headlamp system |
JP7376480B2 (ja) | 2018-07-20 | 2023-11-08 | 株式会社 資生堂 | ウイルス不活化剤 |
WO2020045465A1 (ja) * | 2018-08-29 | 2020-03-05 | 富士フイルム株式会社 | 抗ウイルス用ワイパー |
JP7189049B2 (ja) * | 2019-02-26 | 2022-12-13 | 株式会社ジーシー | 有機ケイ素化合物、歯科用フィラー及び歯科用重合性組成物 |
JP2021070672A (ja) * | 2019-11-01 | 2021-05-06 | ジェクス株式会社 | 害虫忌避剤 |
CN111592945A (zh) * | 2020-06-05 | 2020-08-28 | 上海和黄白猫有限公司 | 一种抗菌衣物清洁喷雾及其制备方法 |
EP4163339A4 (en) | 2020-06-05 | 2024-06-19 | Energyfront Inc. | COATING FILM AND ARTICLES WITH THE COATING FILM FORMED ON THE SURFACE |
WO2022038955A1 (ja) * | 2020-08-20 | 2022-02-24 | 大日本除蟲菊株式会社 | ウイルス不活性化剤組成物およびウイルス不活性化効力増強方法、並びにウイルス不活性化方法 |
JP7115521B2 (ja) * | 2020-09-04 | 2022-08-09 | 信越化学工業株式会社 | 繊維処理剤 |
GB202103959D0 (en) * | 2021-03-22 | 2021-05-05 | Vale Brothers Ltd | Antiviral polymer material |
JP7468469B2 (ja) * | 2021-06-25 | 2024-04-16 | 信越化学工業株式会社 | 有機ケイ素化合物を含有する水溶液組成物 |
EP4108297A1 (en) * | 2021-06-25 | 2022-12-28 | Shin-Etsu Chemical Co., Ltd. | Aqueous solution composition containing organosilicon compound |
CN113563981B (zh) * | 2021-07-06 | 2023-11-10 | 南京优洁境生物科技有限公司 | 新型多酶清洗用阳离子有机硅表面活性剂及其制备方法 |
JP7115621B1 (ja) | 2021-11-29 | 2022-08-09 | 信越化学工業株式会社 | 有機ケイ素化合物を含有する組成物 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4005028A (en) * | 1975-04-22 | 1977-01-25 | The Procter & Gamble Company | Organosilane-containing detergent composition |
US4511486A (en) * | 1981-11-02 | 1985-04-16 | Richardson-Vicks Inc. | Method of cleaning dentures using aerated foams |
GB8314500D0 (en) | 1983-05-25 | 1983-06-29 | Procter & Gamble Ltd | Cleaning compositions |
US4631297A (en) * | 1984-03-12 | 1986-12-23 | Dow Corning Corporation | Antimicrobially effective organic foams and methods for their preparation |
US5411585A (en) | 1991-02-15 | 1995-05-02 | S. C. Johnson & Son, Inc. | Production of stable hydrolyzable organosilane solutions |
EP0640122B1 (en) | 1991-02-15 | 1997-07-16 | S.C. JOHNSON & SON, INC. | Production of stable aqueous hydrolyzable organosilane solutions |
US6632805B1 (en) | 1996-05-07 | 2003-10-14 | Emory University | Methods for using water-stabilized organosilanes |
US6113815A (en) * | 1997-07-18 | 2000-09-05 | Bioshield Technologies, Inc. | Ether-stabilized organosilane compositions and methods for using the same |
US5885951A (en) * | 1997-10-31 | 1999-03-23 | Martin Panich | Aqueous solution for tile, tub and grout cleaning |
DE19929845A1 (de) * | 1999-06-29 | 2001-01-11 | Degussa | Oberflächenmodifiziertes Titandioxid |
BRPI0410570A (pt) * | 2003-05-22 | 2006-06-20 | Coating Systems Lab Inc | revestimentos organos silano de amÈnio quaternário antimicrobiais |
GB2407581A (en) * | 2003-11-01 | 2005-05-04 | Reckitt Benckiser Inc | Hard surface cleaning and disinfecting compositions |
DE102004037044A1 (de) * | 2004-07-29 | 2006-03-23 | Degussa Ag | Mittel zur Ausstattung von auf Cellulose und/oder Stärke basierenden Substraten mit Wasser abweisenden und gleichzeitig pilz-, bakterien-, insekten- sowie algenwidrigen Eigenschaften |
US20060134163A1 (en) * | 2004-12-16 | 2006-06-22 | Bagwell Alison S | Immobilizing anti-microbial compounds on elastomeric articles |
JP4972743B2 (ja) | 2005-11-04 | 2012-07-11 | 国立大学法人広島大学 | 洗浄剤組成物および洗浄方法 |
CN1314320C (zh) * | 2005-11-30 | 2007-05-09 | 山东大学 | 一种有机硅季铵盐杀菌剂的制备方法 |
US8304379B2 (en) * | 2007-07-25 | 2012-11-06 | Hiroshima University | Silicon compound-containing solidified detergent composition and method for producing the same |
US8859009B2 (en) | 2008-05-09 | 2014-10-14 | Hiroshima University | Method of fixing antibacterial agent and article obtained by the method |
US9278107B2 (en) * | 2008-12-25 | 2016-03-08 | Hiroshima University | Antibacterial agent composition and antiviral agent composition comprising silicon-containing compound; antibacterializing method, cleaning/mouth rinsing method; method for fixing antibacterial agent and antiviral agent |
-
2009
- 2009-11-05 US US13/142,088 patent/US9278107B2/en active Active
- 2009-11-05 CN CN201611048813.3A patent/CN107006510B/zh active Active
- 2009-11-05 EP EP09834629.9A patent/EP2377400B1/en active Active
- 2009-11-05 JP JP2010543968A patent/JP4848484B2/ja active Active
- 2009-11-05 CN CN2009801574941A patent/CN102333446A/zh active Pending
- 2009-11-05 WO PCT/JP2009/068929 patent/WO2010073825A1/ja active Application Filing
- 2009-11-05 KR KR1020117017498A patent/KR101649387B1/ko active IP Right Grant
- 2009-11-05 ES ES09834629T patent/ES2869252T3/es active Active
-
2011
- 2011-01-18 JP JP2011008174A patent/JP4830075B2/ja active Active
-
2016
- 2016-01-21 US US15/003,389 patent/US9609872B2/en active Active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022209202A1 (ja) | 2021-03-31 | 2022-10-06 | 株式会社ジーシー | 物品の被覆方法、物品の被覆のための使用、及び重合性組成物 |
Also Published As
Publication number | Publication date |
---|---|
CN107006510B (zh) | 2023-01-03 |
JP2011098976A (ja) | 2011-05-19 |
US9609872B2 (en) | 2017-04-04 |
WO2010073825A1 (ja) | 2010-07-01 |
US9278107B2 (en) | 2016-03-08 |
KR101649387B1 (ko) | 2016-08-18 |
CN102333446A (zh) | 2012-01-25 |
ES2869252T3 (es) | 2021-10-25 |
JPWO2010073825A1 (ja) | 2012-06-14 |
US20160157492A1 (en) | 2016-06-09 |
JP4848484B2 (ja) | 2011-12-28 |
US20110293542A1 (en) | 2011-12-01 |
EP2377400A1 (en) | 2011-10-19 |
CN107006510A (zh) | 2017-08-04 |
EP2377400A4 (en) | 2012-07-11 |
EP2377400B1 (en) | 2021-03-03 |
KR20110103443A (ko) | 2011-09-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4830075B2 (ja) | ケイ素含有化合物を含む抗ウィルス剤組成物、及び抗ウィルス剤固定化方法 | |
US20090035339A1 (en) | Methods of Inactivating Viruses | |
JP4972743B2 (ja) | 洗浄剤組成物および洗浄方法 | |
CA2560830A1 (en) | Method for diluting hypochlorite | |
WO2015078496A1 (en) | Disinfectant cleaner composition having tuberculocidal efficacy and efficacy against specific viruses | |
JP5832201B2 (ja) | 殺ノロウイルス組成物 | |
CN104958283A (zh) | 弱碱性皮肤粘膜清洗消毒组合物及其制造方法和用途 | |
JP2024123115A (ja) | ノロウイルス感染抑制剤、消毒剤及び洗浄剤 | |
BG62631B1 (bg) | Микробициден състав с ниска токсичност, съдържащ кватернеренамониев радикал | |
US20050232847A1 (en) | Method for diluting hypochlorite | |
JP2017008443A (ja) | 繊維製品用抗ウイルス組成物 | |
US20230151302A1 (en) | Cationic surfactants, in particular ethyl lauroyl arginate LAE, for treating or preventing infections and contaminations with Coronavirus | |
JP2020033279A (ja) | 抗ノロウイルス剤、消毒剤及び洗浄剤 | |
JP7340290B2 (ja) | 抗エンベロープウイルス中性洗浄剤、消毒剤組成物、及びエンベロープウイルスの不活性化方法 | |
EP4195924A1 (en) | Disinfectant composition | |
CN118647269A (zh) | 病毒或菌灭活剂组合物 | |
RU2152804C1 (ru) | Дезинфицирующее средство | |
MXPA06010982A (en) | Method for diluting hypochlorite | |
BG704Y1 (bg) | Състав на дезинфекционен разтвор |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20110118 |
|
A871 | Explanation of circumstances concerning accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A871 Effective date: 20110118 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110127 |
|
A975 | Report on accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A971005 Effective date: 20110323 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110426 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110616 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20110726 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110810 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20110810 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110818 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20110810 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 4830075 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20140930 Year of fee payment: 3 |
|
A072 | Dismissal of procedure [no reply to invitation to correct request for examination] |
Free format text: JAPANESE INTERMEDIATE CODE: A072 Effective date: 20120110 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |