JP4766750B2 - 位置特定可能なアレイによるリガーゼ検出反応を用いた核酸配列差異の検出 - Google Patents
位置特定可能なアレイによるリガーゼ検出反応を用いた核酸配列差異の検出 Download PDFInfo
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- JP4766750B2 JP4766750B2 JP2000606786A JP2000606786A JP4766750B2 JP 4766750 B2 JP4766750 B2 JP 4766750B2 JP 2000606786 A JP2000606786 A JP 2000606786A JP 2000606786 A JP2000606786 A JP 2000606786A JP 4766750 B2 JP4766750 B2 JP 4766750B2
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- oligonucleotide probe
- oligonucleotide
- ligation
- nucleotide sequence
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
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- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
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- B01J2219/00324—Reactor vessels in a multiple arrangement the reactor vessels or wells being arranged in plates moving in parallel to each other
- B01J2219/00326—Movement by rotation
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- B01J2219/00416—Vacuum
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- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
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- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
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- B01J2219/00623—Immobilisation or binding
- B01J2219/00626—Covalent
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01J2219/00603—Making arrays on substantially continuous surfaces
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- B01J2219/00632—Introduction of reactive groups to the surface
- B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
- B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00729—Peptide nucleic acids [PNA]
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12535799P | 1999-03-19 | 1999-03-19 | |
| US60/125,357 | 1999-03-19 | ||
| PCT/US2000/007006 WO2000056927A2 (en) | 1999-03-19 | 2000-03-17 | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011091716A Division JP2011200230A (ja) | 1999-03-19 | 2011-04-18 | 位置特定可能なアレイによるリガーゼ検出反応を用いた核酸配列差異の検出 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003520570A JP2003520570A (ja) | 2003-07-08 |
| JP2003520570A5 JP2003520570A5 (https=) | 2010-09-30 |
| JP4766750B2 true JP4766750B2 (ja) | 2011-09-07 |
Family
ID=22419369
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000606786A Expired - Fee Related JP4766750B2 (ja) | 1999-03-19 | 2000-03-17 | 位置特定可能なアレイによるリガーゼ検出反応を用いた核酸配列差異の検出 |
| JP2011091716A Withdrawn JP2011200230A (ja) | 1999-03-19 | 2011-04-18 | 位置特定可能なアレイによるリガーゼ検出反応を用いた核酸配列差異の検出 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011091716A Withdrawn JP2011200230A (ja) | 1999-03-19 | 2011-04-18 | 位置特定可能なアレイによるリガーゼ検出反応を用いた核酸配列差異の検出 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6506594B1 (https=) |
| EP (1) | EP1208223A2 (https=) |
| JP (2) | JP4766750B2 (https=) |
| AU (1) | AU781661C (https=) |
| CA (1) | CA2366249A1 (https=) |
| WO (1) | WO2000056927A2 (https=) |
Families Citing this family (178)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000033244A2 (en) * | 1998-11-27 | 2000-06-08 | Synaptics (Uk) Limited | Position sensor |
| US20020150921A1 (en) * | 1996-02-09 | 2002-10-17 | Francis Barany | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| US6852487B1 (en) | 1996-02-09 | 2005-02-08 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| EP2369007B1 (en) | 1996-05-29 | 2015-07-29 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
| US6506594B1 (en) * | 1999-03-19 | 2003-01-14 | Cornell Res Foundation Inc | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| US20060275782A1 (en) * | 1999-04-20 | 2006-12-07 | Illumina, Inc. | Detection of nucleic acid reactions on bead arrays |
| US20030207295A1 (en) * | 1999-04-20 | 2003-11-06 | Kevin Gunderson | Detection of nucleic acid reactions on bead arrays |
| US20020119448A1 (en) | 1999-06-23 | 2002-08-29 | Joseph A. Sorge | Methods of enriching for and identifying polymorphisms |
| US7041445B2 (en) | 1999-11-15 | 2006-05-09 | Clontech Laboratories, Inc. | Long oligonucleotide arrays |
| US6235483B1 (en) * | 2000-01-31 | 2001-05-22 | Agilent Technologies, Inc. | Methods and kits for indirect labeling of nucleic acids |
| US6872552B2 (en) * | 2000-02-29 | 2005-03-29 | Burt D. Ensley | Method of reconstituting nucleic acid molecules |
| WO2001079548A2 (en) | 2000-04-14 | 2001-10-25 | Cornell Research Foundation, Inc. | Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction |
| EP1164201A1 (en) * | 2000-06-14 | 2001-12-19 | Facultés Universitaires Notre-Dame de la Paix | Reverse detection for identification and/or quantification of nucleotide target sequences on biochips |
| AU784561B2 (en) * | 2000-06-23 | 2006-05-04 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Positively-charged peptide nucleic acid analogs with improved properties |
| EP1186671A3 (en) * | 2000-09-05 | 2003-12-17 | Agilent Technologies, Inc. (a Delaware corporation) | Method for hybridization of arrays on siliceous surfaces |
| DE60131903T2 (de) * | 2000-10-24 | 2008-11-27 | The Board of Trustees of the Leland S. Stanford Junior University, Palo Alto | Direkte multiplex charakterisierung von genomischer dna |
| US7091034B2 (en) * | 2000-12-15 | 2006-08-15 | Burstein Technologies, Inc. | Detection system for disk-based laboratory and improved optical bio-disc including same |
| JP3605039B2 (ja) * | 2001-01-09 | 2004-12-22 | 株式会社日立製作所 | 核酸マイクロアレイ、その製造方法及びそれを用いた核酸検出方法 |
| JP4189471B2 (ja) * | 2001-01-25 | 2008-12-03 | クラスターテクノロジー株式会社 | アモルファスカーボン基材 |
| US7473767B2 (en) | 2001-07-03 | 2009-01-06 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
| JP2003294742A (ja) * | 2002-03-29 | 2003-10-15 | Inst Of Physical & Chemical Res | ハイブリダイゼーション用基板及びその使用方法 |
| EP1491888B1 (en) | 2002-04-03 | 2008-09-17 | Mitsubishi Rayon Co., Ltd. | Microarray comprising gel having biosubstance fixed thereto as well as manufacture and use thereof |
| US20070275411A1 (en) | 2006-05-25 | 2007-11-29 | Mcgall Glenn H | Silane mixtures |
| US7332273B2 (en) | 2002-06-20 | 2008-02-19 | Affymetrix, Inc. | Antireflective coatings for high-resolution photolithographic synthesis of DNA arrays |
| US7038037B2 (en) * | 2002-06-20 | 2006-05-02 | Isis Pharmaceuticals, Inc. | Method for sequential support-bound synthesis of conjugated oligomeric compounds |
| WO2004025258A2 (en) * | 2002-09-10 | 2004-03-25 | Sydney Kimmel Cancer Center | Gene segregation and biological sample classification methods |
| US7070922B2 (en) * | 2002-12-04 | 2006-07-04 | International Business Machines Corporation | Surface treatment |
| WO2004058052A2 (en) | 2002-12-20 | 2004-07-15 | Applera Corporation | Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof |
| CA2513899C (en) | 2003-01-29 | 2013-03-26 | 454 Corporation | Methods of amplifying and sequencing nucleic acids |
| CN103396933B (zh) | 2003-02-26 | 2016-04-20 | 凯利达基因组股份有限公司 | 通过杂交进行的随机阵列dna分析 |
| EP1604040B1 (en) * | 2003-03-07 | 2010-10-13 | Rubicon Genomics, Inc. | Amplification and analysis of whole genome and whole transcriptome libraries generated by a dna polymerization process |
| US8206913B1 (en) | 2003-03-07 | 2012-06-26 | Rubicon Genomics, Inc. | Amplification and analysis of whole genome and whole transcriptome libraries generated by a DNA polymerization process |
| WO2005001113A2 (en) * | 2003-06-27 | 2005-01-06 | Thomas Jefferson University | Methods for detecting nucleic acid variations |
| US20050042363A1 (en) * | 2003-08-18 | 2005-02-24 | Kukhtin Alexander V. | Method for fabrication of biochips with a macroporous polymer substrate |
| US20050266417A1 (en) * | 2003-09-12 | 2005-12-01 | Francis Barany | Methods for identifying target nucleic acid molecules |
| WO2005056837A2 (en) | 2003-11-26 | 2005-06-23 | Applera Corporation | Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof |
| DE10359173B4 (de) * | 2003-12-17 | 2006-11-09 | Robert Bosch Gmbh | Messvorrichtung mit mehreren auf einem Substrat angeordneten potentiometrischen Elektrodenpaaren |
| KR100580642B1 (ko) * | 2004-01-12 | 2006-05-16 | 삼성전자주식회사 | 표면에 활성화된 카르복실기를 갖는 기판을 이용하여 생물분자를 고체 기판상에 고밀도로 고정화하는 방법 및 그에 의하여 제조되는 마이크로어레이 |
| CA2555704A1 (en) | 2004-02-10 | 2005-08-25 | Cornell Research Foundation, Inc. | Method for detection of promoter methylation status |
| DE602005023710D1 (de) * | 2004-02-20 | 2010-11-04 | Japan Science & Tech Agency | Dna-array zur analyse der dna-methylierung, konstruktionsverfahren dafür sowie verfahren zur analyse der dna-methylierung |
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- 2000-03-17 JP JP2000606786A patent/JP4766750B2/ja not_active Expired - Fee Related
- 2000-03-17 EP EP00916438A patent/EP1208223A2/en not_active Withdrawn
- 2000-03-17 CA CA002366249A patent/CA2366249A1/en not_active Abandoned
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Also Published As
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|---|---|
| WO2000056927A3 (en) | 2002-03-14 |
| JP2003520570A (ja) | 2003-07-08 |
| AU781661C (en) | 2005-12-01 |
| WO2000056927A2 (en) | 2000-09-28 |
| JP2011200230A (ja) | 2011-10-13 |
| AU781661B2 (en) | 2005-06-02 |
| US20030175750A1 (en) | 2003-09-18 |
| EP1208223A2 (en) | 2002-05-29 |
| AU3754500A (en) | 2000-10-09 |
| US6506594B1 (en) | 2003-01-14 |
| CA2366249A1 (en) | 2000-09-28 |
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