JP4766750B2 - 位置特定可能なアレイによるリガーゼ検出反応を用いた核酸配列差異の検出 - Google Patents
位置特定可能なアレイによるリガーゼ検出反応を用いた核酸配列差異の検出 Download PDFInfo
- Publication number
- JP4766750B2 JP4766750B2 JP2000606786A JP2000606786A JP4766750B2 JP 4766750 B2 JP4766750 B2 JP 4766750B2 JP 2000606786 A JP2000606786 A JP 2000606786A JP 2000606786 A JP2000606786 A JP 2000606786A JP 4766750 B2 JP4766750 B2 JP 4766750B2
- Authority
- JP
- Japan
- Prior art keywords
- oligonucleotide probe
- oligonucleotide
- ligation
- nucleotide sequence
- target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00324—Reactor vessels in a multiple arrangement the reactor vessels or wells being arranged in plates moving in parallel to each other
- B01J2219/00326—Movement by rotation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00414—Means for dispensing and evacuation of reagents using suction
- B01J2219/00416—Vacuum
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/0059—Sequential processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00599—Solution-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00623—Immobilisation or binding
- B01J2219/00626—Covalent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00632—Introduction of reactive groups to the surface
- B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
- B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00729—Peptide nucleic acids [PNA]
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12535799P | 1999-03-19 | 1999-03-19 | |
| US60/125,357 | 1999-03-19 | ||
| PCT/US2000/007006 WO2000056927A2 (en) | 1999-03-19 | 2000-03-17 | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011091716A Division JP2011200230A (ja) | 1999-03-19 | 2011-04-18 | 位置特定可能なアレイによるリガーゼ検出反応を用いた核酸配列差異の検出 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003520570A JP2003520570A (ja) | 2003-07-08 |
| JP2003520570A5 JP2003520570A5 (https=) | 2010-09-30 |
| JP4766750B2 true JP4766750B2 (ja) | 2011-09-07 |
Family
ID=22419369
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000606786A Expired - Fee Related JP4766750B2 (ja) | 1999-03-19 | 2000-03-17 | 位置特定可能なアレイによるリガーゼ検出反応を用いた核酸配列差異の検出 |
| JP2011091716A Withdrawn JP2011200230A (ja) | 1999-03-19 | 2011-04-18 | 位置特定可能なアレイによるリガーゼ検出反応を用いた核酸配列差異の検出 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011091716A Withdrawn JP2011200230A (ja) | 1999-03-19 | 2011-04-18 | 位置特定可能なアレイによるリガーゼ検出反応を用いた核酸配列差異の検出 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6506594B1 (https=) |
| EP (1) | EP1208223A2 (https=) |
| JP (2) | JP4766750B2 (https=) |
| AU (1) | AU781661C (https=) |
| CA (1) | CA2366249A1 (https=) |
| WO (1) | WO2000056927A2 (https=) |
Families Citing this family (178)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020150921A1 (en) * | 1996-02-09 | 2002-10-17 | Francis Barany | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| US6852487B1 (en) * | 1996-02-09 | 2005-02-08 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| EP1736554B1 (en) | 1996-05-29 | 2013-10-09 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
| CA2352363A1 (en) * | 1998-11-27 | 2000-06-08 | Synaptics (Uk) Limited | Position sensor |
| US6506594B1 (en) * | 1999-03-19 | 2003-01-14 | Cornell Res Foundation Inc | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| US20060275782A1 (en) * | 1999-04-20 | 2006-12-07 | Illumina, Inc. | Detection of nucleic acid reactions on bead arrays |
| US20030215821A1 (en) * | 1999-04-20 | 2003-11-20 | Kevin Gunderson | Detection of nucleic acid reactions on bead arrays |
| US20020119448A1 (en) | 1999-06-23 | 2002-08-29 | Joseph A. Sorge | Methods of enriching for and identifying polymorphisms |
| US7041445B2 (en) * | 1999-11-15 | 2006-05-09 | Clontech Laboratories, Inc. | Long oligonucleotide arrays |
| US6235483B1 (en) * | 2000-01-31 | 2001-05-22 | Agilent Technologies, Inc. | Methods and kits for indirect labeling of nucleic acids |
| US6872552B2 (en) | 2000-02-29 | 2005-03-29 | Burt D. Ensley | Method of reconstituting nucleic acid molecules |
| EP1303639A2 (en) | 2000-04-14 | 2003-04-23 | Cornell Research Foundation, Inc. | Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction |
| EP1164201A1 (en) * | 2000-06-14 | 2001-12-19 | Facultés Universitaires Notre-Dame de la Paix | Reverse detection for identification and/or quantification of nucleotide target sequences on biochips |
| EP1292606A4 (en) * | 2000-06-23 | 2004-03-24 | Yissum Res Dev Co | POSITIVELY CHARGED PEPTIDIC NUCLEIC ACID ANALOGS WITH IMPROVED PROPERTIES |
| EP1186671A3 (en) * | 2000-09-05 | 2003-12-17 | Agilent Technologies, Inc. (a Delaware corporation) | Method for hybridization of arrays on siliceous surfaces |
| DE60131903T2 (de) * | 2000-10-24 | 2008-11-27 | The Board of Trustees of the Leland S. Stanford Junior University, Palo Alto | Direkte multiplex charakterisierung von genomischer dna |
| US7091034B2 (en) * | 2000-12-15 | 2006-08-15 | Burstein Technologies, Inc. | Detection system for disk-based laboratory and improved optical bio-disc including same |
| JP3605039B2 (ja) * | 2001-01-09 | 2004-12-22 | 株式会社日立製作所 | 核酸マイクロアレイ、その製造方法及びそれを用いた核酸検出方法 |
| JP4189471B2 (ja) * | 2001-01-25 | 2008-12-03 | クラスターテクノロジー株式会社 | アモルファスカーボン基材 |
| US7473767B2 (en) | 2001-07-03 | 2009-01-06 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
| JP2003294742A (ja) * | 2002-03-29 | 2003-10-15 | Inst Of Physical & Chemical Res | ハイブリダイゼーション用基板及びその使用方法 |
| WO2003083475A1 (en) * | 2002-04-03 | 2003-10-09 | Mitsubishi Rayon Co., Ltd. | Gel having biosubstance fixed thereto and microarray utilizing the gel |
| US7038037B2 (en) * | 2002-06-20 | 2006-05-02 | Isis Pharmaceuticals, Inc. | Method for sequential support-bound synthesis of conjugated oligomeric compounds |
| US7332273B2 (en) | 2002-06-20 | 2008-02-19 | Affymetrix, Inc. | Antireflective coatings for high-resolution photolithographic synthesis of DNA arrays |
| US20070275411A1 (en) | 2006-05-25 | 2007-11-29 | Mcgall Glenn H | Silane mixtures |
| US20040053317A1 (en) * | 2002-09-10 | 2004-03-18 | Sidney Kimmel Cancer Center | Gene segregation and biological sample classification methods |
| US7070922B2 (en) * | 2002-12-04 | 2006-07-04 | International Business Machines Corporation | Surface treatment |
| CA2941594C (en) | 2002-12-20 | 2021-07-06 | Celera Corporation | Genetic polymorphisms of the protein receptor c (procr) associated with myocardial infarction, methods of detection and uses thereof |
| WO2005003375A2 (en) | 2003-01-29 | 2005-01-13 | 454 Corporation | Methods of amplifying and sequencing nucleic acids |
| EP2365095A1 (en) | 2003-02-26 | 2011-09-14 | Callida Genomics, Inc. | Random array DNA analysis by hybridization |
| EP1604040B1 (en) * | 2003-03-07 | 2010-10-13 | Rubicon Genomics, Inc. | Amplification and analysis of whole genome and whole transcriptome libraries generated by a dna polymerization process |
| US8206913B1 (en) | 2003-03-07 | 2012-06-26 | Rubicon Genomics, Inc. | Amplification and analysis of whole genome and whole transcriptome libraries generated by a DNA polymerization process |
| WO2005001113A2 (en) * | 2003-06-27 | 2005-01-06 | Thomas Jefferson University | Methods for detecting nucleic acid variations |
| US20050042363A1 (en) * | 2003-08-18 | 2005-02-24 | Kukhtin Alexander V. | Method for fabrication of biochips with a macroporous polymer substrate |
| WO2005026329A2 (en) * | 2003-09-12 | 2005-03-24 | Cornell Research Foundation, Inc. | Methods for identifying target nucleic acid molecules |
| CA2547072C (en) | 2003-11-26 | 2015-06-23 | Applera Corporation | Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof |
| DE10359173B4 (de) * | 2003-12-17 | 2006-11-09 | Robert Bosch Gmbh | Messvorrichtung mit mehreren auf einem Substrat angeordneten potentiometrischen Elektrodenpaaren |
| KR100580642B1 (ko) * | 2004-01-12 | 2006-05-16 | 삼성전자주식회사 | 표면에 활성화된 카르복실기를 갖는 기판을 이용하여 생물분자를 고체 기판상에 고밀도로 고정화하는 방법 및 그에 의하여 제조되는 마이크로어레이 |
| CA2555704A1 (en) | 2004-02-10 | 2005-08-25 | Cornell Research Foundation, Inc. | Method for detection of promoter methylation status |
| DE602005023710D1 (de) * | 2004-02-20 | 2010-11-04 | Japan Science & Tech Agency | Dna-array zur analyse der dna-methylierung, konstruktionsverfahren dafür sowie verfahren zur analyse der dna-methylierung |
| KR100590550B1 (ko) * | 2004-03-12 | 2006-06-19 | 삼성전자주식회사 | 동일한 표적핵산에 결합하는 프로브 폴리뉴클레오티드사이의 거리가 최대가 되도록 배열되어 있는마이크로어레이 및 그를 제조하는 방법 |
| US7723126B2 (en) * | 2004-03-24 | 2010-05-25 | Wisconsin Alumni Research Foundation | Plasma-enhanced functionalization of inorganic oxide surfaces |
| US7767220B2 (en) * | 2004-04-23 | 2010-08-03 | Boston Scientific Scimed, Inc. | Implantable or insertable medical articles having covalently modified, biocompatible surfaces |
| JP5236286B2 (ja) | 2004-05-07 | 2013-07-17 | セレラ コーポレーション | 肝線維症に関連する遺伝的多型、その検出方法および使用 |
| US7338763B2 (en) * | 2004-06-02 | 2008-03-04 | Eppendorf Array Technologies S.A. | Method and kit for the detection and/or quantification of homologous nucleotide sequences on arrays |
| US7785843B2 (en) * | 2004-06-23 | 2010-08-31 | Sequenom, Inc. | Target-specific compomers and methods of use |
| US20060009038A1 (en) * | 2004-07-12 | 2006-01-12 | International Business Machines Corporation | Processing for overcoming extreme topography |
| WO2006034387A1 (en) | 2004-09-21 | 2006-03-30 | Applera Corporation | TWO-COLOR REAL-TIME/END-POINT QUANTITATION OF MICRORNAS (miRNAs) |
| WO2006064745A1 (ja) * | 2004-12-17 | 2006-06-22 | Toyo Boseki Kabushiki Kaisha | 塩基多型の同定方法 |
| US20060199207A1 (en) * | 2005-02-24 | 2006-09-07 | Matysiak Stefan M | Self-assembly of molecules using combinatorial hybridization |
| EP2113572B1 (en) | 2005-03-11 | 2012-12-05 | Celera Corporation | Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof |
| US7494776B2 (en) * | 2005-07-07 | 2009-02-24 | Beckman Coulter, Inc. | Labeled complementary oligonucleotides to detect oligonucleotide-linked ligands |
| US7799530B2 (en) | 2005-09-23 | 2010-09-21 | Celera Corporation | Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof |
| EP1963531B1 (en) | 2005-12-23 | 2011-09-21 | Nanostring Technologies, Inc. | Nanoreporters and methods of manufacturing and use thereof |
| US20070264130A1 (en) * | 2006-01-27 | 2007-11-15 | Phluid, Inc. | Infusion Pumps and Methods for Use |
| WO2007092538A2 (en) | 2006-02-07 | 2007-08-16 | President And Fellows Of Harvard College | Methods for making nucleotide probes for sequencing and synthesis |
| WO2007116129A1 (en) * | 2006-04-10 | 2007-10-18 | Wallac Oy | A universal labeling system |
| CN1896284B (zh) * | 2006-06-30 | 2013-09-11 | 博奥生物有限公司 | 一种鉴别等位基因类型的方法 |
| WO2008039998A2 (en) * | 2006-09-28 | 2008-04-03 | President And Fellows Of Harvard College | Methods for sequencing dna |
| US7910303B2 (en) | 2006-10-20 | 2011-03-22 | Celera Corporation | Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof |
| US8029902B2 (en) * | 2006-12-11 | 2011-10-04 | Wisconsin Alumni Research Foundation | Plasma-enhanced functionalization of substrate surfaces with quaternary ammonium and quaternary phosphonium groups |
| EP2183386A1 (en) | 2007-05-31 | 2010-05-12 | Yale University | A genetic lesion associated with cancer |
| JP2009011247A (ja) * | 2007-07-05 | 2009-01-22 | Sumitomo Bakelite Co Ltd | 遺伝子の検出方法 |
| US8039212B2 (en) | 2007-11-05 | 2011-10-18 | Celera Corporation | Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof |
| US8852864B2 (en) * | 2008-01-17 | 2014-10-07 | Sequenom Inc. | Methods and compositions for the analysis of nucleic acids |
| US8986253B2 (en) * | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
| US20090221620A1 (en) | 2008-02-20 | 2009-09-03 | Celera Corporation | Gentic polymorphisms associated with stroke, methods of detection and uses thereof |
| JP2009268665A (ja) * | 2008-05-07 | 2009-11-19 | Canon Inc | 吸入装置 |
| WO2009143188A2 (en) * | 2008-05-19 | 2009-11-26 | Diperna Paul M | Disposable pump reservoir and related methods |
| EP3093351B1 (en) | 2008-07-09 | 2018-04-18 | Celera Corporation | Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof |
| US8408421B2 (en) * | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
| AU2009293019A1 (en) * | 2008-09-19 | 2010-03-25 | Tandem Diabetes Care Inc. | Solute concentration measurement device and related methods |
| EP2192409B1 (en) * | 2008-11-26 | 2014-04-23 | Corning Incorporated | Label independent detection biosensor composition and methods thereof |
| RU2572826C2 (ru) | 2008-12-02 | 2016-01-20 | Чиралджен, Лтд. | Способ синтеза модифицированных по атому фосфора нуклеиновых кислот |
| KR20100089688A (ko) * | 2009-02-04 | 2010-08-12 | 삼성전자주식회사 | 표적핵산의 서열을 분석하는 방법 |
| AU2010221721A1 (en) | 2009-02-06 | 2011-08-18 | Yale University | A SNP marker of breast and ovarian cancer risk |
| KR101829182B1 (ko) | 2009-04-02 | 2018-03-29 | 플루이다임 코포레이션 | 표적 핵산의 바코딩을 위한 멀티 프라이머 증폭 방법 |
| CN104404134B (zh) | 2009-04-03 | 2017-05-10 | 莱弗斯基因股份有限公司 | 多重核酸检测方法和系统 |
| AU2010265889A1 (en) | 2009-06-25 | 2012-01-19 | Yale University | Single nucleotide polymorphisms in BRCA1 and cancer risk |
| CA2767253A1 (en) | 2009-07-06 | 2011-01-13 | Ontorii, Inc. | Novel nucleic acid prodrugs and methods of use thereof |
| EP3284494A1 (en) | 2009-07-30 | 2018-02-21 | Tandem Diabetes Care, Inc. | Portable infusion pump system |
| JP5663491B2 (ja) | 2009-10-29 | 2015-02-04 | 日本碍子株式会社 | 標的核酸の検出方法 |
| US20110269735A1 (en) | 2010-04-19 | 2011-11-03 | Celera Corporation | Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof |
| US20140342940A1 (en) | 2011-01-25 | 2014-11-20 | Ariosa Diagnostics, Inc. | Detection of Target Nucleic Acids using Hybridization |
| US8700338B2 (en) | 2011-01-25 | 2014-04-15 | Ariosa Diagnosis, Inc. | Risk calculation for evaluation of fetal aneuploidy |
| US11203786B2 (en) | 2010-08-06 | 2021-12-21 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
| US20130261003A1 (en) | 2010-08-06 | 2013-10-03 | Ariosa Diagnostics, In. | Ligation-based detection of genetic variants |
| US11031095B2 (en) | 2010-08-06 | 2021-06-08 | Ariosa Diagnostics, Inc. | Assay systems for determination of fetal copy number variation |
| US20120034603A1 (en) | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
| US20130040375A1 (en) | 2011-08-08 | 2013-02-14 | Tandem Diagnotics, Inc. | Assay systems for genetic analysis |
| US10533223B2 (en) | 2010-08-06 | 2020-01-14 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
| US10167508B2 (en) | 2010-08-06 | 2019-01-01 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities |
| JP5868324B2 (ja) | 2010-09-24 | 2016-02-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
| US20120108651A1 (en) | 2010-11-02 | 2012-05-03 | Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) | Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof |
| US11270781B2 (en) | 2011-01-25 | 2022-03-08 | Ariosa Diagnostics, Inc. | Statistical analysis for non-invasive sex chromosome aneuploidy determination |
| US9994897B2 (en) | 2013-03-08 | 2018-06-12 | Ariosa Diagnostics, Inc. | Non-invasive fetal sex determination |
| US8756020B2 (en) | 2011-01-25 | 2014-06-17 | Ariosa Diagnostics, Inc. | Enhanced risk probabilities using biomolecule estimations |
| WO2012103031A2 (en) | 2011-01-25 | 2012-08-02 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities |
| US10131947B2 (en) | 2011-01-25 | 2018-11-20 | Ariosa Diagnostics, Inc. | Noninvasive detection of fetal aneuploidy in egg donor pregnancies |
| EP2675914A1 (en) | 2011-02-18 | 2013-12-25 | Yale University, Inc. | The kras-variant and endometriosis |
| WO2012118745A1 (en) | 2011-02-28 | 2012-09-07 | Arnold Oliphant | Assay systems for detection of aneuploidy and sex determination |
| US20140065615A1 (en) | 2011-03-21 | 2014-03-06 | Yale University | The KRAS Variant and Tumor Biology |
| US8759036B2 (en) | 2011-03-21 | 2014-06-24 | Affymetrix, Inc. | Methods for synthesizing pools of probes |
| SG194722A1 (en) | 2011-05-09 | 2013-12-30 | Fluidigm Corp | Probe based nucleic acid detection |
| AU2012284265B2 (en) | 2011-07-19 | 2017-08-17 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| US8712697B2 (en) | 2011-09-07 | 2014-04-29 | Ariosa Diagnostics, Inc. | Determination of copy number variations using binomial probability calculations |
| EP2607495A1 (en) * | 2011-12-23 | 2013-06-26 | Genomica S.A.U. | Method for detection of KRAS mutations |
| JP6012767B2 (ja) | 2012-02-07 | 2016-10-25 | ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー | 基板、ペプチドアレイ、および方法 |
| US9045803B2 (en) | 2012-02-29 | 2015-06-02 | Abbott Molecular Inc. | Hepatitis B virus typing and resistance assay |
| US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
| US10289800B2 (en) | 2012-05-21 | 2019-05-14 | Ariosa Diagnostics, Inc. | Processes for calculating phased fetal genomic sequences |
| CN102719538A (zh) * | 2012-06-07 | 2012-10-10 | 上海交通大学 | 非侵入性产前诊断高危遗传性耳聋的基因芯片及制备方法 |
| KR102062565B1 (ko) * | 2012-06-20 | 2020-01-06 | 도레이 카부시키가이샤 | 핵산의 검출 방법 및 핵산 검출 키트 |
| CN104684923B (zh) | 2012-07-13 | 2018-09-28 | 株式会社新日本科学 | 手性核酸佐剂 |
| SG11201500239VA (en) | 2012-07-13 | 2015-03-30 | Wave Life Sciences Japan | Asymmetric auxiliary group |
| JP6453212B2 (ja) | 2012-07-13 | 2019-01-16 | ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. | キラル制御 |
| JP2015522293A (ja) | 2012-07-19 | 2015-08-06 | アリオサ ダイアグノスティックス インコーポレイテッドAriosa Diagnostics,Inc. | 多重化連続ライゲーションに基づく遺伝子変異体の検出 |
| US10059983B2 (en) | 2012-09-10 | 2018-08-28 | Genesky Diagnostics (Suzhou) Inc. | Multiplex nucleic acid analysis |
| CA2886605A1 (en) | 2012-09-28 | 2014-04-03 | Cepheid | Two-primer pcr for microrna multiplex assay |
| US10006909B2 (en) * | 2012-09-28 | 2018-06-26 | Vibrant Holdings, Llc | Methods, systems, and arrays for biomolecular analysis |
| US10286376B2 (en) | 2012-11-14 | 2019-05-14 | Vibrant Holdings, Llc | Substrates, systems, and methods for array synthesis and biomolecular analysis |
| US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
| ES2746237T3 (es) | 2013-03-14 | 2020-03-05 | Univ Cornell | Método para la cuantificación relativa de cambios en la metilación del ADN, usando reacciones combinadas de nucleasa, ligamiento, y polimerasa |
| CN112037860B (zh) | 2013-06-13 | 2024-02-23 | 豪夫迈·罗氏有限公司 | 用于非入侵性性染色体非整倍性确定的统计分析 |
| WO2015026873A1 (en) * | 2013-08-19 | 2015-02-26 | Singular Bio, Inc. | Assays for single molecule detection and use thereof |
| WO2015035087A1 (en) | 2013-09-04 | 2015-03-12 | Fluidigm Corporation | Proximity assays for detecting nucleic acids and proteins in a single cell |
| WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| JPWO2015108046A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
| WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| ES2917473T3 (es) | 2014-01-16 | 2022-07-08 | Wave Life Sciences Ltd | Diseño quiral |
| US10260111B1 (en) | 2014-01-20 | 2019-04-16 | Brett Eric Etchebarne | Method of detecting sepsis-related microorganisms and detecting antibiotic-resistant sepsis-related microorganisms in a fluid sample |
| PT3126523T (pt) | 2014-04-01 | 2020-05-15 | Univ Cornell | Deteção da metilação de adn utilizando reações de ligação e nuclease combinadas |
| US10526601B2 (en) | 2014-05-23 | 2020-01-07 | Digenomix Corporation | Haploidome determination by digitized transposons |
| EP3175236B1 (en) * | 2014-08-01 | 2019-08-21 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
| US10480036B2 (en) | 2014-08-22 | 2019-11-19 | Cepheid | Methods of detecting influenza |
| WO2016069853A2 (en) | 2014-10-30 | 2016-05-06 | Cepheid | Methods of detecting ebola |
| CN114369596B (zh) | 2014-12-15 | 2025-07-08 | 塞弗德公司 | 底数大于2的指数核酸扩增 |
| KR101742681B1 (ko) | 2015-01-30 | 2017-06-01 | 에스디 바이오센서 주식회사 | 상보적 염기서열 내지는 미스-매치된 염기를 포함하는 상보적인 염기서열과 연결된 pcr 프라이머 및 이를 이용한 핵산 증폭 방법 |
| JP2018509896A (ja) | 2015-02-27 | 2018-04-12 | フリューダイム・コーポレイション | 高処理能力研究用の単一細胞核酸 |
| WO2016205233A2 (en) | 2015-06-15 | 2016-12-22 | Cepheid | Integrated purification and measurement of dna methylation and co-measurement of mutations and/or mrna expression levels in an automated reaction cartridge |
| CA3011363A1 (en) | 2016-01-12 | 2017-07-20 | Interleukin Genetics, Inc. | Methods for predicting response to treatment |
| WO2017189906A1 (en) | 2016-04-27 | 2017-11-02 | Mira Dx, Inc. | Immune-based treatment of kras-variant cancer patients |
| JP2018068268A (ja) * | 2016-11-04 | 2018-05-10 | 株式会社Gsp研究所 | 染色体の構造異常を迅速に検出するための方法、促進剤およびそれを含むキット |
| JP2020503857A (ja) | 2016-12-12 | 2020-02-06 | セファイド | 自動反応カートリッジにおける統合化イムノpcr及び核酸分析 |
| MX2019006628A (es) | 2016-12-12 | 2019-11-12 | Cepheid | Purificacion y medicion integradas de metilacion de adn y co-medicion de mutaciones y/o niveles de expresion de arnm en un cartucho de reaccion automatizado. |
| US10329620B2 (en) | 2017-01-12 | 2019-06-25 | Cardioforecast Ltd. | Methods and kits for treating cardiovascular disease |
| CA3078158A1 (en) | 2017-10-06 | 2019-04-11 | Cartana Ab | Rna templated ligation |
| US12235273B2 (en) | 2018-05-04 | 2025-02-25 | Abbott Laboratories | HBV diagnostic, prognostic, and therapeutic methods and products |
| CN112770776B (zh) | 2018-07-30 | 2025-08-19 | 瑞德库尔有限责任公司 | 用于样品处理或分析的方法和系统 |
| CA3118000A1 (en) | 2018-10-29 | 2020-05-07 | Cepheid | Exponential base-3 nucleic acid amplification with reduced amplification time using nested overlapping primers |
| EP3921418A4 (en) | 2019-02-06 | 2023-02-08 | Singular Genomics Systems, Inc. | Compositions and methods for nucleic acid sequencing |
| US20220249660A1 (en) | 2019-06-06 | 2022-08-11 | Sitokine Limited | Compositions and methods for treating lung, colorectal and breast cancer |
| WO2021028469A1 (en) | 2019-08-12 | 2021-02-18 | Sitokine Limited | Compositions and methods for treating cytokine release syndrome and neurotoxicity |
| WO2021085454A1 (ja) | 2019-10-29 | 2021-05-06 | 東レ株式会社 | バイオチップの製造方法 |
| EP3901286A1 (en) | 2020-04-24 | 2021-10-27 | Mirnax Biosens, S.L. | Bivalent reverse primer |
| EP4055189B1 (en) | 2019-11-04 | 2025-01-01 | Mirnax Biosens, S.L. | Bivalent reverse primer |
| WO2021155063A1 (en) | 2020-01-29 | 2021-08-05 | Readcoor, Llc | Compositions and methods for analyte detection |
| WO2021205013A1 (en) | 2020-04-09 | 2021-10-14 | Sitokine Limited | Compositions and methods for treating covid-19 |
| CA3176983A1 (en) | 2020-04-27 | 2021-11-04 | Cepheid | Exponential base-3 and greater nucleic acid amplification with cycling probe |
| KR20230030639A (ko) | 2020-06-26 | 2023-03-06 | 세페이드 | Sars-cov-2, 인플루엔자 및 rsv를 검출하는 방법 |
| US20230265492A1 (en) * | 2020-07-27 | 2023-08-24 | Nanjing GenScript Biotech Co., Ltd. | Surface linker of semiconductor chip, preparation method therefor and application thereof |
| EP4226158A1 (en) | 2020-10-06 | 2023-08-16 | Cepheid | Methods of diagnosing tuberculosis and differentiating between active and latent tuberculosis |
| US12379344B2 (en) | 2021-06-09 | 2025-08-05 | Avery Digital Data, Inc. | Electronic devices for polymer synthesis and assembly |
| EP4419715A1 (en) | 2021-10-22 | 2024-08-28 | Cepheid | Compositions and methods of diagnosing and treating tuberculosis |
| EP4526479A1 (en) | 2022-05-19 | 2025-03-26 | Cepheid | Mvp cartridge and methods of use and manufacture |
| EP4587840A1 (en) | 2022-09-15 | 2025-07-23 | Abbott Laboratories | Hbv diagnostic, prognostic, and therapeutic methods and products |
| CN120641576A (zh) | 2022-12-16 | 2025-09-12 | 塞弗德公司 | Mpox演化支ii生物标志物组 |
| IL322298A (en) | 2023-01-23 | 2025-09-01 | Next Gen Diagnostics Llc | Methods for rapid identification of resistance to Escherichia coli |
| KR20250138809A (ko) | 2023-01-30 | 2025-09-22 | 세페이드 | 호흡기 바이오마커 패널 |
| WO2025006633A1 (en) | 2023-06-27 | 2025-01-02 | Cepheid | Pancoronavirus biomarker panel |
| WO2025064410A1 (en) | 2023-09-18 | 2025-03-27 | Cepheid | Three-phase nested amplification and multi-phasic detection |
| CN117358168A (zh) * | 2023-10-24 | 2024-01-09 | 苏州拉索生物芯片科技有限公司 | 一种改性二氧化硅微球的制备方法及应用 |
| WO2025101548A2 (en) | 2023-11-08 | 2025-05-15 | Cepheid | Her2 low quantification method |
| WO2025175133A1 (en) | 2024-02-14 | 2025-08-21 | Cepheid | Melt shape genotyping |
| WO2025179142A1 (en) | 2024-02-22 | 2025-08-28 | Cepheid | Maximizing optical channel capabilities for target detection |
| WO2025207561A1 (en) | 2024-03-27 | 2025-10-02 | Cepheid | Isothermal amplification using novel synthetic oligonucleotides |
| WO2026019604A1 (en) | 2024-07-19 | 2026-01-22 | Cepheid | Exponential base-x amplification with hairpin nested primers and universal flanking primers |
| WO2026055639A1 (en) | 2024-09-06 | 2026-03-12 | Cepheid | Sample in sequencing-ready library out automated library preparation solution |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997031256A2 (en) * | 1996-02-09 | 1997-08-28 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| WO1998003673A1 (en) * | 1996-07-19 | 1998-01-29 | Cornell Research Foundation, Inc. | High fidelity detection of nucleic acid differences by ligase detection reaction |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5258506A (en) * | 1984-10-16 | 1993-11-02 | Chiron Corporation | Photolabile reagents for incorporation into oligonucleotide chains |
| US4883750A (en) | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
| US5525464A (en) * | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
| GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
| US4988617A (en) | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
| US5700637A (en) * | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
| WO1990011372A1 (en) * | 1989-03-21 | 1990-10-04 | Collaborative Research, Inc. | Multiplex dna diagnostic test |
| US5035996A (en) * | 1989-06-01 | 1991-07-30 | Life Technologies, Inc. | Process for controlling contamination of nucleic acid amplification reactions |
| US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5527681A (en) * | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
| US5104792A (en) * | 1989-12-21 | 1992-04-14 | The United States Of America As Represented By The Department Of Health And Human Services | Method for amplifying unknown nucleic acid sequences |
| US5494810A (en) * | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
| WO1992001814A2 (en) * | 1990-07-24 | 1992-02-06 | F. Hoffmann-La-Roche Ag | The reduction of non-specific amplification during in vitro nucleic acid amplification using modified nucleic acid bases |
| CA2046713A1 (en) * | 1990-10-16 | 1992-04-17 | Richard M. Martinelli | Amplification of midivariant dna templates |
| DE69132905T2 (de) | 1990-12-06 | 2002-08-01 | Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) | Detektion von Nukleinsäuresequenzen |
| EP0566670A4 (en) * | 1990-12-17 | 1993-12-08 | Idexx Laboratories, Inc. | Nucleic acid sequence detection by triple helix formation |
| US5290925A (en) * | 1990-12-20 | 1994-03-01 | Abbott Laboratories | Methods, kits, and reactive supports for 3' labeling of oligonucleotides |
| RU1794088C (ru) | 1991-03-18 | 1993-02-07 | Институт Молекулярной Биологии Ан@ Ссср | Способ определени нуклеотидной последовательности ДНК и устройство дл его осуществлени |
| WO1992021079A1 (en) * | 1991-05-24 | 1992-11-26 | The President And Fellows Of Harvard College | Parallel sequential reactor |
| US5278298A (en) * | 1991-05-29 | 1994-01-11 | Merck & Co., Inc. | Eimeria brunetti 16s rDNA probes |
| ES2091976T3 (es) * | 1991-06-20 | 1996-11-16 | Hoffmann La Roche | Metodos perfeccionados para la amplificacion del acido nucleico. |
| US5371241A (en) * | 1991-07-19 | 1994-12-06 | Pharmacia P-L Biochemicals Inc. | Fluorescein labelled phosphoramidites |
| DE69223980T2 (de) * | 1991-10-15 | 1998-05-28 | Multilyte Ltd | Bindungstest unter benutzung eines markierten reagens |
| US5594121A (en) * | 1991-11-07 | 1997-01-14 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified purines |
| US5412087A (en) * | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
| US5324633A (en) | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
| WO1993017126A1 (en) * | 1992-02-19 | 1993-09-02 | The Public Health Research Institute Of The City Of New York, Inc. | Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids |
| US5470705A (en) * | 1992-04-03 | 1995-11-28 | Applied Biosystems, Inc. | Probe composition containing a binding domain and polymer chain and methods of use |
| ATE173767T1 (de) | 1992-04-03 | 1998-12-15 | Perkin Elmer Corp | Proben zusammensetzung und verfahren |
| US5981176A (en) | 1992-06-17 | 1999-11-09 | City Of Hope | Method of detecting and discriminating between nucleic acid sequences |
| US6180338B1 (en) * | 1992-08-04 | 2001-01-30 | Beckman Coulter, Inc. | Method, reagent and kit for the detection and amplification of nucleic acid sequences |
| AU5355594A (en) | 1992-10-09 | 1994-05-09 | Oncor, Inc. | Methods for the detection of chromosome structural abnormalities by (in situ) hybridization to fixed tissue |
| US5795714A (en) | 1992-11-06 | 1998-08-18 | Trustees Of Boston University | Method for replicating an array of nucleic acid probes |
| JP2575270B2 (ja) | 1992-11-10 | 1997-01-22 | 浜松ホトニクス株式会社 | 核酸の塩基配列決定方法、単一分子検出方法、その装置及び試料の作成方法 |
| US5593840A (en) * | 1993-01-27 | 1997-01-14 | Oncor, Inc. | Amplification of nucleic acid sequences |
| WO1994017206A1 (en) | 1993-01-27 | 1994-08-04 | Oncor, Inc. | Method for amplifying nucleic acid sequences |
| JPH08508636A (ja) | 1993-01-27 | 1996-09-17 | オンコール インコーポレーテッド | 核酸配列の増幅 |
| US5593826A (en) * | 1993-03-22 | 1997-01-14 | Perkin-Elmer Corporation, Applied Biosystems, Inc. | Enzymatic ligation of 3'amino-substituted oligonucleotides |
| CA2122203C (en) * | 1993-05-11 | 2001-12-18 | Melinda S. Fraiser | Decontamination of nucleic acid amplification reactions |
| US5858659A (en) | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
| US5731171A (en) * | 1993-07-23 | 1998-03-24 | Arch Development Corp. | Sequence independent amplification of DNA |
| US5415839A (en) | 1993-10-21 | 1995-05-16 | Abbott Laboratories | Apparatus and method for amplifying and detecting target nucleic acids |
| US6156501A (en) * | 1993-10-26 | 2000-12-05 | Affymetrix, Inc. | Arrays of modified nucleic acid probes and methods of use |
| US5429807A (en) * | 1993-10-28 | 1995-07-04 | Beckman Instruments, Inc. | Method and apparatus for creating biopolymer arrays on a solid support surface |
| US5352582A (en) * | 1993-10-28 | 1994-10-04 | Hewlett-Packard Company | Holographic based bio-assay |
| US5876924A (en) * | 1994-06-22 | 1999-03-02 | Mount Sinai School Of Medicine | Nucleic acid amplification method hybridization signal amplification method (HSAM) |
| US5942391A (en) * | 1994-06-22 | 1999-08-24 | Mount Sinai School Of Medicine | Nucleic acid amplification method: ramification-extension amplification method (RAM) |
| US5834181A (en) | 1994-07-28 | 1998-11-10 | Genzyme Corporation | High throughput screening method for sequences or genetic alterations in nucleic acids |
| JP3102800B2 (ja) * | 1994-08-19 | 2000-10-23 | パーキン−エルマー コーポレイション | 増幅及び連結反応の共役法 |
| US5648213A (en) | 1994-08-30 | 1997-07-15 | Beckman Instruments, Inc. | Compositions and methods for use in detection of analytes |
| US5695934A (en) * | 1994-10-13 | 1997-12-09 | Lynx Therapeutics, Inc. | Massively parallel sequencing of sorted polynucleotides |
| US5512441A (en) * | 1994-11-15 | 1996-04-30 | American Health Foundation | Quantative method for early detection of mutant alleles and diagnostic kits for carrying out the method |
| US5667974A (en) * | 1995-06-07 | 1997-09-16 | Abbott Laboratories | Method for detecting nucleic acid sequences using competitive amplification |
| US5723320A (en) * | 1995-08-29 | 1998-03-03 | Dehlinger; Peter J. | Position-addressable polynucleotide arrays |
| AU714486B2 (en) * | 1995-11-21 | 2000-01-06 | Yale University | Unimolecular segment amplification and detection |
| EP1736554B1 (en) * | 1996-05-29 | 2013-10-09 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
| US6682918B1 (en) * | 1996-07-19 | 2004-01-27 | Arch Development Corporation | Bacterial sucrose synthase compositions and methods of use |
| US5837659A (en) * | 1997-08-21 | 1998-11-17 | International Flavors & Fragrances Inc. | Process for producing C9 C11 and C13 alkanols and microorganism capable of the same |
| US6506594B1 (en) * | 1999-03-19 | 2003-01-14 | Cornell Res Foundation Inc | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
-
2000
- 2000-03-16 US US09/526,992 patent/US6506594B1/en not_active Expired - Lifetime
- 2000-03-17 CA CA002366249A patent/CA2366249A1/en not_active Abandoned
- 2000-03-17 JP JP2000606786A patent/JP4766750B2/ja not_active Expired - Fee Related
- 2000-03-17 EP EP00916438A patent/EP1208223A2/en not_active Withdrawn
- 2000-03-17 WO PCT/US2000/007006 patent/WO2000056927A2/en not_active Ceased
- 2000-03-17 AU AU37545/00A patent/AU781661C/en not_active Ceased
-
2002
- 2002-10-15 US US10/272,152 patent/US20030175750A1/en not_active Abandoned
-
2011
- 2011-04-18 JP JP2011091716A patent/JP2011200230A/ja not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997031256A2 (en) * | 1996-02-09 | 1997-08-28 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| WO1998003673A1 (en) * | 1996-07-19 | 1998-01-29 | Cornell Research Foundation, Inc. | High fidelity detection of nucleic acid differences by ligase detection reaction |
Also Published As
| Publication number | Publication date |
|---|---|
| US20030175750A1 (en) | 2003-09-18 |
| US6506594B1 (en) | 2003-01-14 |
| CA2366249A1 (en) | 2000-09-28 |
| JP2003520570A (ja) | 2003-07-08 |
| JP2011200230A (ja) | 2011-10-13 |
| WO2000056927A3 (en) | 2002-03-14 |
| WO2000056927A2 (en) | 2000-09-28 |
| AU3754500A (en) | 2000-10-09 |
| AU781661C (en) | 2005-12-01 |
| EP1208223A2 (en) | 2002-05-29 |
| AU781661B2 (en) | 2005-06-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4766750B2 (ja) | 位置特定可能なアレイによるリガーゼ検出反応を用いた核酸配列差異の検出 | |
| JP4294732B2 (ja) | アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出 | |
| JP2003520570A5 (https=) | ||
| JP5992895B2 (ja) | リガーゼ検出反応を用いた核酸配列の違いの検出のための位置特定可能なアレイの設計方法 | |
| US6852487B1 (en) | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays | |
| US20020150921A1 (en) | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20070314 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20090305 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100215 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20100511 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20100518 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20100812 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100813 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20101018 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110117 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110124 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110418 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20110516 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20110614 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 4766750 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20140624 Year of fee payment: 3 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |