JP4765037B2 - 慢性リンパ球性白血病の処置のためのアンタゴニスト抗ｃｄ４０モノクローナル抗体の使用 - Google Patents

慢性リンパ球性白血病の処置のためのアンタゴニスト抗ｃｄ４０モノクローナル抗体の使用 Download PDF

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JP4765037B2
JP4765037B2 JP2006538510A JP2006538510A JP4765037B2 JP 4765037 B2 JP4765037 B2 JP 4765037B2 JP 2006538510 A JP2006538510 A JP 2006538510A JP 2006538510 A JP2006538510 A JP 2006538510A JP 4765037 B2 JP4765037 B2 JP 4765037B2
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seq
residues
monoclonal antibody
variable domain
chain variable
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JP2007510664A5 (enExample
JP2007510664A (ja
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リ ロン，
モハンマド ルクマン，
アシャ ヤバンナバー，
イザベル ザロー，
シャロン リー オーカーマン，
Original Assignee
ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド
ゾーマ テクノロジー リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2006538510A 2003-11-04 2004-11-04 慢性リンパ球性白血病の処置のためのアンタゴニスト抗ｃｄ４０モノクローナル抗体の使用 Expired - Fee Related JP4765037B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US51733703P 2003-11-04 2003-11-04
US60/517,337 2003-11-04
US52557903P 2003-11-26 2003-11-26
US60/525,579 2003-11-26
US56571004P 2004-04-27 2004-04-27
US60/565,710 2004-04-27
US61179404P 2004-09-21 2004-09-21
US60/611,794 2004-09-21
PCT/US2004/036954 WO2005044304A2 (en) 2003-11-04 2004-11-04 Use of antagonist anti-cd40 antibodies for treatment of chronic lymphocytic leukemia

Related Child Applications (1)

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JP2011007386A Division JP2011116760A (ja) 2003-11-04 2011-01-17 慢性リンパ球性白血病の処置のためのアンタゴニスト抗ｃｄ４０モノクローナル抗体の使用

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JP2007510664A JP2007510664A (ja) 2007-04-26
JP2007510664A5 JP2007510664A5 (enExample) 2007-11-22
JP4765037B2 true JP4765037B2 (ja) 2011-09-07

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JP2006538510A Expired - Fee Related JP4765037B2 (ja) 2003-11-04 2004-11-04 慢性リンパ球性白血病の処置のためのアンタゴニスト抗ｃｄ４０モノクローナル抗体の使用
JP2011007386A Withdrawn JP2011116760A (ja) 2003-11-04 2011-01-17 慢性リンパ球性白血病の処置のためのアンタゴニスト抗ｃｄ４０モノクローナル抗体の使用

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US (1) US20070110754A1 (enExample)
EP (2) EP2243491A1 (enExample)
JP (2) JP4765037B2 (enExample)
KR (1) KR20070028295A (enExample)
CN (1) CN1929862B (enExample)
AT (1) ATE474598T1 (enExample)
AU (1) AU2004287480B2 (enExample)
CA (1) CA2544364A1 (enExample)
CY (1) CY1110836T1 (enExample)
DE (1) DE602004028270D1 (enExample)
DK (1) DK1682177T3 (enExample)
IL (1) IL175393A0 (enExample)
PL (1) PL1682177T3 (enExample)
PT (1) PT1682177E (enExample)
SI (1) SI1682177T1 (enExample)
WO (1) WO2005044304A2 (enExample)

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DK1684805T3 (da) * 2003-11-04 2010-10-04 Novartis Vaccines & Diagnostic Anvendelse af antagonist anti-CD40-monoklonale antistoffer til behandling af multipel myeloma
SI1680141T1 (sl) * 2003-11-04 2010-12-31 Novartis Vaccines & Diagnostic Postopki terapije za trdne tumorje, ki izražajo CD-40 celično-površinski antigen
US20050281815A1 (en) * 2004-02-26 2005-12-22 Dani Eshel CD40 splice variants and their uses
US20080057070A1 (en) * 2004-11-04 2008-03-06 Chiron Corporation Antagonist Anti-Cd40 Monoclonal Antibodies and Methods for Their Use
CN101351478A (zh) * 2005-11-01 2009-01-21 诺华有限公司 抗cd40抗体的应用
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AU2004287480B2 (en) 2011-09-15
IL175393A0 (en) 2006-09-05
HK1095269A1 (en) 2007-05-04
WO2005044304A2 (en) 2005-05-19
EP1682177A2 (en) 2006-07-26
CN1929862A (zh) 2007-03-14
PT1682177E (pt) 2010-11-29
CN1929862B (zh) 2012-02-15
JP2011116760A (ja) 2011-06-16
ATE474598T1 (de) 2010-08-15
WO2005044304A3 (en) 2005-08-25
EP2243491A1 (en) 2010-10-27
KR20070028295A (ko) 2007-03-12
CY1110836T1 (el) 2015-06-10
AU2004287480A1 (en) 2005-05-19
EP1682177B8 (en) 2010-09-01
CA2544364A1 (en) 2005-05-19
US20070110754A1 (en) 2007-05-17
SI1682177T1 (sl) 2010-12-31
EP1682177B1 (en) 2010-07-21
DE602004028270D1 (de) 2010-09-02
PL1682177T3 (pl) 2011-03-31
DK1682177T3 (da) 2010-11-01
JP2007510664A (ja) 2007-04-26

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