IL175393A0 - Use of antagonist anti-cd40 antibodies for treatment of chronic lymphocytic leukemia - Google Patents
Use of antagonist anti-cd40 antibodies for treatment of chronic lymphocytic leukemiaInfo
- Publication number
- IL175393A0 IL175393A0 IL175393A IL17539306A IL175393A0 IL 175393 A0 IL175393 A0 IL 175393A0 IL 175393 A IL175393 A IL 175393A IL 17539306 A IL17539306 A IL 17539306A IL 175393 A0 IL175393 A0 IL 175393A0
- Authority
- IL
- Israel
- Prior art keywords
- antigen
- antibody
- binding fragment
- antagonist anti
- antagonist
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 5
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 title 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 title 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 3
- 108010029697 CD40 Ligand Proteins 0.000 abstract 2
- 102100032937 CD40 ligand Human genes 0.000 abstract 2
- 101100099884 Homo sapiens CD40 gene Proteins 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 108010063916 CD40 Antigens Proteins 0.000 abstract 1
- 101150013553 CD40 gene Proteins 0.000 abstract 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 230000004654 survival pathway Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51733703P | 2003-11-04 | 2003-11-04 | |
| US52557903P | 2003-11-26 | 2003-11-26 | |
| US56571004P | 2004-04-27 | 2004-04-27 | |
| US61179404P | 2004-09-21 | 2004-09-21 | |
| PCT/US2004/036954 WO2005044304A2 (en) | 2003-11-04 | 2004-11-04 | Use of antagonist anti-cd40 antibodies for treatment of chronic lymphocytic leukemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL175393A0 true IL175393A0 (en) | 2006-09-05 |
Family
ID=34577850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL175393A IL175393A0 (en) | 2003-11-04 | 2006-05-02 | Use of antagonist anti-cd40 antibodies for treatment of chronic lymphocytic leukemia |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20070110754A1 (enExample) |
| EP (2) | EP1682177B8 (enExample) |
| JP (2) | JP4765037B2 (enExample) |
| KR (1) | KR20070028295A (enExample) |
| CN (1) | CN1929862B (enExample) |
| AT (1) | ATE474598T1 (enExample) |
| AU (1) | AU2004287480B2 (enExample) |
| CA (1) | CA2544364A1 (enExample) |
| CY (1) | CY1110836T1 (enExample) |
| DE (1) | DE602004028270D1 (enExample) |
| DK (1) | DK1682177T3 (enExample) |
| IL (1) | IL175393A0 (enExample) |
| PL (1) | PL1682177T3 (enExample) |
| PT (1) | PT1682177E (enExample) |
| SI (1) | SI1682177T1 (enExample) |
| WO (1) | WO2005044304A2 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1684805T3 (pl) * | 2003-11-04 | 2010-12-31 | Novartis Vaccines & Diagnostics Inc | Sposoby leczenia szpiczaka mnogiego z zastosowaniem antagonistycznych monoklonalnych przeciwciał przeciwko CD40 |
| US8277810B2 (en) | 2003-11-04 | 2012-10-02 | Novartis Vaccines & Diagnostics, Inc. | Antagonist anti-CD40 antibodies |
| ATE516819T1 (de) * | 2003-11-04 | 2011-08-15 | Novartis Vaccines & Diagnostic | Verfahren zur behandlung von b-zell-bedingtem krebs |
| KR101403910B1 (ko) * | 2003-11-04 | 2014-06-09 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 길항제 항-ｃｄ４０ 단클론성 항체 및 그것의 사용 방법 |
| US20070098717A1 (en) * | 2003-11-04 | 2007-05-03 | Chiron Corporation | Methods of therapy for solid tumors expressing the cd40 cell-surface antigen |
| WO2005108428A2 (en) * | 2004-02-26 | 2005-11-17 | Compugen Ltd. | Cd40 splice variants and their uses |
| US20080057070A1 (en) * | 2004-11-04 | 2008-03-06 | Chiron Corporation | Antagonist Anti-Cd40 Monoclonal Antibodies and Methods for Their Use |
| WO2007053661A2 (en) * | 2005-11-01 | 2007-05-10 | Novartis Ag | Uses of anti-cd40 antibodies |
| ES2400660T3 (es) * | 2005-11-01 | 2013-04-11 | Novartis Ag | Usos de anticuerpos anti-CD40 |
| CN100503827C (zh) * | 2006-03-16 | 2009-06-24 | 复旦大学 | 一种乙型肝炎病毒疫苗增效蛋白及其基因 |
| CN101426817B (zh) | 2006-04-21 | 2013-07-10 | 诺华有限公司 | 拮抗性抗-cd40抗体药物组合物 |
| BRPI0820707A2 (pt) | 2007-11-07 | 2015-06-16 | Genentech Inc | Métodos e composição para avaliar a responsividade do linfoma de células b para o tratamento com anticorpos anti-cd40 |
| KR101787768B1 (ko) | 2009-04-18 | 2017-10-18 | 제넨테크, 인크. | 항-ｃｄ４０ 항체를 사용한 치료에 대한 ｂ-세포 림프종의 반응성 평가를 위한 방법 |
| EP3372617B1 (en) | 2010-04-02 | 2024-07-24 | Amunix Pharmaceuticals, Inc. | Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same |
| AR083847A1 (es) | 2010-11-15 | 2013-03-27 | Novartis Ag | Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40 |
| WO2012075111A1 (en) | 2010-11-30 | 2012-06-07 | Novartis Ag | Uses of anti-cd40 antibodies in combination therapy for b cell-related cancers |
| PL2683406T3 (pl) | 2011-03-11 | 2019-11-29 | Beth Israel Deaconess Medical Ct Inc | Przeciwciała anty-cd40 i ich zastosowania |
| JP2016011258A (ja) * | 2012-10-26 | 2016-01-21 | 株式会社ペルセウスプロテオミクス | 抗ヒトｃｄ４０モノクローナル抗体及びその利用 |
| BR112018004296B1 (pt) | 2015-09-04 | 2020-05-05 | Primatope Therapeutics Inc | anticorpos anti-cd40 humanizados e usos dos mesmos |
| CN109071665B (zh) | 2016-04-18 | 2022-11-01 | 塞德斯医疗公司 | 结合人cd40的激动性抗体及其用途 |
| JP7461741B2 (ja) | 2016-06-20 | 2024-04-04 | カイマブ・リミテッド | 抗ｐｄ－ｌ１およびｉｌ－２サイトカイン |
| CN112638375A (zh) | 2018-06-15 | 2021-04-09 | 旗舰创业创新五公司 | 通过后细胞信号传导因子的调节来增加免疫活性 |
| AR117091A1 (es) * | 2018-11-19 | 2021-07-07 | Bristol Myers Squibb Co | Anticuerpos monoclonales antagonistas contra cd40 y sus usos |
| BR112021010414A2 (pt) * | 2018-11-30 | 2021-09-08 | Jiangsu Hengrui Medicine Co., Ltd. | Composição farmacêutica compreendendo um anticorpo cd40, método para preparar uma preparação liofilizada, preparação liofilizada, uso das mesmas e produto que compreende um recipiente contendo as mesmas |
| EP3962493A2 (en) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor |
| BR112022010680A2 (pt) | 2019-12-03 | 2022-08-16 | Evotec Int Gmbh | Proteínas de ligação ao antígeno associado ao interferon e uso das mesmas |
| WO2021127217A1 (en) | 2019-12-17 | 2021-06-24 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
| EP4172323A1 (en) | 2020-06-29 | 2023-05-03 | Flagship Pioneering Innovations V, Inc. | Viruses engineered to promote thanotransmission and their use in treating cancer |
| KR20230165276A (ko) | 2021-03-31 | 2023-12-05 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 타노트랜스미션 폴리펩티드 및 암의 치료에서의 이의 용도 |
| AU2022303363A1 (en) | 2021-06-29 | 2024-01-18 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
| US12234294B2 (en) | 2021-11-05 | 2025-02-25 | Kiniksa Pharmaceuticals, Gmbh | Pharmaceutical composition of a humanized anti-CD40 antibody |
| US20240174732A1 (en) | 2022-10-05 | 2024-05-30 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additional polypeptides and their use in treating cancer |
| US20240269251A1 (en) | 2023-01-09 | 2024-08-15 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
| WO2025184567A1 (en) | 2024-03-01 | 2025-09-04 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response |
| US20250277048A1 (en) | 2024-03-01 | 2025-09-04 | Regeneron Pharmaceuticals, Inc. | The use of cd40 inhibitors for inhibiting an immune response and enabling immunogen administration and re-administration |
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| ATE516819T1 (de) * | 2003-11-04 | 2011-08-15 | Novartis Vaccines & Diagnostic | Verfahren zur behandlung von b-zell-bedingtem krebs |
| PL1684805T3 (pl) * | 2003-11-04 | 2010-12-31 | Novartis Vaccines & Diagnostics Inc | Sposoby leczenia szpiczaka mnogiego z zastosowaniem antagonistycznych monoklonalnych przeciwciał przeciwko CD40 |
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-
2004
- 2004-11-04 US US10/577,642 patent/US20070110754A1/en not_active Abandoned
- 2004-11-04 CA CA002544364A patent/CA2544364A1/en not_active Abandoned
- 2004-11-04 PT PT04810417T patent/PT1682177E/pt unknown
- 2004-11-04 SI SI200431527T patent/SI1682177T1/sl unknown
- 2004-11-04 WO PCT/US2004/036954 patent/WO2005044304A2/en not_active Ceased
- 2004-11-04 KR KR1020067010901A patent/KR20070028295A/ko not_active Abandoned
- 2004-11-04 DK DK04810417.8T patent/DK1682177T3/da active
- 2004-11-04 PL PL04810417T patent/PL1682177T3/pl unknown
- 2004-11-04 EP EP04810417A patent/EP1682177B8/en not_active Expired - Lifetime
- 2004-11-04 DE DE602004028270T patent/DE602004028270D1/de not_active Expired - Lifetime
- 2004-11-04 AT AT04810417T patent/ATE474598T1/de active
- 2004-11-04 JP JP2006538510A patent/JP4765037B2/ja not_active Expired - Fee Related
- 2004-11-04 AU AU2004287480A patent/AU2004287480B2/en not_active Ceased
- 2004-11-04 CN CN2004800397684A patent/CN1929862B/zh not_active Expired - Fee Related
- 2004-11-04 EP EP10007491A patent/EP2243491A1/en not_active Withdrawn
-
2006
- 2006-05-02 IL IL175393A patent/IL175393A0/en unknown
-
2010
- 2010-10-18 CY CY20101100928T patent/CY1110836T1/el unknown
-
2011
- 2011-01-17 JP JP2011007386A patent/JP2011116760A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20070110754A1 (en) | 2007-05-17 |
| EP1682177B8 (en) | 2010-09-01 |
| JP2011116760A (ja) | 2011-06-16 |
| JP2007510664A (ja) | 2007-04-26 |
| WO2005044304A3 (en) | 2005-08-25 |
| KR20070028295A (ko) | 2007-03-12 |
| SI1682177T1 (sl) | 2010-12-31 |
| ATE474598T1 (de) | 2010-08-15 |
| EP2243491A1 (en) | 2010-10-27 |
| CN1929862A (zh) | 2007-03-14 |
| DK1682177T3 (da) | 2010-11-01 |
| EP1682177B1 (en) | 2010-07-21 |
| CN1929862B (zh) | 2012-02-15 |
| DE602004028270D1 (de) | 2010-09-02 |
| EP1682177A2 (en) | 2006-07-26 |
| PT1682177E (pt) | 2010-11-29 |
| WO2005044304A2 (en) | 2005-05-19 |
| AU2004287480B2 (en) | 2011-09-15 |
| CY1110836T1 (el) | 2015-06-10 |
| CA2544364A1 (en) | 2005-05-19 |
| JP4765037B2 (ja) | 2011-09-07 |
| HK1095269A1 (en) | 2007-05-04 |
| PL1682177T3 (pl) | 2011-03-31 |
| AU2004287480A1 (en) | 2005-05-19 |
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