JP4758607B2 - 生分解性ポリマー組成物、及びその使用方法 - Google Patents

生分解性ポリマー組成物、及びその使用方法 Download PDF

Info

Publication number
JP4758607B2
JP4758607B2 JP2003506884A JP2003506884A JP4758607B2 JP 4758607 B2 JP4758607 B2 JP 4758607B2 JP 2003506884 A JP2003506884 A JP 2003506884A JP 2003506884 A JP2003506884 A JP 2003506884A JP 4758607 B2 JP4758607 B2 JP 4758607B2
Authority
JP
Japan
Prior art keywords
polymer
formula
composition
weight
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2003506884A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004538347A (ja
JP2004538347A5 (enExample
Inventor
ヘイニーズ ジャスティン
フー ジエ
フィーゲル ジェニファー
Original Assignee
ジョンズ ホプキンズ ユニヴァーシティー スクール オブ メディシン
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ジョンズ ホプキンズ ユニヴァーシティー スクール オブ メディシン filed Critical ジョンズ ホプキンズ ユニヴァーシティー スクール オブ メディシン
Publication of JP2004538347A publication Critical patent/JP2004538347A/ja
Publication of JP2004538347A5 publication Critical patent/JP2004538347A5/ja
Application granted granted Critical
Publication of JP4758607B2 publication Critical patent/JP4758607B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyethers (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)
JP2003506884A 2001-06-22 2002-06-21 生分解性ポリマー組成物、及びその使用方法 Expired - Lifetime JP4758607B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29972901P 2001-06-22 2001-06-22
US60/299,729 2001-06-22
PCT/US2002/019772 WO2003000237A2 (en) 2001-06-22 2002-06-21 Biodegradable polymer coompositions

Publications (3)

Publication Number Publication Date
JP2004538347A JP2004538347A (ja) 2004-12-24
JP2004538347A5 JP2004538347A5 (enExample) 2006-01-05
JP4758607B2 true JP4758607B2 (ja) 2011-08-31

Family

ID=23156038

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003506884A Expired - Lifetime JP4758607B2 (ja) 2001-06-22 2002-06-21 生分解性ポリマー組成物、及びその使用方法

Country Status (7)

Country Link
US (1) US7163697B2 (enExample)
EP (1) EP1406593B1 (enExample)
JP (1) JP4758607B2 (enExample)
AT (1) ATE478656T1 (enExample)
AU (1) AU2002322289A1 (enExample)
DE (1) DE60237449D1 (enExample)
WO (1) WO2003000237A2 (enExample)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60231555D1 (de) * 2001-11-23 2009-04-23 Theodore James Anastasiou Verbesserte synthese von polyanhydriden
US7351749B2 (en) * 2002-12-16 2008-04-01 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Process for manufacture of personal care products utilizing a concentrate water phase
US7662864B2 (en) * 2003-06-04 2010-02-16 Rutgers, The State University Of New Jersey Solution polymerization processes to prepare a polymer that degrades to release a physiologically active agent
WO2005044236A1 (en) * 2003-10-27 2005-05-19 Control Delivery Systems, Inc. Suspension delivery system for the sustained and controlled local release of pharmaceuticals
JP2005206491A (ja) * 2004-01-21 2005-08-04 Medgel Corp 肺気腫を治療するための経肺投与用製剤
WO2005072710A2 (en) * 2004-01-28 2005-08-11 Johns Hopkins University Drugs and gene carrier particles that rapidly move through mucous barriers
EP1856179B1 (en) * 2004-12-10 2013-05-15 Kala Pharmaceuticals, Inc. Functionalized poly (ether-anhydride) block copolymers
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
FR2887886B1 (fr) * 2005-07-01 2010-01-08 Oreal Polymere cationique neutralise, composition le comprenant et procede de traitement cosmetique
US20070225472A1 (en) * 2006-03-23 2007-09-27 Varshney Sunil K Polyanhydride polymers and their uses in biomedical devices
WO2007123793A2 (en) * 2006-04-04 2007-11-01 Stc.Unm Swellable particles for drug delivery
US20080014170A1 (en) * 2006-07-14 2008-01-17 Olexander Hnojewyj Drug delivery polyanhydride composition and method
ITMI20061539A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Impianti sottocutanei in grado di rilasciare il principio attivo per un periodo prolungato di tempo
EP2359808B1 (en) 2006-08-09 2013-05-22 Intarcia Therapeutics, Inc Osmotic delivery systems and piston assemblies
CA2663003C (en) * 2006-09-08 2018-02-13 Justin Hanes Compositions and methods for enhancing transport through mucus
US20090169628A1 (en) 2006-10-17 2009-07-02 Armark Authentication Technologies, Llc Article and method for focused delivery of therapeutic and/or diagnostic materials
NO20065147L (no) * 2006-11-08 2008-05-09 Ntnu Tech Transfer As Nanokompositter basert på cellulosewhiskers og celluloseplast
JP5578655B2 (ja) 2007-03-02 2014-08-27 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ 微粒子による薬物送達
WO2008128140A1 (en) * 2007-04-13 2008-10-23 The Regents Of The University Of Michigan Delivery device and method for forming the same
CN104000779A (zh) 2007-04-23 2014-08-27 精达制药公司 促胰岛素释放肽的混悬制剂及其应用
US20080311172A1 (en) * 2007-04-25 2008-12-18 Schapira Jay N Programmed-release, nanostructured biological construct
WO2009088777A1 (en) * 2007-12-31 2009-07-16 Armark Authentication Technologies, Llc Article and method for focused delivery of therapeutic and/or diagnostic materials
CA2726861C (en) 2008-02-13 2014-05-27 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
JP5713897B2 (ja) * 2008-07-16 2015-05-07 エボニック コーポレイションＥｖｏｎｉｋ Ｃｏｒｐｏｒａｔｉｏｎ 生理活性ペプチドを含有する微粒子を調製するためのプロセス
SI2341905T2 (sl) * 2008-09-04 2024-02-29 Amylin Pharmaceuticals, Llc Formulacije s podaljšanim sproščanjem z uporabo brezvodnih nosilcev
US8822610B2 (en) 2008-12-22 2014-09-02 ATRP Solutions, Inc. Control over controlled radical polymerization processes
US8815971B2 (en) * 2008-12-22 2014-08-26 ATRP Solutions, Inc. Control over controlled radical polymerization processes
US9783628B2 (en) 2009-04-23 2017-10-10 ATRP Solutions, Inc. Dual-mechanism thickening agents for hydraulic fracturing fluids
US8569421B2 (en) 2009-04-23 2013-10-29 ATRP Solutions, Inc. Star macromolecules for personal and home care
US8173750B2 (en) 2009-04-23 2012-05-08 ATRP Solutions, Inc. Star macromolecules for personal and home care
NO2462246T3 (enExample) 2009-09-28 2018-02-03
WO2011084458A2 (en) * 2009-12-15 2011-07-14 The Johns Hopkins University Polymer-based compositions and methods for treatment of peritoneal disorders
US9587064B2 (en) 2010-12-08 2017-03-07 ATRP Solutions, Inc. Salt-tolerant star macromolecules
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
US9827191B2 (en) 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
WO2013166385A1 (en) 2012-05-03 2013-11-07 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
WO2013166408A1 (en) 2012-05-03 2013-11-07 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
JP6294885B2 (ja) 2012-08-30 2018-03-14 エーティーアールピー ソリューションズ インコーポレイテッドＡＴＲＰ Ｓｏｌｕｔｉｏｎｓ，Ｉｎｃ． 星形高分子、星形高分子組成物および星形高分子の製造方法
CA2899349C (en) 2013-02-04 2021-09-21 ATRP Solutions, Inc. Salt-tolerant star macromolecules
JP6669499B2 (ja) 2013-02-15 2020-03-18 カラ ファーマシューティカルズ インコーポレイテッド 治療用化合物
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
WO2014130612A1 (en) 2013-02-20 2014-08-28 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CN108530458A (zh) 2013-11-01 2018-09-14 卡拉制药公司 治疗化合物的结晶形式及其用途
WO2015168143A1 (en) * 2014-04-28 2015-11-05 The Johns Hopkins University Biopolymer-encapsulated glycosyltransferase inhibitor compositions and methods for treating diabetes and cardiac indications
US10023521B2 (en) 2014-06-13 2018-07-17 Rutgers, The State University Of New Jersey Process and intermediates for preparing poly(anhydride-esters)
MX385886B (es) 2014-07-03 2025-03-18 Pilot Polymer Tech Inc Macromoleculas estrellas compatibles con tensoactivos.
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US10925639B2 (en) 2015-06-03 2021-02-23 Intarcia Therapeutics, Inc. Implant placement and removal systems
HK1257499A1 (zh) 2015-11-12 2019-10-25 Graybug Vision, Inc. 用於治疗的聚集性微粒
TWI754643B (zh) 2016-05-16 2022-02-11 美商因塔希亞治療公司 升糖素受體選擇性多肽和彼之使用方法
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
AU2017324713B2 (en) 2016-09-08 2020-08-13 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
EP3509423A4 (en) 2016-09-08 2020-05-13 Kala Pharmaceuticals, Inc. CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
EP3509421A4 (en) 2016-09-08 2020-05-20 Kala Pharmaceuticals, Inc. CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
WO2018129058A1 (en) 2017-01-03 2018-07-12 Intarcia Therapeutics, Inc. Methods comprising continuous administration of a glp-1 receptor agonist and co-adminstration of a drug
CN110662543A (zh) 2017-03-23 2020-01-07 灰色视觉公司 用于治疗眼部疾病的药物和组合物
MX2019013363A (es) 2017-05-10 2020-01-13 Graybug Vision Inc Microparticulas de liberacion extendida y suspensiones de las mismas para terapia medica.
CA3139852A1 (en) 2019-05-13 2020-11-19 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Polymer-based implant for retinal therapy and methods of making and using the same
CN112495319B (zh) * 2020-09-29 2023-07-04 海丰生物科技（北京）有限公司 一种环瓜氨酸肽双微球偶联物及其制备方法与应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6291527A (ja) * 1985-10-02 1987-04-27 サンド・アクチエンゲゼルシヤフト 新規ポリジカルボン酸無水物とその製造方法および用途
JPS63199227A (ja) * 1986-10-17 1988-08-17 マサチューセッツ　インスティチュート　オブ　テテクノロジー 無水物コポリマーの製造方法
JPS63258924A (ja) * 1986-08-01 1988-10-26 マサチユ−セツツ　インステイチユ−ト　オブ　テクノロジ− 高分子ポリ酸無水物
JPH09504308A (ja) * 1993-07-23 1997-04-28 マサチューセッツ インスティチュート オブ テクノロジー 非直鎖状の親水性−疎水性マルチブロックコポリマーのナノ粒子およびマイクロ粒子
JPH09509161A (ja) * 1994-02-17 1997-09-16 モデイ，パンカイ ポリラクチド被覆ミクロスフィアの状態にある薬物類、ワクチン類及びホルモン類
US5718921A (en) * 1987-03-13 1998-02-17 Massachusetts Institute Of Technology Microspheres comprising polymer and drug dispersed there within
JP2000143538A (ja) * 1998-11-04 2000-05-23 Teijin Ltd 免疫調節剤を含有する医薬組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6291527A (ja) * 1985-10-02 1987-04-27 サンド・アクチエンゲゼルシヤフト 新規ポリジカルボン酸無水物とその製造方法および用途
JPS63258924A (ja) * 1986-08-01 1988-10-26 マサチユ−セツツ　インステイチユ−ト　オブ　テクノロジ− 高分子ポリ酸無水物
JPS63199227A (ja) * 1986-10-17 1988-08-17 マサチューセッツ　インスティチュート　オブ　テテクノロジー 無水物コポリマーの製造方法
US5718921A (en) * 1987-03-13 1998-02-17 Massachusetts Institute Of Technology Microspheres comprising polymer and drug dispersed there within
JPH09504308A (ja) * 1993-07-23 1997-04-28 マサチューセッツ インスティチュート オブ テクノロジー 非直鎖状の親水性−疎水性マルチブロックコポリマーのナノ粒子およびマイクロ粒子
JPH09509161A (ja) * 1994-02-17 1997-09-16 モデイ，パンカイ ポリラクチド被覆ミクロスフィアの状態にある薬物類、ワクチン類及びホルモン類
JP2000143538A (ja) * 1998-11-04 2000-05-23 Teijin Ltd 免疫調節剤を含有する医薬組成物

Also Published As

Publication number Publication date
JP2004538347A (ja) 2004-12-24
AU2002322289A1 (en) 2003-01-08
WO2003000237A2 (en) 2003-01-03
WO2003000237A8 (en) 2004-12-23
US7163697B2 (en) 2007-01-16
WO2003000237A3 (en) 2003-03-27
EP1406593A2 (en) 2004-04-14
US20030086895A1 (en) 2003-05-08
EP1406593B1 (en) 2010-08-25
DE60237449D1 (de) 2010-10-07
ATE478656T1 (de) 2010-09-15

Similar Documents

Publication Publication Date Title
JP4758607B2 (ja) 生分解性ポリマー組成物、及びその使用方法
ES2407979T3 (es) Copolímeros de bloques de poli(éter-anhídrido) funcionalizados
Bala et al. PLGA nanoparticles in drug delivery: the state of the art
CN102885783B (zh) 一种纳米药物微球
US5679377A (en) Protein microspheres and methods of using them
US20100226985A1 (en) Viscoelastic aqueous gels comprising microspheres
US20050175668A1 (en) Lapachone delivery systems, compositions and uses related thereto
CN102885784B (zh) 纳米颗粒混悬液包油－油包纳米药物制备微球的方法
Patel et al. Biodegradable polymers: emerging excipients for the pharmaceutical and medical device industries
CN111973757A (zh) 介孔氧化硅纳米粒子控释系统、其制备方法及其应用
CN103330680A (zh) 纳米药物透皮制剂及其制备方法
JP2004501188A (ja) インスリンの放出制御製剤及びその方法
Davis Drug delivery systems
US20110070320A1 (en) Biodegradable thermoresponsive 3-arm polyethylene glycol poly(lactide-co-glycolide) copolymer for ginseng administration
CN104288093A (zh) 纳米药物透皮制剂在肿瘤中的应用
Sonawane et al. PLGA: a wow smart biodegradable polymer in drug delivery system
CN115120738B (zh) 一种咪喹莫特前药纳米粒及其制备方法和应用
KR20120098906A (ko) 서방성 제제
Pandey et al. Toward Eco‐friendly Nanotechnology‐based Polymers for Drug Delivery Applications
CN119968199A (zh) 长效丙酸氟替卡松注射混悬液用于治疗和预防胃肠道炎症的用途
US20030134892A1 (en) Compositions for treatment of head and neck cancers, and methods of making and using the same
KR100752702B1 (ko) 생분해성 고분자 나노입자 및 그 제조방법
Ita Drug Delivery: Advances and Emerging Strategies
US20050238616A1 (en) Compositions for treatment of central nervous system neoplasms, and methods of making and using the same
CN113855695B (zh) 一种结肠释药口服复方药物组合物及其制备方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050621

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050621

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20080321

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080520

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080820

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20080820

RD13 Notification of appointment of power of sub attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7433

Effective date: 20080820

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20080820

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080820

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080924

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20081120

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090609

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090907

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090914

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091209

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100511

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100806

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100813

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101109

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20110517

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20110603

R150 Certificate of patent or registration of utility model

Ref document number: 4758607

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140610

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term