JP4758252B2 - 細胞賦活剤及びこれを含有する皮膚外用剤 - Google Patents
細胞賦活剤及びこれを含有する皮膚外用剤 Download PDFInfo
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- JP4758252B2 JP4758252B2 JP2006055906A JP2006055906A JP4758252B2 JP 4758252 B2 JP4758252 B2 JP 4758252B2 JP 2006055906 A JP2006055906 A JP 2006055906A JP 2006055906 A JP2006055906 A JP 2006055906A JP 4758252 B2 JP4758252 B2 JP 4758252B2
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- CRPCXAMJWCDHFM-UHFFFAOYSA-M sodium;5-oxopyrrolidine-2-carboxylate Chemical compound [Na+].[O-]C(=O)C1CCC(=O)N1 CRPCXAMJWCDHFM-UHFFFAOYSA-M 0.000 description 1
- GSZUGBAEBARHAW-UHFFFAOYSA-N sophoraflavone B Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C=2OC3=CC(O)=CC=C3C(=O)C=2)C=C1 GSZUGBAEBARHAW-UHFFFAOYSA-N 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 239000001845 taraxacum officinale leaf extract Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- UUJLHYCIMQOUKC-UHFFFAOYSA-N trimethyl-[oxo(trimethylsilylperoxy)silyl]peroxysilane Chemical compound C[Si](C)(C)OO[Si](=O)OO[Si](C)(C)C UUJLHYCIMQOUKC-UHFFFAOYSA-N 0.000 description 1
- 239000008513 turmeric extract Substances 0.000 description 1
- 229940052016 turmeric extract Drugs 0.000 description 1
- 235000020240 turmeric extract Nutrition 0.000 description 1
- 230000017260 vegetative to reproductive phase transition of meristem Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 239000009538 yokuinin Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Description
更に、皮膚表面のシーリングによる保湿(エモリエント)剤として、ホホバ油、マカデミアナッツ油、オリーブ油、杏仁油、パーシック油、サフラワー油、ヒマワリ油、アボガド油、メドゥホーム油、ツバキ油、アーモンド油、エゴマ油、ゴマ油、ボラージ(ルリジサ)油、カカオ脂、シア脂等が挙げられる。
正常ヒト新生児皮膚表皮角化細胞(クラボウ社製)を、表皮角化細胞増殖用培地(クラボウ社製)を用いて、直径24マルチウェルプレートに6000個/ウェルにて播種し、5%vol二酸化炭素環境下、37℃で24時間培養した。培養後シラカンバ樹液を最終濃度10%添加した例(実施例1)、比較例として無添加の例(比較例1)及び陽性対象として最終濃度1.5mMとなるように塩化カルシウムを添加し例(比較例2)を3日間培養した。培養後、細胞の形態を撮影後、MTT(3−(4,5−Dimethyl−2−thiazolyl)−2,5−diphenyl−2H−tetrazorium bromide)アッセイ法にて生細胞の存在率を評価した。その結果を図1〜3(細胞形態)及び4(生細胞数比較)に示す。
(成分) (%)
(1)グリセリン 3.0
(2)1,3−ブチレングリコール 2.0
(3)プロピレングリコール 4.0
(4)オレイルアルコール 0.1
(5)モノラウリン酸ポリオキシエチレン(20E.O.)
ソルビタン 1.5
(6)ポリオキシエチレン(20E.O.)ラウリル
エーテル 0.5
(7)スクワラン 0.5
(8)エチルアルコール 20.0
(9)パラオキシ安息香酸メチル 0.1
(10)酢酸dl−α−トコフェロール*1 0.5
(11)香料 適量
(12)グリチルリチン酸ジカリウム*2 0.5
(13)ローズマリー抽出物*3 0.5
(14)dl−ピロリドンカルボン酸ナトリウム*4 0.2
(15)ローカストビーンガム 1.0
(16)ヨクイニン抽出物*5 0.5
(17)シラカンバ樹液*6 20.0
(18)精製水 残量
*1 エーザイ社製
*2 丸善製薬社製
*3 丸善製薬社製
*4 味の素社製
*5 丸善製薬社製
*6 さっぷ社製(森の雫)
A.成分(1)〜(11)を混合溶解する。
B.成分(12)〜(18)を混合溶解する。
C.AにBを加え均一に混合して化粧水を得た。
(成分) (%)
(1)スクワラン 20.0
(2)ミツロウ 5.0
(3)ホホバ油 5.0
(4)モノステアリン酸グリセリル 2.0
(5)モノステアリン酸ポリオキシエチレン(20E.O.)
ソルビタン 2.0
(6)モノステアリン酸ソルビタン 2.0
(7)フィトステロール*1 0.5
(8)キャンデリラロウ 1.0
(9)グリセリン 5.0
(10)パラオキシ安息香酸メチル 0.1
(11)ユリ抽出物*2 1.0
(12)ニンジン抽出物*3 1.0
(13)イチョウ抽出物*4 1.0
(14)タイソウ抽出物*5 1.0
(15)クララ抽出物*6 1.0
(16)加水分解米抽出物*7 1.0
(17)甘草抽出物*8 1.0
(18)トウキ抽出物*9 1.0
(19)シラカンバ樹液*10 5.0
(20)精製水 残量
(21)香料 適量
*1 エーザイ社製
*2 丸善製薬社製
*3 丸善製薬社製
*4 常磐植物化学研究所社製
*5 丸善製薬社製
*6 丸善製薬社製
*7 テクノーブル社製
*8 丸善製薬社製
*9 日本粉末薬品社製
*10 さっぷ社製(森の雫)
A.成分(1)〜(10)を加熱混合し、70℃に保つ。
B.成分(11)〜(20)を加熱混合し、70℃に保つ。
C.AにBを加えて乳化する。
D.Cを冷却後、成分(21)を加えて混合しクリームを得た。
(成分) (%)
(1)パラフィンワックス 10.0
(2)ミツロウ 3.0
(3)ワセリン 15.0
(4)流動パラフィン 41.0
(5)セスキオレイン酸ソルビタン 4.2
(6)モノオレイン酸ポリオキシエチレン(20E.O.)
ソルビタン 0.8
(7)水素添加大豆リン脂質 0.5
(8)メドゥホーム油*1 1.0
(9)パラオキシ安息香酸メチル 0.1
(10)クインスシード抽出物*2 1.0
(11)サボンソウ抽出物*3 1.0
(12)ゼニアオイ抽出物*4 1.0
(13)シラカンバ樹液*5 5.0
(14)精製水 残量
(15)香料 適量
*1 日本サーファクタント社製
*2 香栄興業社製
*3 丸善製薬社製
*4 丸善製薬社製
*5 さっぷ社製(森の雫)
A.成分(1)〜(9)を加熱混合し、70℃に保つ。
B.成分(10)〜(14)を加熱混合し、70℃に保つ。
C.AにBを加えて乳化する。
D.Cを冷却後、成分(15)を加えて混合しクレンジングクリームを得た。
(成分) (%)
(1)モノステアリン酸ソルビタン 0.3
(2)モノオレイン酸ポリオキシエチレン(20E.O.)
ソルビタン 0.1
(3)親油型モノステアリン酸グリセリル 0.2
(4)ステアリン酸 0.5
(5)セタノール 0.5
(6)スクワラン 3.0
(7)流動パラフィン 4.0
(8)植物性スクワラン*1 0.2
(9)トリ−2−エチルヘキサン酸グリセリル 2.0
(10)ジメチルポリシロキサン 1.0
(11)水素添加大豆リン脂質 0.1
(12)ニコチン酸dl−α−トコフェロール*2 0.05
(13)パラオキシ安息香酸エチル 0.1
(14)カルボキシビニルポリマー 0.1
(15)水酸化ナトリウム 0.05
(16)グリセリン 5.0
(17)1,3−ブチレングリコール 7.0
(18)精製水 残量
(19)シラカンバ樹液*3 10.0
(20)シャクヤク抽出物*4 2.0
(21)霊芝抽出物*5 2.0
(22)ヒアルロン酸ナトリウム1%水溶液*6 5.0
(23)アセチルグルタミン酸*7 0.3
(24)エチルアルコール 5.0
(25)多孔質シリカ 3.0
(26)香料 適量
*1 日光ケミカルズ社製
*2 エーザイ社製
*3 さっぷ社製(森の雫)
*4 丸善製薬社製
*5 丸善製薬社製
*6 日光ケミカルズ社製
*7 協和醗酵社製
A.成分(14)〜(23)を加熱混合し、70℃に保つ。
B.成分(1)〜(13)を加熱混合し、70℃に保つ。
C.AにBを加えて乳化する。
D.Cを冷却後、成分(24)、(25)、(26)を加えて混合し乳液を得た。
(成分) (%)
(1)モノステアリン酸ソルビタン 0.3
(2)モノオレイン酸ポリオキシエチレン(20E.O.)
ソルビタン 0.1
(3)親油型モノステアリン酸グリセリル 0.2
(4)ステアリン酸 0.5
(5)セタノール 0.5
(6)スクワラン 3.0
(7)流動パラフィン 4.0
(8)トリ−2−エチルヘキサン酸グリセリル 2.0
(9)ジメチルポリシロキサン 1.0
(10)水素添加大豆リン脂質 0.1
(11)ルチン*1 0.2
(12)パラオキシ安息香酸メチル 0.1
(13)カルボキシビニルポリマー 0.1
(14)水酸化ナトリウム 0.05
(15)グリセリン 5.0
(16)1,3−ブチレングリコール 7.0
(17)シラカンバ樹液*2 3.0
(18)精製水 残量
(19)酵母抽出物*3 0.5
(20)アシタバ抽出物*4 0.5
(21)ホップ抽出物*5 0.5
(22)モモ抽出物*6 0.5
(23)エチルアルコール 5.0
(24)多孔質シリカ 3.0
(25)香料 適量
*1 シグマ社製
*2 さっぷ社製(森の雫)
*3 BIO−DELL社製
*4 丸善製薬社製
*5 丸善製薬社製
*6 丸善製薬社製
A.成分(13)〜(22)を加熱混合し、70℃に保つ。
B.成分(1)〜(12)を加熱混合し、70℃に保つ。
C.AにBを加えて均一に乳化する。
D.Cを冷却後、成分(23)、(24)、(25)を加えて混合し乳液を得た。
(成分) (%)
(1)ポリビニルアルコール 13.0
(2)無水ケイ酸 0.5
(3)ポリエチレングリコール 0.5
(4)メドゥホーム油*1 0.2
(5)ポリオキシプロピレン(10P.O.)
メチルグルコシド 5.0
(6)グリセリン 5.0
(7)精製水 残量
(8)茶抽出物*2 1.0
(9)ハマナス抽出物*3 1.0
(10)無水カフェイン*4 1.0
(11)シラカンバ樹液*5 5.0
(12)リン酸−L−アスコルビルマグネシウム*6 3.0
(13)精製水 10.0
(14)パラオキシ安息香酸エチル 0.1
(15)エチルアルコール 13.0
(16)香料 適量
*1 日本サーファクタント工業社製
*2 丸善製薬社製
*3 丸善製薬社製
*4 純正薬品工業社製
*5 さっぷ社製(森の雫)
*6 日光ケミカルズ社製
A.成分(1)〜(7)を混合し、70℃に加熱し溶解する。
B.成分(8)〜(13)を混合溶解する。
C.成分(14)〜(16)を混合溶解する。
D.BをAに加え、混合した後、冷却し、更にCを混合してパックを得た。
(成分) (%)
(1)セスキオレイン酸ソルビタン 3.0
(2)自己乳化型モノステアリン酸グリセリル 2.0
(3)ステアリン酸アルミニウム 0.5
(4)セレシンワックス 5.0
(5)スクワラン 10.0
(6)流動パラフィン 15.0
(7)ワセリン 5.0
(8)酸化チタン 8.0
(9)タルク 4.0
(10)着色顔料 適量
(11)パラオキシ安息香酸メチル 0.05
(12)プロピレングリコール 5.0
(13)キンギンカ抽出物*1 1.0
(14)シラカバ抽出物*2 1.0
(15)マロニエ抽出物*3 1.0
(16)シラカンバ樹液*4 10.0
(17)精製水 残量
(18)香料 適量
*1 長岡香料社製
*2 丸善製薬社製
*3 香栄興業社製
*4 さっぷ社製(森の雫)
A.成分(1)〜(11)を加熱混合し、70℃に保つ。
B.成分(12)〜(17)を加熱混合し、70℃に保つ。
C.AにBを加えて乳化する。
D.Cを冷却後、成分(18)を加えて混合しクリームファンデーションを得た。
(成分) (%)
(1)液状ラノリン 2.0
(2)流動パラフィン 5.0
(3)ステアリン酸 2.0
(4)セタノール 1.0
(5)自己乳化型モノステアリン酸グリセリル 1.0
(6)パラメトキシケイ皮酸−2−エチルヘキシル 8.0
(7)4−tert−ブチル−4’−メトキシ
ジベンゾイルメタン 2.0
(8)パルミチン酸レチノール*1 0.2
(9)パラオキシ安息香酸メチル 0.1
(10)グリセリン 5.0
(11)トリエタノールアミン 1.0
(12)カルボキシメチルセルロース 0.2
(13)ベントナイト 0.5
(14)シラカバ抽出液*2 5.0
(15)精製水 残量
(16)マンニトール*3 0.1
(17)シラカンバ樹液*4 5.0
(18)アスパラガス抽出物*5 0.5
(19)甘草抽出物*6 0.5
(20)酸化チタン 6.0
(21)微粒子酸化チタン 2.0
(22)微粒子酸化亜鉛 5.0
(23)マイカ 2.0
(24)タルク 4.0
(25)着色顔料 4.0
(26)香料 適量
*1 日本ロシュ社製
*2 丸善製薬社製
*3 シグマ社製
*4 さっぷ社製(森の雫)
*5 丸善製薬社製
*6 丸善製薬社製
A.成分(1)〜(9)を混合溶解する。
B.Aに成分(20)〜(25)を加え、均一に混合し、70℃に保つ。
C.成分(10)〜(19)を均一に溶解し、70℃に保つ。
D.CにBを添加して乳化する。
E.Dを冷却後、成分(26)を加えて混合しリキッドファンデーションを得た。
(実施例12)日焼け止め乳液
(成分) (%)
(1)ポリオキシアルキレン変性オルガノポリシロキサン 1.0
(2)ジメチルポリシロキサン 5.0
(3)オクタメチルシクロテトラシロキサン 20.0
(4)イソノナン酸イソトリデシル 5.0
(5)パラメトキシケイ皮酸−2−エチルヘキシル 5.0
(6)パラオキシ安息香酸メチル 0.1
(7)シリコーン処理微粒子酸化チタン 10.0
(8)シリコーン処理微粒子酸化亜鉛 10.0
(9)ポリスチレン末 3.0
(10)トリメチルシロキシケイ酸 0.5
(11)ジプロピレングリコール 3.0
(12)エチルアルコール 10.0
(13)シラカンバ樹液*1 10.0
(14)食塩 0.2
(15)精製水 残量
(16)β−カロチン*2 0.01
(17)カミツレ抽出物*3 1.0
(18)ワレモコウ抽出物*4 1.0
(19)香料 適量
*1 さっぷ社製(森の雫)
*2 シグマ社製
*3 丸善製薬社製
*4 丸善製薬社製
A.成分(1)〜(10)を混合し、70℃に保つ。
B.成分(11)〜(15)を混合し、70℃に保つ。
C.AにBを添加して、均一に乳化する。
D.Cを冷却後、成分(16)〜(19)を加えて混合し日焼け止め乳液を得た。
Claims (1)
- シラカンバ(Betula platyphylla Sukatchevva r.japonica Hara)樹液を有効成分とする表皮角化細胞の角化促進剤。
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
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JP2006055906A JP4758252B2 (ja) | 2006-03-02 | 2006-03-02 | 細胞賦活剤及びこれを含有する皮膚外用剤 |
KR1020070014692A KR101448993B1 (ko) | 2006-02-16 | 2007-02-13 | 자작나무 수액을 유효성분으로 하는 약효제 및 그의 사용 |
TW096105565A TWI445542B (zh) | 2006-02-16 | 2007-02-14 | Birch sap as to the efficacy of their use for the active ingredient |
CN2007100799033A CN101023915B (zh) | 2006-02-16 | 2007-02-16 | 以桦树树液为有效成分的药效剂及其用途 |
HK07113668.7A HK1105283A1 (en) | 2006-02-16 | 2007-12-14 | Pharmaceutical preparations comprising birch bark sap as active ingredient and uses thereof |
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JPS61289016A (ja) * | 1985-06-17 | 1986-12-19 | Pola Chem Ind Inc | 皮膚外用剤 |
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JPH09291018A (ja) * | 1996-04-25 | 1997-11-11 | Sunstar Inc | 口腔用組成物 |
JPH09291013A (ja) * | 1996-04-25 | 1997-11-11 | Sunstar Inc | 皮膚化粧料 |
JPH09291012A (ja) * | 1996-04-25 | 1997-11-11 | Sunstar Inc | 消炎性皮膚化粧料 |
JP3955655B2 (ja) * | 1997-02-27 | 2007-08-08 | サンスター株式会社 | 新規ジアリルヘプタノイド系化合物 |
JPH10279466A (ja) * | 1997-04-07 | 1998-10-20 | Kose Corp | 外用剤 |
JP2001039854A (ja) * | 1999-07-30 | 2001-02-13 | Sanko Bussan Kk | 皮膚外用剤 |
JP2003137761A (ja) * | 2001-10-31 | 2003-05-14 | Nippon Barrier Free:Kk | 皮膚化粧料及びその製造方法 |
JP4091825B2 (ja) * | 2002-02-05 | 2008-05-28 | 株式会社コーセー | 皮膚外用剤 |
JP2003321379A (ja) * | 2002-05-07 | 2003-11-11 | Ichimaru Pharcos Co Ltd | 抗アレルギー剤 |
JP2005306850A (ja) * | 2004-03-24 | 2005-11-04 | Kose Corp | 抗皮膚障害剤、及びこれを含有する皮膚外用剤 |
JP2005281135A (ja) * | 2004-03-26 | 2005-10-13 | Shiseido Co Ltd | 皮膚外用剤 |
JP5068952B2 (ja) * | 2006-02-16 | 2012-11-07 | 株式会社コーセー | インボルクリン産生促進剤 |
JP4938319B2 (ja) * | 2006-02-24 | 2012-05-23 | 株式会社コーセー | コレステロール産生促進剤及びこれを含有する皮膚外用剤 |
JP2007217325A (ja) * | 2006-02-16 | 2007-08-30 | Kose Corp | プロフィラグリン及び/又はフィラグリン産生促進剤 |
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