JP4754067B2 - 鼻孔投与用組成物 - Google Patents

鼻孔投与用組成物 Download PDF

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Publication number
JP4754067B2
JP4754067B2 JP2000522892A JP2000522892A JP4754067B2 JP 4754067 B2 JP4754067 B2 JP 4754067B2 JP 2000522892 A JP2000522892 A JP 2000522892A JP 2000522892 A JP2000522892 A JP 2000522892A JP 4754067 B2 JP4754067 B2 JP 4754067B2
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JP
Japan
Prior art keywords
apomorphine
composition
drug
nasal
plasma concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2000522892A
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English (en)
Japanese (ja)
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JP2001524509A5 (https=
JP2001524509A (ja
Inventor
イルム・リスベス
ワッツ・ピーター・ジェームス
Original Assignee
アルキメデス ディヴェロプメント リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9725519.4A external-priority patent/GB9725519D0/en
Priority claimed from GBGB9805253.3A external-priority patent/GB9805253D0/en
Application filed by アルキメデス ディヴェロプメント リミテッド filed Critical アルキメデス ディヴェロプメント リミテッド
Publication of JP2001524509A publication Critical patent/JP2001524509A/ja
Publication of JP2001524509A5 publication Critical patent/JP2001524509A5/ja
Application granted granted Critical
Publication of JP4754067B2 publication Critical patent/JP4754067B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2000522892A 1997-12-02 1998-11-27 鼻孔投与用組成物 Expired - Fee Related JP4754067B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9725519.4A GB9725519D0 (en) 1997-12-02 1997-12-02 Nasal formulation
GB9725519.4 1997-12-02
GB9805253.3 1998-03-13
GBGB9805253.3A GB9805253D0 (en) 1998-03-13 1998-03-13 Nasal formulation
PCT/GB1998/003572 WO1999027905A1 (en) 1997-12-02 1998-11-27 Compositions for nasal administration

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010227620A Division JP2011026341A (ja) 1997-12-02 2010-10-07 鼻孔投与用組成物

Publications (3)

Publication Number Publication Date
JP2001524509A JP2001524509A (ja) 2001-12-04
JP2001524509A5 JP2001524509A5 (https=) 2010-01-14
JP4754067B2 true JP4754067B2 (ja) 2011-08-24

Family

ID=26312701

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000522892A Expired - Fee Related JP4754067B2 (ja) 1997-12-02 1998-11-27 鼻孔投与用組成物
JP2010227620A Withdrawn JP2011026341A (ja) 1997-12-02 2010-10-07 鼻孔投与用組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010227620A Withdrawn JP2011026341A (ja) 1997-12-02 2010-10-07 鼻孔投与用組成物

Country Status (13)

Country Link
US (2) US6342251B1 (https=)
EP (1) EP1035833B1 (https=)
JP (2) JP4754067B2 (https=)
AR (1) AR017694A1 (https=)
AT (1) ATE303131T1 (https=)
AU (1) AU751182B2 (https=)
CA (1) CA2312839C (https=)
DE (1) DE69831421T2 (https=)
DK (1) DK1035833T3 (https=)
ES (1) ES2249846T3 (https=)
NO (1) NO329381B1 (https=)
NZ (1) NZ504786A (https=)
WO (1) WO1999027905A1 (https=)

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US6566368B2 (en) * 1994-04-22 2003-05-20 Pentech Pharmaceuticals, Inc. Apomorphine-containing dosage form for ameliorating male erectile dysfunction
US7022683B1 (en) * 1998-05-13 2006-04-04 Carrington Laboratories, Inc. Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
TWI223598B (en) * 1998-06-22 2004-11-11 Pfizer Ireland Pharmaceuticals An intranasal pharmaceutical composition for the treatment of male erectile dysfunction or female sexual disorders, an intranasal delivery system or device and sildenafil mesylate
US6200591B1 (en) 1998-06-25 2001-03-13 Anwar A. Hussain Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction
DE19834507A1 (de) * 1998-07-31 2000-02-03 Hexal Ag Pharmazeutische, wasserlösliche Tablettenformulierung zur Anwendung von Sildenafil
DE19834506A1 (de) * 1998-07-31 2000-02-03 Hexal Ag Transmucosales therapeutisches System zur Anwendung von Sildenafil
US6436950B1 (en) * 1998-08-14 2002-08-20 Nastech Pharmaceutical Company, Inc. Nasal delivery of apomorphine
US20020002175A1 (en) * 2000-09-19 2002-01-03 Charanjit Behl Nasal delivery of apomorphine in combination with glycol derivatives
KR20020015310A (ko) * 1999-04-06 2002-02-27 로버트 엘. 로브 신체적인 성적반응을 변화시키는 방법
US6632419B2 (en) * 1999-05-04 2003-10-14 Aradigm Corporation Increasing libido in humans via acute testosterone administration
US7258850B2 (en) * 1999-05-04 2007-08-21 Aradigm Corporation Methods and compositions for treating erectile dysfunction
BR0005797A (pt) * 2000-03-20 2001-10-16 Abbott Lab Métodos para o tratamento de disfunção sexual com apomorfina em nìveis de concentração plasmática especificados
BR0109515A (pt) 2000-04-07 2004-08-10 Tap Pharmaceutical Prod Inc Derivados da apomorfina e métodos para seu uso
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US6777000B2 (en) * 2001-02-28 2004-08-17 Carrington Laboratories, Inc. In-situ gel formation of pectin
US7494669B2 (en) 2001-02-28 2009-02-24 Carrington Laboratories, Inc. Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
CN1543338B (zh) 2001-08-16 2010-06-16 Cmp医疗有限公司 壳多糖微粒及其医疗用途
US7666876B2 (en) * 2002-03-19 2010-02-23 Vernalis (R&D) Limited Buprenorphine formulations for intranasal delivery
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US7923029B2 (en) * 2002-04-11 2011-04-12 Medimmune Llc Spray freeze dry of compositions for pulmonary administration
WO2004003145A2 (en) * 2002-06-28 2004-01-08 Nastech Pharmaceutical Company Inc. Compositions and methods for modulating physiology of epithelial junctional adhesion molecules for enhanced mucosal delivery of therapeutic compounds
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GB0304636D0 (en) * 2003-02-28 2003-04-02 Britannia Pharmaceuticals Ltd Pharmaceutical composition for nasal delivery
RU2364400C2 (ru) * 2003-04-14 2009-08-20 Вектура Лтд Фармацевтические композиции
US20040204439A1 (en) * 2003-04-14 2004-10-14 Staniforth John Nicholas Composition, device, and method for treating sexual dysfunction via inhalation
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US20050090518A1 (en) * 2003-10-24 2005-04-28 Nastech Pharmaceutical Company Inc. Method for treating parkinson's disease using apomorphine and apomorphine prodrugs
US20050129679A1 (en) * 2003-12-15 2005-06-16 Nastech Pharmaceutical Company Inc. Method for opening tight junctions
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US20070110788A1 (en) * 2005-11-14 2007-05-17 Hissong James B Injectable formulation capable of forming a drug-releasing device
AU2007285472B2 (en) * 2006-03-30 2013-10-24 Engene, Inc. Non-viral compositions and methods for transfecting gut cells in vivo
BRPI0710654B1 (pt) 2006-04-21 2021-11-03 Toko Yakuhin Kogyo Kabushiki Kaisha Preparação de adesivo para pele/mucosa do tipo gel, pulverizável, e sistema de administração usando a preparação
GB2437488A (en) * 2006-04-25 2007-10-31 Optinose As Pharmaceutical oily formulation for nasal or buccal administration
US7976873B2 (en) * 2006-05-10 2011-07-12 Medtronic Xomed, Inc. Extracellular polysaccharide solvating system for treatment of bacterial ear conditions
US20070264296A1 (en) * 2006-05-10 2007-11-15 Myntti Matthew F Biofilm extracellular polysachharide solvating system
US7959943B2 (en) * 2006-05-10 2011-06-14 Medtronics Xomed, Inc. Solvating system and sealant for medical use in the middle or inner ear
US7993675B2 (en) * 2006-05-10 2011-08-09 Medtronic Xomed, Inc. Solvating system and sealant for medical use in the sinuses and nasal passages
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GB0721394D0 (en) * 2007-10-31 2007-12-12 Vectura Group Plc Compositions for trating parkinson's disease
EP2057982A1 (en) 2007-11-09 2009-05-13 Archimedes Development Limited Intranasal compositions
EP2296637B1 (en) 2008-04-24 2014-04-02 Medtronic, Inc Chitosan-containing protective composition
CN102216381B (zh) 2008-04-24 2016-06-15 麦德托尼克公司 可再水化的多糖颗粒和海绵体
EP2310002B1 (en) 2008-04-24 2016-11-02 Medtronic, Inc Protective gel based on chitosan and oxidized polysaccharide
WO2009132224A2 (en) 2008-04-24 2009-10-29 Medtronic, Inc. Rehydratable thiolated polysaccharide particles and sponge
CA2727432C (en) 2008-06-12 2016-10-11 Medtronic Xomed, Inc. Method for treating chronic wounds with an extracellular polymeric substance solvating system
US8580801B2 (en) 2008-07-23 2013-11-12 Robert I. Henkin Phosphodiesterase inhibitor treatment
EP2346324A4 (en) 2008-10-06 2012-10-10 Microbial Defense Systems Llc ANTIMICROBIAL COMPOSITION AND METHODS OF MAKING AND USING
CZ302789B6 (cs) 2009-11-25 2011-11-09 Zentiva, K. S. Zpusob zvýšení rozpustnosti farmaceuticky aktivních látek a cílený (kontrolovaný) transport do streva
US10653133B2 (en) 2011-05-10 2020-05-19 Next Science IP Holdings Pty Ltd Antimicrobial solid and methods of making and using same
KR20160033220A (ko) 2013-07-23 2016-03-25 알러간, 인코포레이티드 베타-3-아드레날린 수용체 작용제와 함께 데스모프레신을 포함하는 방법 및 조성물
US10598672B2 (en) 2014-02-18 2020-03-24 Cyrano Therapeutics, Inc. Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell
ES2923438T3 (es) * 2014-11-20 2022-09-27 Serenity Pharmaceuticals Llc Composiciones que comprenden bajas dosis de desmopresina en combinación con un antagonista del receptor alfaadrenérgico
EP3056219B1 (fr) * 2015-02-12 2018-08-22 Laboratoires Chemineau Composition à base de plantes de la famille des malvaceae pour une administration sur les muqueuses
FR3032618A1 (fr) * 2015-02-12 2016-08-19 Laboratoires Chemineau Composition a base de plantes de la famille des malvaceae pour une administration dans la cavite nasale
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
JP7606530B2 (ja) 2020-03-24 2024-12-25 シラノ セラピューティクス， インコーポレイテッド コロナウイルス感染症による化学感覚機能障害の治療
KR20240134157A (ko) * 2022-01-06 2024-09-06 시라노 테라퓨틱스, 아이엔씨. 파킨슨 치료제의 개선된 코 투여

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63258862A (ja) * 1987-04-14 1988-10-26 ル・ラボラトワール・メラム・ソシエテ・アノニム １−［（１，１−ジフェニル）−１−アルケニル］ピペラジン誘導体、その製造方法およびそれを含有する薬剤組成物
US4826683A (en) * 1987-01-09 1989-05-02 Bates Harry L Decongestant
JPH0436233A (ja) * 1990-05-29 1992-02-06 Biomaterial Universe Kk 生理活性物質含有生体内分解吸収性の徐放性製剤
JPH05194215A (ja) * 1991-07-22 1993-08-03 Recordati Sa ５−ベンゾイル−２，３−ジヒドロ−１ｈ−ピロリジン−１−カルボン酸を含有する鼻内投与用治療組成物
WO1994022460A1 (en) * 1993-04-05 1994-10-13 University Patents, Inc. Diagnosis and treatment of erectile dysfunction
JPH072695A (ja) * 1993-04-07 1995-01-06 Pfizer Inc ペプチドの持続放出
JPH07215877A (ja) * 1994-02-04 1995-08-15 Kanebo Ltd 点鼻液剤
WO1995028930A1 (en) * 1994-04-22 1995-11-02 Pentech Pharmaceuticals, Inc. Dosage forms and method for ameliorating male erectile dysfunction
WO1996003142A1 (en) * 1994-07-26 1996-02-08 Danbiosyst Uk Limited Drug delivery composition for the nasal administration of antiviral agents

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US4826683A (en) * 1987-01-09 1989-05-02 Bates Harry L Decongestant
JPS63258862A (ja) * 1987-04-14 1988-10-26 ル・ラボラトワール・メラム・ソシエテ・アノニム １−［（１，１−ジフェニル）−１−アルケニル］ピペラジン誘導体、その製造方法およびそれを含有する薬剤組成物
JPH0436233A (ja) * 1990-05-29 1992-02-06 Biomaterial Universe Kk 生理活性物質含有生体内分解吸収性の徐放性製剤
JPH05194215A (ja) * 1991-07-22 1993-08-03 Recordati Sa ５−ベンゾイル−２，３−ジヒドロ−１ｈ−ピロリジン−１−カルボン酸を含有する鼻内投与用治療組成物
WO1994022460A1 (en) * 1993-04-05 1994-10-13 University Patents, Inc. Diagnosis and treatment of erectile dysfunction
JPH072695A (ja) * 1993-04-07 1995-01-06 Pfizer Inc ペプチドの持続放出
JPH07215877A (ja) * 1994-02-04 1995-08-15 Kanebo Ltd 点鼻液剤
WO1995028930A1 (en) * 1994-04-22 1995-11-02 Pentech Pharmaceuticals, Inc. Dosage forms and method for ameliorating male erectile dysfunction
WO1996003142A1 (en) * 1994-07-26 1996-02-08 Danbiosyst Uk Limited Drug delivery composition for the nasal administration of antiviral agents

Also Published As

Publication number Publication date
US6342251B1 (en) 2002-01-29
ATE303131T1 (de) 2005-09-15
DK1035833T3 (da) 2006-01-09
DE69831421T2 (de) 2006-06-22
EP1035833A1 (en) 2000-09-20
NO20002851D0 (no) 2000-06-02
ES2249846T3 (es) 2006-04-01
AU1253599A (en) 1999-06-16
WO1999027905A1 (en) 1999-06-10
NZ504786A (en) 2005-07-29
NO20002851L (no) 2000-06-02
AU751182B2 (en) 2002-08-08
EP1035833B1 (en) 2005-08-31
JP2011026341A (ja) 2011-02-10
DE69831421D1 (de) 2005-10-06
JP2001524509A (ja) 2001-12-04
US20010046519A1 (en) 2001-11-29
NO329381B1 (no) 2010-10-04
CA2312839A1 (en) 1999-06-10
CA2312839C (en) 2008-01-15
AR017694A1 (es) 2001-09-12

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