AR017694A1 - Una composicion para la administracion nasal de un farmaco para tratar la disfuncion erectil, el uso de dicha composicion en la fabricacion de unmedicamento, y un procedimiento para la preparacion de la composicion - Google Patents
Una composicion para la administracion nasal de un farmaco para tratar la disfuncion erectil, el uso de dicha composicion en la fabricacion de unmedicamento, y un procedimiento para la preparacion de la composicionInfo
- Publication number
- AR017694A1 AR017694A1 ARP980106027A ARP980106027A AR017694A1 AR 017694 A1 AR017694 A1 AR 017694A1 AR P980106027 A ARP980106027 A AR P980106027A AR P980106027 A ARP980106027 A AR P980106027A AR 017694 A1 AR017694 A1 AR 017694A1
- Authority
- AR
- Argentina
- Prior art keywords
- composition
- procedure
- drug
- erectile dysfunction
- nasal administration
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Una composicion para la administracion nasal que comprende un fármaco para tratar la disfuncion eréctil, en donde la composicion está adaptadapara proveer un aumento inicial en el nivel en plasma seguido de un nivel sostenido del fármaco en el plasma. Preferiblemente, el fármaco es un compuestoque tiene actividad antagonista alfa-adrenoreceptor, un compuesto que actua primariamente mediante bloqueo de la recaptacion de serotonina en lasterminales nerviosas, un compuesto con actividad antagonistadel receptor D2 central, o un inhibidor selectivo y competitiva de la V-fosfodiesterasasdel tipo c-GMP. Preferiblemente, la composicion incluye uno o más excipientes farmacéuticamente aceptables, por ejemplo un material polisacárido tal comopectina,gellan, o almidon o un copolímero de bloque tal como un poloxámero (copolímero de bloque polioxietileno-polioxipropileno) o quitosano. Seprovee también un procedimiento para elaborar estas composiciones.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9725519.4A GB9725519D0 (en) | 1997-12-02 | 1997-12-02 | Nasal formulation |
GBGB9805253.3A GB9805253D0 (en) | 1998-03-13 | 1998-03-13 | Nasal formulation |
Publications (1)
Publication Number | Publication Date |
---|---|
AR017694A1 true AR017694A1 (es) | 2001-09-12 |
Family
ID=26312701
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980106027A AR017694A1 (es) | 1997-12-02 | 1998-11-27 | Una composicion para la administracion nasal de un farmaco para tratar la disfuncion erectil, el uso de dicha composicion en la fabricacion de unmedicamento, y un procedimiento para la preparacion de la composicion |
Country Status (13)
Country | Link |
---|---|
US (2) | US6342251B1 (es) |
EP (1) | EP1035833B1 (es) |
JP (2) | JP4754067B2 (es) |
AR (1) | AR017694A1 (es) |
AT (1) | ATE303131T1 (es) |
AU (1) | AU751182B2 (es) |
CA (1) | CA2312839C (es) |
DE (1) | DE69831421T2 (es) |
DK (1) | DK1035833T3 (es) |
ES (1) | ES2249846T3 (es) |
NO (1) | NO329381B1 (es) |
NZ (1) | NZ504786A (es) |
WO (1) | WO1999027905A1 (es) |
Families Citing this family (57)
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US6566368B2 (en) * | 1994-04-22 | 2003-05-20 | Pentech Pharmaceuticals, Inc. | Apomorphine-containing dosage form for ameliorating male erectile dysfunction |
US7022683B1 (en) * | 1998-05-13 | 2006-04-04 | Carrington Laboratories, Inc. | Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation |
TWI223598B (en) * | 1998-06-22 | 2004-11-11 | Pfizer Ireland Pharmaceuticals | An intranasal pharmaceutical composition for the treatment of male erectile dysfunction or female sexual disorders, an intranasal delivery system or device and sildenafil mesylate |
US6200591B1 (en) | 1998-06-25 | 2001-03-13 | Anwar A. Hussain | Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction |
DE19834507A1 (de) * | 1998-07-31 | 2000-02-03 | Hexal Ag | Pharmazeutische, wasserlösliche Tablettenformulierung zur Anwendung von Sildenafil |
DE19834506A1 (de) * | 1998-07-31 | 2000-02-03 | Hexal Ag | Transmucosales therapeutisches System zur Anwendung von Sildenafil |
US6436950B1 (en) * | 1998-08-14 | 2002-08-20 | Nastech Pharmaceutical Company, Inc. | Nasal delivery of apomorphine |
US20020002175A1 (en) * | 2000-09-19 | 2002-01-03 | Charanjit Behl | Nasal delivery of apomorphine in combination with glycol derivatives |
AU4203600A (en) * | 1999-04-06 | 2000-10-23 | Zonagen, Inc. | Methods for modulating the human sexual response |
US6632419B2 (en) * | 1999-05-04 | 2003-10-14 | Aradigm Corporation | Increasing libido in humans via acute testosterone administration |
US7258850B2 (en) * | 1999-05-04 | 2007-08-21 | Aradigm Corporation | Methods and compositions for treating erectile dysfunction |
BR0005797A (pt) * | 2000-03-20 | 2001-10-16 | Abbott Lab | Métodos para o tratamento de disfunção sexual com apomorfina em nìveis de concentração plasmática especificados |
CZ20023637A3 (cs) | 2000-04-07 | 2003-02-12 | Tap Pharmaceutical Products, Inc. | Deriváty apomorfinu a způsoby jejich použití |
AU2001282373A1 (en) * | 2000-05-26 | 2001-12-03 | Horphag Research Limited | Use of proanthocyanidins as an active ingredient of a stimulator and l-arginine or its salts as a source of nitric oxide to relieve symptoms of erectile dysfuntion |
US7494669B2 (en) * | 2001-02-28 | 2009-02-24 | Carrington Laboratories, Inc. | Delivery of physiological agents with in-situ gels comprising anionic polysaccharides |
US6777000B2 (en) * | 2001-02-28 | 2004-08-17 | Carrington Laboratories, Inc. | In-situ gel formation of pectin |
ES2295391T3 (es) | 2001-08-16 | 2008-04-16 | Cmp Therapeutics Limited | Microparticulas de quitina y sus usos medicos. |
US7666876B2 (en) * | 2002-03-19 | 2010-02-23 | Vernalis (R&D) Limited | Buprenorphine formulations for intranasal delivery |
AU2003234090A1 (en) | 2002-04-11 | 2003-10-27 | Medimmune Vaccines, Inc. | Spray freeze dry of compositions for pulmonary administration |
AU2003230908A1 (en) * | 2002-04-11 | 2003-10-27 | Medimmune Vaccines, Inc. | Spray freeze dry of compositions for intranasal administration |
AU2003279750A1 (en) * | 2002-06-28 | 2004-01-19 | Nastech Pharmaceutical Company Inc. | Compositions and methods for modulating physiology of epithelial junctional adhesion molecules for enhanced mucosal delivery of therapeutic compounds |
GB0300531D0 (en) | 2003-01-10 | 2003-02-12 | West Pharm Serv Drug Res Ltd | Pharmaceutical compositions |
GB0304636D0 (en) * | 2003-02-28 | 2003-04-02 | Britannia Pharmaceuticals Ltd | Pharmaceutical composition for nasal delivery |
CA2522231A1 (en) * | 2003-04-14 | 2004-10-21 | Vectura Ltd | Pharmaceutical compositions comprising apomorphine for pulmonary inhalation |
US20040204439A1 (en) * | 2003-04-14 | 2004-10-14 | Staniforth John Nicholas | Composition, device, and method for treating sexual dysfunction via inhalation |
CN100575955C (zh) * | 2003-04-30 | 2009-12-30 | 纳斯泰克制药公司 | 密蛋白的未表达作为肿瘤转移的标记物 |
US20050090518A1 (en) * | 2003-10-24 | 2005-04-28 | Nastech Pharmaceutical Company Inc. | Method for treating parkinson's disease using apomorphine and apomorphine prodrugs |
US20050129679A1 (en) * | 2003-12-15 | 2005-06-16 | Nastech Pharmaceutical Company Inc. | Method for opening tight junctions |
WO2006085987A2 (en) | 2004-07-09 | 2006-08-17 | University Of Iowa Research Foundation | Rna interference in respiratory epitheial cells |
US20070110788A1 (en) * | 2005-11-14 | 2007-05-17 | Hissong James B | Injectable formulation capable of forming a drug-releasing device |
EP2034954B1 (en) * | 2006-03-30 | 2019-02-20 | Engene, Inc. | Non-viral compositions and methods for transfecting gut cells in vivo |
KR101488025B1 (ko) | 2006-04-21 | 2015-01-29 | 도쿄 야쿠힌 고교 가부시키가이샤 | 스프레이용 겔 타입 피부/점막-부착형 제제 및 이를 이용한투여 시스템 |
GB2437488A (en) * | 2006-04-25 | 2007-10-31 | Optinose As | Pharmaceutical oily formulation for nasal or buccal administration |
US7959943B2 (en) * | 2006-05-10 | 2011-06-14 | Medtronics Xomed, Inc. | Solvating system and sealant for medical use in the middle or inner ear |
US20070264296A1 (en) * | 2006-05-10 | 2007-11-15 | Myntti Matthew F | Biofilm extracellular polysachharide solvating system |
US7976873B2 (en) * | 2006-05-10 | 2011-07-12 | Medtronic Xomed, Inc. | Extracellular polysaccharide solvating system for treatment of bacterial ear conditions |
US7993675B2 (en) | 2006-05-10 | 2011-08-09 | Medtronic Xomed, Inc. | Solvating system and sealant for medical use in the sinuses and nasal passages |
US8088095B2 (en) * | 2007-02-08 | 2012-01-03 | Medtronic Xomed, Inc. | Polymeric sealant for medical use |
GB0715285D0 (en) * | 2007-08-06 | 2007-09-12 | Britannia Pharmaceuticals Ltd | Improvements in or relating to powdered medicaments for nasal delivery |
WO2009040595A1 (en) * | 2007-09-28 | 2009-04-02 | Wockhardt Research Centre | Multi-dose pharmaceutical composition of analgesic for nasal administration |
GB0721394D0 (en) * | 2007-10-31 | 2007-12-12 | Vectura Group Plc | Compositions for trating parkinson's disease |
EP2057982A1 (en) * | 2007-11-09 | 2009-05-13 | Archimedes Development Limited | Intranasal compositions |
AU2009240512B2 (en) * | 2008-04-24 | 2014-07-10 | Medtronic, Inc. | Protective gel based on chitosan and oxidized polysaccharide |
EP2291524A2 (en) | 2008-04-24 | 2011-03-09 | Medtronic, Inc | Rehydratable thiolated polysaccharide particles and sponge |
AU2009240510B2 (en) | 2008-04-24 | 2014-08-21 | Medtronic, Inc. | Rehydratable polysaccharide particles and sponge |
AU2009240513B2 (en) | 2008-04-24 | 2015-03-26 | Medtronic, Inc. | Chitosan-containing protective composition |
WO2009152374A2 (en) | 2008-06-12 | 2009-12-17 | Medtronic Xomed, Inc. | Method for treating chronic wounds |
EP2346324A4 (en) | 2008-10-06 | 2012-10-10 | Microbial Defense Systems Llc | ANTIMICROBIAL COMPOSITION AND METHODS OF MAKING AND USING |
CZ302789B6 (cs) | 2009-11-25 | 2011-11-09 | Zentiva, K. S. | Zpusob zvýšení rozpustnosti farmaceuticky aktivních látek a cílený (kontrolovaný) transport do streva |
AU2012253476B2 (en) | 2011-05-10 | 2015-09-24 | Next Science IP Holdings Pty Ltd | Antimicrobial solid and methods of making and using same |
EP3024474B1 (en) | 2013-07-23 | 2022-01-05 | Serenity Pharmaceuticals LLC | Compositions comprising desmopressin in combination with a beta-3 adrenergic receptor agonist |
WO2015126944A1 (en) | 2014-02-18 | 2015-08-27 | Henkin Robert I | Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell |
DK3220942T3 (da) * | 2014-11-20 | 2022-07-18 | Serenity Pharmaceuticals Llc | Sammensætninger omfattende lav dosis af desmopressin i kombination med en alpha-adrenerg receptorantagonist |
EP3056219B1 (fr) * | 2015-02-12 | 2018-08-22 | Laboratoires Chemineau | Composition à base de plantes de la famille des malvaceae pour une administration sur les muqueuses |
FR3032618A1 (fr) * | 2015-02-12 | 2016-08-19 | Laboratoires Chemineau | Composition a base de plantes de la famille des malvaceae pour une administration dans la cavite nasale |
WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
WO2023133463A1 (en) * | 2022-01-06 | 2023-07-13 | Cyrano Therapeutics, Inc. | Improved nasal administration of parkinson's therapeutics |
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JPS62123112A (ja) | 1985-11-22 | 1987-06-04 | Sunstar Inc | 軟膏基剤 |
DE3601132A1 (de) | 1986-01-16 | 1987-07-23 | Christian Bannert | Verfahren zur behandlung der schleimhaut |
JPS62236862A (ja) | 1986-04-09 | 1987-10-16 | Nippon Kayaku Co Ltd | 人工粘液 |
JPH01501708A (ja) * | 1987-01-08 | 1989-06-15 | ナステツク フアーマスーテイカル カンパニー,インコーポレイテツド | アミノ酸の経鼻投与 |
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DE3827561C1 (es) | 1988-08-13 | 1989-12-28 | Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De | |
US5707644A (en) * | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
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JPH0597706A (ja) | 1991-04-09 | 1993-04-20 | Chemex Block Drug Jv | アフタ性潰瘍および他の粘膜皮膚障害の処置方法 |
IT1250691B (it) * | 1991-07-22 | 1995-04-21 | Giancarlo Santus | Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac. |
US5318780A (en) | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
ES2239369T3 (es) * | 1993-03-26 | 2005-09-16 | Franciscus Wilhelmus Henricus Maria Merkus | Composiciones farmaceuticas para administracion intranasal de dihidroergotamina. |
EP0696919B1 (en) * | 1993-04-05 | 2002-01-30 | Competitive Technologies, Inc. | Diagnosis and treatment of erectile dysfunction |
NZ250844A (en) * | 1993-04-07 | 1996-03-26 | Pfizer | Treatment of non-insulin dependant diabetes with peptides; composition |
GB9310412D0 (en) * | 1993-05-20 | 1993-07-07 | Danbiosyst Uk | Nasal nicotine system |
EP0792161A4 (en) * | 1993-07-12 | 1998-04-29 | Virus Res Inst | MICROENCAPSULATED VACCINES BASED ON HYDROGEL |
JP3696265B2 (ja) * | 1994-02-04 | 2005-09-14 | 日本オルガノン株式会社 | 点鼻液剤 |
PT758895E (pt) * | 1994-04-22 | 2000-05-31 | Univ Kingston | Formas de dosagem sublingual contendo apomorfina para uso no tratamento da disfuncao erectil |
GB9414966D0 (en) * | 1994-07-26 | 1994-09-14 | Danbiosyst Uk | Pharmaceutical compositions for the nasal administration of antiviral agents |
GB9707934D0 (en) * | 1997-04-18 | 1997-06-04 | Danbiosyst Uk | Improved delivery of drugs to mucosal surfaces |
-
1998
- 1998-11-27 DE DE69831421T patent/DE69831421T2/de not_active Expired - Lifetime
- 1998-11-27 AU AU12535/99A patent/AU751182B2/en not_active Ceased
- 1998-11-27 JP JP2000522892A patent/JP4754067B2/ja not_active Expired - Fee Related
- 1998-11-27 WO PCT/GB1998/003572 patent/WO1999027905A1/en active IP Right Grant
- 1998-11-27 CA CA002312839A patent/CA2312839C/en not_active Expired - Fee Related
- 1998-11-27 NZ NZ504786A patent/NZ504786A/en not_active IP Right Cessation
- 1998-11-27 AT AT98955814T patent/ATE303131T1/de active
- 1998-11-27 DK DK98955814T patent/DK1035833T3/da active
- 1998-11-27 EP EP98955814A patent/EP1035833B1/en not_active Expired - Lifetime
- 1998-11-27 AR ARP980106027A patent/AR017694A1/es unknown
- 1998-11-27 ES ES98955814T patent/ES2249846T3/es not_active Expired - Lifetime
-
2000
- 2000-06-02 NO NO20002851A patent/NO329381B1/no not_active IP Right Cessation
- 2000-06-02 US US09/586,139 patent/US6342251B1/en not_active Expired - Lifetime
-
2001
- 2001-08-01 US US09/920,698 patent/US20010046519A1/en not_active Abandoned
-
2010
- 2010-10-07 JP JP2010227620A patent/JP2011026341A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
ES2249846T3 (es) | 2006-04-01 |
DE69831421T2 (de) | 2006-06-22 |
EP1035833B1 (en) | 2005-08-31 |
AU751182B2 (en) | 2002-08-08 |
DK1035833T3 (da) | 2006-01-09 |
JP2011026341A (ja) | 2011-02-10 |
NO20002851L (no) | 2000-06-02 |
US6342251B1 (en) | 2002-01-29 |
ATE303131T1 (de) | 2005-09-15 |
WO1999027905A1 (en) | 1999-06-10 |
NO20002851D0 (no) | 2000-06-02 |
CA2312839A1 (en) | 1999-06-10 |
AU1253599A (en) | 1999-06-16 |
NO329381B1 (no) | 2010-10-04 |
US20010046519A1 (en) | 2001-11-29 |
NZ504786A (en) | 2005-07-29 |
JP2001524509A (ja) | 2001-12-04 |
DE69831421D1 (de) | 2005-10-06 |
EP1035833A1 (en) | 2000-09-20 |
JP4754067B2 (ja) | 2011-08-24 |
CA2312839C (en) | 2008-01-15 |
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