JP4740864B2 - 生分解性ポリ（β−アミノエステル）およびその使用 - Google Patents

生分解性ポリ（β−アミノエステル）およびその使用 Download PDF

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JP4740864B2
JP4740864B2 JP2006533421A JP2006533421A JP4740864B2 JP 4740864 B2 JP4740864 B2 JP 4740864B2 JP 2006533421 A JP2006533421 A JP 2006533421A JP 2006533421 A JP2006533421 A JP 2006533421A JP 4740864 B2 JP4740864 B2 JP 4740864B2
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poly
polymer
group
amine
dna
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JP2007504353A (ja
JP2007504353A5 (https=
Inventor
ロバート ランジャー，
デービット エム． リン，
ダニエル ジー． アンダーソン，
エーキン アキンク，
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Massachusetts Institute of Technology
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Massachusetts Institute of Technology
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/44—Polyester-amides
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
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    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
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    • C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/40—Polyesters derived from ester-forming derivatives of polycarboxylic acids or of polyhydroxy compounds, other than from esters thereof
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    • C08G63/685—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen
    • C08G63/6854—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen derived from polycarboxylic acids and polyhydroxy compounds
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • C08L79/02—Polyamines
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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
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  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2006533421A 2003-05-28 2004-05-26 生分解性ポリ（β−アミノエステル）およびその使用 Expired - Lifetime JP4740864B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/446,444 2003-05-28
US10/446,444 US7427394B2 (en) 2000-10-10 2003-05-28 Biodegradable poly(β-amino esters) and uses thereof
PCT/US2004/016521 WO2004106411A2 (en) 2003-05-28 2004-05-26 Biodegradable poly(beta-amino esters) and uses thereof

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JP2010069008A Division JP5558154B2 (ja) 2003-05-28 2010-03-24 生分解性ポリ（β−アミノエステル）およびその使用

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JP2007504353A JP2007504353A (ja) 2007-03-01
JP2007504353A5 JP2007504353A5 (https=) 2010-05-13
JP4740864B2 true JP4740864B2 (ja) 2011-08-03

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JP2006533421A Expired - Lifetime JP4740864B2 (ja) 2003-05-28 2004-05-26 生分解性ポリ（β−アミノエステル）およびその使用
JP2010069008A Expired - Fee Related JP5558154B2 (ja) 2003-05-28 2010-03-24 生分解性ポリ（β−アミノエステル）およびその使用
JP2014013391A Pending JP2014129536A (ja) 2003-05-28 2014-01-28 生分解性ポリ（β−アミノエステル）およびその使用

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JP2010069008A Expired - Fee Related JP5558154B2 (ja) 2003-05-28 2010-03-24 生分解性ポリ（β−アミノエステル）およびその使用
JP2014013391A Pending JP2014129536A (ja) 2003-05-28 2014-01-28 生分解性ポリ（β−アミノエステル）およびその使用

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Country Link
US (1) US7427394B2 (https=)
EP (2) EP1639029B1 (https=)
JP (3) JP4740864B2 (https=)
AT (2) ATE366769T1 (https=)
CA (1) CA2527722C (https=)
DE (2) DE602004007518T2 (https=)
ES (2) ES2350055T3 (https=)
PT (1) PT1639029E (https=)
WO (1) WO2004106411A2 (https=)

Families Citing this family (155)

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US20080281041A1 (en) 1999-06-07 2008-11-13 Rozema David B Reversibly Masked Polymers
USRE43612E1 (en) 2000-10-10 2012-08-28 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
US6998115B2 (en) * 2000-10-10 2006-02-14 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
US7223851B2 (en) * 2003-02-06 2007-05-29 General Dynamics Advanced Information Systems, Inc. Nucleic acid-binding polymers
US7309757B2 (en) 2003-06-20 2007-12-18 Agency For Science, Technology And Research Polymers for the delivery of bioactive agents and methods of their preparation
US7883720B2 (en) 2003-07-09 2011-02-08 Wisconsin Alumni Research Foundation Charge-dynamic polymers and delivery of anionic compounds
US7943179B2 (en) * 2003-09-23 2011-05-17 Massachusetts Institute Of Technology pH triggerable polymeric particles
US20050123596A1 (en) * 2003-09-23 2005-06-09 Kohane Daniel S. pH-triggered microparticles
EP1730286A4 (en) * 2004-03-04 2007-09-05 Massachusetts Inst Technology THERAPEUTIC ANTICIPLE DNA
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JP5558154B2 (ja) 2014-07-23
DE602004028418D1 (de) 2010-09-09
ATE366769T1 (de) 2007-08-15
JP2007504353A (ja) 2007-03-01
EP1903068B1 (en) 2010-07-28
WO2004106411A2 (en) 2004-12-09
JP2010180412A (ja) 2010-08-19
PT1639029E (pt) 2007-09-26
ATE475685T1 (de) 2010-08-15
JP2014129536A (ja) 2014-07-10
EP1903068A1 (en) 2008-03-26
DE602004007518T2 (de) 2008-03-20
EP1639029B1 (en) 2007-07-11
WO2004106411A3 (en) 2005-01-20
DE602004007518D1 (de) 2007-08-23
US20040071654A1 (en) 2004-04-15
ES2290737T3 (es) 2008-02-16
EP1639029A2 (en) 2006-03-29
CA2527722A1 (en) 2004-12-09
US7427394B2 (en) 2008-09-23
CA2527722C (en) 2013-04-16

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