JP4727990B2 - モルヒネ−６−グルクロニドの塩 - Google Patents

モルヒネ−６−グルクロニドの塩 Download PDF

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Publication number
JP4727990B2
JP4727990B2 JP2004528672A JP2004528672A JP4727990B2 JP 4727990 B2 JP4727990 B2 JP 4727990B2 JP 2004528672 A JP2004528672 A JP 2004528672A JP 2004528672 A JP2004528672 A JP 2004528672A JP 4727990 B2 JP4727990 B2 JP 4727990B2
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solution
morphine
organic solvent
treatment
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JP2004528672A
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English (en)
Japanese (ja)
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JP2006500360A (ja
JP2006500360A5 (https=
Inventor
エイトケン グラハム，ジョン
フランツマイアー，ルドルフ
コホ，アンドレアス
シュナイダー，ヘルビク
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セネス リミティド
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Publication of JP2006500360A5 publication Critical patent/JP2006500360A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2004528672A 2002-08-14 2003-08-14 モルヒネ−６−グルクロニドの塩 Expired - Fee Related JP4727990B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0218811.8 2002-08-14
GBGB0218811.8A GB0218811D0 (en) 2002-08-14 2002-08-14 Salts of morphine-6-glucuronide
PCT/GB2003/003562 WO2004016633A1 (en) 2002-08-14 2003-08-14 Salt of morphine-6-glucuronide

Publications (3)

Publication Number Publication Date
JP2006500360A JP2006500360A (ja) 2006-01-05
JP2006500360A5 JP2006500360A5 (https=) 2006-09-28
JP4727990B2 true JP4727990B2 (ja) 2011-07-20

Family

ID=9942230

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004528672A Expired - Fee Related JP4727990B2 (ja) 2002-08-14 2003-08-14 モルヒネ−６−グルクロニドの塩

Country Status (17)

Country Link
US (1) US20060166900A1 (https=)
EP (1) EP1537132B1 (https=)
JP (1) JP4727990B2 (https=)
KR (1) KR101077501B1 (https=)
AT (1) ATE315041T1 (https=)
AU (1) AU2003255790B2 (https=)
CA (1) CA2494812C (https=)
DE (1) DE60303149T2 (https=)
DK (1) DK1537132T3 (https=)
EA (1) EA008212B1 (https=)
ES (1) ES2256790T3 (https=)
GB (1) GB0218811D0 (https=)
IL (1) IL166596A0 (https=)
NO (1) NO20051261L (https=)
PL (1) PL211031B1 (https=)
WO (1) WO2004016633A1 (https=)
ZA (1) ZA200501053B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101534808A (zh) 2005-06-27 2009-09-16 拜维尔实验室国际有限公司 丁氨苯丙酮盐的改良释放配制品
FR2939437B1 (fr) * 2008-12-10 2010-12-17 Sanofi Aventis Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique
FR2939796B1 (fr) * 2008-12-11 2010-12-17 Sanofi Aventis Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique
CN107028968B (zh) * 2016-02-03 2020-12-04 江苏恒瑞医药股份有限公司 一种含有葡萄糖醛酸吗啡或其可药用盐的药物组合物
EP3528873A2 (en) 2016-10-21 2019-08-28 Somniferum Labs LLC Apparatus for controlled delivery of opioid and other medications
CN110054656B (zh) * 2019-05-28 2021-02-02 宜昌人福药业有限责任公司 一种10-羰基/羟基吗啡-6-葡萄糖苷酸的合成方法
CN113831373B (zh) * 2020-06-23 2023-05-16 宜昌人福药业有限责任公司 一种吗啡-6-葡萄糖苷酸脱水物杂质的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908389A (en) * 1986-08-27 1990-03-13 Warner-Lambert Company Penetration enhancement system
FR2680786B1 (fr) * 1991-09-04 1995-03-10 Irepa Procede de synthese de glucuronides d'epoxy-4,5 morphinanes.
DE4403709A1 (de) * 1994-02-07 1995-08-10 Lohmann Therapie Syst Lts Pharmazeutische Zusammensetzung zur systemischen transdermalen Verabreichung mit dem Wirkstoff Morphin-6-glucuronid
US5460826A (en) * 1994-06-27 1995-10-24 Alza Corporation Morphine therapy
EP0816375A1 (en) * 1995-11-29 1998-01-07 Rolabo Sl Glycoconjugates of opiated substances
DK1017696T3 (da) * 1997-09-25 2002-07-08 Lohmann Therapie Syst Lts Syreadditionssalte af morfin-alkaloider og deres anvendelse
US6740641B2 (en) * 2001-07-27 2004-05-25 Euro-Celtique, S.A. Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain

Also Published As

Publication number Publication date
AU2003255790B2 (en) 2010-05-27
EA008212B1 (ru) 2007-04-27
KR20050055710A (ko) 2005-06-13
PL211031B1 (pl) 2012-04-30
KR101077501B1 (ko) 2011-10-28
ZA200501053B (en) 2005-10-26
PL373553A1 (en) 2005-09-05
CA2494812A1 (en) 2004-02-26
DE60303149D1 (de) 2006-03-30
DK1537132T3 (da) 2006-05-08
JP2006500360A (ja) 2006-01-05
GB0218811D0 (en) 2002-09-18
WO2004016633A1 (en) 2004-02-26
CA2494812C (en) 2011-03-08
ES2256790T3 (es) 2006-07-16
EP1537132B1 (en) 2006-01-04
ATE315041T1 (de) 2006-02-15
AU2003255790A1 (en) 2004-03-03
EA200500175A1 (ru) 2005-08-25
EP1537132A1 (en) 2005-06-08
DE60303149T2 (de) 2006-09-28
IL166596A0 (en) 2006-01-15
NO20051261L (no) 2005-03-11
US20060166900A1 (en) 2006-07-27

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