JP4698681B2 - アミノピリミジン類の化合物及びその塩の調製方法と薬物の用途 - Google Patents

アミノピリミジン類の化合物及びその塩の調製方法と薬物の用途 Download PDF

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JP4698681B2
JP4698681B2 JP2007548675A JP2007548675A JP4698681B2 JP 4698681 B2 JP4698681 B2 JP 4698681B2 JP 2007548675 A JP2007548675 A JP 2007548675A JP 2007548675 A JP2007548675 A JP 2007548675A JP 4698681 B2 JP4698681 B2 JP 4698681B2
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methyl
amino
pyridyl
pyrimidinyl
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JP2008526692A5 (cg-RX-API-DMAC7.html
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▲飄▼▲揚▼ ▲孫▼
▲愛▼▲鋒▼ 呂
保海 ▲楊▼
春勇 胡
ワン，ウェイボ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007548675A 2004-12-31 2005-12-26 アミノピリミジン類の化合物及びその塩の調製方法と薬物の用途 Expired - Fee Related JP4698681B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN200410103077.8 2004-12-31
CN200410103077 2004-12-31
CNA2005101074022A CN1939910A (zh) 2004-12-31 2005-09-30 氨基嘧啶类化合物及其盐和其制备方法与药物用途
CN200510107402.2 2005-09-30
PCT/CN2005/002308 WO2006069525A1 (en) 2004-12-31 2005-12-26 Aminopyrimidine compounds and their salts, process for preparation and pharmaceutical use thereof

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JP2008526692A JP2008526692A (ja) 2008-07-24
JP2008526692A5 JP2008526692A5 (cg-RX-API-DMAC7.html) 2011-03-10
JP4698681B2 true JP4698681B2 (ja) 2011-06-08

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US (1) US8183242B2 (cg-RX-API-DMAC7.html)
EP (1) EP1840122B1 (cg-RX-API-DMAC7.html)
JP (1) JP4698681B2 (cg-RX-API-DMAC7.html)
CN (1) CN1939910A (cg-RX-API-DMAC7.html)
CA (1) CA2602738C (cg-RX-API-DMAC7.html)
ES (1) ES2436758T3 (cg-RX-API-DMAC7.html)
WO (1) WO2006069525A1 (cg-RX-API-DMAC7.html)

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US8367686B2 (en) 2007-06-07 2013-02-05 Intra-Cellular Therapies, Inc. Heterocycle compounds and uses thereof
WO2011075560A1 (en) * 2009-12-17 2011-06-23 Merck Sharp & Dohme Corp. Aminopyrimidines as syk inhibitors
CN102796079B (zh) * 2011-05-27 2016-06-29 江苏豪森药业集团有限公司 一种甲磺酸氟马替尼的制备方法
CN102816147B (zh) * 2011-06-09 2016-06-08 江苏豪森药业集团有限公司 甲磺酸氟马替尼晶型b及其制备方法和用途
CN102816146A (zh) * 2011-06-10 2012-12-12 江苏豪森医药集团连云港宏创医药有限公司 甲磺酸氟马替尼晶型a及其制备方法和用途
CN103709147A (zh) * 2012-10-09 2014-04-09 江苏豪森医药集团连云港宏创医药有限公司 甲磺酸氟马替尼晶型及其制备方法和用途
CN103360366B (zh) * 2013-07-26 2015-04-01 天津禾盛医药技术开发有限公司 N-(5-硝基-2-甲基吡啶基-3-)-4-(3-吡啶基)-2-嘧啶胺及其中间体的制备方法
CN103396395B (zh) * 2013-07-26 2014-09-03 天津法莫西医药科技有限公司 一种合成n-（5-硝基-2-甲基吡啶基-3-）-4-（3-吡啶基）-2-嘧啶胺及其中间体的方法
CN105884746B (zh) * 2016-05-05 2018-09-21 江苏豪森药业集团有限公司 氟马替尼的合成方法
CN107652269A (zh) * 2016-07-26 2018-02-02 江苏豪森药业集团有限公司 甲磺酸氟马替尼中间体纯化方法
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
CN109438365B (zh) * 2018-12-06 2022-04-05 华南师范大学 N-(3-((4-三氟甲基)-2-嘧啶基)氨基苯基)-2,6-二氟苯磺酰胺衍生物
US11384083B2 (en) 2019-02-15 2022-07-12 Incyte Corporation Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
WO2020180959A1 (en) 2019-03-05 2020-09-10 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors
JP2022523562A (ja) * 2019-03-05 2022-04-25 ホンイー アンド アソシエイツ エルエルシー 神経変性疾患および癌の治療のための化合物
WO2020205560A1 (en) 2019-03-29 2020-10-08 Incyte Corporation Sulfonylamide compounds as cdk2 inhibitors
WO2020223469A1 (en) 2019-05-01 2020-11-05 Incyte Corporation N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer
WO2020223558A1 (en) 2019-05-01 2020-11-05 Incyte Corporation Tricyclic amine compounds as cdk2 inhibitors
PE20221010A1 (es) 2019-08-14 2022-06-15 Incyte Corp Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2
WO2021072232A1 (en) 2019-10-11 2021-04-15 Incyte Corporation Bicyclic amines as cdk2 inhibitors
CN111072636B (zh) * 2019-12-16 2022-08-23 江苏豪森药业集团有限公司 氟马替尼的合成方法
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
JP2024540411A (ja) 2021-11-08 2024-10-31 プロジェントス・セラピューティクス・インコーポレイテッド 血小板由来成長因子受容体（ｐｄｇｆｒ）アルファ阻害剤及びその使用
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors

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TW225528B (cg-RX-API-DMAC7.html) * 1992-04-03 1994-06-21 Ciba Geigy Ag
GB9610044D0 (en) 1996-05-14 1996-07-17 Sandoz Ltd Improvements in or relating to organic compounds
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GB9919778D0 (en) * 1999-08-21 1999-10-27 Zeneca Ltd Chemical compounds
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CA2602738C (en) 2011-12-20
EP1840122A4 (en) 2011-03-09
HK1095146A1 (en) 2007-04-27
JP2008526692A (ja) 2008-07-24
US8183242B2 (en) 2012-05-22
ES2436758T3 (es) 2014-01-07
CN1939910A (zh) 2007-04-04
EP1840122A1 (en) 2007-10-03
US20080312251A1 (en) 2008-12-18
EP1840122B1 (en) 2013-08-28
CA2602738A1 (en) 2006-07-06
WO2006069525A1 (en) 2006-07-06

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