JP4662385B2 - 硫酸化多糖または硫酸化オリゴ糖の分析方法、硫酸化多糖または硫酸化オリゴ糖を含む薬学的組成物および医薬の製造方法 - Google Patents

硫酸化多糖または硫酸化オリゴ糖の分析方法、硫酸化多糖または硫酸化オリゴ糖を含む薬学的組成物および医薬の製造方法 Download PDF

Info

Publication number
JP4662385B2
JP4662385B2 JP2008506877A JP2008506877A JP4662385B2 JP 4662385 B2 JP4662385 B2 JP 4662385B2 JP 2008506877 A JP2008506877 A JP 2008506877A JP 2008506877 A JP2008506877 A JP 2008506877A JP 4662385 B2 JP4662385 B2 JP 4662385B2
Authority
JP
Japan
Prior art keywords
sulfated
activity
inhibitory activity
analysis method
tumor cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2008506877A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2007111321A1 (ja
Inventor
一幸 菅原
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Science and Technology Agency
National Institute of Japan Science and Technology Agency
Original Assignee
Japan Science and Technology Agency
National Institute of Japan Science and Technology Agency
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Science and Technology Agency, National Institute of Japan Science and Technology Agency filed Critical Japan Science and Technology Agency
Publication of JPWO2007111321A1 publication Critical patent/JPWO2007111321A1/ja
Application granted granted Critical
Publication of JP4662385B2 publication Critical patent/JP4662385B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2008506877A 2006-03-26 2007-03-26 硫酸化多糖または硫酸化オリゴ糖の分析方法、硫酸化多糖または硫酸化オリゴ糖を含む薬学的組成物および医薬の製造方法 Expired - Fee Related JP4662385B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006084337 2006-03-26
JP2006084337 2006-03-26
PCT/JP2007/056276 WO2007111321A1 (ja) 2006-03-26 2007-03-26 硫酸化多糖または硫酸化オリゴ糖の分析方法、硫酸化多糖または硫酸化オリゴ糖を含む薬学的組成物および医薬、薬学的組成物および医薬の製造方法、疾患の治療、診断、症状の軽減および予防方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010244708A Division JP5198538B2 (ja) 2006-03-26 2010-10-29 硫酸化多糖または硫酸化オリゴ糖を含む薬学的組成物および医薬

Publications (2)

Publication Number Publication Date
JPWO2007111321A1 JPWO2007111321A1 (ja) 2009-08-13
JP4662385B2 true JP4662385B2 (ja) 2011-03-30

Family

ID=38541238

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008506877A Expired - Fee Related JP4662385B2 (ja) 2006-03-26 2007-03-26 硫酸化多糖または硫酸化オリゴ糖の分析方法、硫酸化多糖または硫酸化オリゴ糖を含む薬学的組成物および医薬の製造方法
JP2010244708A Expired - Fee Related JP5198538B2 (ja) 2006-03-26 2010-10-29 硫酸化多糖または硫酸化オリゴ糖を含む薬学的組成物および医薬

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010244708A Expired - Fee Related JP5198538B2 (ja) 2006-03-26 2010-10-29 硫酸化多糖または硫酸化オリゴ糖を含む薬学的組成物および医薬

Country Status (2)

Country Link
JP (2) JP4662385B2 (enExample)
WO (1) WO2007111321A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5097608B2 (ja) * 2008-04-25 2012-12-12 生化学工業株式会社 糖鎖配列の同定方法
CN101936948A (zh) * 2010-08-06 2011-01-05 浙江省肿瘤医院 血清多肽的质谱检测方法
JP5871500B2 (ja) * 2011-06-20 2016-03-01 公益財団法人先端医療振興財団 α−Klotho/FGF23複合体形成阻害化合物
CN103869002B (zh) * 2012-12-11 2015-05-27 深圳海王药业有限公司 一种测定低聚凤梨参糖胺聚糖含量的分析方法
CN103592382B (zh) * 2013-10-29 2015-08-19 中国海洋大学 一种检测及确定虫草多糖中共价连接的硫酸根的方法
CN104004114A (zh) * 2014-06-06 2014-08-27 嘉兴纽迪康生物科技有限公司 低分子量硫酸软骨素的制备方法
US11474100B2 (en) * 2019-05-14 2022-10-18 Hong Kong Baptist University Chromophore-labeled oligosaccharide markers and methods of use thereof
CN110279862B (zh) * 2019-07-09 2022-04-08 上海市第六人民医院 一种抗癌组合物及其在制备治疗骨肉瘤的药物中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0482836A (ja) * 1990-07-24 1992-03-16 Seikagaku Kogyo Co Ltd 癌転移抑制剤
JP2006047240A (ja) * 2004-08-09 2006-02-16 National Institute Of Advanced Industrial & Technology オリゴ糖の同定方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0482836A (ja) * 1990-07-24 1992-03-16 Seikagaku Kogyo Co Ltd 癌転移抑制剤
JP2006047240A (ja) * 2004-08-09 2006-02-16 National Institute Of Advanced Industrial & Technology オリゴ糖の同定方法

Also Published As

Publication number Publication date
JP2011059126A (ja) 2011-03-24
JPWO2007111321A1 (ja) 2009-08-13
JP5198538B2 (ja) 2013-05-15
WO2007111321A1 (ja) 2007-10-04

Similar Documents

Publication Publication Date Title
JP5198538B2 (ja) 硫酸化多糖または硫酸化オリゴ糖を含む薬学的組成物および医薬
JP2011059126A5 (enExample)
US7601488B2 (en) Hyaluronic acid oligosaccharide fractions and drugs containing the same
CN110446511B (zh) 短效的基于肝素的抗凝血剂化合物和方法
CZ341097A3 (cs) Sulfatované oligosacharidy, způsob jejich výroby a použití
WO1996009828A1 (en) Highly sulfated maltooligosaccharides with heparin-like properties
JPWO2000006608A1 (ja) 新規グリコサミノグリカン及び該物質を有効成分とする医薬組成物
Mizumoto et al. Highly sulfated hexasaccharide sequences isolated from chondroitin sulfate of shark fin cartilage: insights into the sugar sequences with bioactivities
AU700451B2 (en) Highly sulfated maltooligosaccharides with heparin-like properties
Uchimura et al. Design and Synthesis of 6‐O‐Phosphorylated Heparan Sulfate Oligosaccharides to Inhibit Amyloid β Aggregation
JP2019501263A (ja) 硫酸化ヘパリン由来オリゴ糖及びその調製法と施用
EP3349776B1 (en) Pharmaceutical association of growth factor receptor agonist and adhesion protein inhibitor for converting a neoplastic cell into a non-neoplastic cell and uses thereof
AU2010283614B2 (en) FGF receptor-activating N-acyl octasaccharides, preparation thereof, and therapeutic use thereof
JP2017507210A (ja) N−脱硫酸化グルコサミノグリカンの誘導体、及び薬物としての使用
WO2012160337A1 (en) Sulfated oligosaccharides for use in treatment of neurodegenerative diseases
JP2010518251A (ja) ビオチンまたはビオチン誘導体との少なくとも1つの共有結合を含むヘパリン、これらの調製方法およびこれらの使用
WO2005092348A1 (ja) ヘパリン様オリゴ糖含有hgf産生促進薬剤
HUP0300330A2 (hu) Oligoszacharidok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
JP7706185B2 (ja) カタツムリ粘液(achatina fulica)由来のヘパリン様物質の単離、精製、および特徴付けの新規な方法ならびにその使用
JP5344787B2 (ja) イカ軟骨のコンドロイチン硫酸由来の硫酸化八糖及び十糖
JP4884373B2 (ja) 抗デルマタン硫酸抗体と機能性硫酸化オリゴ糖
JPH0616687A (ja) ヘパリン不飽和4糖およびその製造法
JPH03185001A (ja) ヘパリンのn―アセチル化物及びその製造方法
Joshi Chemical synthesis of 3-o-sulfated heparan sulfate oligosaccharides as diagnostic biomarkers and standards for exploring protein-carbohydrate interactions
Paiotta Synthesis of Glycoderivatives as Molecular Tools in Medicinal Chemistry and Nano-Medicinal Chemistry

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100917

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101104

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20101222

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20101227

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140114

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S533 Written request for registration of change of name

Free format text: JAPANESE INTERMEDIATE CODE: R313533

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees