JP4560582B2 - 肝細胞成長因子（ｈｇｆ）結合蛋白質 - Google Patents

肝細胞成長因子（ｈｇｆ）結合蛋白質 Download PDF

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JP4560582B2
JP4560582B2 JP2009513297A JP2009513297A JP4560582B2 JP 4560582 B2 JP4560582 B2 JP 4560582B2 JP 2009513297 A JP2009513297 A JP 2009513297A JP 2009513297 A JP2009513297 A JP 2009513297A JP 4560582 B2 JP4560582 B2 JP 4560582B2
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seq
sequence
variable region
cdr
chain variable
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JP2009539348A (ja
JP2009539348A5 (enExample
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メイ ハン，
エス． カーク ライト，
ウィリアム エム． ジュニア ウィンストン，
リン ブレオー，
チエ リン，
ビジャン エテマド−ギルバートソン，
クリスティン クヌーエル，
ジェノ ギュリス，
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アベオ ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2009513297A 2006-06-02 2007-06-01 肝細胞成長因子（ｈｇｆ）結合蛋白質 Expired - Fee Related JP4560582B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81071406P 2006-06-02 2006-06-02
US86046106P 2006-11-21 2006-11-21
PCT/US2007/012950 WO2007143098A2 (en) 2006-06-02 2007-06-01 Hepatocyte growth factor (hgf) binding proteins

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JP2010167648A Division JP5528246B2 (ja) 2006-06-02 2010-07-26 肝細胞成長因子（ｈｇｆ）結合蛋白質

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JP2009539348A JP2009539348A (ja) 2009-11-19
JP2009539348A5 JP2009539348A5 (enExample) 2010-08-05
JP4560582B2 true JP4560582B2 (ja) 2010-10-13

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JP2010167648A Expired - Fee Related JP5528246B2 (ja) 2006-06-02 2010-07-26 肝細胞成長因子（ｈｇｆ）結合蛋白質

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US (5) US7659378B2 (enExample)
EP (2) EP2380908A1 (enExample)
JP (2) JP4560582B2 (enExample)
KR (1) KR101196184B1 (enExample)
AR (1) AR061170A1 (enExample)
AT (1) ATE533787T1 (enExample)
AU (1) AU2007254853B2 (enExample)
BR (1) BRPI0712223A2 (enExample)
CA (1) CA2654019A1 (enExample)
ES (1) ES2378097T3 (enExample)
IL (2) IL195038A0 (enExample)
MX (1) MX2008015138A (enExample)
NO (1) NO20085422L (enExample)
NZ (1) NZ573819A (enExample)
WO (1) WO2007143098A2 (enExample)

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AU2007254853B2 (en) 2011-11-17
US8575318B2 (en) 2013-11-05
IL219655A0 (en) 2012-06-28
EP2029627A2 (en) 2009-03-04
WO2007143098A8 (en) 2009-01-08
MX2008015138A (es) 2009-01-28
KR20090026315A (ko) 2009-03-12
US7659378B2 (en) 2010-02-09
AU2007254853A2 (en) 2009-02-12
EP2380908A1 (en) 2011-10-26
ATE533787T1 (de) 2011-12-15
ES2378097T3 (es) 2012-04-04
EP2029627B1 (en) 2011-11-16
BRPI0712223A2 (pt) 2012-07-10
US20140178934A1 (en) 2014-06-26
HK1129394A1 (en) 2009-11-27
AU2007254853A1 (en) 2007-12-13
NZ573819A (en) 2011-09-30
US20080038257A1 (en) 2008-02-14
NO20085422L (no) 2009-02-27
JP5528246B2 (ja) 2014-06-25
KR101196184B1 (ko) 2012-11-01
US20100173361A1 (en) 2010-07-08
US8268315B2 (en) 2012-09-18
WO2007143098A2 (en) 2007-12-13
AR061170A1 (es) 2008-08-06
US20130203970A1 (en) 2013-08-08
US7935502B2 (en) 2011-05-03
IL195038A0 (en) 2011-08-01
WO2007143098A3 (en) 2008-06-12
JP2009539348A (ja) 2009-11-19
JP2010246565A (ja) 2010-11-04
CA2654019A1 (en) 2007-12-13
US20110236377A1 (en) 2011-09-29

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