JP4491348B2 - プレバイオティック組成物 - Google Patents
プレバイオティック組成物 Download PDFInfo
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- JP4491348B2 JP4491348B2 JP2004558076A JP2004558076A JP4491348B2 JP 4491348 B2 JP4491348 B2 JP 4491348B2 JP 2004558076 A JP2004558076 A JP 2004558076A JP 2004558076 A JP2004558076 A JP 2004558076A JP 4491348 B2 JP4491348 B2 JP 4491348B2
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Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
本発明の組成物を比較する無作為二重盲検試験を12ヶ月の治療期間での腸機能、大便微生物叢または結腸プレバイオティック発酵に対する効果を評価すべく、潰瘍性大腸炎患者を対象として標準の栄養サプリメントに対して例えば約0.01〜約1g/kg体重/日、好ましくは約0.05〜約0.5g/kg体重/日、より好ましくは約0.1または0.15〜約0.2g/kg体重/日のFOS及び約0.01〜約1g/kg体重/日、好ましくは約0.05〜約0.5g/kg体重/日、より好ましくは約0.1または0.15〜約0.2g/kg体重/日のGOSを用いて実施する。患者30人を被験者とし得る。排便頻度、排便中の出血の有無、過剰の粘液の発生、排便のコンシステンシー、鼓張、膨満及び腹痛のパラメーターを毎週評価する。大便微生物叢はFISHにより調べられ、有益細菌種(例えば、乳酸桿菌及びビフィドバクテリウム)の数を病的状態に関連する細菌(例えば、クロストリジウム、バクテロイデス、硫酸還元菌)の数と比較する。大便サンプル中の短鎖脂肪酸(酢酸、プロピオン酸、酪酸、乳酸及び吉草酸)も調べる。PCR及びDGGEを用いて全大便DNA抽出物の研究を実施する。
ポジティブコントロールとして用いたフルクトオリゴ糖(FOS)は、フランス国に所在のBeghin−Meiji industriesの92% オリゴ糖を含有するActilight 950P(登録商標)である。
FOS、GOS、XOS、SOS、ABG、AG、WG及びIMOのプレバイオティック能力をインビトロ大便バッチ培養物を用いて調べた。また、オリゴ糖の混合物、すなわち1:1のFOS+GOS、AG+FOS、FOS+XOS、XOS+GOS及びAG+GOSも同様にインビトロで調べた。試験炭水化物のプレオバイオティック特性と比較するためのポジティブコントロールとしてFOSを用いた。単一炭水化物源として試験化合物を用いる大便バッチ培養を公知の代謝疾患も胃腸疾患(例えば、糖尿病、潰瘍性大腸炎、クローン病、消化性潰瘍、IBS、胃腸炎及びガン)もない6人の健康な成人からの大便接種物を用いて実施した。サンプルをその場で採取し、嫌気性室において保持し、採取から5分以内に用いた。0.1M 嫌気性リン酸緩衝液(pH 7.4)中の1:10希釈物を作成し、サンプルをストマッカーにおいて2分間ホモジナイズした。
無菌ケモスタット培地(135ml)を撹拌容器中嫌気性条件(O2非含有N2を連続的に流しながら)下37℃で維持した。培養pHは6.7に維持した。次いで、1%重量/容量の炭水化物源を添加した。各容器に、嫌気性リン酸緩衝食塩液中で調製した新鮮ヒト大便懸濁液(10%w/v,15ml)を接種した。バッチ培養物を24時間維持した。
バッチ培養物のサンプルを0、5、10及び24時間の培養時に採取した。細菌学のために蛍光in situハイブリダイゼーション(FISH)を用いた。全細菌、バクテロイデス種、ビフィドバクテリウム種、クロストリジウム・ペルフリンゲンス/ヒストリチクム亜群及び乳酸桿菌を16S rRNAを標的とする群特異的蛍光標識DNAプローブを用いて選んだ(表1参照)。
ここで集め、検討した結果は各種の可能性あるプレバイオティックの6ランについて合わせた結果である。
結果から、オリゴ糖は本トライアルで試験した可溶性繊維よりも有益細菌、主にビフィドバクテリウム及び乳酸桿菌により非常に選択的に発酵されることが分かる。
FOS 1g
GOS 1g
水解グアーガム(1) 0.2g
グルタミン 1g
エイコサペンタエン酸(EPA) 0.43g
ドコサヘキサエン酸(DHA) 0.28g
(1)Novartis Nutrition CorporationのBenefiber(登録商標)。
本組成物は粉末形態である。1日用量(42g)を消費する前に約200mlの冷水に溶解させなければならない。
Actlight 950P FOS(3) 12.62g
脱脂粉乳 21.49g
全粉乳 9.52g
カカオアロマ 6.55g
MCTオイル 1.07g
チョコレートフレーバー 0.71g
キャラメルフレーバー 0.19g
甘味剤サッカリン−Na 0.07g
バニラ(精製) 0.03g
(2)オランダ国に所在のBorculo Domo Ingredients製で、約28重量%のGOSを含有する;
(3)フランス国のBeghin−Meiji industries製で、約92重量%のFOSを含有する。
FOS(4) 1.25g
GOS(5) 1.25g
タンパク質 9g
炭水化物 21.4g
(スクロース 5g)
(ラントース 0.7g)
脂肪 8.7g
(飽和脂肪酸 0.81g)
(モノ不飽和脂肪酸 4.84g)
(ポリ不飽和脂肪酸 2.54g)
ビタミンA 80μg
ビタミンD 1μg
ビタミンE 1mg
ビタミンC 6mg
ビタミンK 7μg
ビタミンB1 0.14mg
ビタミンB2 0.16mg
ビタミンB16 0.2mg
ビタミンB12 0.14μg
ビオチン 7.5μg
葉酸 20μg
ナイアシン 1.8mg
パントテン酸 0.6mg
ナトリウム 60mg
カリウム 160mg
カルシウム 190mg
マグネシウム 30mg
リン 90mg
クロリド 70mg
鉄 1.5mg
亜鉛 1.5mg
銅 200μg
モリブデン 8μg
マンガン 0.3mg
クロム 10μg
セレン 6μg
フロリド 150μg
ヨウ素 15μg
(4)オランダ国のBorculo Domo IngredientsのVivinal GOS;
(5)ベルギー国のOrafitのRaftilose P95。
Claims (11)
- フルクトオリゴ糖(FOS)及びガラクトオリゴ糖(GOS)を含み、FOS:GOSの重量比が0.5から2.0である、炎症性腸疾患および潰瘍性大腸炎をコントロールするためのプレバイオティック組成物。
- FOSが2から7の重合度を有する鎖からなるオリゴフルクトースを最高95重量%含み、GOSが2から7の重合度を有する鎖からなるオリゴガラクトースを最高95重量%含む請求項1に記載の組成物。
- FOSとGOSのブレンドの量が組成物の全重量に基づいて0.05から40重量%である請求項1または2のいずれかに記載の組成物。
- 高カロリー組成物である請求項1から3のいずれかに記載の組成物。
- 組成物の全カロリー含量に基づいて1en%以上のタンパク質を含む請求項1から4のいずれかに記載の組成物。
- 完全配合食である請求項1から5のいずれかに記載の組成物。
- 100mlあたり1から3gのFOS、1から3gのGOS、2から20gのタンパク質、1から30gの炭水化物、0.5から20gの脂肪、ミネラル及びビタミンを含む請求項1から6のいずれかに記載の組成物。
- 100mlあたり1.25gのFOS、1.25gのGOS、9gのタンパク質、22gの炭水化物及び9gの脂肪を含む請求項7に記載の組成物。
- 即消費組成物である請求項1から8のいずれか1項に記載の組成物。
- 薬剤として使用するための請求項1から5のいずれか1項に記載の組成物。
- さらにグルタミンを含む請求項1から10のいずれか1項に記載の組成物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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GBGB0229015.3A GB0229015D0 (en) | 2002-12-12 | 2002-12-12 | New Compound |
PCT/EP2003/014087 WO2004052121A1 (en) | 2002-12-12 | 2003-12-11 | Prebiotic compositions |
Publications (2)
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JP2006509797A JP2006509797A (ja) | 2006-03-23 |
JP4491348B2 true JP4491348B2 (ja) | 2010-06-30 |
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JP2004558076A Expired - Lifetime JP4491348B2 (ja) | 2002-12-12 | 2003-12-11 | プレバイオティック組成物 |
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CN (1) | CN1731938B (ja) |
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CA (1) | CA2508693C (ja) |
DK (1) | DK1571923T3 (ja) |
ES (1) | ES2449016T3 (ja) |
GB (1) | GB0229015D0 (ja) |
HK (1) | HK1083054A1 (ja) |
MX (1) | MXPA05006266A (ja) |
NZ (1) | NZ540576A (ja) |
PL (1) | PL213665B1 (ja) |
PT (1) | PT1571923E (ja) |
RU (1) | RU2358474C2 (ja) |
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BRPI0317272B1 (pt) | 2016-03-22 |
JP2006509797A (ja) | 2006-03-23 |
ES2449016T3 (es) | 2014-03-17 |
EP1571923B1 (en) | 2014-01-22 |
MXPA05006266A (es) | 2005-08-19 |
TWI337080B (en) | 2011-02-11 |
US20110003768A1 (en) | 2011-01-06 |
PT1571923E (pt) | 2014-03-28 |
PL213665B1 (pl) | 2013-04-30 |
US8241658B2 (en) | 2012-08-14 |
PL377411A1 (pl) | 2006-02-06 |
CA2508693C (en) | 2013-08-13 |
WO2004052121A1 (en) | 2004-06-24 |
RU2358474C2 (ru) | 2009-06-20 |
US7794746B2 (en) | 2010-09-14 |
DK1571923T3 (en) | 2014-02-17 |
US20040131659A1 (en) | 2004-07-08 |
TW200505462A (en) | 2005-02-16 |
GB0229015D0 (en) | 2003-01-15 |
RU2005121665A (ru) | 2006-04-27 |
HK1083054A1 (en) | 2006-06-23 |
CN1731938B (zh) | 2011-12-28 |
BR0317272A (pt) | 2005-11-08 |
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