JP4464681B2 - 抗腫瘍薬としてのチオペン−およびチアゾール−スルホンアミド - Google Patents

抗腫瘍薬としてのチオペン−およびチアゾール−スルホンアミド Download PDF

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Publication number
JP4464681B2
JP4464681B2 JP2003538145A JP2003538145A JP4464681B2 JP 4464681 B2 JP4464681 B2 JP 4464681B2 JP 2003538145 A JP2003538145 A JP 2003538145A JP 2003538145 A JP2003538145 A JP 2003538145A JP 4464681 B2 JP4464681 B2 JP 4464681B2
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Japan
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mmol
solution
alkyl
added
sulfonamide
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JP2003538145A
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JP2005511547A (ja
JP2005511547A5 (enExample
Inventor
アルフォンソ・デ・ディオス
コーラ・スー・グロスマン
フィリップ・アーサー・ヒップスカインド
ホ−シェン・リン
カレン・リン・ロブ
ベアトリス・ロペス・デ・ウラルデ・ガルメンディア
ホセ・エドゥアルド・ロペス
メアリー・マーガレット・メイダー
マイケル・エンリコ・リチェット
チュアン・シー
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イーライ リリー アンド カンパニー
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Publication of JP2005511547A5 publication Critical patent/JP2005511547A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2003538145A 2001-10-25 2002-10-15 抗腫瘍薬としてのチオペン−およびチアゾール−スルホンアミド Expired - Fee Related JP4464681B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35201201P 2001-10-25 2001-10-25
PCT/US2002/031568 WO2003035629A1 (en) 2001-10-25 2002-10-15 Thiopene- amd thiazolesulfonamides as antineoplastic agents

Publications (3)

Publication Number Publication Date
JP2005511547A JP2005511547A (ja) 2005-04-28
JP2005511547A5 JP2005511547A5 (enExample) 2006-01-05
JP4464681B2 true JP4464681B2 (ja) 2010-05-19

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JP2003538145A Expired - Fee Related JP4464681B2 (ja) 2001-10-25 2002-10-15 抗腫瘍薬としてのチオペン−およびチアゾール−スルホンアミド

Country Status (33)

Country Link
US (2) US7084170B2 (enExample)
EP (1) EP1442030B1 (enExample)
JP (1) JP4464681B2 (enExample)
KR (1) KR100913471B1 (enExample)
CN (1) CN1298709C (enExample)
AR (1) AR037248A1 (enExample)
AT (1) ATE338033T1 (enExample)
AU (1) AU2002334817B2 (enExample)
BR (1) BR0212386A (enExample)
CA (1) CA2463300C (enExample)
CY (1) CY1106247T1 (enExample)
DE (1) DE60214413T2 (enExample)
DK (1) DK1442030T3 (enExample)
EA (1) EA006081B1 (enExample)
EC (1) ECSP045078A (enExample)
EG (1) EG26021A (enExample)
ES (1) ES2269816T3 (enExample)
HR (1) HRP20040371B1 (enExample)
HU (1) HUP0401638A3 (enExample)
IL (2) IL160851A0 (enExample)
MX (1) MXPA04003886A (enExample)
MY (1) MY130718A (enExample)
NO (1) NO20041316L (enExample)
NZ (1) NZ531136A (enExample)
PE (1) PE20030574A1 (enExample)
PL (1) PL208083B1 (enExample)
PT (1) PT1442030E (enExample)
SI (1) SI1442030T1 (enExample)
SV (1) SV2004001367A (enExample)
TW (1) TWI281916B (enExample)
UA (1) UA75716C2 (enExample)
WO (1) WO2003035629A1 (enExample)
ZA (1) ZA200403089B (enExample)

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PT1401825E (pt) * 2001-06-11 2009-10-23 Virochem Pharma Inc Compostos e métodos para o tratamento ou para a prevenção de infecções com flavivírus
SE0102616D0 (sv) * 2001-07-25 2001-07-25 Astrazeneca Ab Novel compounds
US7375131B2 (en) * 2002-06-06 2008-05-20 Smithklinebeecham Corp. NF-κB inhibitors
CN100413861C (zh) 2002-12-10 2008-08-27 维勒凯姆制药股份有限公司 用于治疗或预防黄病毒感染的化合物
SE0300092D0 (sv) * 2003-01-15 2003-01-15 Astrazeneca Ab Novel compounds
SE0300091D0 (sv) * 2003-01-15 2003-01-15 Astrazeneca Ab Novel compounds
US20050085531A1 (en) * 2003-10-03 2005-04-21 Hodge Carl N. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
JP5134247B2 (ja) * 2004-09-13 2013-01-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホンアミド含有化合物の血管新生阻害物質との併用
US8772269B2 (en) 2004-09-13 2014-07-08 Eisai R&D Management Co., Ltd. Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
WO2006030947A1 (ja) * 2004-09-13 2006-03-23 Eisai R & D Management Co., Ltd. スルホンアミド含有化合物の血管新生阻害物質との併用
WO2006090921A1 (ja) * 2005-02-28 2006-08-31 Eisai R & D Management Co., Ltd. スルホンアミド化合物のリンパ球活性化抑制作用
KR20070114774A (ko) * 2005-02-28 2007-12-04 에자이 알앤드디 매니지먼트 가부시키가이샤 술폰아미드 화합물의 혈관 신생 저해 물질과의 신규 병용
DE602006021401D1 (de) 2005-02-28 2011-06-01 Eisai R&D Man Co Ltd Neue kombinierte anwendung einer sulfonamid-verbindung zur behandlung von krebs
NZ563909A (en) 2005-05-13 2011-10-28 Virochem Pharma Inc Thiophene derivatives and their use for the treatment or prevention of flavivirus infections
US7208506B2 (en) 2005-07-07 2007-04-24 Hoffmann-La Roche Inc. Heteroarylethenyl derivatives, their manufacture and use as pharmaceutical agents
US7625896B2 (en) * 2005-11-25 2009-12-01 Hoffman-La Roche Inc. Pyridylsulfonamide derivatives
JPWO2007123274A1 (ja) 2006-04-20 2009-09-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホンアミド化合物の新規感受性マーカー
US7939532B2 (en) * 2006-10-26 2011-05-10 Hoffmann-La Roche Inc. Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents
CA2670260A1 (en) 2006-11-15 2008-05-22 Virochem Pharma Inc. Thiophene analogues for the treatment or prevention of flavivirus infections
US7879884B2 (en) 2007-05-16 2011-02-01 Hoffmann-La Roche Inc. Aryl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents
CN101899008B (zh) * 2010-05-20 2012-10-17 中国人民解放军第二军医大学 N-取代嘧啶磺酰基-取代苯甲酰胺类化合物及其制备药物的用途
CN103450149B (zh) * 2012-06-01 2015-10-14 中国科学院上海有机化学研究所 苯基噻吩磺酰胺类化合物及其制备方法和用途
JP6364967B2 (ja) * 2014-05-30 2018-08-01 東ソー株式会社 ジチエノベンゾジチオフェンの製造方法
CN106588868A (zh) * 2016-11-16 2017-04-26 武汉理工大学 一种2‑溴‑3‑噻吩甲酸中间体的合成方法
CN108558822B (zh) * 2018-06-01 2020-12-18 盐城锦明药业有限公司 N-((5-溴噻吩-2-基)磺酰基)-2,4-二氯苯甲酰胺的合成方法
CN110835345A (zh) * 2018-08-17 2020-02-25 中国科学院上海药物研究所 一类细胞周期依赖性激酶的降解剂、其制备方法、药物组合物及其用途
CN109265437A (zh) * 2018-10-19 2019-01-25 凯莱英医药集团（天津）股份有限公司 一种3-羟基噻吩-2-羧酸酯类化合物的制备方法
WO2024251876A1 (en) * 2023-06-07 2024-12-12 KRæFTENS BEKæMPELSE PROTACs AND HyT-PD MOLECULES FOR TARGETED PROTEIN DEGRADATION OF DCAF15 AND THEIR USE IN THE TREATMENT OF AMYLOIDOSIS
WO2025031360A1 (zh) * 2023-08-09 2025-02-13 上海科技大学 磺酰胺类化合物及其用途

Family Cites Families (7)

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ZA813332B (en) * 1980-06-21 1982-05-26 Pfizer Larvicides and isecticides
ZA915371B (en) * 1990-07-17 1993-03-31 Lilly Co Eli Antitumor compositions and methods of treatment
US5177074A (en) * 1991-03-26 1993-01-05 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
US5169860A (en) * 1992-03-13 1992-12-08 Eli Lilly And Company Antitumor compositions and methods of treatment
AU737038B2 (en) * 1996-07-05 2001-08-09 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Anti-viral pharmaceutical compositions containing saturated 1,2-dithiaheterocyclic compounds and uses thereof
CA2267998A1 (en) * 1996-10-04 1998-04-09 Eli Lilly And Company Antitumor compositions and methods of treatment
JP4316787B2 (ja) 2000-01-11 2009-08-19 壽製薬株式会社 エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、

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Publication number Publication date
US20060223871A1 (en) 2006-10-05
ES2269816T3 (es) 2007-04-01
HUP0401638A3 (en) 2012-09-28
ATE338033T1 (de) 2006-09-15
CN1575286A (zh) 2005-02-02
DK1442030T3 (da) 2006-12-27
PT1442030E (pt) 2006-12-29
NO20041316L (no) 2004-03-30
EA006081B1 (ru) 2005-08-25
EA200400582A1 (ru) 2004-08-26
ZA200403089B (en) 2005-04-22
CY1106247T1 (el) 2011-06-08
CA2463300A1 (en) 2003-05-01
MXPA04003886A (es) 2004-07-08
MY130718A (en) 2007-07-31
PL368234A1 (en) 2005-03-21
EG26021A (en) 2012-12-10
PL208083B1 (pl) 2011-03-31
SI1442030T1 (sl) 2006-12-31
WO2003035629A1 (en) 2003-05-01
CA2463300C (en) 2011-07-19
EP1442030A1 (en) 2004-08-04
CN1298709C (zh) 2007-02-07
SV2004001367A (es) 2004-02-24
EP1442030B1 (en) 2006-08-30
US7084170B2 (en) 2006-08-01
US7250430B2 (en) 2007-07-31
HUP0401638A2 (hu) 2004-11-29
US20040198784A1 (en) 2004-10-07
BR0212386A (pt) 2004-07-27
HRP20040371A2 (en) 2004-08-31
KR100913471B1 (ko) 2009-08-25
HRP20040371B1 (en) 2012-07-31
DE60214413D1 (de) 2006-10-12
KR20040062583A (ko) 2004-07-07
JP2005511547A (ja) 2005-04-28
IL160851A0 (en) 2004-08-31
PE20030574A1 (es) 2003-07-03
TWI281916B (en) 2007-06-01
ECSP045078A (es) 2004-06-28
DE60214413T2 (de) 2007-03-08
AU2002334817B2 (en) 2008-02-21
UA75716C2 (en) 2006-05-15
AR037248A1 (es) 2004-11-03
IL160851A (en) 2009-11-18
HK1068337A1 (en) 2005-04-29
NZ531136A (en) 2006-08-31

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