AU2002334817B2 - Thiopene- and Thiazolesulfonamides as Antineoplastic Agents - Google Patents
Thiopene- and Thiazolesulfonamides as Antineoplastic Agents Download PDFInfo
- Publication number
- AU2002334817B2 AU2002334817B2 AU2002334817A AU2002334817A AU2002334817B2 AU 2002334817 B2 AU2002334817 B2 AU 2002334817B2 AU 2002334817 A AU2002334817 A AU 2002334817A AU 2002334817 A AU2002334817 A AU 2002334817A AU 2002334817 B2 AU2002334817 B2 AU 2002334817B2
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- halo
- compound
- sulfonamide
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35201201P | 2001-10-25 | 2001-10-25 | |
| US60/352,012 | 2001-10-25 | ||
| PCT/US2002/031568 WO2003035629A1 (en) | 2001-10-25 | 2002-10-15 | Thiopene- amd thiazolesulfonamides as antineoplastic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2002334817A1 AU2002334817A1 (en) | 2003-07-03 |
| AU2002334817B2 true AU2002334817B2 (en) | 2008-02-21 |
Family
ID=23383421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002334817A Ceased AU2002334817B2 (en) | 2001-10-25 | 2002-10-15 | Thiopene- and Thiazolesulfonamides as Antineoplastic Agents |
Country Status (33)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2363396A1 (en) * | 2001-06-11 | 2011-09-07 | Virochem Pharma Inc. | Thiophene derivatives as antiviral agents for flavivirus infection |
| SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| US7375131B2 (en) * | 2002-06-06 | 2008-05-20 | Smithklinebeecham Corp. | NF-κB inhibitors |
| DE60332482D1 (de) | 2002-12-10 | 2010-06-17 | Virochem Pharma Inc | Verbindungen und methoden zum behandeln oder vorbeugen von flavivirus infektionen |
| SE0300091D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
| SE0300092D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
| US20050085531A1 (en) * | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
| JP5134247B2 (ja) * | 2004-09-13 | 2013-01-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド含有化合物の血管新生阻害物質との併用 |
| US8772269B2 (en) | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
| WO2006030941A1 (ja) * | 2004-09-13 | 2006-03-23 | Eisai R & D Management Co., Ltd. | スルホンアミド含有化合物の血管新生阻害物質との併用 |
| KR20070114774A (ko) * | 2005-02-28 | 2007-12-04 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 술폰아미드 화합물의 혈관 신생 저해 물질과의 신규 병용 |
| PL1859793T3 (pl) | 2005-02-28 | 2011-09-30 | Eisai R&D Man Co Ltd | Nowe połączone zastosowanie związku sulfonamidowego w leczeniu choroby nowotworowej |
| WO2006090927A1 (ja) * | 2005-02-28 | 2006-08-31 | Eisai R & D Management Co., Ltd. | スルホンアミド化合物の摂食亢進作用 |
| JP5030947B2 (ja) * | 2005-05-13 | 2012-09-19 | ヴァイロケム・ファーマ・インコーポレーテッド | フラビウイルス感染の治療及び予防のための化合物及び方法 |
| US7208506B2 (en) | 2005-07-07 | 2007-04-24 | Hoffmann-La Roche Inc. | Heteroarylethenyl derivatives, their manufacture and use as pharmaceutical agents |
| US7625896B2 (en) * | 2005-11-25 | 2009-12-01 | Hoffman-La Roche Inc. | Pyridylsulfonamide derivatives |
| EP2015070A4 (en) | 2006-04-20 | 2010-04-21 | Eisai R&D Man Co Ltd | Novel marker for sensitivity against sulfonamide compound |
| US7939532B2 (en) | 2006-10-26 | 2011-05-10 | Hoffmann-La Roche Inc. | Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents |
| SG176488A1 (en) * | 2006-11-15 | 2011-12-29 | Virochem Pharma Inc | Thiophene analogues for the treatment or prevention of flavivirus infections |
| WO2008138594A1 (en) | 2007-05-16 | 2008-11-20 | F. Hoffmann-La Roche Ag | Aryl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents |
| CN101899008B (zh) * | 2010-05-20 | 2012-10-17 | 中国人民解放军第二军医大学 | N-取代嘧啶磺酰基-取代苯甲酰胺类化合物及其制备药物的用途 |
| CN103450149B (zh) * | 2012-06-01 | 2015-10-14 | 中国科学院上海有机化学研究所 | 苯基噻吩磺酰胺类化合物及其制备方法和用途 |
| JP6364967B2 (ja) * | 2014-05-30 | 2018-08-01 | 東ソー株式会社 | ジチエノベンゾジチオフェンの製造方法 |
| CN106588868A (zh) * | 2016-11-16 | 2017-04-26 | 武汉理工大学 | 一种2‑溴‑3‑噻吩甲酸中间体的合成方法 |
| CN108558822B (zh) * | 2018-06-01 | 2020-12-18 | 盐城锦明药业有限公司 | N-((5-溴噻吩-2-基)磺酰基)-2,4-二氯苯甲酰胺的合成方法 |
| CN110835345A (zh) * | 2018-08-17 | 2020-02-25 | 中国科学院上海药物研究所 | 一类细胞周期依赖性激酶的降解剂、其制备方法、药物组合物及其用途 |
| CN109265437A (zh) * | 2018-10-19 | 2019-01-25 | 凯莱英医药集团（天津）股份有限公司 | 一种3-羟基噻吩-2-羧酸酯类化合物的制备方法 |
| EP4724106A1 (en) * | 2023-06-07 | 2026-04-15 | Kræftens bekæmpelse | Protacs and hyt-pd molecules for targeted protein degradation of dcaf15 and their use in the treatment of amyloidosis |
| WO2025031361A1 (zh) * | 2023-08-09 | 2025-02-13 | 上海科技大学 | 磺酰胺类化合物作为制备治疗癌症药物的用途 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0042731A1 (en) * | 1980-06-21 | 1981-12-30 | Pfizer Limited | Larvicides, insecticides, acaricides and miticides, processes for preparing them and compositions containing them |
| EP0513979A1 (en) * | 1991-03-26 | 1992-11-19 | Merck & Co. Inc. | Angiotensin II antagonists incorporating a substituted thiophene or furan |
| EP0560554A2 (en) * | 1992-03-13 | 1993-09-15 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
| US5302724A (en) * | 1990-07-17 | 1994-04-12 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
| WO1998014440A1 (en) * | 1996-10-04 | 1998-04-09 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE310738T1 (de) * | 1996-07-05 | 2005-12-15 | Us Gov Health & Human Serv | Gesättigte 1,2-dithiaheterocyclische verbindungen enthaltende antivirale pharmazeutische zubereitungen |
| JP4316787B2 (ja) | 2000-01-11 | 2009-08-19 | 壽製薬株式会社 | エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、 |
-
2002
- 2002-10-11 TW TW091123452A patent/TWI281916B/zh not_active IP Right Cessation
- 2002-10-15 DK DK02802117T patent/DK1442030T3/da active
- 2002-10-15 DE DE60214413T patent/DE60214413T2/de not_active Expired - Lifetime
- 2002-10-15 EP EP02802117A patent/EP1442030B1/en not_active Expired - Lifetime
- 2002-10-15 NZ NZ531136A patent/NZ531136A/en not_active IP Right Cessation
- 2002-10-15 PL PL368234A patent/PL208083B1/pl not_active IP Right Cessation
- 2002-10-15 CA CA2463300A patent/CA2463300C/en not_active Expired - Fee Related
- 2002-10-15 US US10/490,935 patent/US7084170B2/en not_active Expired - Fee Related
- 2002-10-15 IL IL16085102A patent/IL160851A0/xx unknown
- 2002-10-15 AU AU2002334817A patent/AU2002334817B2/en not_active Ceased
- 2002-10-15 CN CNB028212150A patent/CN1298709C/zh not_active Expired - Fee Related
- 2002-10-15 WO PCT/US2002/031568 patent/WO2003035629A1/en not_active Ceased
- 2002-10-15 ES ES02802117T patent/ES2269816T3/es not_active Expired - Lifetime
- 2002-10-15 HR HRP20040371AA patent/HRP20040371B1/xx not_active IP Right Cessation
- 2002-10-15 SI SI200230399T patent/SI1442030T1/sl unknown
- 2002-10-15 KR KR1020047006058A patent/KR100913471B1/ko not_active Expired - Fee Related
- 2002-10-15 HU HU0401638A patent/HUP0401638A3/hu unknown
- 2002-10-15 EA EA200400582A patent/EA006081B1/ru not_active IP Right Cessation
- 2002-10-15 UA UA20040403046A patent/UA75716C2/uk unknown
- 2002-10-15 AT AT02802117T patent/ATE338033T1/de active
- 2002-10-15 BR BR0212386-0A patent/BR0212386A/pt not_active IP Right Cessation
- 2002-10-15 MX MXPA04003886A patent/MXPA04003886A/es active IP Right Grant
- 2002-10-15 JP JP2003538145A patent/JP4464681B2/ja not_active Expired - Fee Related
- 2002-10-15 PT PT02802117T patent/PT1442030E/pt unknown
- 2002-10-21 EG EG2002101152A patent/EG26021A/en active
- 2002-10-23 MY MYPI20023959A patent/MY130718A/en unknown
- 2002-10-23 AR ARP020104007A patent/AR037248A1/es active IP Right Grant
- 2002-10-24 SV SV2002001367A patent/SV2004001367A/es unknown
- 2002-10-25 PE PE2002001051A patent/PE20030574A1/es not_active Application Discontinuation
-
2004
- 2004-03-11 IL IL160851A patent/IL160851A/en not_active IP Right Cessation
- 2004-03-30 NO NO20041316A patent/NO20041316L/no not_active Application Discontinuation
- 2004-04-22 ZA ZA200403089A patent/ZA200403089B/en unknown
- 2004-04-23 EC EC2004005078A patent/ECSP045078A/es unknown
-
2006
- 2006-06-06 US US11/447,457 patent/US7250430B2/en not_active Expired - Fee Related
- 2006-11-16 CY CY20061101669T patent/CY1106247T1/el unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0042731A1 (en) * | 1980-06-21 | 1981-12-30 | Pfizer Limited | Larvicides, insecticides, acaricides and miticides, processes for preparing them and compositions containing them |
| US5302724A (en) * | 1990-07-17 | 1994-04-12 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
| EP0513979A1 (en) * | 1991-03-26 | 1992-11-19 | Merck & Co. Inc. | Angiotensin II antagonists incorporating a substituted thiophene or furan |
| EP0560554A2 (en) * | 1992-03-13 | 1993-09-15 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
| WO1998014440A1 (en) * | 1996-10-04 | 1998-04-09 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |