PE20030574A1 - N-[benzoil]heteroarilsulfonamida como agentes antineoplasicos - Google Patents
N-[benzoil]heteroarilsulfonamida como agentes antineoplasicosInfo
- Publication number
- PE20030574A1 PE20030574A1 PE2002001051A PE2002001051A PE20030574A1 PE 20030574 A1 PE20030574 A1 PE 20030574A1 PE 2002001051 A PE2002001051 A PE 2002001051A PE 2002001051 A PE2002001051 A PE 2002001051A PE 20030574 A1 PE20030574 A1 PE 20030574A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- halo
- heteroarylsulfonamide
- benzoil
- antineoplastic agents
- Prior art date
Links
- 229940034982 antineoplastic agent Drugs 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- YTHIAEMLCRISON-UHFFFAOYSA-N 4-chloro-n-(5-chlorothiophen-2-yl)sulfonyl-2-methylbenzamide Chemical compound CC1=CC(Cl)=CC=C1C(=O)NS(=O)(=O)C1=CC=C(Cl)S1 YTHIAEMLCRISON-UHFFFAOYSA-N 0.000 abstract 1
- 206010003571 Astrocytoma Diseases 0.000 abstract 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 abstract 1
- 201000009030 Carcinoma Diseases 0.000 abstract 1
- 201000010915 Glioblastoma multiforme Diseases 0.000 abstract 1
- 208000007641 Pinealoma Diseases 0.000 abstract 1
- 208000005017 glioblastoma Diseases 0.000 abstract 1
- WWONFUQGBVOKOF-UHFFFAOYSA-N n-(5-bromothiophen-2-yl)sulfonyl-2,4-dichlorobenzamide Chemical compound ClC1=CC(Cl)=CC=C1C(=O)NS(=O)(=O)C1=CC=C(Br)S1 WWONFUQGBVOKOF-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35201201P | 2001-10-25 | 2001-10-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030574A1 true PE20030574A1 (es) | 2003-07-03 |
Family
ID=23383421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002001051A PE20030574A1 (es) | 2001-10-25 | 2002-10-25 | N-[benzoil]heteroarilsulfonamida como agentes antineoplasicos |
Country Status (33)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002344854B2 (en) * | 2001-06-11 | 2008-11-06 | Vertex Pharmaceuticals (Canada) Incorporated | Thiophene derivatives as antiviral agents for flavivirus infection |
| SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| WO2003104218A1 (en) * | 2002-06-06 | 2003-12-18 | Smithkline Beecham Corporation | Nf-:b inhibitors |
| CN100413861C (zh) | 2002-12-10 | 2008-08-27 | 维勒凯姆制药股份有限公司 | 用于治疗或预防黄病毒感染的化合物 |
| SE0300091D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
| SE0300092D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
| US20050085531A1 (en) * | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
| EP1797877A4 (en) * | 2004-09-13 | 2010-12-15 | Eisai Co Ltd | JOINT USE OF A SULFONAMIDE-BASED COMPOUND AND AN ANGIOGENESIS INHIBITOR |
| JP5134247B2 (ja) * | 2004-09-13 | 2013-01-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド含有化合物の血管新生阻害物質との併用 |
| US8772269B2 (en) | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
| JPWO2006090930A1 (ja) * | 2005-02-28 | 2008-07-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド化合物の新規併用 |
| WO2006090928A1 (ja) * | 2005-02-28 | 2006-08-31 | Eisai R & D Management Co., Ltd. | スルホンアミド化合物の血管新生阻害物質との新規併用 |
| WO2006090927A1 (ja) * | 2005-02-28 | 2006-08-31 | Eisai R & D Management Co., Ltd. | スルホンアミド化合物の摂食亢進作用 |
| CN101218224B (zh) * | 2005-05-13 | 2013-05-08 | Viro化学制药公司 | 治疗或预防黄病毒感染的组合物和方法 |
| US7208506B2 (en) | 2005-07-07 | 2007-04-24 | Hoffmann-La Roche Inc. | Heteroarylethenyl derivatives, their manufacture and use as pharmaceutical agents |
| US7625896B2 (en) * | 2005-11-25 | 2009-12-01 | Hoffman-La Roche Inc. | Pyridylsulfonamide derivatives |
| JPWO2007123274A1 (ja) | 2006-04-20 | 2009-09-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド化合物の新規感受性マーカー |
| US7939532B2 (en) | 2006-10-26 | 2011-05-10 | Hoffmann-La Roche Inc. | Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents |
| PT2104674E (pt) | 2006-11-15 | 2013-07-26 | Virochem Pharma Inc | Análogos de tiofeno para o tratamento ou prevenção de infeções por flavivírus |
| EP2148861A1 (en) | 2007-05-16 | 2010-02-03 | F. Hoffmann-Roche AG | Aryl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents |
| CN101899008B (zh) * | 2010-05-20 | 2012-10-17 | 中国人民解放军第二军医大学 | N-取代嘧啶磺酰基-取代苯甲酰胺类化合物及其制备药物的用途 |
| CN103450149B (zh) * | 2012-06-01 | 2015-10-14 | 中国科学院上海有机化学研究所 | 苯基噻吩磺酰胺类化合物及其制备方法和用途 |
| JP6364967B2 (ja) * | 2014-05-30 | 2018-08-01 | 東ソー株式会社 | ジチエノベンゾジチオフェンの製造方法 |
| CN106588868A (zh) * | 2016-11-16 | 2017-04-26 | 武汉理工大学 | 一种2‑溴‑3‑噻吩甲酸中间体的合成方法 |
| CN108558822B (zh) * | 2018-06-01 | 2020-12-18 | 盐城锦明药业有限公司 | N-((5-溴噻吩-2-基)磺酰基)-2,4-二氯苯甲酰胺的合成方法 |
| CN110835345A (zh) * | 2018-08-17 | 2020-02-25 | 中国科学院上海药物研究所 | 一类细胞周期依赖性激酶的降解剂、其制备方法、药物组合物及其用途 |
| CN109265437A (zh) * | 2018-10-19 | 2019-01-25 | 凯莱英医药集团（天津）股份有限公司 | 一种3-羟基噻吩-2-羧酸酯类化合物的制备方法 |
| WO2024251876A1 (en) * | 2023-06-07 | 2024-12-12 | KRæFTENS BEKæMPELSE | PROTACs AND HyT-PD MOLECULES FOR TARGETED PROTEIN DEGRADATION OF DCAF15 AND THEIR USE IN THE TREATMENT OF AMYLOIDOSIS |
| WO2025031360A1 (zh) * | 2023-08-09 | 2025-02-13 | 上海科技大学 | 磺酰胺类化合物及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA813332B (en) * | 1980-06-21 | 1982-05-26 | Pfizer | Larvicides and isecticides |
| ZA915371B (en) * | 1990-07-17 | 1993-03-31 | Lilly Co Eli | Antitumor compositions and methods of treatment |
| US5177074A (en) * | 1991-03-26 | 1993-01-05 | Merck & Co., Inc. | Angiotensin ii antagonists incorporating a substituted thiophene or furan |
| US5169860A (en) * | 1992-03-13 | 1992-12-08 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
| US6046228A (en) * | 1996-07-05 | 2000-04-04 | The United States Of America As Represented By The Department Of Health And Human Services | Anti-viral pharmaceutical compositions containing saturated 1,2-dithiaheterocyclic compounds and uses thereof |
| AU4799797A (en) * | 1996-10-04 | 1998-04-24 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
| JP4316787B2 (ja) | 2000-01-11 | 2009-08-19 | 壽製薬株式会社 | エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、 |
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2002
- 2002-10-11 TW TW091123452A patent/TWI281916B/zh not_active IP Right Cessation
- 2002-10-15 CA CA2463300A patent/CA2463300C/en not_active Expired - Fee Related
- 2002-10-15 UA UA20040403046A patent/UA75716C2/uk unknown
- 2002-10-15 CN CNB028212150A patent/CN1298709C/zh not_active Expired - Fee Related
- 2002-10-15 SI SI200230399T patent/SI1442030T1/sl unknown
- 2002-10-15 AT AT02802117T patent/ATE338033T1/de active
- 2002-10-15 EP EP02802117A patent/EP1442030B1/en not_active Expired - Lifetime
- 2002-10-15 MX MXPA04003886A patent/MXPA04003886A/es active IP Right Grant
- 2002-10-15 NZ NZ531136A patent/NZ531136A/en not_active IP Right Cessation
- 2002-10-15 DE DE60214413T patent/DE60214413T2/de not_active Expired - Lifetime
- 2002-10-15 US US10/490,935 patent/US7084170B2/en not_active Expired - Fee Related
- 2002-10-15 EA EA200400582A patent/EA006081B1/ru not_active IP Right Cessation
- 2002-10-15 HR HRP20040371AA patent/HRP20040371B1/xx not_active IP Right Cessation
- 2002-10-15 WO PCT/US2002/031568 patent/WO2003035629A1/en not_active Ceased
- 2002-10-15 AU AU2002334817A patent/AU2002334817B2/en not_active Ceased
- 2002-10-15 DK DK02802117T patent/DK1442030T3/da active
- 2002-10-15 HU HU0401638A patent/HUP0401638A3/hu unknown
- 2002-10-15 ES ES02802117T patent/ES2269816T3/es not_active Expired - Lifetime
- 2002-10-15 PL PL368234A patent/PL208083B1/pl not_active IP Right Cessation
- 2002-10-15 PT PT02802117T patent/PT1442030E/pt unknown
- 2002-10-15 KR KR1020047006058A patent/KR100913471B1/ko not_active Expired - Fee Related
- 2002-10-15 IL IL16085102A patent/IL160851A0/xx unknown
- 2002-10-15 JP JP2003538145A patent/JP4464681B2/ja not_active Expired - Fee Related
- 2002-10-15 BR BR0212386-0A patent/BR0212386A/pt not_active IP Right Cessation
- 2002-10-21 EG EG2002101152A patent/EG26021A/en active
- 2002-10-23 MY MYPI20023959A patent/MY130718A/en unknown
- 2002-10-23 AR ARP020104007A patent/AR037248A1/es active IP Right Grant
- 2002-10-24 SV SV2002001367A patent/SV2004001367A/es unknown
- 2002-10-25 PE PE2002001051A patent/PE20030574A1/es not_active Application Discontinuation
-
2004
- 2004-03-11 IL IL160851A patent/IL160851A/en not_active IP Right Cessation
- 2004-03-30 NO NO20041316A patent/NO20041316L/no not_active Application Discontinuation
- 2004-04-22 ZA ZA200403089A patent/ZA200403089B/en unknown
- 2004-04-23 EC EC2004005078A patent/ECSP045078A/es unknown
-
2006
- 2006-06-06 US US11/447,457 patent/US7250430B2/en not_active Expired - Fee Related
- 2006-11-16 CY CY20061101669T patent/CY1106247T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |