JP4444493B2 - カプサイシン受容体およびカプサイシン受容体関連ポリペプチドをコードする核酸配列ならびにその使用 - Google Patents
カプサイシン受容体およびカプサイシン受容体関連ポリペプチドをコードする核酸配列ならびにその使用 Download PDFInfo
- Publication number
- JP4444493B2 JP4444493B2 JP2000509807A JP2000509807A JP4444493B2 JP 4444493 B2 JP4444493 B2 JP 4444493B2 JP 2000509807 A JP2000509807 A JP 2000509807A JP 2000509807 A JP2000509807 A JP 2000509807A JP 4444493 B2 JP4444493 B2 JP 4444493B2
- Authority
- JP
- Japan
- Prior art keywords
- capsaicin receptor
- capsaicin
- polypeptide
- receptor
- vanilloid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91546197A | 1997-08-20 | 1997-08-20 | |
| US08/915,461 | 1997-08-20 | ||
| US7215198P | 1998-01-22 | 1998-01-22 | |
| US60/072,151 | 1998-01-22 | ||
| PCT/US1998/017466 WO1999009140A1 (en) | 1997-08-20 | 1998-08-20 | Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001514879A JP2001514879A (ja) | 2001-09-18 |
| JP2001514879A5 JP2001514879A5 (https=) | 2006-02-16 |
| JP4444493B2 true JP4444493B2 (ja) | 2010-03-31 |
Family
ID=26753050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000509807A Expired - Lifetime JP4444493B2 (ja) | 1997-08-20 | 1998-08-20 | カプサイシン受容体およびカプサイシン受容体関連ポリペプチドをコードする核酸配列ならびにその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6335180B1 (https=) |
| EP (1) | EP1009804B1 (https=) |
| JP (1) | JP4444493B2 (https=) |
| AT (1) | ATE253111T1 (https=) |
| AU (1) | AU742391B2 (https=) |
| CA (1) | CA2298540A1 (https=) |
| DE (1) | DE69819345T2 (https=) |
| WO (1) | WO1999009140A1 (https=) |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6444440B1 (en) | 1997-03-07 | 2002-09-03 | Human Genome Sciences, Inc. | Vanilloid receptor-2 |
| AU742391B2 (en) | 1997-08-20 | 2002-01-03 | Regents Of The University Of California, The | Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof |
| CA2309903C (en) * | 1998-01-22 | 2012-03-27 | The Regents Of The University Of California | Nucleic acid sequences encoding capsaicin receptor |
| EP1066381A1 (en) * | 1998-01-27 | 2001-01-10 | Smithkline Beecham Plc | Human vanilloid receptor homologues |
| EP0943683A1 (en) * | 1998-03-10 | 1999-09-22 | Smithkline Beecham Plc | Human vanilloid receptor homologue Vanilrep1 |
| EP0953638A1 (en) * | 1998-03-11 | 1999-11-03 | Synthelabo | Human vanilloid receptor-like cation channel |
| US6906178B2 (en) | 1998-08-11 | 2005-06-14 | Human Genome Sciences, Inc. | Vanilloid receptor-2 |
| AU2148000A (en) * | 1998-11-13 | 2000-06-05 | Millennium Pharmaceuticals, Inc. | Novel members of the capsaicin/vanilloid receptor family of proteins and uses thereof |
| US7063951B1 (en) | 1998-11-13 | 2006-06-20 | Millennium Pharmaceuticals, Inc. | Members of the capsaicin/vanilloid receptor family of proteins and uses thereof |
| GB9826359D0 (en) * | 1998-12-01 | 1999-01-27 | Glaxo Group Ltd | Novel receptors |
| GB9827016D0 (en) | 1998-12-08 | 1999-02-03 | Merck Sharp & Dohme | Receptor protein |
| GB9907097D0 (en) | 1999-03-26 | 1999-05-19 | Novartis Ag | Organic compounds |
| AU4237400A (en) * | 1999-04-15 | 2000-11-02 | Ortho-Mcneil Pharmaceutical, Inc. | Dna encoding the human vanilloid receptor vr1 |
| US6421613B1 (en) * | 1999-07-09 | 2002-07-16 | Pioneer Hi-Bred International, Inc. | Data processing of the maize prolifera genetic sequence |
| US6482611B1 (en) | 1999-09-23 | 2002-11-19 | Neurogen Corporation | Human capsaicin receptor and uses thereof |
| US6455278B1 (en) * | 2000-02-08 | 2002-09-24 | Ortho-Mcneil Pharmaceutical, Inc. | DNA encoding human vanilloid receptor VR3 |
| AU2001234150A1 (en) * | 2000-02-25 | 2001-09-03 | Daiichi Pharmaceutical Co., Ltd. | Novel protein and gene encoding the same |
| DE10043674A1 (de) * | 2000-09-02 | 2002-03-21 | Gruenenthal Gmbh | Antisense Oligonukleotide |
| NZ524894A (en) * | 2000-09-02 | 2005-03-24 | Gruenenthal Chemie | Antisense oligonucleotides against VR1 |
| US7112685B2 (en) | 2000-10-10 | 2006-09-26 | Ortho-Mcneil Pharmaceutical, Inc. | Labeled resiniferatoxin derivatives |
| JP2004511803A (ja) | 2000-10-16 | 2004-04-15 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | バニロイド受容体についての改良リガンド結合アッセイ |
| CA2436941A1 (en) * | 2000-12-01 | 2002-06-06 | Bristol-Myers Squibb Company | Novel human nucleic acid molecules and polypeptides encoding a novel human ion channel expressed in spinal cord and brain |
| US20030171275A1 (en) * | 2000-12-20 | 2003-09-11 | Baughn Mariah R. | Transporters and ion channels |
| GB0128161D0 (en) * | 2001-11-23 | 2002-01-16 | Merck Sharp & Dohme | Receptor protein |
| WO2003066595A2 (en) | 2002-02-01 | 2003-08-14 | Euro-Celtique S.A. | 2 - piperazine - pyridines useful for treating pain |
| CA2517027A1 (en) | 2002-02-25 | 2003-09-04 | Vaxiion Therapeutics, Inc. | Minicell compositions and methods |
| US6974818B2 (en) | 2002-03-01 | 2005-12-13 | Euro-Celtique S.A. | 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain |
| WO2003087158A2 (en) * | 2002-04-16 | 2003-10-23 | Bayer Healthcare Ag | Regulation of human transient receptor potential channel |
| US7883846B2 (en) * | 2002-05-31 | 2011-02-08 | Sloan-Kettering Institute For Cancer Research | Heterologous stimulus-gated ion channels and methods of using same |
| BR0313255A (pt) | 2002-08-08 | 2005-07-12 | Amgen Inc | Composto, composição farmacêutica, uso de um composto e métodos de fabricar um medicamento e de preparar um composto |
| AU2003259846A1 (en) * | 2002-08-16 | 2004-03-03 | The General Hospital Corporation | Non-invasive functional imaging of peripheral nervous system activation in humans and animals |
| US7582635B2 (en) * | 2002-12-24 | 2009-09-01 | Purdue Pharma, L.P. | Therapeutic agents useful for treating pain |
| EP1615880A4 (en) * | 2003-04-08 | 2007-03-07 | Algorx Pharmaceuticals Inc | PREPARATION AND CLEANING OF SYNTHETIC TRANS CAPSAICIN |
| MY142655A (en) * | 2003-06-12 | 2010-12-15 | Euro Celtique Sa | Therapeutic agents useful for treating pain |
| WO2005006881A2 (en) * | 2003-07-09 | 2005-01-27 | Virginia Commonwealth University | Salt taste modification |
| AU2004259357B2 (en) * | 2003-07-24 | 2010-02-18 | Euro-Celtique S.A. | Piperidine compounds and pharmaceutical compositions containing them |
| SI1867644T1 (sl) * | 2003-07-24 | 2009-10-31 | Euro Celtique Sa | Heteroaril-tetrahidropiperidilne spojine, koristne za zdravljenje ali preprečevanje bolečine |
| EP1867644B1 (en) | 2003-07-24 | 2009-05-20 | Euro-Celtique S.A. | Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain |
| PL1942106T3 (pl) | 2003-08-01 | 2012-02-29 | Euro Celtique Sa | Środki lecznicze użyteczne do leczenia bólu |
| EP1664041B1 (en) | 2003-09-22 | 2008-07-02 | Euro-Celtique S.A. | Phenyl-carboxamide compounds useful for treating pain |
| PL1664016T3 (pl) * | 2003-09-22 | 2009-04-30 | Euro Celtique Sa | Środki terapeutyczne przydatne do leczenia bólu |
| ES2322907T3 (es) * | 2003-12-30 | 2009-07-01 | Euro-Celtique S.A. | Piperazinas utiles para el tratamiento de dolor. |
| US7751805B2 (en) * | 2004-02-20 | 2010-07-06 | Google Inc. | Mobile image-based information retrieval system |
| US20070159522A1 (en) * | 2004-02-20 | 2007-07-12 | Harmut Neven | Image-based contextual advertisement method and branded barcodes |
| US20050266435A1 (en) * | 2004-03-09 | 2005-12-01 | David Hackos | VR1 receptors and uses thereof |
| GB0412769D0 (en) | 2004-06-08 | 2004-07-07 | Novartis Ag | Organic compounds |
| EA200701131A1 (ru) * | 2004-11-24 | 2007-12-28 | Алгоркс Фармасьютикалз, Инк. | Гелеобразная препаративная форма капсаициноида и способы её применения |
| CN101213301B (zh) * | 2005-05-31 | 2013-02-27 | 德福根有限公司 | 用于防治昆虫和蜘蛛类动物的RNAi |
| US8679096B2 (en) | 2007-06-21 | 2014-03-25 | Board Of Regents Of The University Of Nebraska | Multifunctional operational component for robotic devices |
| CA2861159C (en) | 2006-06-22 | 2018-02-27 | Board Of Regents Of The University Of Nebraska | Magnetically coupleable robotic devices and related methods |
| US20080153845A1 (en) * | 2006-10-27 | 2008-06-26 | Redpoint Bio Corporation | Trpv1 antagonists and uses thereof |
| WO2008133973A1 (en) | 2007-04-27 | 2008-11-06 | Purdue Pharma L.P. | Therapeutic agents useful for treating pain |
| DK2142529T3 (da) | 2007-04-27 | 2014-02-10 | Purdue Pharma Lp | Trpv1-antagonister og anvendelser deraf |
| CA2690808C (en) | 2007-07-12 | 2016-09-27 | Board Of Regents Of The University Of Nebraska | Methods and systems of actuation in robotic devices |
| EP2178431A4 (en) | 2007-08-15 | 2017-01-18 | Board of Regents of the University of Nebraska | Medical inflation, attachment, and delivery devices and related methods |
| WO2009114143A1 (en) * | 2008-03-12 | 2009-09-17 | Brown University | Treatment and prophylaxis of epilepsy and febrile seizures |
| US8703962B2 (en) * | 2008-10-24 | 2014-04-22 | Purdue Pharma L.P. | Monocyclic compounds and their use as TRPV1 ligands |
| US8759362B2 (en) * | 2008-10-24 | 2014-06-24 | Purdue Pharma L.P. | Bicycloheteroaryl compounds and their use as TRPV1 ligands |
| US8546388B2 (en) * | 2008-10-24 | 2013-10-01 | Purdue Pharma L.P. | Heterocyclic TRPV1 receptor ligands |
| WO2010124200A2 (en) * | 2009-04-23 | 2010-10-28 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for cancer |
| EP2449112A1 (en) | 2009-07-01 | 2012-05-09 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for severe combined immunodeficiency (scid) |
| EP2460016A2 (en) * | 2009-07-30 | 2012-06-06 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for pharmacokinetics |
| WO2011017518A2 (en) * | 2009-08-05 | 2011-02-10 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for drug metabolism |
| EP2467013A2 (en) * | 2009-08-20 | 2012-06-27 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for pain |
| EP4275634A3 (en) | 2011-06-10 | 2024-01-10 | Board of Regents of the University of Nebraska | Surgical end effector |
| HRP20170507T1 (hr) | 2011-06-22 | 2017-06-02 | Purdue Pharma Lp | Trpv1 antagonisti uključujući dihidroksi supstituente i njihove uporabe |
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| US9394293B2 (en) | 2011-08-10 | 2016-07-19 | Purdue Pharma L.P. | TRPV1 antagonists including dihydroxy substituent and uses thereof |
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| US9498292B2 (en) | 2012-05-01 | 2016-11-22 | Board Of Regents Of The University Of Nebraska | Single site robotic device and related systems and methods |
| JP6228196B2 (ja) | 2012-06-22 | 2017-11-08 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | ローカル制御ロボット手術デバイス |
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| US12295680B2 (en) | 2012-08-08 | 2025-05-13 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems and related methods |
| EP2882331A4 (en) | 2012-08-08 | 2016-03-23 | Univ Nebraska | ROBOTIC SURGICAL DEVICES, SYSTEMS AND CORRESPONDING METHODS |
| CA2905948C (en) | 2013-03-14 | 2022-01-11 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to robotic surgical devices, end effectors, and controllers |
| CA2906672C (en) | 2013-03-14 | 2022-03-15 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to force control surgical systems |
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| JP6479790B2 (ja) | 2013-07-17 | 2019-03-06 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | ロボット外科的デバイス、システムおよび関連する方法 |
| US9427415B2 (en) | 2014-04-01 | 2016-08-30 | The Procter & Gamble Company | Methods and compositions for modifying sensorial perception |
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| CN115337111B (zh) | 2016-11-22 | 2025-04-25 | 内布拉斯加大学董事会 | 改进的粗定位装置及相关系统和方法 |
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| WO2018112199A1 (en) | 2016-12-14 | 2018-06-21 | Virtual Incision Corporation | Releasable attachment device for coupling to medical devices and related systems and methods |
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| CN117140580A (zh) | 2018-01-05 | 2023-12-01 | 内布拉斯加大学董事会 | 具有紧凑型关节设计的单臂机器人装置及相关系统和方法 |
| CN121714364A (zh) | 2019-01-07 | 2026-03-24 | 虚拟切割有限公司 | 机器人辅助手术系统以及相关装置和方法 |
| CN110045108B (zh) * | 2019-05-28 | 2021-10-29 | 江南大学 | 一种基于辣椒碱指标的地沟油酶联免疫检测试剂盒及其检测方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5074977A (en) | 1987-05-05 | 1991-12-24 | The Washington Technology Center | Digital biosensors and method of using same |
| EP0432188B1 (en) | 1988-08-18 | 1996-03-27 | AUSTRALIAN MEMBRANE AND BIOTECHNOLOGY RESEARCH INSTITUTE LTD. Commonwealth Scientific and Industrial Research Organization | Improvements in sensitivity and selectivity of ion channel membrane biosensors |
| CA2045640C (en) | 1989-01-27 | 1999-01-05 | Bruce Andrew Cornell | Receptor membranes and ionophore gating |
| US5491097A (en) | 1989-06-15 | 1996-02-13 | Biocircuits Corporation | Analyte detection with multilayered bioelectronic conductivity sensors |
| US5328847A (en) | 1990-02-20 | 1994-07-12 | Case George D | Thin membrane sensor with biochemical switch |
| US5232684A (en) * | 1990-06-29 | 1993-08-03 | The United States Of America As Represented By The Department Of Health And Human Services | Labelled resiniferatoxin, compositions thereof, and methods for using the same |
| AU742391B2 (en) | 1997-08-20 | 2002-01-03 | Regents Of The University Of California, The | Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof |
| EP1066381A1 (en) | 1998-01-27 | 2001-01-10 | Smithkline Beecham Plc | Human vanilloid receptor homologues |
| EP0943683A1 (en) * | 1998-03-10 | 1999-09-22 | Smithkline Beecham Plc | Human vanilloid receptor homologue Vanilrep1 |
| EP0953638A1 (en) | 1998-03-11 | 1999-11-03 | Synthelabo | Human vanilloid receptor-like cation channel |
| AU2148000A (en) | 1998-11-13 | 2000-06-05 | Millennium Pharmaceuticals, Inc. | Novel members of the capsaicin/vanilloid receptor family of proteins and uses thereof |
| GB9826359D0 (en) * | 1998-12-01 | 1999-01-27 | Glaxo Group Ltd | Novel receptors |
| AU4237400A (en) | 1999-04-15 | 2000-11-02 | Ortho-Mcneil Pharmaceutical, Inc. | Dna encoding the human vanilloid receptor vr1 |
| CA2428827A1 (en) | 1999-11-12 | 2001-05-17 | Abbott Laboratories | Human vanilloid receptor gene |
| AU2001247460A1 (en) | 2000-03-15 | 2001-09-24 | Millennium Pharmaceuticals, Inc. | 18615 and 48003, human ion channels and uses therefor |
| JP3501775B2 (ja) | 2000-05-31 | 2004-03-02 | ファイザー株式会社 | ヒトバニロイド受容体様タンパク質 |
-
1998
- 1998-08-20 AU AU91156/98A patent/AU742391B2/en not_active Expired
- 1998-08-20 CA CA002298540A patent/CA2298540A1/en not_active Abandoned
- 1998-08-20 AT AT98943332T patent/ATE253111T1/de not_active IP Right Cessation
- 1998-08-20 EP EP98943332A patent/EP1009804B1/en not_active Expired - Lifetime
- 1998-08-20 JP JP2000509807A patent/JP4444493B2/ja not_active Expired - Lifetime
- 1998-08-20 WO PCT/US1998/017466 patent/WO1999009140A1/en not_active Ceased
- 1998-08-20 DE DE69819345T patent/DE69819345T2/de not_active Expired - Lifetime
-
1999
- 1999-01-22 US US09/235,451 patent/US6335180B1/en not_active Expired - Lifetime
-
2001
- 2001-10-15 US US09/978,303 patent/US6790629B2/en not_active Expired - Lifetime
-
2004
- 2004-08-09 US US10/915,017 patent/US7097991B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1009804A1 (en) | 2000-06-21 |
| DE69819345D1 (de) | 2003-12-04 |
| DE69819345T2 (de) | 2004-07-15 |
| EP1009804A4 (en) | 2001-05-16 |
| ATE253111T1 (de) | 2003-11-15 |
| US20050095650A1 (en) | 2005-05-05 |
| AU9115698A (en) | 1999-03-08 |
| JP2001514879A (ja) | 2001-09-18 |
| AU742391B2 (en) | 2002-01-03 |
| US7097991B2 (en) | 2006-08-29 |
| EP1009804B1 (en) | 2003-10-29 |
| US20030049728A1 (en) | 2003-03-13 |
| WO1999009140A1 (en) | 1999-02-25 |
| US6335180B1 (en) | 2002-01-01 |
| CA2298540A1 (en) | 1999-02-25 |
| US6790629B2 (en) | 2004-09-14 |
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