CA2298540A1 - Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof - Google Patents
Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof Download PDFInfo
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- CA2298540A1 CA2298540A1 CA002298540A CA2298540A CA2298540A1 CA 2298540 A1 CA2298540 A1 CA 2298540A1 CA 002298540 A CA002298540 A CA 002298540A CA 2298540 A CA2298540 A CA 2298540A CA 2298540 A1 CA2298540 A1 CA 2298540A1
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- capsaicin receptor
- capsaicin
- leu
- polypeptide
- receptor
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91546197A | 1997-08-20 | 1997-08-20 | |
| US08/915,461 | 1997-08-20 | ||
| US7215198P | 1998-01-22 | 1998-01-22 | |
| US60/072,151 | 1998-01-22 | ||
| PCT/US1998/017466 WO1999009140A1 (en) | 1997-08-20 | 1998-08-20 | Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2298540A1 true CA2298540A1 (en) | 1999-02-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002298540A Abandoned CA2298540A1 (en) | 1997-08-20 | 1998-08-20 | Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6335180B1 (https=) |
| EP (1) | EP1009804B1 (https=) |
| JP (1) | JP4444493B2 (https=) |
| AT (1) | ATE253111T1 (https=) |
| AU (1) | AU742391B2 (https=) |
| CA (1) | CA2298540A1 (https=) |
| DE (1) | DE69819345T2 (https=) |
| WO (1) | WO1999009140A1 (https=) |
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| US6444440B1 (en) | 1997-03-07 | 2002-09-03 | Human Genome Sciences, Inc. | Vanilloid receptor-2 |
| AU742391B2 (en) | 1997-08-20 | 2002-01-03 | Regents Of The University Of California, The | Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof |
| CA2309903C (en) * | 1998-01-22 | 2012-03-27 | The Regents Of The University Of California | Nucleic acid sequences encoding capsaicin receptor |
| EP1066381A1 (en) * | 1998-01-27 | 2001-01-10 | Smithkline Beecham Plc | Human vanilloid receptor homologues |
| EP0943683A1 (en) * | 1998-03-10 | 1999-09-22 | Smithkline Beecham Plc | Human vanilloid receptor homologue Vanilrep1 |
| EP0953638A1 (en) * | 1998-03-11 | 1999-11-03 | Synthelabo | Human vanilloid receptor-like cation channel |
| US6906178B2 (en) | 1998-08-11 | 2005-06-14 | Human Genome Sciences, Inc. | Vanilloid receptor-2 |
| AU2148000A (en) * | 1998-11-13 | 2000-06-05 | Millennium Pharmaceuticals, Inc. | Novel members of the capsaicin/vanilloid receptor family of proteins and uses thereof |
| US7063951B1 (en) | 1998-11-13 | 2006-06-20 | Millennium Pharmaceuticals, Inc. | Members of the capsaicin/vanilloid receptor family of proteins and uses thereof |
| GB9826359D0 (en) * | 1998-12-01 | 1999-01-27 | Glaxo Group Ltd | Novel receptors |
| GB9827016D0 (en) | 1998-12-08 | 1999-02-03 | Merck Sharp & Dohme | Receptor protein |
| GB9907097D0 (en) | 1999-03-26 | 1999-05-19 | Novartis Ag | Organic compounds |
| AU4237400A (en) * | 1999-04-15 | 2000-11-02 | Ortho-Mcneil Pharmaceutical, Inc. | Dna encoding the human vanilloid receptor vr1 |
| US6421613B1 (en) * | 1999-07-09 | 2002-07-16 | Pioneer Hi-Bred International, Inc. | Data processing of the maize prolifera genetic sequence |
| US6482611B1 (en) | 1999-09-23 | 2002-11-19 | Neurogen Corporation | Human capsaicin receptor and uses thereof |
| US6455278B1 (en) * | 2000-02-08 | 2002-09-24 | Ortho-Mcneil Pharmaceutical, Inc. | DNA encoding human vanilloid receptor VR3 |
| AU2001234150A1 (en) * | 2000-02-25 | 2001-09-03 | Daiichi Pharmaceutical Co., Ltd. | Novel protein and gene encoding the same |
| DE10043674A1 (de) * | 2000-09-02 | 2002-03-21 | Gruenenthal Gmbh | Antisense Oligonukleotide |
| NZ524894A (en) * | 2000-09-02 | 2005-03-24 | Gruenenthal Chemie | Antisense oligonucleotides against VR1 |
| US7112685B2 (en) | 2000-10-10 | 2006-09-26 | Ortho-Mcneil Pharmaceutical, Inc. | Labeled resiniferatoxin derivatives |
| JP2004511803A (ja) | 2000-10-16 | 2004-04-15 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | バニロイド受容体についての改良リガンド結合アッセイ |
| CA2436941A1 (en) * | 2000-12-01 | 2002-06-06 | Bristol-Myers Squibb Company | Novel human nucleic acid molecules and polypeptides encoding a novel human ion channel expressed in spinal cord and brain |
| US20030171275A1 (en) * | 2000-12-20 | 2003-09-11 | Baughn Mariah R. | Transporters and ion channels |
| GB0128161D0 (en) * | 2001-11-23 | 2002-01-16 | Merck Sharp & Dohme | Receptor protein |
| WO2003066595A2 (en) | 2002-02-01 | 2003-08-14 | Euro-Celtique S.A. | 2 - piperazine - pyridines useful for treating pain |
| CA2517027A1 (en) | 2002-02-25 | 2003-09-04 | Vaxiion Therapeutics, Inc. | Minicell compositions and methods |
| US6974818B2 (en) | 2002-03-01 | 2005-12-13 | Euro-Celtique S.A. | 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain |
| WO2003087158A2 (en) * | 2002-04-16 | 2003-10-23 | Bayer Healthcare Ag | Regulation of human transient receptor potential channel |
| US7883846B2 (en) * | 2002-05-31 | 2011-02-08 | Sloan-Kettering Institute For Cancer Research | Heterologous stimulus-gated ion channels and methods of using same |
| BR0313255A (pt) | 2002-08-08 | 2005-07-12 | Amgen Inc | Composto, composição farmacêutica, uso de um composto e métodos de fabricar um medicamento e de preparar um composto |
| AU2003259846A1 (en) * | 2002-08-16 | 2004-03-03 | The General Hospital Corporation | Non-invasive functional imaging of peripheral nervous system activation in humans and animals |
| US7582635B2 (en) * | 2002-12-24 | 2009-09-01 | Purdue Pharma, L.P. | Therapeutic agents useful for treating pain |
| EP1615880A4 (en) * | 2003-04-08 | 2007-03-07 | Algorx Pharmaceuticals Inc | PREPARATION AND CLEANING OF SYNTHETIC TRANS CAPSAICIN |
| MY142655A (en) * | 2003-06-12 | 2010-12-15 | Euro Celtique Sa | Therapeutic agents useful for treating pain |
| WO2005006881A2 (en) * | 2003-07-09 | 2005-01-27 | Virginia Commonwealth University | Salt taste modification |
| AU2004259357B2 (en) * | 2003-07-24 | 2010-02-18 | Euro-Celtique S.A. | Piperidine compounds and pharmaceutical compositions containing them |
| SI1867644T1 (sl) * | 2003-07-24 | 2009-10-31 | Euro Celtique Sa | Heteroaril-tetrahidropiperidilne spojine, koristne za zdravljenje ali preprečevanje bolečine |
| EP1867644B1 (en) | 2003-07-24 | 2009-05-20 | Euro-Celtique S.A. | Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain |
| PL1942106T3 (pl) | 2003-08-01 | 2012-02-29 | Euro Celtique Sa | Środki lecznicze użyteczne do leczenia bólu |
| EP1664041B1 (en) | 2003-09-22 | 2008-07-02 | Euro-Celtique S.A. | Phenyl-carboxamide compounds useful for treating pain |
| PL1664016T3 (pl) * | 2003-09-22 | 2009-04-30 | Euro Celtique Sa | Środki terapeutyczne przydatne do leczenia bólu |
| ES2322907T3 (es) * | 2003-12-30 | 2009-07-01 | Euro-Celtique S.A. | Piperazinas utiles para el tratamiento de dolor. |
| US7751805B2 (en) * | 2004-02-20 | 2010-07-06 | Google Inc. | Mobile image-based information retrieval system |
| US20070159522A1 (en) * | 2004-02-20 | 2007-07-12 | Harmut Neven | Image-based contextual advertisement method and branded barcodes |
| US20050266435A1 (en) * | 2004-03-09 | 2005-12-01 | David Hackos | VR1 receptors and uses thereof |
| GB0412769D0 (en) | 2004-06-08 | 2004-07-07 | Novartis Ag | Organic compounds |
| EA200701131A1 (ru) * | 2004-11-24 | 2007-12-28 | Алгоркс Фармасьютикалз, Инк. | Гелеобразная препаративная форма капсаициноида и способы её применения |
| CN101213301B (zh) * | 2005-05-31 | 2013-02-27 | 德福根有限公司 | 用于防治昆虫和蜘蛛类动物的RNAi |
| US8679096B2 (en) | 2007-06-21 | 2014-03-25 | Board Of Regents Of The University Of Nebraska | Multifunctional operational component for robotic devices |
| CA2861159C (en) | 2006-06-22 | 2018-02-27 | Board Of Regents Of The University Of Nebraska | Magnetically coupleable robotic devices and related methods |
| US20080153845A1 (en) * | 2006-10-27 | 2008-06-26 | Redpoint Bio Corporation | Trpv1 antagonists and uses thereof |
| WO2008133973A1 (en) | 2007-04-27 | 2008-11-06 | Purdue Pharma L.P. | Therapeutic agents useful for treating pain |
| DK2142529T3 (da) | 2007-04-27 | 2014-02-10 | Purdue Pharma Lp | Trpv1-antagonister og anvendelser deraf |
| CA2690808C (en) | 2007-07-12 | 2016-09-27 | Board Of Regents Of The University Of Nebraska | Methods and systems of actuation in robotic devices |
| EP2178431A4 (en) | 2007-08-15 | 2017-01-18 | Board of Regents of the University of Nebraska | Medical inflation, attachment, and delivery devices and related methods |
| WO2009114143A1 (en) * | 2008-03-12 | 2009-09-17 | Brown University | Treatment and prophylaxis of epilepsy and febrile seizures |
| US8703962B2 (en) * | 2008-10-24 | 2014-04-22 | Purdue Pharma L.P. | Monocyclic compounds and their use as TRPV1 ligands |
| US8759362B2 (en) * | 2008-10-24 | 2014-06-24 | Purdue Pharma L.P. | Bicycloheteroaryl compounds and their use as TRPV1 ligands |
| US8546388B2 (en) * | 2008-10-24 | 2013-10-01 | Purdue Pharma L.P. | Heterocyclic TRPV1 receptor ligands |
| WO2010124200A2 (en) * | 2009-04-23 | 2010-10-28 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for cancer |
| EP2449112A1 (en) | 2009-07-01 | 2012-05-09 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for severe combined immunodeficiency (scid) |
| EP2460016A2 (en) * | 2009-07-30 | 2012-06-06 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for pharmacokinetics |
| WO2011017518A2 (en) * | 2009-08-05 | 2011-02-10 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for drug metabolism |
| EP2467013A2 (en) * | 2009-08-20 | 2012-06-27 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for pain |
| EP4275634A3 (en) | 2011-06-10 | 2024-01-10 | Board of Regents of the University of Nebraska | Surgical end effector |
| HRP20170507T1 (hr) | 2011-06-22 | 2017-06-02 | Purdue Pharma Lp | Trpv1 antagonisti uključujući dihidroksi supstituente i njihove uporabe |
| WO2013009887A1 (en) | 2011-07-11 | 2013-01-17 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems and related methods |
| US9394293B2 (en) | 2011-08-10 | 2016-07-19 | Purdue Pharma L.P. | TRPV1 antagonists including dihydroxy substituent and uses thereof |
| EP3730031A1 (en) | 2011-10-03 | 2020-10-28 | Board of Regents of the University of Nebraska | Robotic surgical devices and systems |
| WO2013106569A2 (en) | 2012-01-10 | 2013-07-18 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices for surgical access and insertion |
| US9498292B2 (en) | 2012-05-01 | 2016-11-22 | Board Of Regents Of The University Of Nebraska | Single site robotic device and related systems and methods |
| JP6228196B2 (ja) | 2012-06-22 | 2017-11-08 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | ローカル制御ロボット手術デバイス |
| US9770305B2 (en) | 2012-08-08 | 2017-09-26 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems, and related methods |
| US12295680B2 (en) | 2012-08-08 | 2025-05-13 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems and related methods |
| EP2882331A4 (en) | 2012-08-08 | 2016-03-23 | Univ Nebraska | ROBOTIC SURGICAL DEVICES, SYSTEMS AND CORRESPONDING METHODS |
| CA2905948C (en) | 2013-03-14 | 2022-01-11 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to robotic surgical devices, end effectors, and controllers |
| CA2906672C (en) | 2013-03-14 | 2022-03-15 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to force control surgical systems |
| US10667883B2 (en) | 2013-03-15 | 2020-06-02 | Virtual Incision Corporation | Robotic surgical devices, systems, and related methods |
| JP6479790B2 (ja) | 2013-07-17 | 2019-03-06 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | ロボット外科的デバイス、システムおよび関連する方法 |
| US9427415B2 (en) | 2014-04-01 | 2016-08-30 | The Procter & Gamble Company | Methods and compositions for modifying sensorial perception |
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| WO2018081189A1 (en) | 2016-10-25 | 2018-05-03 | The Procter & Gamble Company | Fibrous structures |
| WO2018081190A1 (en) | 2016-10-25 | 2018-05-03 | The Procter & Gamble Company | Fibrous structures |
| CN115337111B (zh) | 2016-11-22 | 2025-04-25 | 内布拉斯加大学董事会 | 改进的粗定位装置及相关系统和方法 |
| CN110462259B (zh) | 2016-11-29 | 2022-10-28 | 虚拟切割有限公司 | 具有用户存在检测的用户控制器及相关系统和方法 |
| WO2018112199A1 (en) | 2016-12-14 | 2018-06-21 | Virtual Incision Corporation | Releasable attachment device for coupling to medical devices and related systems and methods |
| CN111417333B (zh) | 2017-09-27 | 2023-08-29 | 虚拟切割有限公司 | 具有跟踪相机技术的机器人手术设备及相关系统和方法 |
| CN117140580A (zh) | 2018-01-05 | 2023-12-01 | 内布拉斯加大学董事会 | 具有紧凑型关节设计的单臂机器人装置及相关系统和方法 |
| CN121714364A (zh) | 2019-01-07 | 2026-03-24 | 虚拟切割有限公司 | 机器人辅助手术系统以及相关装置和方法 |
| CN110045108B (zh) * | 2019-05-28 | 2021-10-29 | 江南大学 | 一种基于辣椒碱指标的地沟油酶联免疫检测试剂盒及其检测方法 |
| GB201918103D0 (en) | 2019-12-10 | 2020-01-22 | Oblique Therapeutics Ab | Epitopes and antibodies |
| CN115843233A (zh) | 2020-07-06 | 2023-03-24 | 虚拟切割有限公司 | 手术机器人定位系统及相关装置和方法 |
Family Cites Families (16)
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|---|---|---|---|---|
| US5074977A (en) | 1987-05-05 | 1991-12-24 | The Washington Technology Center | Digital biosensors and method of using same |
| EP0432188B1 (en) | 1988-08-18 | 1996-03-27 | AUSTRALIAN MEMBRANE AND BIOTECHNOLOGY RESEARCH INSTITUTE LTD. Commonwealth Scientific and Industrial Research Organization | Improvements in sensitivity and selectivity of ion channel membrane biosensors |
| CA2045640C (en) | 1989-01-27 | 1999-01-05 | Bruce Andrew Cornell | Receptor membranes and ionophore gating |
| US5491097A (en) | 1989-06-15 | 1996-02-13 | Biocircuits Corporation | Analyte detection with multilayered bioelectronic conductivity sensors |
| US5328847A (en) | 1990-02-20 | 1994-07-12 | Case George D | Thin membrane sensor with biochemical switch |
| US5232684A (en) * | 1990-06-29 | 1993-08-03 | The United States Of America As Represented By The Department Of Health And Human Services | Labelled resiniferatoxin, compositions thereof, and methods for using the same |
| AU742391B2 (en) | 1997-08-20 | 2002-01-03 | Regents Of The University Of California, The | Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof |
| EP1066381A1 (en) | 1998-01-27 | 2001-01-10 | Smithkline Beecham Plc | Human vanilloid receptor homologues |
| EP0943683A1 (en) * | 1998-03-10 | 1999-09-22 | Smithkline Beecham Plc | Human vanilloid receptor homologue Vanilrep1 |
| EP0953638A1 (en) | 1998-03-11 | 1999-11-03 | Synthelabo | Human vanilloid receptor-like cation channel |
| AU2148000A (en) | 1998-11-13 | 2000-06-05 | Millennium Pharmaceuticals, Inc. | Novel members of the capsaicin/vanilloid receptor family of proteins and uses thereof |
| GB9826359D0 (en) * | 1998-12-01 | 1999-01-27 | Glaxo Group Ltd | Novel receptors |
| AU4237400A (en) | 1999-04-15 | 2000-11-02 | Ortho-Mcneil Pharmaceutical, Inc. | Dna encoding the human vanilloid receptor vr1 |
| CA2428827A1 (en) | 1999-11-12 | 2001-05-17 | Abbott Laboratories | Human vanilloid receptor gene |
| AU2001247460A1 (en) | 2000-03-15 | 2001-09-24 | Millennium Pharmaceuticals, Inc. | 18615 and 48003, human ion channels and uses therefor |
| JP3501775B2 (ja) | 2000-05-31 | 2004-03-02 | ファイザー株式会社 | ヒトバニロイド受容体様タンパク質 |
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- 1998-08-20 JP JP2000509807A patent/JP4444493B2/ja not_active Expired - Lifetime
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| DE69819345T2 (de) | 2004-07-15 |
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| AU9115698A (en) | 1999-03-08 |
| JP2001514879A (ja) | 2001-09-18 |
| AU742391B2 (en) | 2002-01-03 |
| US7097991B2 (en) | 2006-08-29 |
| EP1009804B1 (en) | 2003-10-29 |
| US20030049728A1 (en) | 2003-03-13 |
| JP4444493B2 (ja) | 2010-03-31 |
| WO1999009140A1 (en) | 1999-02-25 |
| US6335180B1 (en) | 2002-01-01 |
| US6790629B2 (en) | 2004-09-14 |
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