DE69819345D1 - Für den capsaicin rezeptor kodierende nukleinsäuresequenzen und dem capsaicin rezeptor ähnliche polypeptide und ihre verwendung - Google Patents
Für den capsaicin rezeptor kodierende nukleinsäuresequenzen und dem capsaicin rezeptor ähnliche polypeptide und ihre verwendungInfo
- Publication number
- DE69819345D1 DE69819345D1 DE69819345T DE69819345T DE69819345D1 DE 69819345 D1 DE69819345 D1 DE 69819345D1 DE 69819345 T DE69819345 T DE 69819345T DE 69819345 T DE69819345 T DE 69819345T DE 69819345 D1 DE69819345 D1 DE 69819345D1
- Authority
- DE
- Germany
- Prior art keywords
- capsaicin receptor
- receptor
- polypeptides
- capsaicin
- related aspects
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000011040 TRPV Cation Channels Human genes 0.000 title abstract 10
- 108010062740 TRPV Cation Channels Proteins 0.000 title abstract 10
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 150000007523 nucleic acids Chemical group 0.000 title 1
- 238000000034 method Methods 0.000 abstract 4
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical class COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 abstract 3
- 102000040430 polynucleotide Human genes 0.000 abstract 3
- 108091033319 polynucleotide Proteins 0.000 abstract 3
- 239000002157 polynucleotide Substances 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 229960002504 capsaicin Drugs 0.000 abstract 1
- 235000017663 capsaicin Nutrition 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US915461 | 1986-10-06 | ||
US91546197A | 1997-08-20 | 1997-08-20 | |
US7215198P | 1998-01-22 | 1998-01-22 | |
US72151P | 1998-01-22 | ||
PCT/US1998/017466 WO1999009140A1 (en) | 1997-08-20 | 1998-08-20 | Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69819345D1 true DE69819345D1 (de) | 2003-12-04 |
DE69819345T2 DE69819345T2 (de) | 2004-07-15 |
Family
ID=26753050
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69819345T Expired - Lifetime DE69819345T2 (de) | 1997-08-20 | 1998-08-20 | Für den capsaicin rezeptor kodierende nukleinsäuresequenzen und dem capsaicin rezeptor ähnliche polypeptide und ihre verwendung |
Country Status (8)
Country | Link |
---|---|
US (3) | US6335180B1 (de) |
EP (1) | EP1009804B1 (de) |
JP (1) | JP4444493B2 (de) |
AT (1) | ATE253111T1 (de) |
AU (1) | AU742391B2 (de) |
CA (1) | CA2298540A1 (de) |
DE (1) | DE69819345T2 (de) |
WO (1) | WO1999009140A1 (de) |
Families Citing this family (94)
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US6444440B1 (en) | 1997-03-07 | 2002-09-03 | Human Genome Sciences, Inc. | Vanilloid receptor-2 |
AU742391B2 (en) | 1997-08-20 | 2002-01-03 | Regents Of The University Of California, The | Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof |
AU2466799A (en) * | 1998-01-22 | 1999-08-09 | Regents Of The University Of California, The | Nucleic acid sequences encoding capsaicin receptors |
JP2002500885A (ja) * | 1998-01-27 | 2002-01-15 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ヒトバニロイド受容体相同体 |
EP0943683A1 (de) | 1998-03-10 | 1999-09-22 | Smithkline Beecham Plc | Menschliches Vanilloid Rezeptorhomolog Vanilrep1 |
EP0953638A1 (de) * | 1998-03-11 | 1999-11-03 | Synthelabo | Dem menschlichen Vanilloid Rezeptor ähnlicher Kationenkanal |
US6906178B2 (en) | 1998-08-11 | 2005-06-14 | Human Genome Sciences, Inc. | Vanilloid receptor-2 |
WO2000029577A1 (en) * | 1998-11-13 | 2000-05-25 | Millennium Pharmaceuticals, Inc. | Novel members of the capsaicin/vanilloid receptor family of proteins and uses thereof |
US7063951B1 (en) | 1998-11-13 | 2006-06-20 | Millennium Pharmaceuticals, Inc. | Members of the capsaicin/vanilloid receptor family of proteins and uses thereof |
GB9826359D0 (en) * | 1998-12-01 | 1999-01-27 | Glaxo Group Ltd | Novel receptors |
GB9827016D0 (en) | 1998-12-08 | 1999-02-03 | Merck Sharp & Dohme | Receptor protein |
GB9907097D0 (en) * | 1999-03-26 | 1999-05-19 | Novartis Ag | Organic compounds |
AU4237400A (en) * | 1999-04-15 | 2000-11-02 | Ortho-Mcneil Pharmaceutical, Inc. | Dna encoding the human vanilloid receptor vr1 |
US6421613B1 (en) * | 1999-07-09 | 2002-07-16 | Pioneer Hi-Bred International, Inc. | Data processing of the maize prolifera genetic sequence |
US6482611B1 (en) | 1999-09-23 | 2002-11-19 | Neurogen Corporation | Human capsaicin receptor and uses thereof |
US6455278B1 (en) * | 2000-02-08 | 2002-09-24 | Ortho-Mcneil Pharmaceutical, Inc. | DNA encoding human vanilloid receptor VR3 |
WO2001062915A1 (fr) * | 2000-02-25 | 2001-08-30 | Daiichi Pharmaceutical Co., Ltd. | Nouvelle proteine et gene codant pour elle |
DE10043674A1 (de) * | 2000-09-02 | 2002-03-21 | Gruenenthal Gmbh | Antisense Oligonukleotide |
HUP0301805A3 (en) * | 2000-09-02 | 2005-12-28 | Gruenenthal Gmbh | Antisense oligonucleotides against vanilloid receptor 1 |
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AU2002232456A1 (en) * | 2000-12-01 | 2002-06-11 | Bristol-Myers Squibb Company | Novel human nucleic acid molecules and polypeptides encoding a novel human ion channel expressed in spinal cord and brain |
US20030171275A1 (en) * | 2000-12-20 | 2003-09-11 | Baughn Mariah R. | Transporters and ion channels |
GB0128161D0 (en) * | 2001-11-23 | 2002-01-16 | Merck Sharp & Dohme | Receptor protein |
DE60332316D1 (de) | 2002-02-01 | 2010-06-10 | Euro Celtique Sa | 2-piperazinpyridine für die schmerzbehandlung |
EP2272946B9 (de) | 2002-02-25 | 2015-06-24 | Vaxiion Therapeutics, LLC | Minizell-Zusammensetzungen und Verfahren |
US6974818B2 (en) * | 2002-03-01 | 2005-12-13 | Euro-Celtique S.A. | 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain |
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WO2004016167A1 (en) * | 2002-08-16 | 2004-02-26 | The General Hospital Corporation | Non-invasive functional imaging of peripheral nervous system activation in humans and animals |
US7582635B2 (en) * | 2002-12-24 | 2009-09-01 | Purdue Pharma, L.P. | Therapeutic agents useful for treating pain |
NZ542887A (en) * | 2003-04-08 | 2008-05-30 | Algorx Pharmaceuticals Inc | Preparation and purification of synthetic capsaicin |
TWI287010B (en) | 2003-06-12 | 2007-09-21 | Euro Celtique Sa | Therapeutic agents useful for treating pain |
US20050031717A1 (en) * | 2003-07-09 | 2005-02-10 | Desimone John A. | Salt taste modification |
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DK1867644T3 (da) * | 2003-07-24 | 2009-09-21 | Euro Celtique Sa | Heteroaryl-tetrahydropyridyl-forbindelser, der er anvendelige til behandling eller forebyggelse af smerte |
JP4686456B2 (ja) | 2003-07-24 | 2011-05-25 | ユーロ−セルティーク エス.エイ. | 疼痛を治療するのに有用な治療薬 |
DK1648880T3 (da) | 2003-08-01 | 2010-05-10 | Euro Celtique Sa | Terapeutiske midler, der kan anvendes til behandling af smerte |
PT1664016E (pt) * | 2003-09-22 | 2008-12-29 | Euro Celtique Sa | Agentes terapêuticos úteis para tratamento da dor |
EP1664041B1 (de) | 2003-09-22 | 2008-07-02 | Euro-Celtique S.A. | Zur behandlung von schmerzen geeignete phenylcarbonsäureamidverbindungen |
EP1727801B1 (de) * | 2003-12-30 | 2009-02-18 | Euro-Celtique S.A. | Zur behandlung von schmerzen geeignete piperazine |
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US20070159522A1 (en) * | 2004-02-20 | 2007-07-12 | Harmut Neven | Image-based contextual advertisement method and branded barcodes |
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GB0412769D0 (en) | 2004-06-08 | 2004-07-07 | Novartis Ag | Organic compounds |
CN101119713A (zh) * | 2004-11-24 | 2008-02-06 | 阿尔高克斯制药公司 | 类辣椒素凝胶制剂及其用途 |
US8759306B2 (en) * | 2005-05-31 | 2014-06-24 | Devgen N.V. | RNAi for the control of insects and arachnids |
US8679096B2 (en) | 2007-06-21 | 2014-03-25 | Board Of Regents Of The University Of Nebraska | Multifunctional operational component for robotic devices |
US8834488B2 (en) | 2006-06-22 | 2014-09-16 | Board Of Regents Of The University Of Nebraska | Magnetically coupleable robotic surgical devices and related methods |
WO2008057300A2 (en) * | 2006-10-27 | 2008-05-15 | Redpoint Bio Corporation | Trpvi antagonists and uses thereof |
CA2685266C (en) * | 2007-04-27 | 2014-01-28 | Purdue Pharma L.P. | Trpv1 antagonists and uses thereof for the treatment of prevention of pain, ui and ulcer, ibd, or ibs in an animal |
CA2685121A1 (en) * | 2007-04-27 | 2008-11-06 | Purdue Pharma L.P. | Therapeutic agents useful for treating pain |
WO2009014917A2 (en) | 2007-07-12 | 2009-01-29 | Board Of Regents Of The University Of Nebraska | Methods and systems of actuation in robotic devices |
JP2010536435A (ja) | 2007-08-15 | 2010-12-02 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | 医療用膨張、取り付けおよび送達装置、ならびに関連する方法 |
WO2009114143A1 (en) * | 2008-03-12 | 2009-09-17 | Brown University | Treatment and prophylaxis of epilepsy and febrile seizures |
US8759362B2 (en) * | 2008-10-24 | 2014-06-24 | Purdue Pharma L.P. | Bicycloheteroaryl compounds and their use as TRPV1 ligands |
US8703962B2 (en) * | 2008-10-24 | 2014-04-22 | Purdue Pharma L.P. | Monocyclic compounds and their use as TRPV1 ligands |
US8546388B2 (en) * | 2008-10-24 | 2013-10-01 | Purdue Pharma L.P. | Heterocyclic TRPV1 receptor ligands |
WO2010124200A2 (en) * | 2009-04-23 | 2010-10-28 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for cancer |
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EP4275634A3 (de) | 2011-06-10 | 2024-01-10 | Board of Regents of the University of Nebraska | Verfahren, systeme und vorrichtungen in zusammenhang mit chirurgischen endeffektoren |
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EP2864086B1 (de) | 2012-06-22 | 2017-04-19 | Board of Regents of the University of Nebraska | Robotische chirurgische vorrichtungen mit lokaler steuerung |
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JP6479790B2 (ja) | 2013-07-17 | 2019-03-06 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | ロボット外科的デバイス、システムおよび関連する方法 |
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CA2961213A1 (en) | 2014-09-12 | 2016-03-17 | Board Of Regents Of The University Of Nebraska | Quick-release end effectors and related systems and methods |
EP4286104A3 (de) | 2014-11-11 | 2024-02-14 | Board of Regents of the University of Nebraska | Robotervorrichtung mit kompaktem gelenkentwurf sowie zugehörige systeme und verfahren |
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EP3457951B1 (de) | 2016-05-18 | 2024-03-06 | Virtual Incision Corporation | Robotische chirurgische vorrichtungen und systeme |
CA3034671A1 (en) | 2016-08-25 | 2018-03-01 | Shane Farritor | Quick-release tool coupler and related systems and methods |
EP3507065A4 (de) | 2016-08-30 | 2020-04-29 | Board of Regents of the University of Nebraska | Robotische vorrichtung mit kompaktem gelenkdesign und einem zusätzlichen freiheitsgrad sowie entsprechende systeme und verfahren |
US10745865B2 (en) | 2016-10-25 | 2020-08-18 | The Procter & Gamble Company | Creped fibrous structures |
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JP2020500674A (ja) | 2016-11-22 | 2020-01-16 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | 改良された全体的位置決めデバイスならびに関連するシステムおよび方法 |
WO2018102430A1 (en) | 2016-11-29 | 2018-06-07 | Virtual Incision Corporation | User controller with user presence detection and related systems and methods |
US10722319B2 (en) | 2016-12-14 | 2020-07-28 | Virtual Incision Corporation | Releasable attachment device for coupling to medical devices and related systems and methods |
EP3687370A4 (de) | 2017-09-27 | 2021-06-30 | Virtual Incision Corporation | Robotische chirurgische vorrichtungen mit verfolgungskameratechnologie und verwandte systeme und verfahren |
CN117140580A (zh) | 2018-01-05 | 2023-12-01 | 内布拉斯加大学董事会 | 具有紧凑型关节设计的单臂机器人装置及相关系统和方法 |
WO2020146348A1 (en) | 2019-01-07 | 2020-07-16 | Virtual Incision Corporation | Robotically assisted surgical system and related devices and methods |
CN110045108B (zh) * | 2019-05-28 | 2021-10-29 | 江南大学 | 一种基于辣椒碱指标的地沟油酶联免疫检测试剂盒及其检测方法 |
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AU742391B2 (en) | 1997-08-20 | 2002-01-03 | Regents Of The University Of California, The | Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof |
JP2002500885A (ja) | 1998-01-27 | 2002-01-15 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ヒトバニロイド受容体相同体 |
EP0943683A1 (de) | 1998-03-10 | 1999-09-22 | Smithkline Beecham Plc | Menschliches Vanilloid Rezeptorhomolog Vanilrep1 |
EP0953638A1 (de) | 1998-03-11 | 1999-11-03 | Synthelabo | Dem menschlichen Vanilloid Rezeptor ähnlicher Kationenkanal |
WO2000029577A1 (en) | 1998-11-13 | 2000-05-25 | Millennium Pharmaceuticals, Inc. | Novel members of the capsaicin/vanilloid receptor family of proteins and uses thereof |
GB9826359D0 (en) * | 1998-12-01 | 1999-01-27 | Glaxo Group Ltd | Novel receptors |
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-
1998
- 1998-08-20 AU AU91156/98A patent/AU742391B2/en not_active Expired
- 1998-08-20 EP EP98943332A patent/EP1009804B1/de not_active Expired - Lifetime
- 1998-08-20 JP JP2000509807A patent/JP4444493B2/ja not_active Expired - Lifetime
- 1998-08-20 AT AT98943332T patent/ATE253111T1/de not_active IP Right Cessation
- 1998-08-20 WO PCT/US1998/017466 patent/WO1999009140A1/en active IP Right Grant
- 1998-08-20 DE DE69819345T patent/DE69819345T2/de not_active Expired - Lifetime
- 1998-08-20 CA CA002298540A patent/CA2298540A1/en not_active Abandoned
-
1999
- 1999-01-22 US US09/235,451 patent/US6335180B1/en not_active Expired - Lifetime
-
2001
- 2001-10-15 US US09/978,303 patent/US6790629B2/en not_active Expired - Lifetime
-
2004
- 2004-08-09 US US10/915,017 patent/US7097991B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1009804B1 (de) | 2003-10-29 |
DE69819345T2 (de) | 2004-07-15 |
EP1009804A4 (de) | 2001-05-16 |
CA2298540A1 (en) | 1999-02-25 |
US20050095650A1 (en) | 2005-05-05 |
ATE253111T1 (de) | 2003-11-15 |
US6790629B2 (en) | 2004-09-14 |
JP2001514879A (ja) | 2001-09-18 |
AU742391B2 (en) | 2002-01-03 |
US6335180B1 (en) | 2002-01-01 |
US20030049728A1 (en) | 2003-03-13 |
EP1009804A1 (de) | 2000-06-21 |
WO1999009140A1 (en) | 1999-02-25 |
AU9115698A (en) | 1999-03-08 |
US7097991B2 (en) | 2006-08-29 |
JP4444493B2 (ja) | 2010-03-31 |
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