JP4444493B2 - カプサイシン受容体およびカプサイシン受容体関連ポリペプチドをコードする核酸配列ならびにその使用 - Google Patents

カプサイシン受容体およびカプサイシン受容体関連ポリペプチドをコードする核酸配列ならびにその使用 Download PDF

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Publication number
JP4444493B2
JP4444493B2 JP2000509807A JP2000509807A JP4444493B2 JP 4444493 B2 JP4444493 B2 JP 4444493B2 JP 2000509807 A JP2000509807 A JP 2000509807A JP 2000509807 A JP2000509807 A JP 2000509807A JP 4444493 B2 JP4444493 B2 JP 4444493B2
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capsaicin receptor
capsaicin
polypeptide
receptor
vanilloid
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JP2000509807A
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JP2001514879A (ja
JP2001514879A5 (cg-RX-API-DMAC10.html
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デビッド ジェイ． ジュリアス
マイケル カテリナ
アンソニー ブレイク
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University of California
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University of California
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2000509807A 1997-08-20 1998-08-20 カプサイシン受容体およびカプサイシン受容体関連ポリペプチドをコードする核酸配列ならびにその使用 Expired - Lifetime JP4444493B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US91546197A 1997-08-20 1997-08-20
US7215198P 1998-01-22 1998-01-22
US60/072,151 1998-01-22
US08/915,461 1998-01-22
PCT/US1998/017466 WO1999009140A1 (en) 1997-08-20 1998-08-20 Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof

Publications (3)

Publication Number Publication Date
JP2001514879A JP2001514879A (ja) 2001-09-18
JP2001514879A5 JP2001514879A5 (cg-RX-API-DMAC10.html) 2006-02-16
JP4444493B2 true JP4444493B2 (ja) 2010-03-31

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JP2000509807A Expired - Lifetime JP4444493B2 (ja) 1997-08-20 1998-08-20 カプサイシン受容体およびカプサイシン受容体関連ポリペプチドをコードする核酸配列ならびにその使用

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US (3) US6335180B1 (cg-RX-API-DMAC10.html)
EP (1) EP1009804B1 (cg-RX-API-DMAC10.html)
JP (1) JP4444493B2 (cg-RX-API-DMAC10.html)
AT (1) ATE253111T1 (cg-RX-API-DMAC10.html)
AU (1) AU742391B2 (cg-RX-API-DMAC10.html)
CA (1) CA2298540A1 (cg-RX-API-DMAC10.html)
DE (1) DE69819345T2 (cg-RX-API-DMAC10.html)
WO (1) WO1999009140A1 (cg-RX-API-DMAC10.html)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6444440B1 (en) 1997-03-07 2002-09-03 Human Genome Sciences, Inc. Vanilloid receptor-2
JP4444493B2 (ja) 1997-08-20 2010-03-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア カプサイシン受容体およびカプサイシン受容体関連ポリペプチドをコードする核酸配列ならびにその使用
DE69910538T2 (de) * 1998-01-22 2004-06-24 The Regents Of The University Of California, Oakland Nukleinsäuresequenzen, welche für capsaicin-rezeptoren kodieren
EP1066381A1 (en) * 1998-01-27 2001-01-10 Smithkline Beecham Plc Human vanilloid receptor homologues
EP0943683A1 (en) * 1998-03-10 1999-09-22 Smithkline Beecham Plc Human vanilloid receptor homologue Vanilrep1
EP0953638A1 (en) * 1998-03-11 1999-11-03 Synthelabo Human vanilloid receptor-like cation channel
US6906178B2 (en) 1998-08-11 2005-06-14 Human Genome Sciences, Inc. Vanilloid receptor-2
US7063951B1 (en) 1998-11-13 2006-06-20 Millennium Pharmaceuticals, Inc. Members of the capsaicin/vanilloid receptor family of proteins and uses thereof
JP2002531069A (ja) * 1998-11-13 2002-09-24 ミレニアム・フアーマシユーチカルズ・インコーポレーテツド タンパク質のカプサイシン／バニロイド受容体ファミリーの新規メンバー及びそれらの使用
GB9826359D0 (en) * 1998-12-01 1999-01-27 Glaxo Group Ltd Novel receptors
GB9827016D0 (en) 1998-12-08 1999-02-03 Merck Sharp & Dohme Receptor protein
GB9907097D0 (en) 1999-03-26 1999-05-19 Novartis Ag Organic compounds
AU4237400A (en) * 1999-04-15 2000-11-02 Ortho-Mcneil Pharmaceutical, Inc. Dna encoding the human vanilloid receptor vr1
US6421613B1 (en) * 1999-07-09 2002-07-16 Pioneer Hi-Bred International, Inc. Data processing of the maize prolifera genetic sequence
US6482611B1 (en) 1999-09-23 2002-11-19 Neurogen Corporation Human capsaicin receptor and uses thereof
US6455278B1 (en) * 2000-02-08 2002-09-24 Ortho-Mcneil Pharmaceutical, Inc. DNA encoding human vanilloid receptor VR3
WO2001062915A1 (fr) * 2000-02-25 2001-08-30 Daiichi Pharmaceutical Co., Ltd. Nouvelle proteine et gene codant pour elle
DE10043674A1 (de) * 2000-09-02 2002-03-21 Gruenenthal Gmbh Antisense Oligonukleotide
PL366039A1 (en) * 2000-09-02 2005-01-24 Grunenthal Gmbh Antisense oligonucleotides against vr1
US7112685B2 (en) 2000-10-10 2006-09-26 Ortho-Mcneil Pharmaceutical, Inc. Labeled resiniferatoxin derivatives
AU2001297015A1 (en) 2000-10-15 2002-04-29 Ortho-Mcneil Pharmaceutical, Inc. Improved ligand binding assays for vanilloid receptors
IL155613A0 (en) * 2000-12-01 2003-11-23 Bristol Myers Squibb Co Novel human nucleic acid molecules and polypeptides emcoding a novel human ion channel expressed in spinal cord and brain
US20030171275A1 (en) * 2000-12-20 2003-09-11 Baughn Mariah R. Transporters and ion channels
GB0128161D0 (en) * 2001-11-23 2002-01-16 Merck Sharp & Dohme Receptor protein
AU2003212882A1 (en) 2002-02-01 2003-09-02 Euro-Celtique S.A. 2 - piperazine - pyridines useful for treating pain
EP2272946B9 (en) 2002-02-25 2015-06-24 Vaxiion Therapeutics, LLC Minicell compositions and methods
US6974818B2 (en) 2002-03-01 2005-12-13 Euro-Celtique S.A. 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain
US20050176010A1 (en) * 2002-04-16 2005-08-11 Bayer Healthcare Ag Regulation of human transient receptor potential channel
US7883846B2 (en) * 2002-05-31 2011-02-08 Sloan-Kettering Institute For Cancer Research Heterologous stimulus-gated ion channels and methods of using same
TW200410945A (en) 2002-08-08 2004-07-01 Amgen Inc Vanilloid receptor ligands and their use in treatments"
AU2003259846A1 (en) * 2002-08-16 2004-03-03 The General Hospital Corporation Non-invasive functional imaging of peripheral nervous system activation in humans and animals
US7582635B2 (en) * 2002-12-24 2009-09-01 Purdue Pharma, L.P. Therapeutic agents useful for treating pain
BRPI0409748A (pt) * 2003-04-08 2006-10-24 Algorx Pharmaceuticals Inc preparação e purificação de capsaicin sintetico
AR044688A1 (es) * 2003-06-12 2005-09-21 Euro Celtique Sa Agentes terapeuticos utiles para el tratamiento del dolor
US20050031717A1 (en) * 2003-07-09 2005-02-10 Desimone John A. Salt taste modification
ES2327684T3 (es) 2003-07-24 2009-11-02 Euro-Celtique S.A. Compuestos heteroaril-tetrahidropiridilo utiles para el tratamiento o la prevencion del dolor.
PL1867644T3 (pl) 2003-07-24 2009-10-30 Euro Celtique Sa Związki heteroarylo-tetrahydropiperydylowe przydatne w leczeniu lub zapobieganiu bólu
EP1648878B9 (en) 2003-07-24 2011-03-16 Euro-Celtique S.A. Piperidine compounds and pharmaceutical compositions containing them
MXPA06001331A (es) * 2003-08-01 2006-05-04 Euro Celtique Sa Agentes terapeuticos utiles para el tratamiento del dolor.
SI1664041T1 (sl) 2003-09-22 2008-12-31 Euro Celtique Sa Fenil-karboksamidne spojine, uporabne za tretiranje bolečine
MXPA06003123A (es) * 2003-09-22 2006-05-31 Euro Celtique Sa Agentes terapeuticos utiles para el tratamiento del dolor.
ES2322907T3 (es) * 2003-12-30 2009-07-01 Euro-Celtique S.A. Piperazinas utiles para el tratamiento de dolor.
US20070159522A1 (en) * 2004-02-20 2007-07-12 Harmut Neven Image-based contextual advertisement method and branded barcodes
US7751805B2 (en) * 2004-02-20 2010-07-06 Google Inc. Mobile image-based information retrieval system
WO2005087807A1 (en) * 2004-03-09 2005-09-22 Renovis, Inc. Vr1 receptors and uses thereof
GB0412769D0 (en) 2004-06-08 2004-07-07 Novartis Ag Organic compounds
CN101119713A (zh) * 2004-11-24 2008-02-06 阿尔高克斯制药公司 类辣椒素凝胶制剂及其用途
CA2610644A1 (en) * 2005-05-31 2006-12-07 Devgen Nv Rnai for control of insects and arachnids
CA2655964C (en) 2006-06-22 2014-10-28 Board Of Regents Of The University Of Nebraska Magnetically coupleable robotic devices and related methods
US8679096B2 (en) 2007-06-21 2014-03-25 Board Of Regents Of The University Of Nebraska Multifunctional operational component for robotic devices
WO2008057300A2 (en) * 2006-10-27 2008-05-15 Redpoint Bio Corporation Trpvi antagonists and uses thereof
EP2142529B1 (en) * 2007-04-27 2013-12-25 Purdue Pharma LP Trpv1 antagonists and uses thereof
CA2685121A1 (en) 2007-04-27 2008-11-06 Purdue Pharma L.P. Therapeutic agents useful for treating pain
JP5591696B2 (ja) 2007-07-12 2014-09-17 ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ 生検要素、アーム装置、および医療装置
JP2010536435A (ja) 2007-08-15 2010-12-02 ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ 医療用膨張、取り付けおよび送達装置、ならびに関連する方法
WO2009114143A1 (en) * 2008-03-12 2009-09-17 Brown University Treatment and prophylaxis of epilepsy and febrile seizures
US8703962B2 (en) * 2008-10-24 2014-04-22 Purdue Pharma L.P. Monocyclic compounds and their use as TRPV1 ligands
US8546388B2 (en) * 2008-10-24 2013-10-01 Purdue Pharma L.P. Heterocyclic TRPV1 receptor ligands
US8759362B2 (en) * 2008-10-24 2014-06-24 Purdue Pharma L.P. Bicycloheteroaryl compounds and their use as TRPV1 ligands
US8722964B2 (en) * 2009-04-23 2014-05-13 Transposagen Biopharmaceuticals, Inc. Genetically engineered or transgenic rats exhibiting a cancer phenotype due to a disruption of germline tumor suppressor genes
EP2449112A1 (en) 2009-07-01 2012-05-09 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for severe combined immunodeficiency (scid)
WO2011014721A2 (en) * 2009-07-30 2011-02-03 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for pharmacokinetics
EP2461672A2 (en) * 2009-08-05 2012-06-13 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for drug metabolism
WO2011022634A2 (en) * 2009-08-20 2011-02-24 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for pain
CA2838637C (en) 2011-06-10 2020-11-17 Board Of Regents Of The University Of Nebraska Methods, systems, and devices relating to surgical end effectors
RS55701B1 (sr) 2011-06-22 2017-07-31 Purdue Pharma Lp Trpv1 antagonisti koji uključuju dihidroksi supstituent i njihove upotrebe
EP3588217A1 (en) 2011-07-11 2020-01-01 Board of Regents of the University of Nebraska Robotic surgical devices, systems and related methods
US9394293B2 (en) 2011-08-10 2016-07-19 Purdue Pharma L.P. TRPV1 antagonists including dihydroxy substituent and uses thereof
EP3730031A1 (en) 2011-10-03 2020-10-28 Board of Regents of the University of Nebraska Robotic surgical devices and systems
WO2013106569A2 (en) 2012-01-10 2013-07-18 Board Of Regents Of The University Of Nebraska Methods, systems, and devices for surgical access and insertion
JP2015531608A (ja) 2012-05-01 2015-11-05 ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ 単孔式ロボット機器および関連システムと方法
WO2013191773A1 (en) 2012-06-22 2013-12-27 Board Of Regents Of The University Of Nebraska Local Control Robotic Surgical Devices and Related Methods
US12295680B2 (en) 2012-08-08 2025-05-13 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems and related methods
US9770305B2 (en) 2012-08-08 2017-09-26 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems, and related methods
EP2882331A4 (en) 2012-08-08 2016-03-23 Univ Nebraska ROBOTIC SURGICAL DEVICES, SYSTEMS AND CORRESPONDING METHODS
US9743987B2 (en) 2013-03-14 2017-08-29 Board Of Regents Of The University Of Nebraska Methods, systems, and devices relating to robotic surgical devices, end effectors, and controllers
US9888966B2 (en) 2013-03-14 2018-02-13 Board Of Regents Of The University Of Nebraska Methods, systems, and devices relating to force control surgical systems
CA2906772C (en) 2013-03-15 2021-09-21 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems and related methods
CA2918531A1 (en) 2013-07-17 2015-01-22 Board Of Regents Of The University Of Nebraska Robotic surgical devices, systems and related methods
MX2016012903A (es) 2014-04-01 2016-12-07 Procter & Gamble Metodos y composiciones para la modificacion de la percepcion sensorial.
EP3868322B1 (en) 2014-09-12 2024-11-20 Board of Regents of the University of Nebraska Quick-release effectors and related systems
US10376322B2 (en) 2014-11-11 2019-08-13 Board Of Regents Of The University Of Nebraska Robotic device with compact joint design and related systems and methods
CN108472030B (zh) 2015-08-03 2021-06-18 内布拉斯加大学董事会 机器人手术装置系统及相关方法
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CA3036897C (en) 2016-10-25 2021-11-16 The Procter & Gamble Company Fibrous structures
US10745864B2 (en) 2016-10-25 2020-08-18 The Procter & Gamble Company Differential pillow height fibrous structures
US11357595B2 (en) 2016-11-22 2022-06-14 Board Of Regents Of The University Of Nebraska Gross positioning device and related systems and methods
CN115553922A (zh) 2016-11-29 2023-01-03 虚拟切割有限公司 具有用户存在检测的用户控制器及相关系统和方法
WO2018112199A1 (en) 2016-12-14 2018-06-21 Virtual Incision Corporation Releasable attachment device for coupling to medical devices and related systems and methods
US11051894B2 (en) 2017-09-27 2021-07-06 Virtual Incision Corporation Robotic surgical devices with tracking camera technology and related systems and methods
CA3087672A1 (en) 2018-01-05 2019-07-11 Board Of Regents Of The University Of Nebraska Single-arm robotic device with compact joint design and related systems and methods
CN121714364A (zh) 2019-01-07 2026-03-24 虚拟切割有限公司 机器人辅助手术系统以及相关装置和方法
CN110045108B (zh) * 2019-05-28 2021-10-29 江南大学 一种基于辣椒碱指标的地沟油酶联免疫检测试剂盒及其检测方法
GB201918103D0 (en) 2019-12-10 2020-01-22 Oblique Therapeutics Ab Epitopes and antibodies
CA3186863A1 (en) 2020-07-06 2022-01-13 Virtual Incision Corporation Surgical robot positioning system and related devices and methods

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5074977A (en) 1987-05-05 1991-12-24 The Washington Technology Center Digital biosensors and method of using same
DE68926118T2 (de) 1988-08-18 1996-08-22 Australian Membrane And Biotechnology Research Institute Ltd. Commonwealth Scientific And Industrial Research Organization, North Ryde, Neusuedwales Verbesserungen an der empfindlichkeit und der selektivität von ionenkanalmembranbiosensoren
WO1990008783A1 (en) 1989-01-27 1990-08-09 Australian Membrane And Biotechnology Research Institute Receptor membranes and ionophore gating
US5491097A (en) 1989-06-15 1996-02-13 Biocircuits Corporation Analyte detection with multilayered bioelectronic conductivity sensors
US5328847A (en) 1990-02-20 1994-07-12 Case George D Thin membrane sensor with biochemical switch
US5232684A (en) * 1990-06-29 1993-08-03 The United States Of America As Represented By The Department Of Health And Human Services Labelled resiniferatoxin, compositions thereof, and methods for using the same
JP4444493B2 (ja) 1997-08-20 2010-03-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア カプサイシン受容体およびカプサイシン受容体関連ポリペプチドをコードする核酸配列ならびにその使用
EP1066381A1 (en) 1998-01-27 2001-01-10 Smithkline Beecham Plc Human vanilloid receptor homologues
EP0943683A1 (en) * 1998-03-10 1999-09-22 Smithkline Beecham Plc Human vanilloid receptor homologue Vanilrep1
EP0953638A1 (en) 1998-03-11 1999-11-03 Synthelabo Human vanilloid receptor-like cation channel
JP2002531069A (ja) 1998-11-13 2002-09-24 ミレニアム・フアーマシユーチカルズ・インコーポレーテツド タンパク質のカプサイシン／バニロイド受容体ファミリーの新規メンバー及びそれらの使用
GB9826359D0 (en) * 1998-12-01 1999-01-27 Glaxo Group Ltd Novel receptors
AU4237400A (en) 1999-04-15 2000-11-02 Ortho-Mcneil Pharmaceutical, Inc. Dna encoding the human vanilloid receptor vr1
WO2001034805A2 (en) 1999-11-12 2001-05-17 Abbott Laboratories Human vanilloid receptor gene
AU2001247460A1 (en) 2000-03-15 2001-09-24 Millennium Pharmaceuticals, Inc. 18615 and 48003, human ion channels and uses therefor
JP3501775B2 (ja) 2000-05-31 2004-03-02 ファイザー株式会社 ヒトバニロイド受容体様タンパク質

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CA2298540A1 (en) 1999-02-25
US7097991B2 (en) 2006-08-29
EP1009804A4 (en) 2001-05-16
US20030049728A1 (en) 2003-03-13
US20050095650A1 (en) 2005-05-05
US6335180B1 (en) 2002-01-01
ATE253111T1 (de) 2003-11-15
DE69819345D1 (de) 2003-12-04
EP1009804B1 (en) 2003-10-29
AU9115698A (en) 1999-03-08
US6790629B2 (en) 2004-09-14
AU742391B2 (en) 2002-01-03
DE69819345T2 (de) 2004-07-15
WO1999009140A1 (en) 1999-02-25
JP2001514879A (ja) 2001-09-18
EP1009804A1 (en) 2000-06-21

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