BRPI0409748A - preparação e purificação de capsaicin sintetico - Google Patents

preparação e purificação de capsaicin sintetico

Info

Publication number
BRPI0409748A
BRPI0409748A BRPI0409748-3A BRPI0409748A BRPI0409748A BR PI0409748 A BRPI0409748 A BR PI0409748A BR PI0409748 A BRPI0409748 A BR PI0409748A BR PI0409748 A BRPI0409748 A BR PI0409748A
Authority
BR
Brazil
Prior art keywords
purification
preparation
capsaicin
trans
synthetic capsaicin
Prior art date
Application number
BRPI0409748-3A
Other languages
English (en)
Inventor
Sharon Mciivain
Wei Chen
Premchandran H Ramiya
Ronald Burch
Richard Carter
Timothy A Anderson
Original Assignee
Algorx Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Algorx Pharmaceuticals Inc filed Critical Algorx Pharmaceuticals Inc
Publication of BRPI0409748A publication Critical patent/BRPI0409748A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/36—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by hydrogenation of carbon-to-carbon unsaturated bonds

Abstract

"PREPARAçãO E PURIFICAçãO DE CAPSAICIN". A presente invenção prove metódos para sintetizar o trans trans isomer do capsaicin e/ou tipos de compostos de capsaicin pelo uso de processos em que a trans geometria é feita pela separação na reação de síntese e levada para o processo completo de síntese
BRPI0409748-3A 2003-04-08 2004-04-08 preparação e purificação de capsaicin sintetico BRPI0409748A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46116403P 2003-04-08 2003-04-08
US53107403P 2003-12-18 2003-12-18
PCT/US2004/010745 WO2004092122A2 (en) 2003-04-08 2004-04-08 Preparation and purification of synthetic capsaicin

Publications (1)

Publication Number Publication Date
BRPI0409748A true BRPI0409748A (pt) 2006-10-24

Family

ID=33303038

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409748-3A BRPI0409748A (pt) 2003-04-08 2004-04-08 preparação e purificação de capsaicin sintetico

Country Status (10)

Country Link
US (2) US20050085652A1 (pt)
EP (1) EP1615880A4 (pt)
JP (1) JP2006522815A (pt)
AU (1) AU2004230915B2 (pt)
BR (1) BRPI0409748A (pt)
CA (1) CA2521925A1 (pt)
EA (1) EA008705B1 (pt)
MX (1) MXPA05010882A (pt)
NZ (1) NZ542887A (pt)
WO (1) WO2004092122A2 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040156931A1 (en) * 2002-12-18 2004-08-12 Algorx Administration of capsaicinoids
CA2510181C (en) * 2002-12-18 2011-03-08 Algorx Pharmaceuticals, Inc. Administration of capsaicinoids
WO2004092122A2 (en) * 2003-04-08 2004-10-28 Algorx Pharmaceuticals, Inc. Preparation and purification of synthetic capsaicin
ES2535045T3 (es) 2003-04-10 2015-05-04 Vanderbilt Royalty Sub L.P. Usos y composiciones para administración de capsaicina
CA2596194A1 (en) * 2004-11-24 2006-06-01 Algorx Pharmaceuticals, Inc. Capsaicinoid gel formulation and uses thereof
CN100410235C (zh) * 2006-06-15 2008-08-13 山东省科学院生物研究所 辣椒碱的化学合成与纯化方法
ITMI20071603A1 (it) * 2007-08-03 2009-02-04 Acraf Trazodone e trazodone cloridrato in forma purificata
WO2011007179A1 (en) * 2009-07-16 2011-01-20 Brightwake Limited Method
US20120027693A1 (en) 2010-07-27 2012-02-02 Bean Bruce P Methods and compositions for preventing and relieving muscle cramps and for recovery from neuromuscular irritability and fatigue following exercise
MX362804B (es) 2012-11-12 2019-02-14 Vizuri Health Sciences Llc Composiciones acuosas de capsaicinoides que comprenden un analgésico y un vehículo acuoso, y uso de las mismas para el tratamiento del dolor.
US20150133561A1 (en) 2013-11-12 2015-05-14 Vizuri Health Sciences Llc Aqueous based capsaicinoid formulations and methods of manufacture and use
EP3570861A4 (en) 2017-01-23 2020-11-18 Flex Pharma, Inc. COMPOSITIONS AND PROCEDURES EFFECTING SPORTING PERFORMANCE
CN110453311A (zh) * 2019-09-23 2019-11-15 浙江理工大学 一种温感壳聚糖纤维及其制备方法
NO345530B1 (en) * 2020-03-20 2021-03-29 Axichem As Synthesis of capsaicin derivatives
CN115850108A (zh) * 2022-12-14 2023-03-28 中国烟草总公司郑州烟草研究院 17-羟基辣椒素及其标记物的合成方法

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Also Published As

Publication number Publication date
CA2521925A1 (en) 2004-10-28
JP2006522815A (ja) 2006-10-05
AU2004230915A1 (en) 2004-10-28
EA008705B1 (ru) 2007-06-29
EP1615880A2 (en) 2006-01-18
WO2004092122A3 (en) 2005-12-29
EA200501582A1 (ru) 2006-06-30
US20070293703A1 (en) 2007-12-20
NZ542887A (en) 2008-05-30
EP1615880A4 (en) 2007-03-07
AU2004230915B2 (en) 2008-08-07
MXPA05010882A (es) 2005-11-25
US20050085652A1 (en) 2005-04-21
WO2004092122A2 (en) 2004-10-28

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B04C Request for examination: application reinstated [chapter 4.3 patent gazette]
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