MX362804B - Composiciones acuosas de capsaicinoides que comprenden un analgésico y un vehículo acuoso, y uso de las mismas para el tratamiento del dolor. - Google Patents
Composiciones acuosas de capsaicinoides que comprenden un analgésico y un vehículo acuoso, y uso de las mismas para el tratamiento del dolor.Info
- Publication number
- MX362804B MX362804B MX2015005879A MX2015005879A MX362804B MX 362804 B MX362804 B MX 362804B MX 2015005879 A MX2015005879 A MX 2015005879A MX 2015005879 A MX2015005879 A MX 2015005879A MX 362804 B MX362804 B MX 362804B
- Authority
- MX
- Mexico
- Prior art keywords
- capsaicinoid
- formulations
- treatment
- corticosteroid
- administration
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/738—Cross-linked polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
Abstract
En este documento se dan a conocer formulaciones de capsaicinoides y métodos de tratamiento los cuales se pueden utilizar para tratar/atenuar el dolor en mamíferos. Típicamente, la administración es por vía de una inyección en un sitio discreto para proporcionar alivio al dolor durante un período de tiempo prolongado. Las formulaciones se administran en un vehículo farmacéuticamente aceptable. Las formulaciones incluyen un agente analgésico en una cantidad suficiente para atenuar los efectos de quemadura e hiperalgésicos de la administración de capsaicinoides. La invención también incluye un método para tratar el dolor por medio de la administración de un corticosteroide seguido por la administración de un capsaicinoide.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261725161P | 2012-11-12 | 2012-11-12 | |
PCT/US2013/069711 WO2014075084A2 (en) | 2012-11-12 | 2013-11-12 | Aqueous based capsaicinoid formulations and methods of manufacture and use |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015005879A MX2015005879A (es) | 2016-02-05 |
MX362804B true MX362804B (es) | 2019-02-14 |
Family
ID=49880927
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015005879A MX362804B (es) | 2012-11-12 | 2013-11-12 | Composiciones acuosas de capsaicinoides que comprenden un analgésico y un vehículo acuoso, y uso de las mismas para el tratamiento del dolor. |
MX2018013715A MX2018013715A (es) | 2012-11-12 | 2015-05-11 | Composiciones acuosas de capsaicinoides que comprenden un analgesico y un vehiculo acuoso, y uso de las mismas para el tratamiento del dolor. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018013715A MX2018013715A (es) | 2012-11-12 | 2015-05-11 | Composiciones acuosas de capsaicinoides que comprenden un analgesico y un vehiculo acuoso, y uso de las mismas para el tratamiento del dolor. |
Country Status (9)
Country | Link |
---|---|
US (2) | US20140142073A1 (es) |
EP (2) | EP2916817B1 (es) |
JP (1) | JP6695140B2 (es) |
KR (2) | KR20150084996A (es) |
CN (1) | CN105101949A (es) |
AU (1) | AU2013341380B2 (es) |
CA (1) | CA2891218A1 (es) |
MX (2) | MX362804B (es) |
WO (1) | WO2014075084A2 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150133561A1 (en) * | 2013-11-12 | 2015-05-14 | Vizuri Health Sciences Llc | Aqueous based capsaicinoid formulations and methods of manufacture and use |
KR102073258B1 (ko) | 2014-04-15 | 2020-02-04 | 비쭈리 헬스 사이언스 엘엘씨 | 통증 완화용 국소 조성물, 제조방법 및 용도 |
JP6948762B2 (ja) * | 2015-10-16 | 2021-10-13 | 株式会社マンダム | Trpv1活性抑制剤作用増幅用組成物 |
WO2017127628A1 (en) * | 2016-01-22 | 2017-07-27 | Centrexion Therapeutics Corporation | Capsaicn sequential dosing method for treatment of morton's neuroma pain |
US11000490B2 (en) * | 2016-11-02 | 2021-05-11 | Centrexion Therapeutics Corporation | Stable aqueous capsaicin injectable formulations and medical uses thereof |
CN111201015A (zh) | 2017-07-20 | 2020-05-26 | 中枢疗法公司 | 使用辣椒素治疗疼痛的方法和组合物 |
WO2020041658A1 (en) * | 2018-08-24 | 2020-02-27 | Centrexion Therapeutics Corporation | Capsaicin sequential dosing method for treatment of knee joint pain |
CN112691091A (zh) * | 2021-01-09 | 2021-04-23 | 胡宝贤 | 低浓度石炭酸的新应用 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4599342A (en) * | 1984-01-16 | 1986-07-08 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
US4702916A (en) * | 1985-12-03 | 1987-10-27 | Warner-Lambert Company | Analgesic stick compositions |
JPS63130540A (ja) * | 1986-11-18 | 1988-06-02 | Sunstar Inc | 鎮痛用組成物 |
JPH0621063B2 (ja) * | 1986-12-06 | 1994-03-23 | サンスタ−株式会社 | 歯科用鎮痛剤組成物 |
ES2179473T5 (es) | 1997-03-13 | 2006-03-01 | James N. Campbell | Composiciones que contienen capsaicina o analogos de capsaicina y un anestesico local. |
JP3022541B1 (ja) * | 1999-01-11 | 2000-03-21 | 株式会社ヘルスサイエンスセンター | 外用剤 |
US6573302B1 (en) * | 1999-09-29 | 2003-06-03 | Medical Merchandising, Inc. | Cream utilizing capsaicin |
US6579543B1 (en) * | 2002-02-22 | 2003-06-17 | Jackie H. McClung | Composition for topical application to skin |
US20040156931A1 (en) | 2002-12-18 | 2004-08-12 | Algorx | Administration of capsaicinoids |
CA2510181C (en) | 2002-12-18 | 2011-03-08 | Algorx Pharmaceuticals, Inc. | Administration of capsaicinoids |
WO2004092122A2 (en) | 2003-04-08 | 2004-10-28 | Algorx Pharmaceuticals, Inc. | Preparation and purification of synthetic capsaicin |
JP5148271B2 (ja) | 2004-06-02 | 2013-02-20 | ニューロジズエックス,インコーポレーテッド | 疼痛処置のためのカプサイシノイド、局所麻酔薬および/または鎮痒薬を含有する処方物 |
JP2006298944A (ja) * | 2004-11-05 | 2006-11-02 | Maruishi Pharmaceutical Co Ltd | インスリン様成長因子−1分泌促進剤 |
CA2596194A1 (en) * | 2004-11-24 | 2006-06-01 | Algorx Pharmaceuticals, Inc. | Capsaicinoid gel formulation and uses thereof |
US20100047181A1 (en) * | 2004-12-22 | 2010-02-25 | Mestex Ag | Mixture of a vanilloid receptor agonist and a substance inhibiting nerve regeneration, use thereof for producing a painkiller, and method for applying said painkiller |
DK1830835T3 (da) | 2004-12-28 | 2012-07-02 | Mestex Ag | Anvendelse af en vanilloid receptorantagonist sammen med et glycosaminoglycan eller proteoglycan til fremstilling af et middel til behandling af smerter |
US20070098660A1 (en) * | 2005-10-27 | 2007-05-03 | Jim Taneri | Methods and compositions for epilation |
US8623335B2 (en) * | 2007-09-10 | 2014-01-07 | Tauna Ann Waddington | Scar and rosacea and other skin care treatment composition and method |
US8158682B2 (en) | 2008-09-12 | 2012-04-17 | Vallinex, Inc. | Instillation administration of capsaicinoids for the treatment of pain |
US8637569B2 (en) | 2009-10-22 | 2014-01-28 | Api Genesis, Llc | Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds |
CA2792729C (en) * | 2010-03-12 | 2016-06-28 | Allergan Industrie, Sas | Fluid compositions for improving skin conditions |
BR112013010958A8 (pt) * | 2010-10-22 | 2017-10-03 | Api Genesis Llc | Métodos para elevar a solubilidade de compostos pouco solúveis e métodos para fabricação e para uso de formulações de tais compostos |
JP6228540B2 (ja) | 2011-09-09 | 2017-11-08 | ヴィズリ・ヘルス・サイエンスィズ・エルエルシー | Trpv1選択的アゴニストを含む疼痛軽減組成物、ならびにその製造および使用 |
-
2013
- 2013-11-12 MX MX2015005879A patent/MX362804B/es active IP Right Grant
- 2013-11-12 WO PCT/US2013/069711 patent/WO2014075084A2/en active Application Filing
- 2013-11-12 CN CN201380070214.XA patent/CN105101949A/zh active Pending
- 2013-11-12 AU AU2013341380A patent/AU2013341380B2/en not_active Ceased
- 2013-11-12 KR KR1020157015545A patent/KR20150084996A/ko not_active IP Right Cessation
- 2013-11-12 JP JP2015542018A patent/JP6695140B2/ja not_active Expired - Fee Related
- 2013-11-12 CA CA2891218A patent/CA2891218A1/en not_active Abandoned
- 2013-11-12 US US14/078,253 patent/US20140142073A1/en not_active Abandoned
- 2013-11-12 EP EP13812219.7A patent/EP2916817B1/en not_active Not-in-force
- 2013-11-12 KR KR1020207028806A patent/KR20200119351A/ko not_active Application Discontinuation
- 2013-11-12 EP EP18182795.7A patent/EP3446680A1/en not_active Withdrawn
-
2015
- 2015-05-11 MX MX2018013715A patent/MX2018013715A/es unknown
-
2018
- 2018-07-26 US US16/045,782 patent/US20190022110A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20200119351A (ko) | 2020-10-19 |
MX2018013715A (es) | 2019-07-29 |
WO2014075084A2 (en) | 2014-05-15 |
WO2014075084A3 (en) | 2014-07-10 |
EP2916817A2 (en) | 2015-09-16 |
MX2015005879A (es) | 2016-02-05 |
JP6695140B2 (ja) | 2020-05-20 |
EP2916817B1 (en) | 2018-09-12 |
EP3446680A1 (en) | 2019-02-27 |
CA2891218A1 (en) | 2014-05-15 |
AU2013341380A2 (en) | 2015-10-22 |
US20190022110A1 (en) | 2019-01-24 |
AU2013341380B2 (en) | 2018-04-26 |
US20140142073A1 (en) | 2014-05-22 |
JP2015536998A (ja) | 2015-12-24 |
KR20150084996A (ko) | 2015-07-22 |
AU2013341380A1 (en) | 2014-05-15 |
CN105101949A (zh) | 2015-11-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HC | Change of company name or juridical status |
Owner name: MICROSOFT TECHNOLOGY LICENSING, LLC |
|
FG | Grant or registration |