MX2018013715A - Composiciones acuosas de capsaicinoides que comprenden un analgesico y un vehiculo acuoso, y uso de las mismas para el tratamiento del dolor. - Google Patents
Composiciones acuosas de capsaicinoides que comprenden un analgesico y un vehiculo acuoso, y uso de las mismas para el tratamiento del dolor.Info
- Publication number
- MX2018013715A MX2018013715A MX2018013715A MX2018013715A MX2018013715A MX 2018013715 A MX2018013715 A MX 2018013715A MX 2018013715 A MX2018013715 A MX 2018013715A MX 2018013715 A MX2018013715 A MX 2018013715A MX 2018013715 A MX2018013715 A MX 2018013715A
- Authority
- MX
- Mexico
- Prior art keywords
- capsaicinoid
- formulations
- treatment
- corticosteroid
- administration
- Prior art date
Links
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 title abstract 4
- 238000009472 formulation Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 239000003246 corticosteroid Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000000917 hyperalgesic effect Effects 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/738—Cross-linked polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
En este documento se dan a conocer formulaciones de capsaicinoides y métodos de tratamiento los cuales se pueden utilizar para tratar/atenuar el dolor en mamíferos. Típicamente, la administración es por vía de una inyección en un sitio discreto para proporcionar alivio al dolor durante un período de tiempo prolongado. Las formulaciones se administran en un vehículo farmacéuticamente aceptable. Las formulaciones incluyen un agente analgésico en una cantidad suficiente para atenuar los efectos de quemadura e hiperalgésicos de la administración de capsaicinoides. La invención también incluye un método para tratar el dolor por medio de la administración de un corticosteroide seguido por la administración de un capsaicinoide.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261725161P | 2012-11-12 | 2012-11-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018013715A true MX2018013715A (es) | 2019-07-29 |
Family
ID=49880927
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015005879A MX362804B (es) | 2012-11-12 | 2013-11-12 | Composiciones acuosas de capsaicinoides que comprenden un analgésico y un vehículo acuoso, y uso de las mismas para el tratamiento del dolor. |
MX2018013715A MX2018013715A (es) | 2012-11-12 | 2015-05-11 | Composiciones acuosas de capsaicinoides que comprenden un analgesico y un vehiculo acuoso, y uso de las mismas para el tratamiento del dolor. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015005879A MX362804B (es) | 2012-11-12 | 2013-11-12 | Composiciones acuosas de capsaicinoides que comprenden un analgésico y un vehículo acuoso, y uso de las mismas para el tratamiento del dolor. |
Country Status (9)
Country | Link |
---|---|
US (2) | US20140142073A1 (es) |
EP (2) | EP2916817B1 (es) |
JP (1) | JP6695140B2 (es) |
KR (2) | KR20150084996A (es) |
CN (1) | CN105101949A (es) |
AU (1) | AU2013341380B2 (es) |
CA (1) | CA2891218A1 (es) |
MX (2) | MX362804B (es) |
WO (1) | WO2014075084A2 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150133561A1 (en) * | 2013-11-12 | 2015-05-14 | Vizuri Health Sciences Llc | Aqueous based capsaicinoid formulations and methods of manufacture and use |
KR102073258B1 (ko) | 2014-04-15 | 2020-02-04 | 비쭈리 헬스 사이언스 엘엘씨 | 통증 완화용 국소 조성물, 제조방법 및 용도 |
JP6948762B2 (ja) * | 2015-10-16 | 2021-10-13 | 株式会社マンダム | Trpv1活性抑制剤作用増幅用組成物 |
AU2017210315A1 (en) * | 2016-01-22 | 2018-08-16 | Centrexion Therapeutics Corporation | Capsaicin sequential dosing method for treatment of morton's neuroma pain |
CN110035740B (zh) * | 2016-11-02 | 2023-08-04 | 中枢疗法公司 | 稳定的水性辣椒素可注射制剂及其医学用途 |
CN111201015A (zh) * | 2017-07-20 | 2020-05-26 | 中枢疗法公司 | 使用辣椒素治疗疼痛的方法和组合物 |
EP3697402A1 (en) * | 2017-10-20 | 2020-08-26 | aXichem AB | Synthetic capsaicin analogues as bioenhancers |
CA3109932A1 (en) * | 2018-08-24 | 2020-02-27 | Centrexion Therapeutics Corporation | Capsaicin sequential dosing method for treatment of knee joint pain |
CN112691091A (zh) * | 2021-01-09 | 2021-04-23 | 胡宝贤 | 低浓度石炭酸的新应用 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4599342A (en) * | 1984-01-16 | 1986-07-08 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
US4702916A (en) * | 1985-12-03 | 1987-10-27 | Warner-Lambert Company | Analgesic stick compositions |
JPS63130540A (ja) * | 1986-11-18 | 1988-06-02 | Sunstar Inc | 鎮痛用組成物 |
JPH0621063B2 (ja) * | 1986-12-06 | 1994-03-23 | サンスタ−株式会社 | 歯科用鎮痛剤組成物 |
JP2001515492A (ja) | 1997-03-13 | 2001-09-18 | エヌ. キャンベル,ジェイムズ | カプサイシンまたはカプサイシンアナログを含有する組成物および局所麻酔 |
JP3022541B1 (ja) * | 1999-01-11 | 2000-03-21 | 株式会社ヘルスサイエンスセンター | 外用剤 |
US6573302B1 (en) * | 1999-09-29 | 2003-06-03 | Medical Merchandising, Inc. | Cream utilizing capsaicin |
US6579543B1 (en) * | 2002-02-22 | 2003-06-17 | Jackie H. McClung | Composition for topical application to skin |
US20040161481A1 (en) | 2002-12-18 | 2004-08-19 | Algorx | Administration of capsaicinoids |
PT1605956E (pt) | 2002-12-18 | 2016-03-09 | Centrexion Therapeutics Corp | Administração de capsaicinóides para o tratamento da osteoartrite |
EA008705B1 (ru) | 2003-04-08 | 2007-06-29 | Алгоркс Фармасьютикалз, Инк. | Получение и очистка синтетического капсаицина |
EP1763370B1 (en) | 2004-06-02 | 2015-04-29 | NeurogesX Inc. | Formulations comprising capsaicin, a local anesthetic and/or an antipruritic agent for the treatment of pain |
JP2006298944A (ja) * | 2004-11-05 | 2006-11-02 | Maruishi Pharmaceutical Co Ltd | インスリン様成長因子−1分泌促進剤 |
US20060148903A1 (en) | 2004-11-24 | 2006-07-06 | Algorx Pharmaceuticals, Inc. | Capsaicinoid gel formulation and uses thereof |
ES2355109T3 (es) * | 2004-12-22 | 2011-03-22 | Mestex Ag | Mezcla de un agonista de receptor de vainilloide con una sustancia inhibidora de la regeneración nerviosa, su utilización para la fabricación de un analgésico y procedimiento de aplicación de este fármaco. |
US8703741B2 (en) | 2004-12-28 | 2014-04-22 | Mestex Ag | Method of treating articular pain using a vanilloid receptor agonist together with a glycosaminoglycan or proteoglycan |
US20070098660A1 (en) * | 2005-10-27 | 2007-05-03 | Jim Taneri | Methods and compositions for epilation |
US8623335B2 (en) * | 2007-09-10 | 2014-01-07 | Tauna Ann Waddington | Scar and rosacea and other skin care treatment composition and method |
US8158682B2 (en) | 2008-09-12 | 2012-04-17 | Vallinex, Inc. | Instillation administration of capsaicinoids for the treatment of pain |
US8637569B2 (en) | 2009-10-22 | 2014-01-28 | Api Genesis, Llc | Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds |
NZ602405A (en) * | 2010-03-12 | 2014-12-24 | Allergan Ind Sas | A fluid composition comprising a hyaluronan polymer and mannitol for improving skin conditions |
JP6105475B2 (ja) * | 2010-10-22 | 2017-03-29 | ヴィズリ・ヘルス・サイエンスィズ・エルエルシー | 可溶性の乏しい化合物の可溶性を増大させる方法ならびにそのような化合物の配合物を作る、および用いる方法 |
KR101769010B1 (ko) | 2011-09-09 | 2017-08-17 | 비쭈리 헬스 사이언스 엘엘씨 | Trpv1 선택적 작용제를 포함하는 통증 완화 조성물, 및 이의 제조방법 및 용도 |
-
2013
- 2013-11-12 CN CN201380070214.XA patent/CN105101949A/zh active Pending
- 2013-11-12 KR KR1020157015545A patent/KR20150084996A/ko not_active IP Right Cessation
- 2013-11-12 WO PCT/US2013/069711 patent/WO2014075084A2/en active Application Filing
- 2013-11-12 EP EP13812219.7A patent/EP2916817B1/en not_active Not-in-force
- 2013-11-12 AU AU2013341380A patent/AU2013341380B2/en not_active Ceased
- 2013-11-12 US US14/078,253 patent/US20140142073A1/en not_active Abandoned
- 2013-11-12 KR KR1020207028806A patent/KR20200119351A/ko not_active Application Discontinuation
- 2013-11-12 JP JP2015542018A patent/JP6695140B2/ja not_active Expired - Fee Related
- 2013-11-12 EP EP18182795.7A patent/EP3446680A1/en not_active Withdrawn
- 2013-11-12 CA CA2891218A patent/CA2891218A1/en not_active Abandoned
- 2013-11-12 MX MX2015005879A patent/MX362804B/es active IP Right Grant
-
2015
- 2015-05-11 MX MX2018013715A patent/MX2018013715A/es unknown
-
2018
- 2018-07-26 US US16/045,782 patent/US20190022110A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MX2015005879A (es) | 2016-02-05 |
EP2916817A2 (en) | 2015-09-16 |
JP6695140B2 (ja) | 2020-05-20 |
KR20200119351A (ko) | 2020-10-19 |
MX362804B (es) | 2019-02-14 |
JP2015536998A (ja) | 2015-12-24 |
AU2013341380B2 (en) | 2018-04-26 |
EP3446680A1 (en) | 2019-02-27 |
CN105101949A (zh) | 2015-11-25 |
CA2891218A1 (en) | 2014-05-15 |
EP2916817B1 (en) | 2018-09-12 |
WO2014075084A2 (en) | 2014-05-15 |
WO2014075084A3 (en) | 2014-07-10 |
US20140142073A1 (en) | 2014-05-22 |
AU2013341380A1 (en) | 2014-05-15 |
US20190022110A1 (en) | 2019-01-24 |
KR20150084996A (ko) | 2015-07-22 |
AU2013341380A2 (en) | 2015-10-22 |
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