MX367070B - Sistemas de administracion de farmaco y metodos para el tratamiento de la prostata. - Google Patents
Sistemas de administracion de farmaco y metodos para el tratamiento de la prostata.Info
- Publication number
- MX367070B MX367070B MX2015002452A MX2015002452A MX367070B MX 367070 B MX367070 B MX 367070B MX 2015002452 A MX2015002452 A MX 2015002452A MX 2015002452 A MX2015002452 A MX 2015002452A MX 367070 B MX367070 B MX 367070B
- Authority
- MX
- Mexico
- Prior art keywords
- gemicitabine
- bladder
- treatment
- methods
- drug delivery
- Prior art date
Links
- 238000012377 drug delivery Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 208000017497 prostate disease Diseases 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract 4
- 229940079593 drug Drugs 0.000 abstract 3
- 210000002700 urine Anatomy 0.000 abstract 2
- 210000002307 prostate Anatomy 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/04—General characteristics of the apparatus implanted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1078—Urinary tract
- A61M2210/1085—Bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/16—Male reproductive, genital organs
- A61M2210/166—Prostate
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nanotechnology (AREA)
- External Artificial Organs (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Abstract
Se proporcionan métodos, dispositivos y medicamentos que incluyen un fármaco, para su uso en el tratamiento de la próstata mediante la administración local del fármaco en la vejiga de un paciente para lograr una concentración sostenida del fármaco en la orina en la vejiga, suficiente para producir una concentración terapéutica del fármaco en la próstata. El fármaco se puede administrar a la vejiga desde un dispositivo de administración de fármaco intravesical insertado en la vejiga, donde el dispositivo libera el fármaco de forma continua en la orina en la vejiga durante un período prolongado de horas o días.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261696029P | 2012-08-31 | 2012-08-31 | |
| PCT/US2013/057841 WO2014036556A2 (en) | 2012-08-31 | 2013-09-03 | Drug delivery systems and methods for treatment of prostate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015002452A MX2015002452A (es) | 2015-06-05 |
| MX367070B true MX367070B (es) | 2019-08-05 |
Family
ID=49162284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015002452A MX367070B (es) | 2012-08-31 | 2013-09-03 | Sistemas de administracion de farmaco y metodos para el tratamiento de la prostata. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9636488B2 (es) |
| EP (1) | EP2890386A2 (es) |
| JP (1) | JP6309009B2 (es) |
| KR (2) | KR20150043508A (es) |
| CN (2) | CN112516154A (es) |
| AU (1) | AU2013308465B2 (es) |
| BR (1) | BR112015004110A2 (es) |
| CA (1) | CA2882575C (es) |
| IL (1) | IL237300B (es) |
| IN (1) | IN2015DN01560A (es) |
| MX (1) | MX367070B (es) |
| RU (1) | RU2678308C2 (es) |
| SG (1) | SG11201501483XA (es) |
| WO (1) | WO2014036556A2 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20211921T1 (hr) | 2012-08-31 | 2022-03-04 | Taris Biomedical Llc | Sustavi isporuke lijeka i postupci za liječenje raka mokraćnog mjehura s oksaliplatinom |
| CA2882575C (en) | 2012-08-31 | 2020-05-26 | Dennis GIESING | Drug delivery systems and methods for treatment of prostate |
| LT3035991T (lt) | 2013-08-19 | 2020-11-10 | Taris Biomedical Llc | Daugiablokiai vaistų vartojimo įtaisai |
| PT3113782T (pt) * | 2014-03-06 | 2023-01-05 | Taris Biomedical Llc | Sistemas e métodos de administração de fármaco para tratamento do cancro da bexiga com gemcitabina |
| US10675289B2 (en) * | 2014-10-02 | 2020-06-09 | University Of Maryland, Baltimore | Methods of treating pancreatic cancer |
| SG10201913416PA (en) | 2016-05-06 | 2020-03-30 | Taris Biomedical Llc | Method of treating lower tract urothelial cancer |
| SG10201913998YA (en) | 2017-07-25 | 2020-03-30 | Taris Biomedical Llc | Methods of treating tumor metastasis |
| CN111787926A (zh) | 2017-11-08 | 2020-10-16 | 塔里斯生物医药公司 | 使用吉西他滨对膀胱癌进行治疗和维持疗法的方法 |
| JP2021532155A (ja) | 2018-08-01 | 2021-11-25 | タリス バイオメディカル エルエルシー | トロスピウムを使用した過活動膀胱の治療方法 |
| US20220107320A1 (en) | 2019-02-15 | 2022-04-07 | Incelldx, Inc. | Assaying Bladder-Associated Samples, Identifying and Treating Bladder-Associated Neoplasia, and Kits for Use Therein |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6171298B1 (en) | 1996-05-03 | 2001-01-09 | Situs Corporation | Intravesical infuser |
| JP2006506385A (ja) | 2002-10-22 | 2006-02-23 | ザ バイオメリックス コーポレーション | 治療剤を小嚢内デリバリーするための方法およびシステム |
| US8361490B2 (en) | 2004-09-16 | 2013-01-29 | Theracoat Ltd. | Biocompatible drug delivery apparatus and methods |
| DE102005020314A1 (de) * | 2005-05-02 | 2006-11-09 | Infineon Technologies Ag | Spannungsversorgungsanordnung zur Versorgung einer ersten elektrischen Last und Verfahren zum Bereitstellen einer elektrischen Leistung |
| EP1933810B1 (en) | 2005-08-11 | 2012-10-10 | Massachusetts Institute of Technology | Intravesical drug delivery device and method |
| CA2649877A1 (en) | 2006-04-24 | 2007-12-21 | Gloucester Pharmaceuticals | Gemcitabine combination therapy |
| EP1913962A1 (en) * | 2006-10-22 | 2008-04-23 | Ophir Perelson | Expandable medical device for the treatment and prevention of cardiovascular diseases |
| CN101616671A (zh) * | 2007-01-19 | 2009-12-30 | 卫材R&D管理有限公司 | 胰腺癌治疗用组合物 |
| JP5560200B2 (ja) | 2007-12-11 | 2014-07-23 | マサチューセッツ インスチテュート オブ テクノロジー | 膀胱および他の身体の小嚢又は管腔を治療するための埋め込み型薬物供給デバイス |
| JP5538359B2 (ja) | 2008-04-04 | 2014-07-02 | リペラ ファーマシューティカルズ, インコーポレイテッド | リポソームボツリヌス毒素を使用する膀胱機能障害の治療 |
| WO2010009335A1 (en) * | 2008-07-17 | 2010-01-21 | Micell Technologies, Inc. | Drug delivery medical device |
| CN102176931B (zh) | 2008-08-09 | 2015-03-04 | 麻省理工学院 | 治疗男性泌尿生殖组织和外周组织的可植入药物递送设备和方法 |
| ES2401008T3 (es) | 2009-06-26 | 2013-04-16 | Taris Biomedical, Inc. | Comprimidos farmacéuticos sólidos para dispositivos implantables para la administración de fármacos |
| US8721621B2 (en) | 2009-09-10 | 2014-05-13 | Taris Biomedical, Inc. | Systems and methods for deploying devices to genitourinary sites |
| US9017312B2 (en) | 2009-09-10 | 2015-04-28 | Taris Biomedical Llc | Implantable device for controlled drug delivery |
| SI2512581T1 (sl) | 2009-12-17 | 2021-09-30 | Taris Biomedical Llc | Vsadljiva naprava z intravezikalno sprejemljivostjo |
| DK2525777T3 (da) | 2010-01-20 | 2019-07-01 | Urogen Pharma Ltd | Materiale og fremgangsmåde til at behandle interne hulrum |
| US20110218488A1 (en) | 2010-03-05 | 2011-09-08 | Taris Biomedical, Inc. | Systems and Methods for Implanting Devices in the Bladder and Other Genitourinary Sites |
| EP3795121A1 (en) | 2010-08-05 | 2021-03-24 | TARIS Biomedical LLC | Ureteral stent drug delivery device |
| US9457176B2 (en) | 2010-10-06 | 2016-10-04 | Taris Biomedical Llc | Implantable drug delivery device with bladder retention feature |
| WO2012048114A1 (en) | 2010-10-06 | 2012-04-12 | Taris Biomedical, Inc. | Time-selective bioresorbable or collapsible drug delivery systems and methods |
| US8979797B2 (en) | 2010-12-16 | 2015-03-17 | Ams Research Corporation | High pressure delivery system and method for treating pelvic disorder using large molecule therapeutics |
| SG191893A1 (en) | 2011-01-10 | 2013-08-30 | Taris Biomedical Inc | Lidocaine regimen for the use of sustained treatment of bladder pain and irritative voiding |
| RU2598057C2 (ru) * | 2011-02-04 | 2016-09-20 | ТАРИС Биомедикал ЛЛК | Имплантируемое устройство для контролируемого высвобождения лекарственного средства с низкой растворимостью |
| US20150005595A1 (en) | 2011-12-30 | 2015-01-01 | Kibur Medical, Inc. | Implantable devices and methods for evaluation of active agents |
| WO2013170069A1 (en) | 2012-05-09 | 2013-11-14 | Massachusetts Institute Of Technology | Medicament, method, and drug delivery device for treatment of ovarian cancer |
| CA2882575C (en) | 2012-08-31 | 2020-05-26 | Dennis GIESING | Drug delivery systems and methods for treatment of prostate |
| HRP20211921T1 (hr) | 2012-08-31 | 2022-03-04 | Taris Biomedical Llc | Sustavi isporuke lijeka i postupci za liječenje raka mokraćnog mjehura s oksaliplatinom |
| AU2013318146B2 (en) | 2012-09-18 | 2018-05-10 | Taris Biomedical Llc | Drug delivery systems and methods for treatment of bladder voiding dysfunction|and other lower urinary tract disorders by using trospium |
| SG11201507294WA (en) | 2013-03-15 | 2015-10-29 | Taris Biomedical Llc | Drug delivery devices with drug-permeable component and methods |
| EP2968120B1 (en) | 2013-03-15 | 2026-01-14 | TARIS Biomedical LLC | Drug delivery devices and methods for drug delivery |
| JP6431528B2 (ja) | 2013-04-10 | 2018-11-28 | マサチューセッツ インスチテュート オブ テクノロジーMassachusetts Institute Of Technology | 癌治療のための薬物局所送達装置及び方法 |
| LT3035991T (lt) | 2013-08-19 | 2020-11-10 | Taris Biomedical Llc | Daugiablokiai vaistų vartojimo įtaisai |
| PT3113782T (pt) | 2014-03-06 | 2023-01-05 | Taris Biomedical Llc | Sistemas e métodos de administração de fármaco para tratamento do cancro da bexiga com gemcitabina |
-
2013
- 2013-09-03 CA CA2882575A patent/CA2882575C/en active Active
- 2013-09-03 CN CN202011468367.8A patent/CN112516154A/zh active Pending
- 2013-09-03 KR KR20157007350A patent/KR20150043508A/ko not_active Ceased
- 2013-09-03 BR BR112015004110A patent/BR112015004110A2/pt not_active Application Discontinuation
- 2013-09-03 MX MX2015002452A patent/MX367070B/es active IP Right Grant
- 2013-09-03 KR KR1020207029566A patent/KR102383496B1/ko not_active Expired - Fee Related
- 2013-09-03 AU AU2013308465A patent/AU2013308465B2/en not_active Ceased
- 2013-09-03 JP JP2015530139A patent/JP6309009B2/ja not_active Expired - Fee Related
- 2013-09-03 EP EP13760226.4A patent/EP2890386A2/en not_active Withdrawn
- 2013-09-03 RU RU2015109298A patent/RU2678308C2/ru active
- 2013-09-03 CN CN201380044809.8A patent/CN104812395A/zh active Pending
- 2013-09-03 WO PCT/US2013/057841 patent/WO2014036556A2/en not_active Ceased
- 2013-09-03 SG SG11201501483XA patent/SG11201501483XA/en unknown
-
2015
- 2015-02-18 IL IL237300A patent/IL237300B/en active IP Right Grant
- 2015-02-23 US US14/628,874 patent/US9636488B2/en not_active Expired - Fee Related
- 2015-02-25 IN IN1560DEN2015 patent/IN2015DN01560A/en unknown
-
2017
- 2017-03-29 US US15/473,437 patent/US10406335B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2015109298A (ru) | 2016-10-20 |
| WO2014036556A3 (en) | 2014-04-17 |
| IL237300B (en) | 2020-02-27 |
| US20170203085A1 (en) | 2017-07-20 |
| KR20150043508A (ko) | 2015-04-22 |
| US10406335B2 (en) | 2019-09-10 |
| US9636488B2 (en) | 2017-05-02 |
| AU2013308465A1 (en) | 2015-03-05 |
| RU2678308C2 (ru) | 2019-01-25 |
| IL237300A0 (en) | 2015-04-30 |
| JP6309009B2 (ja) | 2018-04-11 |
| EP2890386A2 (en) | 2015-07-08 |
| WO2014036556A2 (en) | 2014-03-06 |
| AU2013308465B2 (en) | 2018-05-17 |
| KR20200120774A (ko) | 2020-10-21 |
| BR112015004110A2 (pt) | 2017-07-04 |
| CA2882575C (en) | 2020-05-26 |
| US20150165177A1 (en) | 2015-06-18 |
| JP2015528469A (ja) | 2015-09-28 |
| CN104812395A (zh) | 2015-07-29 |
| CA2882575A1 (en) | 2014-03-06 |
| IN2015DN01560A (es) | 2015-07-03 |
| SG11201501483XA (en) | 2015-03-30 |
| MX2015002452A (es) | 2015-06-05 |
| KR102383496B1 (ko) | 2022-04-08 |
| CN112516154A (zh) | 2021-03-19 |
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