JP4443763B2 - 環式ジペプチドおよびアゼチジノン並びにcns損傷および神経変性疾患の治療におけるそれらの使用 - Google Patents

環式ジペプチドおよびアゼチジノン並びにcns損傷および神経変性疾患の治療におけるそれらの使用 Download PDF

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JP4443763B2
JP4443763B2 JP2000531182A JP2000531182A JP4443763B2 JP 4443763 B2 JP4443763 B2 JP 4443763B2 JP 2000531182 A JP2000531182 A JP 2000531182A JP 2000531182 A JP2000531182 A JP 2000531182A JP 4443763 B2 JP4443763 B2 JP 4443763B2
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JP2003525850A5 (enExample
JP2003525850A (ja
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コジコウスキ,アラン,ピー.
フェイデン,アラン,アイ.
アラルディ,ギアン,ルーカ
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Georgetown University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2000531182A 1998-02-11 1999-02-10 環式ジペプチドおよびアゼチジノン並びにcns損傷および神経変性疾患の治療におけるそれらの使用 Expired - Fee Related JP4443763B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US2218498A 1998-02-11 1998-02-11
US09/022,184 1998-02-11
US9578898P 1998-08-07 1998-08-07
US60/095,788 1998-08-07
US09/246,307 US7202279B1 (en) 1998-02-11 1999-02-08 Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders
US09/246,307 1999-02-08
PCT/US1999/003147 WO1999040931A1 (en) 1998-02-11 1999-02-10 Cyclic dipeptides and azetidinone compounds and their use in treating cns injury and neurodegenerative disorders

Publications (3)

Publication Number Publication Date
JP2003525850A JP2003525850A (ja) 2003-09-02
JP2003525850A5 JP2003525850A5 (enExample) 2006-01-05
JP4443763B2 true JP4443763B2 (ja) 2010-03-31

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JP2000531182A Expired - Fee Related JP4443763B2 (ja) 1998-02-11 1999-02-10 環式ジペプチドおよびアゼチジノン並びにcns損傷および神経変性疾患の治療におけるそれらの使用

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US (2) US7202279B1 (enExample)
EP (1) EP1061936A4 (enExample)
JP (1) JP4443763B2 (enExample)
AU (1) AU774681B2 (enExample)
CA (1) CA2320378A1 (enExample)
WO (1) WO1999040931A1 (enExample)

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US7335644B2 (en) * 2003-03-31 2008-02-26 Council Of Scientific And Industrial Research Anti-hypertensive molecules and process for preparation thereof
CN102210852B (zh) 2003-05-15 2016-10-19 安皮奥制药股份有限公司 T-细胞介导的疾病的治疗
EP1664050B1 (en) 2003-09-03 2015-12-09 Neuren Pharmaceuticals Limited Neuroprotective bicyclic compounds and pharmaceutical compositions containing them
US8519127B2 (en) 2003-09-03 2013-08-27 Mike John Bickerdike Cyclic glycyl-2-allyl proline and its use in treatment of peripheral neuropathy
US8791117B2 (en) 2003-09-03 2014-07-29 Neuren Pharmaceuticals Limited Cyclic glycyl-2-allyl proline improves cognitive performance in impaired animals
KR101530050B1 (ko) * 2007-03-02 2015-06-22 주식회사 노브메타파마 알츠하이머 질환 및 치매를 치료하기 위한 조성물 및 방법
US8173809B2 (en) * 2008-02-07 2012-05-08 Marquette University Cysteine and cystine prodrugs to treat schizophrenia and reduce drug cravings
JP5856843B2 (ja) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ,インコーポレイテッド ジケトピペラジンを用いた医薬組成物
KR101137503B1 (ko) * 2009-07-14 2012-04-20 웰이앤씨 주식회사 고분자 고체 지지체를 이용한 히스티딜-프롤린아미드 유도체의 제조 방법
NZ600755A (en) 2009-12-25 2014-10-31 Suntory Holdings Ltd Learning motivation improvers
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JP2014530063A (ja) 2011-10-10 2014-11-17 アンピオ ファーマシューティカルズ,インコーポレイテッド 免疫寛容が高められた埋込み型医療用デバイス、ならびに製造方法および埋込み方法
PH12014500685B1 (en) 2011-10-10 2018-10-03 Ampio Pharmaceuticals Inc Treatment of degenerative joint disease
HK1198812A1 (en) 2011-10-28 2015-06-12 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
WO2014066435A1 (en) 2012-10-22 2014-05-01 City Of Hope Etp derivatives
CA2906864A1 (en) 2013-03-15 2014-09-18 Ampio Pharmaceuticals, Inc. Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
EP4066836A1 (en) 2014-08-18 2022-10-05 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
EP3310375A4 (en) 2015-06-22 2019-02-20 Ampio Pharmaceuticals, Inc. USE OF LOW-MOLECULAR FRACTIONS OF HUMAN SERUMALBUMINE IN THE TREATMENT OF ILLNESSES
WO2017119481A1 (ja) * 2016-01-08 2017-07-13 サントリーホールディングス株式会社 環状ジペプチド含有神経性疾患予防用組成物
SG10201912843YA (en) 2016-05-26 2020-02-27 Amino Up Chemical Co Ltd Sleep improving agent
MX2018015872A (es) 2016-06-29 2019-04-22 Orion Corp Derivados de benzodioxano y su uso farmaceutico.
CN109952104B (zh) 2016-09-15 2023-03-28 希望之城 二硫etp衍生物
JP7020797B2 (ja) * 2017-04-25 2022-02-16 キリンホールディングス株式会社 自律神経調節用組成物
ES2964549T3 (es) * 2018-07-10 2024-04-08 Novmetapharma Co Ltd Nuevas formas polimórficas de ciclo (-His-Pro)
US11820834B2 (en) 2018-07-10 2023-11-21 Novmetapharma Co., Ltd. Polymorphic forms of Cyclo (-His-Pro) and methods of use to treat kidney disease
KR102133151B1 (ko) 2019-03-28 2020-07-13 주식회사 노브메타파마 Chp(사이클로-히스프로)를 포함하는 복막 섬유증의 예방, 개선 또는 치료용 조성물
US11129878B1 (en) 2020-03-24 2021-09-28 Ampio Pharmaceuticals, Inc. Methods for treating diseases associated with respiratory viruses
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Publication number Publication date
AU774681B2 (en) 2004-07-01
CA2320378A1 (en) 1999-08-19
WO1999040931A1 (en) 1999-08-19
EP1061936A1 (en) 2000-12-27
EP1061936A4 (en) 2005-03-09
US7202279B1 (en) 2007-04-10
JP2003525850A (ja) 2003-09-02
US8044103B2 (en) 2011-10-25
US20070161640A1 (en) 2007-07-12
AU2867899A (en) 1999-08-30

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