JP4433674B2 - 細胞および組織の自動分析のためのシステムおよび方法 - Google Patents

細胞および組織の自動分析のためのシステムおよび方法 Download PDF

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JP4433674B2
JP4433674B2 JP2002583976A JP2002583976A JP4433674B2 JP 4433674 B2 JP4433674 B2 JP 4433674B2 JP 2002583976 A JP2002583976 A JP 2002583976A JP 2002583976 A JP2002583976 A JP 2002583976A JP 4433674 B2 JP4433674 B2 JP 4433674B2
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staining
subcellular compartment
pixel
computer
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JP2004532410A5 (enExample
JP2004532410A (ja
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デビット エル． リム，
ロバート エル． キャムプ，
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Yale University
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    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G06T7/0014—Biomedical image inspection using an image reference approach
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/40—Analysis of texture
    • G06T7/41—Analysis of texture based on statistical description of texture
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20036—Morphological image processing
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20092—Interactive image processing based on input by user
    • G06T2207/20101—Interactive definition of point of interest, landmark or seed
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20212—Image combination
    • G06T2207/20221—Image fusion; Image merging
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30072—Microarray; Biochip, DNA array; Well plate
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30096—Tumor; Lesion

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • General Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Multimedia (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • Quality & Reliability (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Probability & Statistics with Applications (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Image Processing (AREA)
  • Image Analysis (AREA)
JP2002583976A 2001-04-20 2002-04-19 細胞および組織の自動分析のためのシステムおよび方法 Expired - Lifetime JP4433674B2 (ja)

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US28515501P 2001-04-20 2001-04-20
US33472301P 2001-10-31 2001-10-31
US10/062,308 US7219016B2 (en) 2001-04-20 2002-02-01 Systems and methods for automated analysis of cells and tissues
PCT/US2002/012084 WO2002086498A1 (en) 2001-04-20 2002-04-19 Systems and methods for automated analysis of cells and tissues

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JP2004532410A JP2004532410A (ja) 2004-10-21
JP2004532410A5 JP2004532410A5 (enExample) 2005-12-22
JP4433674B2 true JP4433674B2 (ja) 2010-03-17

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JP2002583976A Expired - Lifetime JP4433674B2 (ja) 2001-04-20 2002-04-19 細胞および組織の自動分析のためのシステムおよび方法
JP2008000078A Expired - Lifetime JP4873574B2 (ja) 2001-04-20 2008-01-04 細胞および組織の自動分析のためのシステムおよび方法
JP2011049130A Expired - Lifetime JP5290340B2 (ja) 2001-04-20 2011-03-07 細胞および組織の自動分析のための方法
JP2013022496A Expired - Lifetime JP5612142B2 (ja) 2001-04-20 2013-02-07 細胞および組織の自動分析のための方法

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JP2011049130A Expired - Lifetime JP5290340B2 (ja) 2001-04-20 2011-03-07 細胞および組織の自動分析のための方法
JP2013022496A Expired - Lifetime JP5612142B2 (ja) 2001-04-20 2013-02-07 細胞および組織の自動分析のための方法

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US (8) US7219016B2 (enExample)
EP (1) EP1390747B1 (enExample)
JP (4) JP4433674B2 (enExample)
AU (1) AU2002311827B9 (enExample)
CA (1) CA2442604C (enExample)
ES (1) ES2493765T3 (enExample)
WO (1) WO2002086498A1 (enExample)

Families Citing this family (197)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5161052B2 (ja) * 2008-12-04 2013-03-13 オリンパス株式会社 顕微鏡システム、標本観察方法およびプログラム
US7391929B2 (en) * 2000-02-11 2008-06-24 Sony Corporation Masking tool
IL157872A0 (en) * 2001-03-12 2004-03-28 Monogen Inc A panel for detecting a generic disease state containing a plurality of probes and using cell-based diagnosis
US20030190602A1 (en) * 2001-03-12 2003-10-09 Monogen, Inc. Cell-based detection and differentiation of disease states
US7219016B2 (en) 2001-04-20 2007-05-15 Yale University Systems and methods for automated analysis of cells and tissues
US7695919B2 (en) * 2001-05-10 2010-04-13 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
USRE46351E1 (en) 2001-05-10 2017-03-28 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
USRE44031E1 (en) 2001-05-10 2013-02-26 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
US6989276B2 (en) * 2001-05-10 2006-01-24 Battelle Energy Alliance, Llc Rapid classification of biological components
GB0130862D0 (en) * 2001-12-22 2002-02-06 P W Allen & Company Ltd Method of examining potential cellular abnormalities
EP2261018B1 (en) 2002-06-18 2018-10-17 AMADA Company, Ltd. Method of regulating a servo drive system and servo drive system of a press machine
GB0229734D0 (en) * 2002-12-23 2003-01-29 Qinetiq Ltd Grading oestrogen and progesterone receptors expression
MXPA05011404A (es) * 2003-04-25 2006-05-31 Johnson & Johnson Conservacion del arn en una muestra biologica.
JP2004347454A (ja) * 2003-05-22 2004-12-09 Mitsubishi Rayon Co Ltd シェーディング補正方法
US8068988B2 (en) * 2003-09-08 2011-11-29 Ventana Medical Systems, Inc. Method for automated processing of digital images of tissue micro-arrays (TMA)
WO2005027015A2 (en) 2003-09-10 2005-03-24 Bioimagene, Inc. Method and system for quantitatively analyzing biological samples
US7805003B1 (en) 2003-11-18 2010-09-28 Adobe Systems Incorporated Identifying one or more objects within an image
RU2424792C2 (ru) 2004-05-03 2011-07-27 Хермес Байесайенсиз, Инк. Липосомы, используемые для доставки лекарственных средств
WO2005114578A1 (en) * 2004-05-21 2005-12-01 Bioimagene, Inc. Method and system for automated quantitation of tissue micro-array (tma) digital image analysis
JP2008512376A (ja) * 2004-09-03 2008-04-24 ザ・スクリプス・リサーチ・インステイチユート 単離された系統陰性造血幹細胞及びこれを用いた治療方法
JP4921978B2 (ja) * 2004-11-09 2012-04-25 株式会社カネカ 細胞培養装置、画像処理装置及び細胞検出システム
EP1836557A4 (en) * 2004-11-19 2009-01-21 Trillium Diagnostics Llc SOFTWARE-INTEGRATED FLOW CYTOMETRY TEST FOR QUANTITATING THE HUMAN POLYMORPH-ACID LEUKOCYTIC FC RI RECEPTOR (CD64)
WO2006133460A2 (en) * 2005-06-09 2006-12-14 Yale University Methods for diagnosing and treating breast cancer based on a her/er ratio
CA2632188A1 (en) * 2005-11-10 2007-05-24 Rosetta Inpharmatics Llc Discover biological features using composite images
US20100227316A1 (en) * 2005-12-27 2010-09-09 Olympus Corporation Luminescense measuring apparatus and luminescense measuring method
JP2009526519A (ja) * 2006-01-17 2009-07-23 セルーメン、インコーポレイテッド 生物学的システム応答の予測方法
US8131112B1 (en) * 2006-01-23 2012-03-06 Sandia Corporation Method for detecting cancer in a single cell using mitochondrial correlation microscopy
US20070191675A1 (en) * 2006-02-13 2007-08-16 Joel Gerardo Diaz Sanchez Actinic light colposcope and method to detect lesions in the lower female genital tract produced by human papilloma virus using an actinic light colposcope
EP2049139A4 (en) 2006-04-24 2009-06-24 Gloucester Pharmaceuticals Inc TREATMENT OF TUMORS EXPRESSING RAS
WO2007130677A2 (en) 2006-05-05 2007-11-15 Yale University Use of subcellular localization profiles as prognostic or predictive indicators
CN101484806A (zh) * 2006-05-17 2009-07-15 协乐民公司 一种对组织进行自动分析的方法
US20100009352A1 (en) * 2006-05-24 2010-01-14 Gough Albert H Method for Modeling a Disease
WO2007146730A2 (en) 2006-06-08 2007-12-21 Gloucester Pharmaceuticals Deacetylase inhibitor therapy
WO2007144386A1 (de) * 2006-06-14 2007-12-21 Evotec Technologies Gmbh Verfahren zur aufnahme und auswertung von bildsequenzen
AU2007269654B2 (en) * 2006-06-30 2013-01-10 University Of Southern California Quantifiable internal reference standards for immunohistochemistry and uses thereof
US7709222B2 (en) * 2006-07-13 2010-05-04 Yale University Methods for making cancer prognoses based on subcellular localization of biomarkers
US8060348B2 (en) 2006-08-07 2011-11-15 General Electric Company Systems for analyzing tissue samples
US20080032321A1 (en) * 2006-08-07 2008-02-07 General Electric Company System and methods for analyzing images of tissue samples
US8131476B2 (en) * 2006-08-07 2012-03-06 General Electric Company System and method for co-registering multi-channel images of a tissue micro array
JP5548890B2 (ja) * 2006-09-05 2014-07-16 ジャンセン ダイアグノスティックス，エルエルシー 細胞の画像を格付けするための方法
JP5021254B2 (ja) * 2006-09-06 2012-09-05 オリンパス株式会社 顕微鏡装置の制御方法、顕微鏡装置
US20100112602A1 (en) * 2006-11-10 2010-05-06 Taylor Lansing D Protein-Protein Interaction Biosensors and Methods of Use Thereof
US9201063B2 (en) * 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
US7741045B2 (en) * 2006-11-16 2010-06-22 General Electric Company Sequential analysis of biological samples
US7629125B2 (en) 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
US9697582B2 (en) 2006-11-16 2017-07-04 Visiopharm A/S Methods for obtaining and analyzing images
US9008378B2 (en) 2006-12-20 2015-04-14 The Board Of Trustees Of The Leland Stanford Junior University Arrangement and imaging of biological samples
WO2008097552A2 (en) * 2007-02-05 2008-08-14 Siemens Healthcare Diagnostics, Inc. System and method for cell analysis in microscopy
US9355445B2 (en) * 2007-03-01 2016-05-31 Nec Corporation Breast cancer pathological image diagnosis support system, breast cancer pathological image diagnosis support method, and recording medium recording breast cancer pathological image diagnosis support program
US20080286881A1 (en) * 2007-05-14 2008-11-20 Apel William A Compositions and methods for combining report antibodies
DK2156370T3 (da) * 2007-05-14 2012-01-23 Historx Inc Kompartmentadskillelse ved pixelkarakterisering under anvendelse af billeddata-clustering
US8351674B2 (en) * 2007-05-31 2013-01-08 Battelle Energy Alliance, Llc Image portion identification methods, image parsing methods, image parsing systems, and articles of manufacture
US7907271B2 (en) * 2007-06-15 2011-03-15 Historx, Inc. Method and system for standardizing microscope instruments
WO2009005715A1 (en) * 2007-06-29 2009-01-08 Yale University Methods for a predictive diagnostic test for tamoxifen
WO2009005816A1 (en) * 2007-07-03 2009-01-08 Yale University Methods for differential diagnosis of melanocytic lesions
CA2604317C (en) * 2007-08-06 2017-02-28 Historx, Inc. Methods and system for validating sample images for quantitative immunoassays
CA2596204C (en) * 2007-08-07 2019-02-26 Historx, Inc. Method and system for determining an optimal dilution of a reagent
US7978258B2 (en) * 2007-08-31 2011-07-12 Historx, Inc. Automatic exposure time selection for imaging tissue
JP5040597B2 (ja) * 2007-11-06 2012-10-03 日本電気株式会社 評価システム、評価方法および評価プログラム
US8031924B2 (en) * 2007-11-30 2011-10-04 General Electric Company Methods and systems for removing autofluorescence from images
US8139831B2 (en) * 2007-12-06 2012-03-20 Siemens Aktiengesellschaft System and method for unsupervised detection and gleason grading of prostate cancer whole mounts using NIR fluorscence
EP2227711A4 (en) 2008-01-02 2014-01-22 Univ California TELEMIC ROSCOPY DEVICE WITH HIGH NUMERICAL APERTURE
US8070398B2 (en) * 2008-02-19 2011-12-06 Irwin Industrial Tool Company Multi-blade self feed bit
US8189884B2 (en) * 2008-03-26 2012-05-29 General Electric Company Methods for assessing molecular expression of subcellular molecules
US8135187B2 (en) 2008-03-26 2012-03-13 General Electric Company Method and apparatus for removing tissue autofluorescence
US8731845B2 (en) * 2008-08-15 2014-05-20 Visionpharm A/S Method and a system for determining a target in a biological sample by image analysis
EP2335221B8 (en) 2008-09-16 2016-05-25 Novartis AG Reproducible quantification of biomarker expression
US8729239B2 (en) 2009-04-09 2014-05-20 Nuclea Biotechnologies, Inc. Antibodies against fatty acid synthase
WO2011031517A1 (en) 2009-08-27 2011-03-17 Nuclea Biotechnologies, LLC Method and assay for determining fas expression
US8969009B2 (en) * 2009-09-17 2015-03-03 Vicki S. Thompson Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
US9410965B2 (en) * 2009-09-17 2016-08-09 Battelle Energy Alliance, Llc Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
US9677125B2 (en) * 2009-10-21 2017-06-13 General Electric Company Detection of plurality of targets in biological samples
US9001200B2 (en) 2010-01-12 2015-04-07 Bio-Rad Laboratories, Inc. Cell characterization using multiple focus planes
US10702251B2 (en) 2010-02-25 2020-07-07 Robin Medical Inc. Cryogenic biopsy system and method
US9566047B2 (en) * 2010-02-25 2017-02-14 Erez Nevo Cryogenic biopsy system and method
EP2545357B1 (en) * 2010-03-10 2021-06-02 Beckman Coulter, Inc. Generating pulse parameters in a particle analyzer
AU2011279303B2 (en) 2010-07-12 2015-07-16 Celgene Corporation Romidepsin solid forms and uses thereof
JP5832537B2 (ja) * 2010-08-05 2015-12-16 ケンブリッジ・リサーチ・アンド・インストルメンテーション・インコーポレーテッド 試料の強調視覚評価
US8859502B2 (en) 2010-09-13 2014-10-14 Celgene Corporation Therapy for MLL-rearranged leukemia
WO2012058638A2 (en) 2010-10-29 2012-05-03 President And Fellows Of Harvard College Nucleic acid nanostructure barcode probes
US9535068B2 (en) * 2010-11-12 2017-01-03 William Marsh Rice University Oral cancer point of care diagnostics
WO2012075377A1 (en) 2010-12-03 2012-06-07 Historx, Inc. Identification of cancer patients likely to benefit from radiation therapy
WO2012100190A2 (en) * 2011-01-21 2012-07-26 Carnegie Mellon University Identifying location biomarkers
KR20120102447A (ko) * 2011-03-08 2012-09-18 삼성전자주식회사 진단장치 및 방법
CA2830501C (en) 2011-03-17 2023-10-17 Cernostics, Inc. Systems and compositions for diagnosing barrett's esophagus and methods of using the same
JP5372068B2 (ja) * 2011-05-20 2013-12-18 キヤノン株式会社 撮像システム、画像処理装置
WO2013059105A2 (en) * 2011-10-17 2013-04-25 Nuclea Biotechnologies, Inc. Predictive biomarkers for breast cancer
EA030440B1 (ru) 2011-10-24 2018-08-31 Галозим, Инк. Сопровождающая диагностика для терапии антигиалуронановым агентом и способы ее применения
EP2786151B1 (en) 2011-11-29 2019-07-03 F.Hoffmann-La Roche Ag Methods for prostate cancer analysis
WO2013148498A1 (en) 2012-03-27 2013-10-03 Ventana Medical Systems, Inc. Signaling conjugates and methods of use
KR20140145141A (ko) 2012-03-30 2014-12-22 클래리언트 다이아그노스틱 서비시즈, 인크. 생물학적 샘플의 영상 생성 방법
JP5924406B2 (ja) * 2012-04-23 2016-05-25 日本電気株式会社 画像計測装置、画像計測方法、および、画像計測用プログラム
JP5870851B2 (ja) * 2012-05-29 2016-03-01 ソニー株式会社 情報処理装置、情報処理方法、及びプログラム
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
AU2013202947B2 (en) 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
AU2013277097A1 (en) * 2012-06-20 2015-01-22 Merrimack Pharmaceuticals, Inc. Marker quantitation in single cells in tissue sections
AU2013202506B2 (en) 2012-09-07 2015-06-18 Celgene Corporation Resistance biomarkers for hdac inhibitors
US9378407B2 (en) * 2012-09-11 2016-06-28 Neogenomics Laboratories, Inc. Automated fish reader using learning machines
WO2014062856A1 (en) 2012-10-16 2014-04-24 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
AU2013202507B9 (en) 2012-11-14 2015-08-13 Celgene Corporation Inhibition of drug resistant cancer cells
JP6278519B2 (ja) * 2012-11-28 2018-02-21 国立研究開発法人科学技術振興機構 細胞観察装置、細胞観察方法及びそのプログラム
EP3764084A1 (en) 2013-03-12 2021-01-13 Ventana Medical Systems, Inc. Digitally enhanced microscopy for multiplexed histology
JP6417602B2 (ja) 2013-03-15 2018-11-07 エーザイ インコーポレイテッド 大腸直腸癌の予後を判定する方法
US9064304B2 (en) 2013-03-18 2015-06-23 General Electric Company Image quality assessment of microscopy images
US20140307931A1 (en) * 2013-04-15 2014-10-16 Massachusetts Institute Of Technology Fully automated system and method for image segmentation and quality control of protein microarrays
WO2014197622A2 (en) 2013-06-04 2014-12-11 The Regents Of The University Of California Liver-mimetic device and method for simulation of hepatic function using such device
HK1221747A1 (zh) 2013-07-30 2017-06-09 哈佛学院院长及董事 基於dna的定量成像和超分辨成像
EP3955042B1 (en) 2013-08-26 2024-08-21 S.D. Sight Diagnostics Ltd. Digital microscopy systems, methods and computer program products
AU2014333927A1 (en) * 2013-10-07 2016-03-03 Ventana Medical Systems, Inc. Systems and methods for comprehensive multi-assay tissue analysis
GB201318598D0 (en) * 2013-10-21 2013-12-04 Univ Leicester Improvements in or relating to super-resolution microscopy
NZ630311A (en) 2013-12-27 2016-03-31 Celgene Corp Romidepsin formulations and uses thereof
US11547300B2 (en) * 2014-01-31 2023-01-10 The General Hospital Corporation Methods of treating and imaging tumor micrometastases using photoactive immunoconjugates
JP6604960B2 (ja) * 2014-02-21 2019-11-13 ベンタナ メディカル システムズ， インコーポレイテッド バイオマーカー陽性の腫瘍細胞を識別するための医用画像解析
ES2701092T5 (es) 2014-02-24 2022-05-12 Ventana Med Syst Inc Procedimientos, kits y sistemas para puntuar la respuesta inmunitaria al cáncer por detección simultánea de CD3, CD8, CD20 y FOXP3
JP6757255B2 (ja) 2014-03-11 2020-09-16 プレジデント アンド フェローズ オブ ハーバード カレッジ プログラム可能な核酸プローブを用いた高スループット及び高度多重化イメージング
JP5843054B1 (ja) * 2014-03-24 2016-01-13 コニカミノルタ株式会社 多重免疫染色法に基づく生体物質の定量方法
US9683939B2 (en) 2014-05-12 2017-06-20 Cellomics, Inc. Automated imaging of chromophore labeled samples
HRP20190881T1 (hr) 2014-08-28 2019-07-12 Halozyme, Inc. Kombinacijska terapija s hijaluronan-razgrađujućim enzimom i inhibitorom imunološke kontrolne točke
WO2016044483A1 (en) 2014-09-16 2016-03-24 The Regents Of The University Of California Method for fabrication of microwells for controlled formation of 3-dimensional multicellular-shapes
JP6499506B2 (ja) * 2015-04-30 2019-04-10 富士フイルム株式会社 撮像装置および方法並びに撮像制御プログラム
US11318131B2 (en) 2015-05-18 2022-05-03 Ipsen Biopharm Ltd. Nanoliposomal irinotecan for use in treating small cell lung cancer
KR102557419B1 (ko) 2015-08-07 2023-07-19 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 단백질-단백질 상호작용의 초해상도 영상화
HK1257216A1 (zh) 2015-08-20 2019-10-18 益普生生物制药有限公司 使用脂质体伊立替康和parp抑制剂用於癌症治疗的组合疗法
BR112018002941B1 (pt) 2015-08-21 2023-12-05 Ipsen Biopharm Ltd Uso de irinotecano lipossomal, oxaliplatina, leucovorina e 5- fluorouracil no tratamento de primeira linha de adenocarcinoma metastático do pâncreas
ES2955775T3 (es) 2015-08-27 2023-12-07 Inst Nat Sante Rech Med Métodos para predecir el tiempo de supervivencia de pacientes que padecen cáncer de pulmón
WO2017060397A1 (en) 2015-10-09 2017-04-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of subjects suffering from melanoma metastases
BR112018006922B1 (pt) 2015-10-16 2023-11-21 Ipsen Biopharm Ltd Composições de irinotecano lipossômico estabilizado para armazenamento
WO2017067944A1 (en) 2015-10-19 2017-04-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of subjects suffering from triple negative breast cancer
JP6938489B2 (ja) * 2015-10-23 2021-09-22 ノバルティス・エイジーＮｏｖａｒｔｉｓ ＡＧ 視野に存在する選択された細胞のバイオマーカー陽性率の値を導き出す方法
CN108463727B (zh) * 2015-10-23 2021-06-18 诺华股份有限公司 用于得到细胞间空间接近度的计算机方法和系统
CN108449973B (zh) * 2015-10-23 2022-03-15 诺华股份有限公司 Aqua增强版本后的计算机进程
US20180327499A1 (en) 2015-11-13 2018-11-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti- nkg2d single domain antibodies and uses thereof
US10962544B2 (en) 2015-11-25 2021-03-30 Cernostics, Inc. Methods of predicting progression of Barrett's esophagus
ES2837155T3 (es) 2016-01-04 2021-06-29 Inst Nat Sante Rech Med Uso de PD-1 y Tim-3 como medida de células CD8+ para predecir y tratar el carcinoma de células renales
ES2924741T3 (es) 2016-01-28 2022-10-10 Inst Nat Sante Rech Med Métodos para incrementar la potencia de los inhibidores del punto de control inmunitario
EP3203413A1 (en) * 2016-02-08 2017-08-09 Ecole Polytechnique Federale De Lausanne (Epfl) Method for quantitative measurement of a biomarker by in situ immunofluorescence and uses thereof
WO2017202962A1 (en) 2016-05-24 2017-11-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of non small cell lung cancer (nsclc) that coexists with chronic obstructive pulmonary disease (copd)
WO2018011107A1 (en) 2016-07-11 2018-01-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of er-alpha 46 in methods and kits for assessing the status of breast cancer
WO2018046736A1 (en) 2016-09-12 2018-03-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from cancer
JP6646552B2 (ja) * 2016-09-13 2020-02-14 株式会社日立ハイテクノロジーズ 画像診断支援装置、画像診断支援方法及び試料分析システム
CN110402163A (zh) 2016-11-02 2019-11-01 易普森生物制药有限公司 使用包括脂质体伊立替康、奥沙利铂、5-氟尿嘧啶(和甲酰四氢叶酸)的组合疗法治疗胃癌
US11852635B2 (en) * 2016-11-16 2023-12-26 Nano Somix, Inc Quantification of subpopulations of exosomes and diagnosis of neurogenerative disorders
WO2018094113A1 (en) 2016-11-16 2018-05-24 University Of Washington Systems and methods for cyclic fluorescence imaging
AU2017370751B2 (en) 2016-12-09 2023-11-09 Ultivue, Inc. Improved methods for multiplex imaging using labeled nucleic acid imaging agents
WO2018122249A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from a microsatellite stable colorectal cancer
WO2018122245A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting the survival time of patients suffering from cms3 colorectal cancer
WO2019043138A1 (en) 2017-09-01 2019-03-07 INSERM (Institut National de la Santé et de la Recherche Médicale) METHOD FOR PREDICTING OUTCOME OF CANCER
JP6404425B2 (ja) * 2017-09-27 2018-10-10 株式会社日立エルジーデータストレージ 光画像計測装置
WO2019089858A2 (en) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Methods of assessing or monitoring a response to a cell therapy
EP3713963A1 (en) 2017-11-23 2020-09-30 INSERM (Institut National de la Santé et de la Recherche Médicale) A new marker for predicting the sensitivity to pi3k inhibitors
JP7155262B2 (ja) * 2017-12-05 2022-10-18 デビコー・メディカル・プロダクツ・インコーポレイテッド 適合した撮像を備える生検装置
US11314994B2 (en) * 2018-01-30 2022-04-26 Riken Mask structure optimization device, mask structure optimization method, and program
SG11202008696RA (en) 2018-03-12 2020-10-29 Inst Nat Sante Rech Med Use of caloric restriction mimetics for potentiating chemo-immunotherapy for the treatment of cancers
US11515009B2 (en) 2018-03-19 2022-11-29 International Business Machines Corporation Biomarker quantification in a tissue sample
JP7084193B2 (ja) * 2018-04-10 2022-06-14 ザイオソフト株式会社 医用画像処理装置、医用画像処理方法、及び医用画像処理プログラム
WO2019197683A1 (en) 2018-04-13 2019-10-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting outcome and treatment of patients suffering from prostate cancer or breast cancer
WO2019207030A1 (en) 2018-04-26 2019-10-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting a response with an immune checkpoint inhibitor in a patient suffering from a lung cancer
CN108896363A (zh) * 2018-05-28 2018-11-27 杭州智微信息科技有限公司 一种骨髓涂片数字化的流程方法
WO2020048942A1 (en) 2018-09-04 2020-03-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for enhancing cytotoxic t lymphocyte-dependent immune responses
JP7618950B2 (ja) 2018-09-19 2025-01-22 インサーム （インスティテュート ナショナル デ ラ サンテ エ デ ラ ルシェルシェ メディカル） 免疫チェックポイント治療に抵抗性のある癌の治療のための方法および医薬組成物
EP3860578A1 (en) 2018-10-01 2021-08-11 Institut National de la Santé et de la Recherche Médicale (INSERM) Use of inhibitors of stress granule formation for targeting the regulation of immune responses
WO2020120592A1 (en) 2018-12-12 2020-06-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for predicting and treating melanoma
US20220047556A1 (en) 2018-12-17 2022-02-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of sulconazole as a furin inhibitor
KR20220008253A (ko) 2019-01-03 2022-01-20 엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔 (인쎄름) 암을 앓는 대상에서 cd8+ t 세포 의존성 면역 반응을 향상시키기 위한 방법 및 약학적 조성물
MX2021008396A (es) 2019-01-10 2021-11-04 Innovacorium Inc Composiciones de administración farmacéutica y sus usos.
TW202102272A (zh) 2019-03-29 2021-01-16 美商樂天醫藥生技股份有限公司 光免疫療法之方法及相關之生物標記
US20220177978A1 (en) 2019-04-02 2022-06-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
WO2020208060A1 (en) 2019-04-09 2020-10-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of sk2 inhibitors in combination with immune checkpoint blockade therapy for the treatment of cancer
WO2020245155A1 (en) 2019-06-03 2020-12-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for modulating a treatment regimen
WO2020245208A1 (en) 2019-06-04 2020-12-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of cd9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis
CA3157889A1 (en) 2019-10-17 2021-04-22 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for diagnosing nasal intestinal type adenocarcinomas
US10652484B1 (en) 2019-10-18 2020-05-12 Center For Quantitative Cytometry Method to obtain data cubes of low intensity intrinsic spectral images when imaging under high illumination conditions without the use of filters
US10670512B1 (en) 2019-10-18 2020-06-02 Center For Quantitative Cytometry Apparatus to perform intrinsic hyper-spectral flow cytometry
WO2021094356A1 (en) * 2019-11-11 2021-05-20 Miltenyi Biotec B.V. & Co. KG Serial multichannel microscopy
AU2020400401A1 (en) 2019-12-12 2022-06-02 S.D. Sight Diagnostics Ltd Analyzing an analyte disposed within a medium
EP4073491A1 (en) * 2019-12-12 2022-10-19 S.D. Sight Diagnostics Ltd. Off-focus microscopic images of a sample
EP4090770A1 (en) 2020-01-17 2022-11-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treating melanoma
WO2021170777A1 (en) 2020-02-28 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing, prognosing and managing treatment of breast cancer
US11551360B2 (en) 2020-04-28 2023-01-10 QATAR UNIVERSITY, Office of Academic Research Device and method for cancer detection
US20230221316A1 (en) * 2020-05-20 2023-07-13 Roche Diagnostics Operations, Inc. Use of automated platforms for preparation of biomarker and romanowsky-type stained sample printed on a slide
WO2021241061A1 (ja) * 2020-05-29 2021-12-02 ソニーグループ株式会社 情報処理装置、情報処理方法、コンピュータプログラム、およびターゲット分子検出システム
WO2022002873A1 (en) 2020-06-30 2022-01-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies
EP4172628A1 (en) 2020-06-30 2023-05-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapy and radical surgery
CN112201300B (zh) * 2020-10-23 2022-05-13 天津大学 基于深度图像特征和阈值学习策略的蛋白质亚细胞定位的方法
WO2022200303A1 (en) 2021-03-23 2022-09-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of t cell-lymphomas
US20240210404A1 (en) 2021-04-27 2024-06-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of lymph node metastasis and/or recurrence of patients suffering from a t1 cancer treated by endoscopic resection
WO2023091351A1 (en) * 2021-11-17 2023-05-25 Becton, Dickinson And Company Methods for dynamic real-time adjustment of a data acquisition parameter in a flow cytometer
EP4472740A1 (en) 2022-01-31 2024-12-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Cd38 as a biomarker and biotarget in t-cell lymphomas
CA3245129A1 (en) 2022-03-17 2023-09-21 Univ Paris Cite METHODS FOR PREDICTING RESPONSE TO IMMUNOTHERAPEUTIC TREATMENT IN A CANCER PATIENT
EP4508432A1 (en) 2022-04-11 2025-02-19 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of t-cell malignancies
WO2023198874A1 (en) 2022-04-15 2023-10-19 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of t cell-lymphomas
WO2024003310A1 (en) 2022-06-30 2024-01-04 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of acute lymphoblastic leukemia
EP4558823A1 (en) 2022-07-22 2025-05-28 Institut National de la Santé et de la Recherche Médicale Garp as a biomarker and biotarget in t-cell malignancies
WO2024023283A1 (en) 2022-07-29 2024-02-01 Institut National de la Santé et de la Recherche Médicale Lrrc33 as a biomarker and biotarget in cutaneous t-cell lymphomas
JP2025536268A (ja) 2022-10-12 2025-11-05 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Ｔ細胞悪性腫瘍におけるバイオマーカー及びバイオターゲットとしてのｃｄ８１
WO2024153636A1 (en) 2023-01-17 2024-07-25 Institut National de la Santé et de la Recherche Médicale Vasorin as a biomarker and biotarget in nephrology
WO2025045894A1 (en) 2023-08-28 2025-03-06 Institut National de la Santé et de la Recherche Médicale Methods and kits for diagnosing cause of nephrotic syndrome and guiding therapy

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US26420A (en) 1859-12-13 Improvement in seeding-machines
US4998284A (en) 1987-11-17 1991-03-05 Cell Analysis Systems, Inc. Dual color camera microscope and methodology for cell staining and analysis
JP2628302B2 (ja) * 1987-04-14 1997-07-09 富士レビオ株式会社 凝集判定方法および装置
JP2852096B2 (ja) * 1990-03-29 1999-01-27 オリンパス光学工業株式会社 被検体通過中の散乱光成分抑制方法およびその装置
US5386819A (en) 1990-03-29 1995-02-07 Olympus Optical Co., Ltd. Method and apparatus for inhibiting a scattered component in a light having passed through an examined object
JPH0474950A (ja) * 1990-07-16 1992-03-10 Hitachi Ltd 発光検出型遺伝物質検出装置
US5784162A (en) * 1993-08-18 1998-07-21 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for biological research, medical diagnostics and therapy
US5936731A (en) * 1991-02-22 1999-08-10 Applied Spectral Imaging Ltd. Method for simultaneous detection of multiple fluorophores for in situ hybridization and chromosome painting
US6026174A (en) * 1992-10-14 2000-02-15 Accumed International, Inc. System and method for automatically detecting malignant cells and cells having malignancy-associated changes
US6229649B1 (en) * 1994-10-04 2001-05-08 The United States Of America As Represented By The Secretary Of The Air Force Pseudo deconvolution method of recovering a distorted optical image
JP2000501829A (ja) * 1995-07-19 2000-02-15 モルフォメトリックス テクノロジーズ インク． 画像解析用の多スペクトル分割
EP0864082B1 (en) * 1995-11-30 2003-04-02 Chromavision Medical Systems, Inc. Method for automated image analysis of biological specimens
US6151405A (en) * 1996-11-27 2000-11-21 Chromavision Medical Systems, Inc. System and method for cellular specimen grading
US5998151A (en) 1995-12-01 1999-12-07 The United States Of America As Represented By The Department Of Health And Human Services Methods for predicting the efficacy of a chemotherapeutic regimen for gastrointestinal cancers using antibodies specific for thymidylate synthase
US6165734A (en) * 1995-12-12 2000-12-26 Applied Spectral Imaging Ltd. In-situ method of analyzing cells
US5989835A (en) * 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
US6727071B1 (en) * 1997-02-27 2004-04-27 Cellomics, Inc. System for cell-based screening
WO1999028745A1 (en) * 1997-11-27 1999-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Identification and characterization of interacting molecules by automated interaction mating
BR9908767B1 (pt) * 1998-03-16 2011-09-06 sistema de formação de imagem confocal, sistema de focalização para uso com um substrato, e, processos de examinar um objeto, e de focalização para uso com um substrato.
US20030036855A1 (en) * 1998-03-16 2003-02-20 Praelux Incorporated, A Corporation Of New Jersey Method and apparatus for screening chemical compounds
US6492325B1 (en) * 1998-05-22 2002-12-10 Boys Town National Research Hospital Use of α1β1 integrin receptor inhibitors and TGF-β1 inhibitors in the treatment of kidney disease
US6337472B1 (en) * 1998-10-19 2002-01-08 The University Of Texas System Board Of Regents Light imaging microscope having spatially resolved images
EP1131470A4 (en) 1998-10-28 2004-11-10 Vysis Inc CELLULAR NETWORKS AND METHODS FOR DETECTION AND USE OF GENETIC DISORDER MARKERS
US7666609B1 (en) 1998-12-01 2010-02-23 Shanghai Cp Guojian Pharmaceutical Co. Ltd. Method and composition for diagnosis of melanocytic lesions
US6351712B1 (en) * 1998-12-28 2002-02-26 Rosetta Inpharmatics, Inc. Statistical combining of cell expression profiles
US6251601B1 (en) 1999-02-02 2001-06-26 Vysis, Inc. Simultaneous measurement of gene expression and genomic abnormalities using nucleic acid microarrays
JP2000283853A (ja) * 1999-03-31 2000-10-13 Mitsubishi Electric Corp 波面センサ
EP1230383A2 (en) * 1999-04-08 2002-08-14 Sir Mortimer B. Davis Jewish General Hospital Quantitative assay for expression of genes in microarray
WO2000062247A1 (en) * 1999-04-13 2000-10-19 Chromavision Medical Systems, Inc. Histological reconstruction and automated image analysis
WO2001020044A2 (en) 1999-09-17 2001-03-22 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services, The National Institutes Of Health Signal counting for in situ hybridization
WO2001022086A1 (en) 1999-09-24 2001-03-29 Jonathan Cohen A high-throughput system for evaluating the clinical utility of molecular targets in tissue samples
US7050087B2 (en) * 2000-12-06 2006-05-23 Bioview Ltd. Data acquisition and display system and method
US6466690C1 (en) * 2000-12-19 2008-11-18 Bacus Res Lab Inc Method and apparatus for processing an image of a tissue sample microarray
WO2002100157A2 (en) 2001-02-21 2002-12-19 Amnis Corporation Method and apparatus for labeling and analyzing cellular components
US7219016B2 (en) * 2001-04-20 2007-05-15 Yale University Systems and methods for automated analysis of cells and tissues
US7229774B2 (en) 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
FI20020653A0 (fi) 2002-04-05 2002-04-05 Taipale Automotive Oy Menetelmä ajoneuvoa ajavan henkilön sekä hänen ajotapansa tunnistamiseksi
US20060024692A1 (en) 2002-09-30 2006-02-02 Oncotherapy Science, Inc. Method for diagnosing non-small cell lung cancers
EP2439285B1 (en) 2004-03-31 2019-05-08 The General Hospital Corporation Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments
US7862995B2 (en) 2004-12-10 2011-01-04 Targeted Molecular Diagnostics Methods and materials for predicting responsiveness to treatment with dual tyrosine kinase inhibitor
WO2006113747A2 (en) 2005-04-19 2006-10-26 Prediction Sciences Llc Diagnostic markers of breast cancer treatment and progression and methods of use thereof
GB0524190D0 (en) * 2005-11-28 2006-01-04 Helse Stavanger Hf Method
US7709222B2 (en) * 2006-07-13 2010-05-04 Yale University Methods for making cancer prognoses based on subcellular localization of biomarkers
US20100240035A1 (en) 2007-06-01 2010-09-23 The Regents Of The University Of California Multigene prognostic assay for lung cancer
WO2009005715A1 (en) 2007-06-29 2009-01-08 Yale University Methods for a predictive diagnostic test for tamoxifen
WO2009005816A1 (en) 2007-07-03 2009-01-08 Yale University Methods for differential diagnosis of melanocytic lesions
WO2011047019A1 (en) 2009-10-13 2011-04-21 Yale University An objective, quantitative method to predict histological subtype in non-small cell lung cancer
CA2779484A1 (en) 2009-10-30 2011-05-05 Yale University A melanoma prognostic model using tissue microarrays and genetic algorithms
WO2012116122A2 (en) 2011-02-22 2012-08-30 Yale University A protein expression-based classifier for prediction of recurrence in adenocarcinoma

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