JP4405732B2 - β−カルボリン誘導体ならびにうつ病および不安に対する医薬的使用 - Google Patents

β−カルボリン誘導体ならびにうつ病および不安に対する医薬的使用 Download PDF

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JP4405732B2
JP4405732B2 JP2002579459A JP2002579459A JP4405732B2 JP 4405732 B2 JP4405732 B2 JP 4405732B2 JP 2002579459 A JP2002579459 A JP 2002579459A JP 2002579459 A JP2002579459 A JP 2002579459A JP 4405732 B2 JP4405732 B2 JP 4405732B2
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compound
acid addition
free base
addition salt
receptor
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JP2004525178A (ja
JP2004525178A5 (https=
Inventor
トーマス・ヨット・トロクスラー
コンスタンツェ・フルト
ダニエル・オイェ
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ノバルティス アクチエンゲゼルシャフト
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2002579459A 2001-04-03 2002-04-02 β−カルボリン誘導体ならびにうつ病および不安に対する医薬的使用 Expired - Fee Related JP4405732B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0108337.7A GB0108337D0 (en) 2001-04-03 2001-04-03 Organic compounds
PCT/EP2002/003624 WO2002081471A1 (en) 2001-04-03 2002-04-02 Beta-carboline derivatives and its pharmaceutical use against depression and anxiety

Publications (3)

Publication Number Publication Date
JP2004525178A JP2004525178A (ja) 2004-08-19
JP2004525178A5 JP2004525178A5 (https=) 2005-12-22
JP4405732B2 true JP4405732B2 (ja) 2010-01-27

Family

ID=9912165

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002579459A Expired - Fee Related JP4405732B2 (ja) 2001-04-03 2002-04-02 β−カルボリン誘導体ならびにうつ病および不安に対する医薬的使用

Country Status (27)

Country Link
US (1) US6861430B2 (https=)
EP (1) EP1377578B1 (https=)
JP (1) JP4405732B2 (https=)
KR (1) KR100564840B1 (https=)
CN (1) CN1309721C (https=)
AR (1) AR035451A1 (https=)
AT (1) ATE517104T1 (https=)
AU (1) AU2002316828B2 (https=)
BR (1) BR0208566B1 (https=)
CA (1) CA2440014C (https=)
CZ (1) CZ295992B6 (https=)
EC (1) ECSP034754A (https=)
ES (1) ES2368389T3 (https=)
GB (1) GB0108337D0 (https=)
HU (1) HUP0400317A3 (https=)
IL (1) IL157545A0 (https=)
MX (1) MXPA03009057A (https=)
MY (1) MY134026A (https=)
NO (1) NO20034413L (https=)
NZ (1) NZ528370A (https=)
PE (1) PE20021018A1 (https=)
PL (1) PL210861B1 (https=)
PT (1) PT1377578E (https=)
RU (1) RU2003130644A (https=)
SK (1) SK12222003A3 (https=)
WO (1) WO2002081471A1 (https=)
ZA (1) ZA200306108B (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
ES2427166T3 (es) * 2003-06-23 2013-10-29 Ono Pharmaceutical Co., Ltd. Compuesto heterocíclico tricíclico novedoso
AR051780A1 (es) * 2004-11-29 2007-02-07 Japan Tobacco Inc Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
WO2006068164A1 (ja) * 2004-12-22 2006-06-29 Ono Pharmaceutical Co., Ltd. 三環式化合物およびその用途
US7879859B2 (en) 2005-11-21 2011-02-01 Merck Sharp & Dohme Corp. Diagnosis and treatment of type 2 diabetes and other disorders
WO2007062175A2 (en) * 2005-11-21 2007-05-31 Amgen Inc. Spiro-substituted tricyclic heterocycles cxcr3 antagonists
EP2178537A4 (en) * 2007-07-19 2011-08-17 Merck Sharp & Dohme BETA-CARBOLIN DERIVATIVES AS ANTIDIBLE COMPOUNDS
WO2009016329A1 (en) * 2007-07-31 2009-02-05 Cambridge Enterprise Limited Use of gabaa receptor antagonists to treat cognitive impairment in patients with psychiatric conditions
US8338604B2 (en) 2008-06-20 2012-12-25 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrazine compounds useful as kinase inhibitors
KR20180011888A (ko) 2008-11-19 2018-02-02 포럼 파마슈티칼즈 인크. (ｒ)-７-클로로-ｎ-(퀴누클리딘-３-일)벤조［ｂ］티오펜-２-카르복사미드 및 그 약학적으로 허용가능한 염을 이용한 인지 장애의 치료
TW201028414A (en) 2009-01-16 2010-08-01 Merck Sharp & Dohme Oxadiazole beta carboline derivatives as antidiabetic compounds
CN102695414A (zh) 2010-01-15 2012-09-26 默沙东公司 作为抗糖尿病化合物的噁二唑β-咔啉衍生物
AR081402A1 (es) 2010-05-17 2012-08-29 Envivo Pharmaceuticals Inc Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il) benzo(b)tiofeno-2-carboxamida monohidrato
CA2872005A1 (en) 2012-05-08 2013-11-14 Forum Pharmaceuticals, Inc. Methods of maintaining, treating or improving cognitive function
CN111349096B (zh) * 2020-04-14 2021-03-09 石河子大学 一种吲哚类化合物及其制备方法、应用
KR102467844B1 (ko) 2021-04-21 2022-11-16 삼성전자주식회사 솔리드 스테이트 드라이브 장치 및 이를 포함하는 데이터 저장 장치

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4118741A1 (de) * 1991-06-05 1992-12-10 Schering Ag Neue hetaryloxy-(beta)-carboline, deren herstellung und verwendung in arzneimitteln
US6057340A (en) * 1998-02-03 2000-05-02 American Home Products Corporation Oxazole derivatives as serotonin-1A receptor agonists
HUP0302962A2 (hu) 1998-06-12 2003-12-29 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Béta-karbolinszármazékok, ezeket a vegyületeket tartalmazó gyógyászati készítmények és a vegyületek alkalmazása

Also Published As

Publication number Publication date
IL157545A0 (en) 2004-03-28
PE20021018A1 (es) 2003-01-13
KR20040008150A (ko) 2004-01-28
CN1309721C (zh) 2007-04-11
HUP0400317A2 (hu) 2004-09-28
US20040132735A1 (en) 2004-07-08
CZ20032655A3 (cs) 2003-12-17
CA2440014C (en) 2010-11-23
NO20034413D0 (no) 2003-10-02
CN1500090A (zh) 2004-05-26
AU2002316828B2 (en) 2006-05-11
BR0208566A (pt) 2004-03-30
JP2004525178A (ja) 2004-08-19
SK12222003A3 (sk) 2004-06-08
HUP0400317A3 (en) 2007-10-29
PL210861B1 (pl) 2012-03-30
KR100564840B1 (ko) 2006-03-28
ECSP034754A (es) 2003-10-28
EP1377578A1 (en) 2004-01-07
ATE517104T1 (de) 2011-08-15
NZ528370A (en) 2005-10-28
ES2368389T3 (es) 2011-11-16
US6861430B2 (en) 2005-03-01
BR0208566B1 (pt) 2013-12-24
NO20034413L (no) 2003-10-02
RU2003130644A (ru) 2005-04-10
CZ295992B6 (cs) 2005-12-14
WO2002081471A1 (en) 2002-10-17
ZA200306108B (en) 2004-07-05
GB0108337D0 (en) 2001-05-23
PT1377578E (pt) 2011-09-23
EP1377578B1 (en) 2011-07-20
PL362571A1 (en) 2004-11-02
CA2440014A1 (en) 2002-10-17
MXPA03009057A (es) 2004-02-12
MY134026A (en) 2007-11-30
AR035451A1 (es) 2004-05-26

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