JP4259869B2 - タンパク質及びペプチド末端配列の決定方法 - Google Patents

タンパク質及びペプチド末端配列の決定方法 Download PDF

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JP4259869B2
JP4259869B2 JP2002561757A JP2002561757A JP4259869B2 JP 4259869 B2 JP4259869 B2 JP 4259869B2 JP 2002561757 A JP2002561757 A JP 2002561757A JP 2002561757 A JP2002561757 A JP 2002561757A JP 4259869 B2 JP4259869 B2 JP 4259869B2
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sequence
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JP2004523751A (ja
JP2004523751A5 (de
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ルーク ヴィー シュナイダー
ロバート ペテシュ
マイケル ピー ホール
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ターゲット ディスカヴァリー インコーポレイテッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6872—Methods for sequencing involving mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Polyesters Or Polycarbonates (AREA)
JP2002561757A 2000-10-19 2001-10-19 タンパク質及びペプチド末端配列の決定方法 Expired - Fee Related JP4259869B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24239800P 2000-10-19 2000-10-19
US24216500P 2000-10-19 2000-10-19
PCT/US2001/049491 WO2002061661A2 (en) 2000-10-19 2001-10-19 Methods for determining protein and peptide terminal sequences

Publications (3)

Publication Number Publication Date
JP2004523751A JP2004523751A (ja) 2004-08-05
JP2004523751A5 JP2004523751A5 (de) 2005-12-22
JP4259869B2 true JP4259869B2 (ja) 2009-04-30

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JP2002561757A Expired - Fee Related JP4259869B2 (ja) 2000-10-19 2001-10-19 タンパク質及びペプチド末端配列の決定方法
JP2002566627A Expired - Fee Related JP4020310B2 (ja) 2000-10-19 2001-10-19 オリゴマー配列の決定のための質量欠損標識
JP2007050865A Expired - Fee Related JP4467589B2 (ja) 2000-10-19 2007-02-28 オリゴマー配列の決定のための質量欠損標識

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JP2007050865A Expired - Fee Related JP4467589B2 (ja) 2000-10-19 2007-02-28 オリゴマー配列の決定のための質量欠損標識

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US (4) US20040209251A1 (de)
EP (3) EP1358458B1 (de)
JP (3) JP4259869B2 (de)
AT (1) ATE552348T1 (de)
AU (2) AU2002246744B2 (de)
CA (2) CA2426580C (de)
DK (1) DK1358458T3 (de)
ES (1) ES2385335T3 (de)
IL (5) IL155281A0 (de)
IS (1) IS6781A (de)
NO (1) NO20033632L (de)
PT (1) PT1358458E (de)
WO (2) WO2002061661A2 (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379971B1 (en) 1998-02-24 2002-04-30 Target Discovery, Inc. Methods for sequencing proteins
US6764817B1 (en) 1999-04-20 2004-07-20 Target Discovery, Inc. Methods for conducting metabolic analyses
US6716636B1 (en) 1999-04-20 2004-04-06 Target Discovery, Inc. Methods for sequencing proteins
WO2000065521A2 (en) 1999-04-23 2000-11-02 Massachusetts Institute Of Technology System and method for polymer notation
JP2004506900A (ja) * 2000-08-11 2004-03-04 アジリックス・コーポレイション 超高感度検出システム
AU2002246744B2 (en) * 2000-10-19 2008-04-10 Target Discovery, Inc. Methods for determining protein and peptide terminal sequences
US20030078739A1 (en) * 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
AU2002365271B2 (en) * 2001-11-06 2008-12-11 Agilix Corporation Sensitive coded detection systems
ITMI20020396A1 (it) * 2002-02-27 2003-08-27 Gian Luigi Gianfranceschi Procedimento per la determinazione automatica della composizione e/o della sequenza di un polimero
WO2004055491A2 (en) * 2002-05-20 2004-07-01 Massachusetts Institute Of Technology Novel method for sequence determination using nmr
US20040172200A1 (en) * 2002-11-22 2004-09-02 Kearney Paul Edward Constellation mapping and uses thereof
JP3817523B2 (ja) * 2003-02-14 2006-09-06 株式会社日立製作所 質量分析データ解析システム
JP4532874B2 (ja) * 2003-10-07 2010-08-25 キヤノン株式会社 質量分析可能な原子群を構成単位とする鎖状構造を有する分子に対して付加情報を付与して、情報記録コードとして利用する方法
US7105806B2 (en) * 2003-11-26 2006-09-12 Applera Corporation Method and apparatus for de-convoluting a convoluted spectrum
GB0329554D0 (en) * 2003-12-22 2004-01-28 Micromass Ltd Mass spectrometer
US7248360B2 (en) * 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
JP4393270B2 (ja) * 2004-05-21 2010-01-06 株式会社日立ハイテクノロジーズ 質量分析装置および異性体分析方法
JP2008519261A (ja) * 2004-10-29 2008-06-05 ターゲット ディスカバリー インク． 重水素化グルコースを用いたグリカン分析
JP2008529035A (ja) * 2005-02-03 2008-07-31 パーキンエルマー エルエーエス，インク． 多次元シグナルを用いる超高感度検出システム
WO2006130474A2 (en) * 2005-05-27 2006-12-07 Ionwerks, Inc. Multi-beam ion mobility time-of-flight mass spectrometer with bipolar ion extraction and zwitterion detection
EP1982349B1 (de) * 2006-02-07 2018-07-25 DH Technologies Development Pte. Ltd. Unterdrückung von chemischem rauschen für die massenspektrometrie
CA2640508C (en) * 2006-02-13 2014-04-15 Olga Ornatsky Gene expression assays conducted by elemental analysis
WO2007095378A2 (en) * 2006-02-15 2007-08-23 University Of Virginia Patent Foundation Mass tagging for quantitative analysis of biomolecules using 13c labeled phenylisocyanate
DE102006035577A1 (de) * 2006-07-27 2008-01-31 Eberhard-Karls-Universität Tübingen Universitätsklinikum Röntgendichtes Konjugat
US7838303B2 (en) * 2006-07-27 2010-11-23 Agilent Technologies, Inc. Peptide derivatization method to increase fragmentation information from MS/MS spectra
CN101809706B (zh) * 2007-06-01 2015-12-09 珀金埃尔默健康科学股份有限公司 大气压离子源性能增强方法
US7820963B2 (en) 2007-08-06 2010-10-26 Metabolic Alayses, Inc. Method for generation and use of isotopic patterns in mass spectral data of simple organisms
US8536520B2 (en) 2007-08-06 2013-09-17 Iroa Technologies Llc Method for generation and use of isotopic patterns in mass spectral data of simple organisms
US7820964B2 (en) * 2007-08-06 2010-10-26 Metabolic Analyses, Inc Method for generation and use of stable isotope patterns in mass spectral data
US8969251B2 (en) 2007-10-02 2015-03-03 Methabolic Analyses, Inc. Generation and use of isotopic patterns in mass spectral phenotypic comparison of organisms
US20090095899A1 (en) * 2007-10-16 2009-04-16 Whitehouse Craig M Atmospheric pressure ion source performance enhancement
WO2010049156A1 (en) * 2008-10-29 2010-05-06 Noxxon Pharma Ag Sequencing of nucleic acid molecules by mass spectrometry
US9863956B2 (en) 2009-07-22 2018-01-09 Agency For Science, Technology And Research Differentiation of isobaric amino acids and other species
US8153961B2 (en) * 2009-08-31 2012-04-10 Thermo Finnigan Llc Methods for acquisition and deductive analysis of mixed fragment peptide mass spectra
PL390797A1 (pl) 2010-03-22 2011-09-26 Instytut Chemii Bioorganicznej Polskiej Akademii Nauk Biblioteka kombinatoryczna, sposób otrzymywania biblioteki kombinatorycznej, sposób identyfikacji sekwencji, sposób sekwencjonowania elementów kombinatorycznych bibliotek oligonukleotydów i/lub analogów oligonukleotydów, zastosowanie łącznika do tworzenia bibliotek kombinatorycznych oraz zestaw do identyfikacji sekwencji
US9405884B2 (en) 2010-06-16 2016-08-02 Abbvie Inc. Methods and systems for the analysis of protein samples
SG186302A1 (en) 2010-06-16 2013-02-28 Abbott Lab Comparison of protein samples
US9046525B2 (en) * 2010-07-30 2015-06-02 California Institute Of Technology Method of determining the oligomeric state of a protein complex
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
WO2012137804A1 (ja) * 2011-04-04 2012-10-11 株式会社Ｊｃｌバイオアッセイ オリゴヌクレオチドの配列決定法
EP2798658B1 (de) * 2011-12-30 2017-03-01 DH Technologies Development Pte. Ltd. Systeme und verfahren zur sequenzierung von peptiden mittels massenspektrometrie
US10593528B2 (en) * 2013-09-23 2020-03-17 Micromass Uk Limited Peak assessment for mass spectrometers
JP2015121500A (ja) * 2013-12-25 2015-07-02 株式会社島津製作所 質量分析方法及び質量分析装置
EP3170006A1 (de) * 2014-07-18 2017-05-24 Thermo Finnigan LLC Verfahren zur massenspektrometrie von mischungen aus proteinen von polypeptiden mittels protonentransferreaktion
EP3193352A1 (de) 2016-01-14 2017-07-19 Thermo Finnigan LLC Verfahren zur massenspektrometriebasierten charakterisierung von biologischen molekülen
EP3460481B1 (de) 2016-01-14 2020-09-02 Thermo Finnigan LLC Verfahren zur hierarchischen multiplexierten massenspektralanalyse von mischungen von proteinen oder polypeptiden
EP3665476A4 (de) * 2017-08-07 2021-05-05 Agency for Science, Technology and Research Schnelle analyse und identifizierung von lipiden aus daten der flüssigkeitschromatografie-massenspektrometrie (lc-ms)
US20190172553A1 (en) * 2017-11-08 2019-06-06 Koninklijke Philips N.V. Using k-mers for rapid quality control of sequencing data without alignment
WO2019232520A1 (en) * 2018-06-01 2019-12-05 Cerno Bioscience Llc Mass spectral analysis of large molecules
WO2020037205A1 (en) 2018-08-17 2020-02-20 Regeneron Pharmaceuticals, Inc. Methods for de novo protein sequencing
KR102648650B1 (ko) * 2018-10-25 2024-03-15 주식회사 엘지화학 고분자 말단기 분석 방법
CN113552204B (zh) * 2020-04-02 2024-06-21 株式会社岛津制作所 质谱分析方法和质谱系统
JP7249980B2 (ja) 2020-10-26 2023-03-31 日本電子株式会社 マススペクトル処理装置及び方法
CN112505328B (zh) * 2020-11-02 2024-02-13 武汉金开瑞生物工程有限公司 一种同位素标记试剂盒和标记方法

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4351760A (en) 1979-09-07 1982-09-28 Syva Company Novel alkyl substituted fluorescent compounds and polyamino acid conjugates
US4391904A (en) 1979-12-26 1983-07-05 Syva Company Test strip kits in immunoassays and compositions therein
US4830010A (en) 1986-04-04 1989-05-16 Marshall Barry J Methods for the diagnosis of gastrointestinal disorders
US4842701A (en) 1987-04-06 1989-06-27 Battelle Memorial Institute Combined electrophoretic-separation and electrospray method and system
US4994155A (en) * 1988-12-09 1991-02-19 Learonal, Inc. High speed tin, lead or tin/lead alloy electroplating
US5174962A (en) * 1988-06-20 1992-12-29 Genomyx, Inc. Apparatus for determining DNA sequences by mass spectrometry
US4994165A (en) 1989-02-16 1991-02-19 Cornell Research Foundation, Inc. Liquid junction coupling for capillary zone electrophoresis/ion spray spectrometry
CA1340966C (en) * 1989-05-19 2000-04-18 Thomas R. Covey Method of protein analysis
US5100778A (en) 1989-10-03 1992-03-31 Monsanto Company Oligosaccharide sequencing
US5667984A (en) * 1991-05-07 1997-09-16 Oxford Glycosystems Ltd. Sequencing of oligosaccharides
DE69229914T2 (de) 1991-05-21 2000-04-20 Analytica Of Brandford, Inc. Verfahren und Apparat zur Verbesserung der Sprühionisation von gelösten Stoffen
CA2132012C (en) 1992-03-25 2003-04-22 John W. Shell Alkyl-substituted cellulose-based sustained-release oral drug dosage forms
ATE166158T1 (de) 1992-07-24 1998-05-15 Us Health Peptide brauchbar als microsequezierungsstandard und verfahren zu ihrer anwendung
US5470753A (en) 1992-09-03 1995-11-28 Selectide Corporation Peptide sequencing using mass spectrometry
US5674698A (en) 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US6194144B1 (en) 1993-01-07 2001-02-27 Sequenom, Inc. DNA sequencing by mass spectrometry
JPH08509857A (ja) 1993-01-07 1996-10-22 シーケノム・インコーポレーテッド マススペクトロメトリーによるｄｎａ配列決定法
GB9310467D0 (en) 1993-05-20 1993-07-07 Oxford Glycosystems Ltd Glycoconjugates
US5386832A (en) 1993-06-11 1995-02-07 New England Deaconess Hospital Liver function breath test using aromatic amino acids
US5503805A (en) 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
US6017693A (en) * 1994-03-14 2000-01-25 University Of Washington Identification of nucleotides, amino acids, or carbohydrates by mass spectrometry
DE4415480C2 (de) 1994-05-02 1999-09-02 Bruker Daltonik Gmbh Vorrichtung und Verfahren zur massenspektrometrischen Untersuchung von Substanzgemischen durch Kopplung kapillarelektrophoretischer Separation (CE) mit Elektrospray-Ionisierung (ESI)
JP3415682B2 (ja) 1994-08-10 2003-06-09 株式会社日立製作所 キャピラリー電気泳動・質量分析計
US5856082A (en) 1994-08-31 1999-01-05 University Of British Columbia Devices and methods for characterizing proteins and peptides
US5766891A (en) * 1994-12-19 1998-06-16 Sloan-Kettering Institute For Cancer Research Method for molecular cloning and polynucleotide synthesis using vaccinia DNA topoisomerase
US6127134A (en) 1995-04-20 2000-10-03 Carnegie Mellon University Difference gel electrophoresis using matched multiple dyes
US5625184A (en) 1995-05-19 1997-04-29 Perseptive Biosystems, Inc. Time-of-flight mass spectrometry analysis of biomolecules
US5827659A (en) 1995-05-19 1998-10-27 Perseptive Biosystems, Inc. Methods and apparatus for sequencing polymers using mass spectrometry
US5700642A (en) 1995-05-22 1997-12-23 Sri International Oligonucleotide sizing using immobilized cleavable primers
US6004770A (en) 1995-06-07 1999-12-21 Arizona State University Board Of Regents Sample presentation apparatus for mass spectrometry
US5872010A (en) 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US6027890A (en) 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US5722642A (en) * 1996-02-16 1998-03-03 Bradshaw; Terry L. Standing privacy fence with a deployable bench
US5800784A (en) 1996-07-09 1998-09-01 Horn; Marcus J. Chemical sample treatment system and cassette, and methods for effecting multistep treatment process
ATE340869T1 (de) 1997-01-15 2006-10-15 Xzillion Gmbh & Co Kg Massenmarkierte hybridisierungssonden
US5953653A (en) 1997-01-28 1999-09-14 Mediaone Group, Inc. Method and system for preventing mobile roaming fraud
GB9710582D0 (en) 1997-05-22 1997-07-16 Oxford Glycosciences Uk Ltd A method for de novo peptide sequence determination
US6090558A (en) 1997-09-19 2000-07-18 Genetrace Systems, Inc. DNA typing by mass spectrometry with polymorphic DNA repeat markers
GB9823646D0 (en) 1997-12-19 1998-12-23 Brax Genomics Ltd Compounds for mass spectrometry
US6379971B1 (en) 1998-02-24 2002-04-30 Target Discovery, Inc. Methods for sequencing proteins
US6428956B1 (en) 1998-03-02 2002-08-06 Isis Pharmaceuticals, Inc. Mass spectrometric methods for biomolecular screening
US5995989A (en) * 1998-04-24 1999-11-30 Eg&G Instruments, Inc. Method and apparatus for compression and filtering of data associated with spectrometry
US6359111B1 (en) * 1998-05-28 2002-03-19 Neorx Corporation Opioid receptor targeting
ATE536422T1 (de) 1998-08-25 2011-12-15 Univ Washington Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen
US6277644B1 (en) 1999-03-22 2001-08-21 Beckman Coulter, Inc. Method for compositional tag sequencing
AU774662B2 (en) 1999-04-20 2004-07-01 Target Discovery, Inc. Polypeptide fingerprinting methods, metabolic profiling, and bioinformatics database
US6677114B1 (en) 1999-04-20 2004-01-13 Target Discovery, Inc. Polypeptide fingerprinting methods and bioinformatics database system
US6391649B1 (en) * 1999-05-04 2002-05-21 The Rockefeller University Method for the comparative quantitative analysis of proteins and other biological material by isotopic labeling and mass spectroscopy
US6699846B2 (en) 2000-03-17 2004-03-02 Corixa Corporation Mono- and disaccharides for the treatment of nitric oxide related disorders
AU2002246744B2 (en) 2000-10-19 2008-04-10 Target Discovery, Inc. Methods for determining protein and peptide terminal sequences
EP1330551A2 (de) 2000-10-30 2003-07-30 Kalobios, Inc. Affinitätsreifung durch kompetitive selektion
US6875668B2 (en) 2000-11-03 2005-04-05 Advanced Micro Devices, Inc. Notched gate structure fabrication
US6900321B2 (en) * 2000-11-07 2005-05-31 Symyx Technologies, Inc. Substituted pyridyl amine complexes, and catalysts
CN1262337C (zh) 2000-11-16 2006-07-05 赛弗根生物系统股份有限公司 质谱分析方法
MXPA03006394A (es) 2001-01-18 2003-10-15 Univ California Instrumento quirurgico paraglaucoma minimamente invasivo y metodo.
EP1438110A4 (de) 2001-02-06 2005-01-26 Electronic Arts Inc Integration von echtzeitdaten in eine spieleanwendung
US7074534B2 (en) 2002-07-10 2006-07-11 E. I. Du Pont De Nemours And Company Polymeric charge transport compositions and electronic devices made with such compositions
JP2005533102A (ja) 2002-07-12 2005-11-04 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム 微小器官によって生物学的プロセスを誘発する方法と装置
JP4116351B2 (ja) 2002-07-16 2008-07-09 ジヤトコ株式会社 車両の制御装置
GB0216571D0 (en) 2002-07-17 2002-08-28 Celltech R&D Ltd Chemical compounds
US20050147985A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Mixtures of isobarically labeled analytes and fragments ions derived therefrom
JP2005241161A (ja) 2004-02-27 2005-09-08 Fujita Corp 変流量変更時の消費エネルギー算出方法および省エネルギー診断方法

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NO20033632D0 (no) 2003-08-15
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