JP4250771B2 - カチオン交換クロマトグラフィーによる因子ＶＩＩＩ／ｖＷＦ複合体の精製方法 - Google Patents

カチオン交換クロマトグラフィーによる因子ＶＩＩＩ／ｖＷＦ複合体の精製方法 Download PDF

Info

Publication number
JP4250771B2
JP4250771B2 JP53706098A JP53706098A JP4250771B2 JP 4250771 B2 JP4250771 B2 JP 4250771B2 JP 53706098 A JP53706098 A JP 53706098A JP 53706098 A JP53706098 A JP 53706098A JP 4250771 B2 JP4250771 B2 JP 4250771B2
Authority
JP
Japan
Prior art keywords
vwf
factor viii
complex
vwf complex
purification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP53706098A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001517212A5 (enExample
JP2001517212A (ja
Inventor
ミッテラー，アルトゥール
フィッシャー，ベルンハルト
シェーンベルガー，エーイヴィント・エル
トーマス−ウルバン，カトリン
ドルナー，フリードリッヒ
アイブル，ヨハン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxalta Innovations GmbH
Original Assignee
Baxter Innovations GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3487946&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP4250771(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter Innovations GmbH filed Critical Baxter Innovations GmbH
Publication of JP2001517212A publication Critical patent/JP2001517212A/ja
Publication of JP2001517212A5 publication Critical patent/JP2001517212A5/ja
Application granted granted Critical
Publication of JP4250771B2 publication Critical patent/JP4250771B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP53706098A 1997-02-27 1998-02-27 カチオン交換クロマトグラフィーによる因子ＶＩＩＩ／ｖＷＦ複合体の精製方法 Expired - Lifetime JP4250771B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AT338/97 1997-02-27
AT0033897A AT406373B (de) 1997-02-27 1997-02-27 Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie
PCT/AT1998/000043 WO1998038220A1 (de) 1997-02-27 1998-02-27 Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie

Publications (3)

Publication Number Publication Date
JP2001517212A JP2001517212A (ja) 2001-10-02
JP2001517212A5 JP2001517212A5 (enExample) 2005-10-06
JP4250771B2 true JP4250771B2 (ja) 2009-04-08

Family

ID=3487946

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53706098A Expired - Lifetime JP4250771B2 (ja) 1997-02-27 1998-02-27 カチオン交換クロマトグラフィーによる因子ＶＩＩＩ／ｖＷＦ複合体の精製方法

Country Status (11)

Country Link
US (3) US6831159B1 (enExample)
EP (1) EP0971958B2 (enExample)
JP (1) JP4250771B2 (enExample)
AR (2) AR010121A1 (enExample)
AT (2) AT406373B (enExample)
AU (1) AU744919B2 (enExample)
CA (1) CA2282841C (enExample)
DE (1) DE59814211D1 (enExample)
ES (1) ES2306471T5 (enExample)
NO (2) NO324902B1 (enExample)
WO (1) WO1998038220A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT406373B (de) 1997-02-27 2000-04-25 Immuno Ag Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie
EP1593388A1 (en) * 2004-05-05 2005-11-09 ZLB Behring GmbH Therapeutic plasma protein-concentrates containing von willebrand factor as high molecular weight multimers
US11197916B2 (en) 2007-12-28 2021-12-14 Takeda Pharmaceutical Company Limited Lyophilized recombinant VWF formulations
ES2298096B1 (es) 2008-01-08 2009-01-01 Grifols, S.A. Procedimiento para la obtencion de un concentrado de factor von willebrand o del complejo de factor viii/factor von willebrand y utilizacionde los mismos.
HRP20130414T1 (en) 2008-10-21 2013-06-30 Baxter International Inc. Lyophilized recombinant vwf formulations
HUE026907T2 (en) * 2009-08-20 2016-07-28 Baxalta Inc Clean VWF to enhance removal of non-lipid enveloped viruses
RU2579977C2 (ru) 2009-11-13 2016-04-10 Грифольс Терапьютикс Инк. СОДЕРЖАЩИЕ ФАКТОР ФОН ВИЛЛЕБРАНДА (vWF) ПРЕПАРАТЫ И СПОСОБЫ, НАБОРЫ И ПРИМЕНЕНИЯ, СВЯЗАННЫЕ С НИМИ
KR101997543B1 (ko) 2010-07-30 2019-07-09 이엠디 밀리포어 코포레이션 크로마토그래피 매질 및 방법
AU2011343813B2 (en) 2010-12-15 2015-05-21 Takeda Pharmaceutical Company Limited Eluate collection using conductivity gradient
DK3412305T3 (da) * 2011-06-10 2021-03-01 Baxalta GmbH Behandling af koagulationssygdom ved administration af rekombinant vwf
HRP20171272T4 (hr) 2011-08-02 2020-08-07 Baxalta GmbH Sustavi i metode za povećanje prinosa proteina iz postupka rekombinatne proizvodnje
NZ631702A (en) 2012-06-15 2017-01-27 Grains Res & Dev Corp Production of long chain polyunsaturated fatty acids in plant cells
US20150315263A1 (en) * 2012-11-30 2015-11-05 Centre For Bioseparation Technology - Vit Monolith-based pseudo-bioaffinity purification methods for factor viii and applications thereof
DK3066119T3 (en) * 2013-11-08 2018-11-12 Csl Ltd NEW PROCEDURE FOR CONCENTRATION OF THE VON WILLEBRAND FACTOR OR COMPLEXES OF IT
EP3082405A4 (en) 2013-12-18 2017-12-13 Commonwealth Scientific and Industrial Research Organisation Lipid comprising long chain polyunsaturated fatty acids
PH12016502586B1 (en) 2014-06-27 2023-07-19 Commw Scient Ind Res Org Lipid comprising docosapentaenoic acid
EP3188816B1 (en) 2014-09-02 2021-06-09 EMD Millipore Corporation Chromatography media comprising discrete porous bundles of nanofibrils
CA2966515C (en) 2014-12-08 2021-04-27 Emd Millipore Corporation Mixed bed ion exchange adsorber
JP7307047B2 (ja) 2017-07-07 2023-07-11 武田薬品工業株式会社 組換えｖｗｆの投与による重度のフォンヴィレブランド病を患う患者における消化管出血の治療
JP2022524291A (ja) 2019-02-01 2022-05-02 武田薬品工業株式会社 組換えＶＷＦ（ｒＶＷＦ）を使用する予防治療法
CN114106145B (zh) * 2021-10-22 2023-09-01 山东泰邦生物制品有限公司 一种血源人凝血因子ⅷ/血管性血友病因子复合物生产工艺

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540573A (en) 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
GB8403473D0 (en) * 1984-02-09 1984-03-14 Special Trustees For St Thomas Purification of factor viii
US5200510A (en) * 1987-06-16 1993-04-06 Zymogenetics, Inc. Method for purifying factor viii:c, von willebrand factor and complexes thereof
FR2651437A1 (fr) 1989-09-05 1991-03-08 Lille Transfusion Sanguine Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total.
NZ237244A (en) * 1990-03-02 1992-10-28 Bio Technology General Corp Cloning and production of human von willebrand factor analogues and compositions thereof
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
IT1256622B (it) † 1992-12-04 1995-12-12 Sclavo Spa Processo per l'estrazione del complesso fattore viii-fattore von willebrand (fviii:c-fvw) da plasma umano totale.
AT401270B (de) 1994-09-26 1996-07-25 Immuno Ag Verfahren zur quantifizierung von genomischer dna
CA2159044A1 (en) * 1994-09-26 1996-03-27 Falko-Guenter Falkner Method of quantitating nucleic acids
DE4435392B4 (de) * 1994-10-04 2008-02-07 Immuno Ag Verfahren zur Trennung von vWF in hochmolekularen vWF und niedermolekularen vWF
DE4435485C1 (de) * 1994-10-04 1996-03-21 Immuno Ag Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor
AT403764B (de) 1996-03-15 1998-05-25 Immuno Ag Stabiler faktor viii/vwf-komplex
CA2251558C (en) 1996-04-12 2005-11-22 Immuno Aktiengesellschaft Highly purified factor viii complex
AT403765B (de) 1996-04-12 1998-05-25 Immuno Ag Verfahren zur herstellung einer präparation enthaltend einen hochgereinigten komplex
AT406373B (de) 1997-02-27 2000-04-25 Immuno Ag Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie
AT405403B (de) 1997-02-27 1999-08-25 Immuno Ag Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie

Also Published As

Publication number Publication date
ES2306471T5 (es) 2012-06-07
ES2306471T3 (es) 2008-11-01
NO994137D0 (no) 1999-08-26
NO20071357L (no) 1999-08-26
US6831159B1 (en) 2004-12-14
AU6080698A (en) 1998-09-18
NO326257B1 (no) 2008-10-27
AU744919B2 (en) 2002-03-07
CA2282841A1 (en) 1998-09-03
EP0971958A1 (de) 2000-01-19
US20050239171A1 (en) 2005-10-27
US20020058625A1 (en) 2002-05-16
EP0971958B2 (de) 2012-02-08
DE59814211D1 (de) 2008-05-21
NO994137L (no) 1999-08-26
WO1998038220A1 (de) 1998-09-03
US7648958B2 (en) 2010-01-19
ATE391728T1 (de) 2008-04-15
CA2282841C (en) 2008-12-02
EP0971958B1 (de) 2008-04-09
US6953837B2 (en) 2005-10-11
AR010121A1 (es) 2000-05-17
AT406373B (de) 2000-04-25
ATA33897A (de) 1999-09-15
NO324902B1 (no) 2007-12-27
JP2001517212A (ja) 2001-10-02
AR059902A2 (es) 2008-05-07

Similar Documents

Publication Publication Date Title
JP4250771B2 (ja) カチオン交換クロマトグラフィーによる因子ＶＩＩＩ／ｖＷＦ複合体の精製方法
US4877608A (en) Pharmaceutical plasma protein formulations in low ionic strength media
RU2088590C1 (ru) Способ получения стандартизированного концентрата человеческого фактора виллебранда и концентрат, полученный этим способом
JP4250770B2 (ja) カチオン交換クロマトグラフィーによるフォンビルブラント因子の精製
CA1329760C (en) Plasma and recombinant protein formulations in high ionic strength media
CA2024667C (en) Process for preparing a concentrate of blood coagulation factor viii-von willebrand factor complex from total plasma
Burnouf‐Radosevich et al. Chromatographic preparation of a therapeutic highly purified von Willebrand factor concentrate from human cryoprecipitate
JP2000506869A (ja) 安定な因子ｖｉｉｉ／▲下ｖ▼ｗｆ複合体
JPH01207239A (ja) 高純度のヒト因子ｉｘ濃縮物および他の血漿蛋白質およびそれらの治療学的使用
AU2003244850B2 (en) Processes for the preparation of fibrinogen
CN101796065A (zh) 纯化因子VIII和Von Willebrand因子的方法
JP3976351B2 (ja) 免疫寛容プロトロンビン複合体の調製
JPH04234400A (ja) 抗血友病因子（第ＶＩＩＩｃ因子）をほとんど含まない高純度のフォン・ヴィレブラント因子を生成する方法
JP4660048B2 (ja) 血漿プロテアーゼからのフィブリノゲンの分離
JPS6160614A (ja) 第８因子製剤およびその製造方法
MXPA02010017A (es) Preparacion activa hemostaticamente, que contiene el factor de von willebrand y metodo para la produccion de la misma.
JP2004123744A (ja) Ｖｉｉｉ因子：ｃ含有フォンビルブラント因子の濃縮物およびそれに関連する方法
JP2931655B2 (ja) 全血漿から血液疑固▲ｖｉｉｉ▼因子―フオン・ビルブラント因子複合体濃縮物の製造方法
JP2002504561A (ja) 第ＶＩＩＩ因子／ｖＷＦ複合体の産生方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050224

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050224

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070731

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20071031

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080617

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080806

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20081014

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20081023

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20081209

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20090105

A72 Notification of change in name of applicant

Free format text: JAPANESE INTERMEDIATE CODE: A721

Effective date: 20081224

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120130

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130130

Year of fee payment: 4

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S533 Written request for registration of change of name

Free format text: JAPANESE INTERMEDIATE CODE: R313533

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term