DE59814211D1 - Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie - Google Patents

Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie

Info

Publication number
DE59814211D1
DE59814211D1 DE59814211T DE59814211T DE59814211D1 DE 59814211 D1 DE59814211 D1 DE 59814211D1 DE 59814211 T DE59814211 T DE 59814211T DE 59814211 T DE59814211 T DE 59814211T DE 59814211 D1 DE59814211 D1 DE 59814211D1
Authority
DE
Germany
Prior art keywords
cation exchange
exchange chromatography
factor viii
vwf complex
cleaning factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE59814211T
Other languages
German (de)
English (en)
Inventor
Artur Mitterer
Bernhard Fischer
Oeyvind L Schoenberger
Kathrin Thomas-Urban
Friedrich Dorner
Johann Eibl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter AG
Original Assignee
Baxter AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3487946&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE59814211(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter AG filed Critical Baxter AG
Application granted granted Critical
Publication of DE59814211D1 publication Critical patent/DE59814211D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE59814211T 1997-02-27 1998-02-27 Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie Expired - Lifetime DE59814211D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0033897A AT406373B (de) 1997-02-27 1997-02-27 Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie
PCT/AT1998/000043 WO1998038220A1 (de) 1997-02-27 1998-02-27 Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie

Publications (1)

Publication Number Publication Date
DE59814211D1 true DE59814211D1 (de) 2008-05-21

Family

ID=3487946

Family Applications (1)

Application Number Title Priority Date Filing Date
DE59814211T Expired - Lifetime DE59814211D1 (de) 1997-02-27 1998-02-27 Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie

Country Status (11)

Country Link
US (3) US6831159B1 (enExample)
EP (1) EP0971958B2 (enExample)
JP (1) JP4250771B2 (enExample)
AR (2) AR010121A1 (enExample)
AT (2) AT406373B (enExample)
AU (1) AU744919B2 (enExample)
CA (1) CA2282841C (enExample)
DE (1) DE59814211D1 (enExample)
ES (1) ES2306471T5 (enExample)
NO (2) NO324902B1 (enExample)
WO (1) WO1998038220A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT406373B (de) 1997-02-27 2000-04-25 Immuno Ag Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie
EP1593388A1 (en) 2004-05-05 2005-11-09 ZLB Behring GmbH Therapeutic plasma protein-concentrates containing von willebrand factor as high molecular weight multimers
US11197916B2 (en) 2007-12-28 2021-12-14 Takeda Pharmaceutical Company Limited Lyophilized recombinant VWF formulations
ES2298096B1 (es) 2008-01-08 2009-01-01 Grifols, S.A. Procedimiento para la obtencion de un concentrado de factor von willebrand o del complejo de factor viii/factor von willebrand y utilizacionde los mismos.
CN103919736A (zh) 2008-10-21 2014-07-16 巴克斯特国际公司 冻干的重组vwf配方
CA2771232A1 (en) 2009-08-20 2011-02-24 Baxter International Inc. Purification of vwf for increased removal of non-lipid enveloped viruses
RU2579977C2 (ru) 2009-11-13 2016-04-10 Грифольс Терапьютикс Инк. СОДЕРЖАЩИЕ ФАКТОР ФОН ВИЛЛЕБРАНДА (vWF) ПРЕПАРАТЫ И СПОСОБЫ, НАБОРЫ И ПРИМЕНЕНИЯ, СВЯЗАННЫЕ С НИМИ
EP2598223B1 (en) * 2010-07-30 2022-04-06 EMD Millipore Corporation Chromatography media and method
US9488625B2 (en) 2010-12-15 2016-11-08 Baxalta GmbH Purification of factor VIII using a conductivity gradient
EP3858375B1 (en) * 2011-06-10 2024-03-20 Takeda Pharmaceutical Company Limited Treatment of coagulation disease by administration of recombinant vwf
WO2013019964A1 (en) 2011-08-02 2013-02-07 Baxter International, Inc. Systems and methods to increase protein yield from recombinant manufacturing processes
PT2861059T (pt) 2012-06-15 2017-08-08 Grains Res & Dev Corp Produção de ácidos gordos polinsaturados de cadeia longa em células vegetais
EP2925777B1 (en) * 2012-11-30 2019-05-01 Centre for Bioseparation Technology-VIT Monolith-based pseudo-bioaffinity purification methods for factor viii and applications thereof
US10246485B2 (en) 2013-11-08 2019-04-02 Csl Limited Method to concentrate von willebrand factor or complexes thereof
WO2015089587A1 (en) 2013-12-18 2015-06-25 Commonwealth Scientific And Industrial Research Organisation Lipid comprising long chain polyunsaturated fatty acids
PH12016502586B1 (en) 2014-06-27 2023-07-19 Commw Scient Ind Res Org Lipid comprising docosapentaenoic acid
WO2016036508A1 (en) 2014-09-02 2016-03-10 Emd Millipore Corporation High surface area fiber media with nano-fibrillated surface features
CA2966515C (en) 2014-12-08 2021-04-27 Emd Millipore Corporation Mixed bed ion exchange adsorber
AU2018298233B2 (en) 2017-07-07 2025-04-24 Takeda Pharmaceutical Company Limited Treatment of gastrointestinal bleeding in patients with severe von willebrand disease by administration of recombinant VWF
CA3128498A1 (en) 2019-02-01 2020-08-06 Bjorn Mellgard Methods of prophylactic treatment using recombinant vwf (rvwf)
CN114106145B (zh) * 2021-10-22 2023-09-01 山东泰邦生物制品有限公司 一种血源人凝血因子ⅷ/血管性血友病因子复合物生产工艺

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540573A (en) 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
GB8403473D0 (en) * 1984-02-09 1984-03-14 Special Trustees For St Thomas Purification of factor viii
US5200510A (en) * 1987-06-16 1993-04-06 Zymogenetics, Inc. Method for purifying factor viii:c, von willebrand factor and complexes thereof
FR2651437A1 (fr) 1989-09-05 1991-03-08 Lille Transfusion Sanguine Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total.
NZ237244A (en) * 1990-03-02 1992-10-28 Bio Technology General Corp Cloning and production of human von willebrand factor analogues and compositions thereof
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
IT1256622B (it) † 1992-12-04 1995-12-12 Sclavo Spa Processo per l'estrazione del complesso fattore viii-fattore von willebrand (fviii:c-fvw) da plasma umano totale.
AT401270B (de) * 1994-09-26 1996-07-25 Immuno Ag Verfahren zur quantifizierung von genomischer dna
CA2159044A1 (en) 1994-09-26 1996-03-27 Falko-Guenter Falkner Method of quantitating nucleic acids
DE4435392B4 (de) * 1994-10-04 2008-02-07 Immuno Ag Verfahren zur Trennung von vWF in hochmolekularen vWF und niedermolekularen vWF
DE4435485C1 (de) 1994-10-04 1996-03-21 Immuno Ag Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor
AT403764B (de) 1996-03-15 1998-05-25 Immuno Ag Stabiler faktor viii/vwf-komplex
AT403765B (de) 1996-04-12 1998-05-25 Immuno Ag Verfahren zur herstellung einer präparation enthaltend einen hochgereinigten komplex
CA2251558C (en) 1996-04-12 2005-11-22 Immuno Aktiengesellschaft Highly purified factor viii complex
AT406373B (de) 1997-02-27 2000-04-25 Immuno Ag Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie
AT405403B (de) 1997-02-27 1999-08-25 Immuno Ag Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie

Also Published As

Publication number Publication date
US6831159B1 (en) 2004-12-14
EP0971958A1 (de) 2000-01-19
NO324902B1 (no) 2007-12-27
ATE391728T1 (de) 2008-04-15
AU744919B2 (en) 2002-03-07
ATA33897A (de) 1999-09-15
AT406373B (de) 2000-04-25
AR010121A1 (es) 2000-05-17
NO326257B1 (no) 2008-10-27
CA2282841A1 (en) 1998-09-03
AR059902A2 (es) 2008-05-07
US6953837B2 (en) 2005-10-11
JP2001517212A (ja) 2001-10-02
US20020058625A1 (en) 2002-05-16
WO1998038220A1 (de) 1998-09-03
CA2282841C (en) 2008-12-02
US7648958B2 (en) 2010-01-19
NO994137L (no) 1999-08-26
NO20071357L (no) 1999-08-26
EP0971958B2 (de) 2012-02-08
JP4250771B2 (ja) 2009-04-08
ES2306471T3 (es) 2008-11-01
NO994137D0 (no) 1999-08-26
AU6080698A (en) 1998-09-18
EP0971958B1 (de) 2008-04-09
ES2306471T5 (es) 2012-06-07
US20050239171A1 (en) 2005-10-27

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