JP4222658B2 - 細胞支持基材、培養装置および液体処理装置 - Google Patents

細胞支持基材、培養装置および液体処理装置 Download PDF

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JP4222658B2
JP4222658B2 JP19239098A JP19239098A JP4222658B2 JP 4222658 B2 JP4222658 B2 JP 4222658B2 JP 19239098 A JP19239098 A JP 19239098A JP 19239098 A JP19239098 A JP 19239098A JP 4222658 B2 JP4222658 B2 JP 4222658B2
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cell
cell support
cells
pore diameter
support substrate
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JP19239098A
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Japanese (ja)
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JP2000004870A5 (enExample
JP2000004870A (ja
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哲寛 木村
則文 徳永
佳孝 大村
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Terumo Corp
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Terumo Corp
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Priority to JP19239098A priority Critical patent/JP4222658B2/ja
Priority to DE69928997T priority patent/DE69928997T2/de
Priority to EP99401562A priority patent/EP0967273B1/en
Priority to US09/338,382 priority patent/US6303375B1/en
Publication of JP2000004870A publication Critical patent/JP2000004870A/ja
Publication of JP2000004870A5 publication Critical patent/JP2000004870A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/78—Cellulose

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Sustainable Development (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • External Artificial Organs (AREA)
JP19239098A 1998-06-23 1998-06-23 細胞支持基材、培養装置および液体処理装置 Expired - Fee Related JP4222658B2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP19239098A JP4222658B2 (ja) 1998-06-23 1998-06-23 細胞支持基材、培養装置および液体処理装置
DE69928997T DE69928997T2 (de) 1998-06-23 1999-06-23 Zellträgermatrix, Vorrichtung für Zellkulturen und Flüssigkeitsbehandlung
EP99401562A EP0967273B1 (en) 1998-06-23 1999-06-23 Cell supporting matrix, cell culture device, and fluid treating device
US09/338,382 US6303375B1 (en) 1998-06-23 1999-06-23 Cell supporting matrix, cell culture device, and fluid treating device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP19239098A JP4222658B2 (ja) 1998-06-23 1998-06-23 細胞支持基材、培養装置および液体処理装置

Publications (3)

Publication Number Publication Date
JP2000004870A JP2000004870A (ja) 2000-01-11
JP2000004870A5 JP2000004870A5 (enExample) 2005-09-29
JP4222658B2 true JP4222658B2 (ja) 2009-02-12

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JP19239098A Expired - Fee Related JP4222658B2 (ja) 1998-06-23 1998-06-23 細胞支持基材、培養装置および液体処理装置

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US (1) US6303375B1 (enExample)
EP (1) EP0967273B1 (enExample)
JP (1) JP4222658B2 (enExample)
DE (1) DE69928997T2 (enExample)

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US6541243B1 (en) * 2000-06-05 2003-04-01 Axon Instruments, Inc. Perfusion chamber for electrophysiological testing of oocytes
US20020045260A1 (en) * 2000-10-17 2002-04-18 Shih-Chieh Hung Method of isolating mesenchymal stem cells
US20040029266A1 (en) * 2002-08-09 2004-02-12 Emilio Barbera-Guillem Cell and tissue culture device
WO2004085606A1 (ja) * 2003-03-24 2004-10-07 National Institute For Environmental Studies 細胞培養基質および細胞接着蛋白質またはペプチドの固相化標品
EP1475434A1 (en) * 2003-05-09 2004-11-10 Oncoscience AG Method for storing tumor cells
GB2401612A (en) * 2003-05-13 2004-11-17 Univ Manchester Method and device for culturing tissue
JP2006025635A (ja) * 2004-07-13 2006-02-02 Kaneka Corp 多孔質の支持体に細胞を内在化させる方法、器具または装置
US7514256B2 (en) * 2005-02-11 2009-04-07 Emilio Barbera-Guillem Bioreactor for selectively controlling the molecular diffusion between fluids
EP1913126B1 (en) 2005-08-12 2019-09-25 Clemson University Research Foundation Co-culture bioreactor system
US8470520B2 (en) 2005-08-26 2013-06-25 Regents Of The University Of Minnesota Decellularization and recellularization of organs and tissues
DE102005058187A1 (de) 2005-12-01 2007-06-14 Carl Zeiss Jena Gmbh Anordnung zur Fokussierung von Beleuchtungseinrichtung für Mikroskope
WO2009108654A2 (en) * 2008-02-25 2009-09-03 Clemson University Differential pressure pump system
EP2413946A2 (en) * 2009-03-31 2012-02-08 Regents of the University of Minnesota Decellularization and recellularization of organs and tissues
EP2611472B1 (en) 2010-09-01 2016-02-10 Regents of the University of Minnesota Methods of recellularizing a tissue or organ for improved transplantability
WO2012163368A1 (en) * 2011-05-30 2012-12-06 Atech System Solutions Ltd. Bioreactor system for continuous cell cultivation
AU2013311288B2 (en) * 2012-09-06 2015-04-16 Pluristem Ltd. Devices and methods for culture of cells
ES2831756T3 (es) 2013-03-15 2021-06-09 Miromatrix Medical Inc Uso de hígado descelularizado por perfusión para la recelularización de células de islotes
ES2751454T3 (es) 2013-05-17 2020-03-31 Siemens Healthcare Diagnostics Inc Liberación y recogida de partículas
FR3017877A1 (fr) * 2014-02-24 2015-08-28 Univ Rouen Materiau pour la culture des cellules, procedes de preparation et ses utilisations
WO2017158791A1 (ja) * 2016-03-17 2017-09-21 富士機械製造株式会社 人工臓器用のセルチャンバー
EP3509651B1 (en) 2016-09-06 2022-12-28 Miromatrix Medical Inc. Use of resected liver serum for whole liver engineering
KR101846732B1 (ko) * 2016-11-04 2018-04-06 단국대학교 천안캠퍼스 산학협력단 신경세포 in vitro 배양방법
KR101856379B1 (ko) * 2016-11-04 2018-05-09 단국대학교 천안캠퍼스 산학협력단 세포 시딩방법
CN112154201B (zh) * 2018-05-22 2024-12-27 形态细胞科技公司 灌注生物反应器、灌注器件、人造肝脏系统及相关方法
WO2019241499A1 (en) 2018-06-13 2019-12-19 Miromatrix Medical Inc. Fistula filler and deployment system
US20200248123A1 (en) 2019-02-05 2020-08-06 Corning Incorporated Packed-bed bioreactor systems and methods of using the same
CN110556046B (zh) * 2019-08-09 2021-05-28 西安交通大学 一种双网络结构三维组织模型及其灌流一体化制备方法
US11118151B2 (en) 2019-11-05 2021-09-14 Corning Incorporated Fixed bed bioreactor and methods of using the same
US20240010972A1 (en) * 2020-11-30 2024-01-11 Corning Incorporated Packed bed bioreactors with controlled zonal porosity

Family Cites Families (14)

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US4440853A (en) * 1980-08-21 1984-04-03 Board Of Trustees Of The Leland Stanford Junior University Microbiological methods using hollow fiber membrane reactor
JPH0746988B2 (ja) 1986-03-14 1995-05-24 日東電工株式会社 付着性動物細胞の培養法および培養装置
GB8729889D0 (en) * 1987-12-22 1988-02-03 Unilever Plc Bio-catalysts support systems
US5595909A (en) * 1988-05-23 1997-01-21 Regents Of The University Of Minnesota Filter device
DE69020248T2 (de) 1989-07-14 1996-01-25 Terumo Corp Filtermaterial zum Abscheiden von Leukozyten und Verfahren zu seiner Herstellung.
JPH0825886B2 (ja) 1989-07-14 1996-03-13 テルモ株式会社 白血球捕捉用フィルター材およびその製造方法
JPH0576364A (ja) 1991-09-20 1993-03-30 Kanegafuchi Chem Ind Co Ltd 動物遊離細胞の固定化物、固定化方法および培養方法
DE69303779T2 (de) * 1992-02-07 1997-01-16 Monsanto Co Biologische künstliche leber
JPH06284883A (ja) 1992-07-10 1994-10-11 Sanyo Chem Ind Ltd 肝細胞培養方法
JPH06153905A (ja) 1992-11-24 1994-06-03 Sanyo Chem Ind Ltd 細胞培養基材および細胞培養方法
JPH06277050A (ja) 1993-03-26 1994-10-04 Kanegafuchi Chem Ind Co Ltd 動物細胞の固定化物および培養方法
JP3511399B2 (ja) 1993-03-31 2004-03-29 株式会社三菱化学ヤトロン 細胞培養基材及び細胞培養方法
AU714517B2 (en) 1995-10-06 2000-01-06 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Academisch Medisch Centrum Solid support for use in cell cultivation, especially for the cultivation of liver cells, biological reactor containing said solid support and the use thereof in bio-artificial liver system
JPH1146759A (ja) 1997-08-06 1999-02-23 Terumo Corp 細胞培養液

Also Published As

Publication number Publication date
US6303375B1 (en) 2001-10-16
DE69928997D1 (de) 2006-01-26
EP0967273B1 (en) 2005-12-21
EP0967273A1 (en) 1999-12-29
JP2000004870A (ja) 2000-01-11
DE69928997T2 (de) 2006-09-21

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