DE69303779T2 - Biologische künstliche leber - Google Patents

Biologische künstliche leber

Info

Publication number
DE69303779T2
DE69303779T2 DE69303779T DE69303779T DE69303779T2 DE 69303779 T2 DE69303779 T2 DE 69303779T2 DE 69303779 T DE69303779 T DE 69303779T DE 69303779 T DE69303779 T DE 69303779T DE 69303779 T2 DE69303779 T2 DE 69303779T2
Authority
DE
Germany
Prior art keywords
artificial liver
containment vessel
perfusion
biological artificial
liver
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69303779T
Other languages
English (en)
Other versions
DE69303779D1 (de
Inventor
George Barker
Dale Beck
Albert Li
Timothy Whitehead
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of DE69303779D1 publication Critical patent/DE69303779D1/de
Publication of DE69303779T2 publication Critical patent/DE69303779T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • A61M1/3489—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents by biological cells, e.g. bioreactor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/16—Particles; Beads; Granular material; Encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/10—Mineral substrates
    • C12N2533/12—Glass

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Sustainable Development (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Immunology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Prostheses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69303779T 1992-02-07 1993-01-06 Biologische künstliche leber Expired - Fee Related DE69303779T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83246192A 1992-02-07 1992-02-07
PCT/US1993/000121 WO1993016171A1 (en) 1992-02-07 1993-01-06 Biological artificial liver

Publications (2)

Publication Number Publication Date
DE69303779D1 DE69303779D1 (de) 1996-08-29
DE69303779T2 true DE69303779T2 (de) 1997-01-16

Family

ID=25261723

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69303779T Expired - Fee Related DE69303779T2 (de) 1992-02-07 1993-01-06 Biologische künstliche leber

Country Status (12)

Country Link
EP (1) EP0579804B1 (de)
JP (1) JP3339685B2 (de)
KR (1) KR100250630B1 (de)
AT (1) ATE140726T1 (de)
AU (1) AU661561B2 (de)
CA (1) CA2107582A1 (de)
DE (1) DE69303779T2 (de)
DK (1) DK0579804T3 (de)
ES (1) ES2090963T3 (de)
GR (1) GR3020619T3 (de)
MX (1) MX9300674A (de)
WO (1) WO1993016171A1 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19831873A1 (de) * 1998-07-16 2000-03-30 Jens Altrichter Verfahren und Einrichtung zur therapeutischen Immunmodulation
DE102008023545A1 (de) * 2008-05-14 2009-11-19 Roderfeld Und Bora Gmbh & Co.Kg Vorrichtung zur Herstellung einer biologisch aktiven Substanz

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712154A (en) * 1995-06-07 1998-01-27 W.R. Grace & Co.-Conn. Dual fiber bioreactor
DE19540487A1 (de) * 1995-10-20 1997-04-24 Olaf Schultz Zellinteraktionssystem zur Induktion künstlicher Gewebe
US5827729A (en) 1996-04-23 1998-10-27 Advanced Tissue Sciences Diffusion gradient bioreactor and extracorporeal liver device using a three-dimensional liver tissue
AUPP108597A0 (en) * 1997-12-22 1998-01-22 Sheil, A G R Prof. Liver support system
JP4222658B2 (ja) 1998-06-23 2009-02-12 テルモ株式会社 細胞支持基材、培養装置および液体処理装置
JP2003519503A (ja) * 2000-01-14 2003-06-24 テラクリン アクチエンゲゼルシャフト 物質混合物中の免疫調節活性物質の濃度を増加及び／または減少させる方法及び装置
AU2001242738A1 (en) * 2000-03-22 2001-10-03 Katsutoshi Naruse Novel artificial organ system
JP4672511B2 (ja) * 2005-10-05 2011-04-20 学校法人早稲田大学 マイクロ反応装置
GB2467645B (en) 2007-07-06 2011-12-21 Univ London A method of proliferating human hepatocyte cells
US8999702B2 (en) 2008-06-11 2015-04-07 Emd Millipore Corporation Stirred tank bioreactor
EP2508607A1 (de) * 2011-04-07 2012-10-10 Helmholtz-Zentrum für Infektionsforschung GmbH Medikament zur Leberregeneration und zur Behandlung von Leberversagen
JP2020074698A (ja) * 2018-11-06 2020-05-21 国立大学法人 東京大学 灌流培養システム及び培養方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1213404A (en) * 1981-11-13 1986-11-04 Theodore E. Spielberg Ultrafiltering hybrid artificial organ
SU1113131A1 (ru) * 1982-05-31 1984-09-15 Рижский Медицинский Институт Способ лечени печеночной недостаточности
US5043260A (en) * 1987-11-02 1991-08-27 Rhode Island Hospital Perfusion device with hepatocytes

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19831873A1 (de) * 1998-07-16 2000-03-30 Jens Altrichter Verfahren und Einrichtung zur therapeutischen Immunmodulation
US6509147B1 (en) 1998-07-16 2003-01-21 Teraklin Aktiengessellschaft Method for therapeutic immunmodulation of plasma
DE102008023545A1 (de) * 2008-05-14 2009-11-19 Roderfeld Und Bora Gmbh & Co.Kg Vorrichtung zur Herstellung einer biologisch aktiven Substanz

Also Published As

Publication number Publication date
ATE140726T1 (de) 1996-08-15
EP0579804A1 (de) 1994-01-26
GR3020619T3 (en) 1996-10-31
DK0579804T3 (da) 1996-08-26
WO1993016171A1 (en) 1993-08-19
MX9300674A (es) 1993-10-01
AU661561B2 (en) 1995-07-27
CA2107582A1 (en) 1993-08-08
KR100250630B1 (ko) 2000-04-01
AU3437393A (en) 1993-09-03
JPH06509476A (ja) 1994-10-27
DE69303779D1 (de) 1996-08-29
EP0579804B1 (de) 1996-07-24
JP3339685B2 (ja) 2002-10-28
ES2090963T3 (es) 1996-10-16

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee