JP4181232B2 - ジクロフェナクナトリウム含有油性外用貼付製剤 - Google Patents
ジクロフェナクナトリウム含有油性外用貼付製剤 Download PDFInfo
- Publication number
- JP4181232B2 JP4181232B2 JP19375997A JP19375997A JP4181232B2 JP 4181232 B2 JP4181232 B2 JP 4181232B2 JP 19375997 A JP19375997 A JP 19375997A JP 19375997 A JP19375997 A JP 19375997A JP 4181232 B2 JP4181232 B2 JP 4181232B2
- Authority
- JP
- Japan
- Prior art keywords
- diclofenac sodium
- acid
- weight
- preparation
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title claims description 35
- 229960001193 diclofenac sodium Drugs 0.000 title claims description 33
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 title claims description 33
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 22
- 239000000194 fatty acid Substances 0.000 claims description 22
- 229930195729 fatty acid Natural products 0.000 claims description 22
- 150000004665 fatty acids Chemical class 0.000 claims description 20
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 claims description 16
- 238000002156 mixing Methods 0.000 claims description 14
- 239000011347 resin Substances 0.000 claims description 12
- 229920005989 resin Polymers 0.000 claims description 12
- 239000000853 adhesive Substances 0.000 claims description 10
- 230000001070 adhesive effect Effects 0.000 claims description 10
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 7
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 7
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 7
- 239000005642 Oleic acid Substances 0.000 claims description 7
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 7
- 239000003963 antioxidant agent Substances 0.000 claims description 7
- 230000003078 antioxidant effect Effects 0.000 claims description 7
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 7
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 7
- 235000021313 oleic acid Nutrition 0.000 claims description 7
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims description 6
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims description 6
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 6
- 229960004488 linolenic acid Drugs 0.000 claims description 6
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims description 3
- VSKJLJHPAFKHBX-UHFFFAOYSA-N 2-methylbuta-1,3-diene;styrene Chemical compound CC(=C)C=C.C=CC1=CC=CC=C1.C=CC1=CC=CC=C1 VSKJLJHPAFKHBX-UHFFFAOYSA-N 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims 1
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- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims 1
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- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 3
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 3
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 3
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- 239000000126 substance Substances 0.000 description 3
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- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
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- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 1
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- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 description 1
- ROGIWVXWXZRRMZ-UHFFFAOYSA-N 2-methylbuta-1,3-diene;styrene Chemical compound CC(=C)C=C.C=CC1=CC=CC=C1 ROGIWVXWXZRRMZ-UHFFFAOYSA-N 0.000 description 1
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
- 208000019300 CLIPPERS Diseases 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
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- 239000002253 acid Substances 0.000 description 1
- 125000002723 alicyclic group Chemical group 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 239000003907 antipyretic analgesic agent Substances 0.000 description 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 description 1
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- 208000021930 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids Diseases 0.000 description 1
- IGBBVTAVILYDIO-KTKRTIGZSA-N cis-undec-2-enoic acid Chemical compound CCCCCCCC\C=C/C(O)=O IGBBVTAVILYDIO-KTKRTIGZSA-N 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
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- KSCKTBJJRVPGKM-UHFFFAOYSA-N octan-1-olate;titanium(4+) Chemical compound [Ti+4].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-] KSCKTBJJRVPGKM-UHFFFAOYSA-N 0.000 description 1
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- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Botany (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19375997A JP4181232B2 (ja) | 1997-07-18 | 1997-07-18 | ジクロフェナクナトリウム含有油性外用貼付製剤 |
| US09/254,925 US6262121B1 (en) | 1997-07-18 | 1998-07-14 | Oily patches for external use containing diclofenac sodium |
| HK99105281.9A HK1020675B (en) | 1997-07-18 | 1998-07-14 | Oil patches for external use containing diclofenac sodium |
| PCT/JP1998/003135 WO1999003461A1 (fr) | 1997-07-18 | 1998-07-14 | Timbres huileux pour usage externe contenant du diclofenac sodium |
| KR1019997002263A KR100540821B1 (ko) | 1997-07-18 | 1998-07-14 | 디클로페낙 나트륨 함유 유성 외용 첩제 |
| DE69801893T DE69801893T2 (de) | 1997-07-18 | 1998-07-14 | Ölige Pflaster mit NA-Diclofenac zur äusseren Anwendung |
| ES98931077T ES2167910T3 (es) | 1997-07-18 | 1998-07-14 | Parches oleosos para uso externo que contienen diclofenaco sodico. |
| CA002265893A CA2265893C (en) | 1997-07-18 | 1998-07-14 | Oily patches for external use containing diclofenac sodium |
| EP98931077A EP0950408B1 (en) | 1997-07-18 | 1998-07-14 | Oily patches for external use containing diclofenac sodium |
| DK98931077T DK0950408T3 (da) | 1997-07-18 | 1998-07-14 | Eksterne olieplastre indeholdende dichlofenac-natrium |
| AU81295/98A AU708584B2 (en) | 1997-07-18 | 1998-07-14 | External oil patches containing diclofenac sodium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19375997A JP4181232B2 (ja) | 1997-07-18 | 1997-07-18 | ジクロフェナクナトリウム含有油性外用貼付製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH1135458A JPH1135458A (ja) | 1999-02-09 |
| JPH1135458A5 JPH1135458A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2005-05-19 |
| JP4181232B2 true JP4181232B2 (ja) | 2008-11-12 |
Family
ID=16313344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP19375997A Expired - Lifetime JP4181232B2 (ja) | 1997-07-18 | 1997-07-18 | ジクロフェナクナトリウム含有油性外用貼付製剤 |
Country Status (10)
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU771637B2 (en) * | 1999-07-15 | 2004-04-01 | Hisamitsu Pharmaceutical Co., Inc. | Percutaneously absorbable preparations |
| KR100363476B1 (ko) * | 2000-06-27 | 2002-12-05 | 대신제약주식회사 | 디크로 페낙 또는 그의 염들을 함유한 경피투과용 경고제 |
| TWI290464B (en) * | 2000-09-01 | 2007-12-01 | Novartis Consumer Health Sa | Treatment of burns |
| WO2002022109A2 (en) * | 2000-09-18 | 2002-03-21 | Laboratoires Fournier S.A. | Patch comprising diclofenac |
| EP1390024A4 (en) * | 2001-05-11 | 2010-02-17 | Merrion Res Iii Ltd | ISOSTEARIC ACID SALTS AS PERMEATION IMPROVERS |
| CA2447444A1 (en) | 2001-05-11 | 2002-11-21 | Orasense, Ltd. | Antisense permeation enhancers |
| JP4865958B2 (ja) * | 2001-05-23 | 2012-02-01 | 株式会社トクホン | 鎮痛抗炎症局所作用型の貼付剤 |
| US20060088579A1 (en) * | 2002-02-07 | 2006-04-27 | Shastri Venkatram P | Transdermal drug delivery systems |
| AU2003211297B2 (en) | 2002-02-19 | 2007-12-06 | Hisamitsu Pharmaceutical Co., Inc. | Percutaneous absorption type plaster |
| ES2397217T3 (es) * | 2003-03-18 | 2013-03-05 | Hisamitsu Pharmaceutical Co., Inc. | Parche que contiene diclofenaco |
| JP4541686B2 (ja) * | 2003-11-19 | 2010-09-08 | 株式会社 メドレックス | 非ステロイド系消炎鎮痛剤を含有するテープ剤 |
| WO2005102306A1 (ja) * | 2004-04-23 | 2005-11-03 | Hisamitsu Pharmaceutical Co., Inc. | 消炎鎮痛貼付剤 |
| KR100663163B1 (ko) * | 2005-10-24 | 2007-01-02 | (주)아모레퍼시픽 | 비스테로이드성 소염진통제를 함유하는 경피 투여 제제 |
| GB0524958D0 (en) * | 2005-12-07 | 2006-01-18 | Pharmakodex Ltd | Transdermal administration of active agents |
| WO2007117706A2 (en) | 2006-04-07 | 2007-10-18 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| US20090238763A1 (en) * | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| PL2046727T3 (pl) | 2006-07-25 | 2014-08-29 | Techfields Biochem Co Ltd | Dodatnio naładowane rozpuszczalne w wodzie proleki diklofenaku o bardzo szybkim stopniu przenikania przez skórę |
| JP5075378B2 (ja) * | 2006-09-08 | 2012-11-21 | 久光製薬株式会社 | 貼付剤製品 |
| KR20220107078A (ko) | 2007-06-04 | 2022-08-01 | 테크필즈 인크 | 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(ｎｓａｉａ) 약물전구체 및 이들의 새로운 의약적 용도 |
| JP5290957B2 (ja) * | 2007-10-09 | 2013-09-18 | アークレイ株式会社 | 免疫関連遺伝子の多型の検出用プローブおよびその用途 |
| AU2009244797B2 (en) | 2008-05-07 | 2015-01-22 | Merrion Research Iii Limited | Compositions of peptides and processes of preparation thereof |
| CN113636965A (zh) | 2008-12-04 | 2021-11-12 | 于崇曦 | 高穿透性组合物及其应用 |
| WO2010087947A2 (en) * | 2009-01-30 | 2010-08-05 | Kydes Pharmaceuticals, Llc | Transdermal delivery of diclofenac, carbamazepine and benzydamine |
| WO2011120033A1 (en) | 2010-03-26 | 2011-09-29 | Merrion Research Iii Limited | Pharmaceutical compositions of selective factor xa inhibitors for oral administration |
| ITMI20111355A1 (it) | 2011-07-20 | 2013-01-21 | Epifarma Srl | Cerotto transdermico contenente diclofenac e tiocolchicoside |
| EP2744506B1 (en) | 2011-08-18 | 2019-10-09 | Upstream Medical Technologies Limited | Cardiovascular therapeutics |
| KR102009546B1 (ko) * | 2012-06-20 | 2019-08-09 | 히사미쓰 세이야꾸 가부시키가이샤 | 첩부제 |
| CN107205948B (zh) | 2015-01-29 | 2021-12-14 | 诺和诺德股份有限公司 | 包含glp-1激动剂和肠溶衣的片剂 |
| JP7069042B2 (ja) | 2016-12-28 | 2022-05-17 | 久光製薬株式会社 | 貼付剤 |
| JP7117748B2 (ja) * | 2017-09-22 | 2022-08-15 | 帝國製薬株式会社 | 貼付剤 |
| JP6744511B1 (ja) * | 2020-02-12 | 2020-08-19 | 久光製薬株式会社 | ジクロフェナクナトリウム含有貼付剤 |
| JP6761553B1 (ja) * | 2020-02-12 | 2020-09-23 | 久光製薬株式会社 | ジクロフェナクナトリウム含有貼付剤 |
| IT202000011686A1 (it) * | 2020-05-20 | 2021-11-20 | Fidia Farm Spa | Cerotto medicato a lento rilascio |
| US11872320B2 (en) | 2021-02-25 | 2024-01-16 | Hisamitsu Pharmaceutical Co., Inc. | Method for treating osteoarthritis |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54138124A (en) | 1978-04-19 | 1979-10-26 | Hisamitsu Pharmaceut Co Inc | Novel plaster and its preparation |
| JPS55133310A (en) | 1979-04-03 | 1980-10-17 | Hisamitsu Pharmaceut Co Inc | Novel paste tape and its production |
| GB2045618B (en) * | 1979-04-03 | 1983-05-11 | Hisamitsu Pharmaceutical Co | Adhesive plaster |
| JPS5933211A (ja) | 1982-08-20 | 1984-02-23 | Sato Seiyaku Kk | 油性軟膏 |
| JPS5976013A (ja) | 1982-10-23 | 1984-04-28 | Toko Yakuhin Kogyo Kk | 外用ゲル製剤 |
| JPS6160608A (ja) | 1984-08-30 | 1986-03-28 | Taisho Pharmaceut Co Ltd | ジクロフェナック湿布剤 |
| JPH0774145B2 (ja) * | 1986-12-15 | 1995-08-09 | 株式会社資生堂 | 結晶性薬物含有乳化組成物 |
| JPH07116026B2 (ja) * | 1987-07-07 | 1995-12-13 | 株式会社資生堂 | ジクロフェナックナトリウム含有乳化外用剤 |
| JPH0736835B2 (ja) | 1988-05-25 | 1995-04-26 | 久光製薬株式会社 | 粘着剤組成物 |
| JPH0749042B2 (ja) | 1988-05-25 | 1995-05-31 | 久光製薬株式会社 | 温熱貼付剤 |
| EP0428352B1 (en) | 1989-11-14 | 1995-08-09 | Beta Pharmaceuticals Co. | Anti-inflammatory compositions for external use |
| JP3100408B2 (ja) | 1991-03-26 | 2000-10-16 | 株式会社資生堂 | ジクロフェナックナトリウム含有皮膚外用製剤 |
| JP3541849B2 (ja) | 1991-04-19 | 2004-07-14 | 久光製薬株式会社 | 消炎鎮痛貼付剤 |
| JP2971224B2 (ja) | 1991-11-30 | 1999-11-02 | 久光製薬株式会社 | エストラジオール経皮吸収貼付剤 |
| JPH06321771A (ja) | 1992-07-31 | 1994-11-22 | Tanabe Seiyaku Co Ltd | 経皮投与用基剤 |
| JPH0656660A (ja) | 1992-07-31 | 1994-03-01 | Nippon Saafuakutanto Kogyo Kk | ジクロフェナクナトリウム含有貼付剤 |
| JPH06219940A (ja) | 1993-01-27 | 1994-08-09 | Shiseido Co Ltd | 貼付剤 |
| DK0698393T3 (da) * | 1993-05-19 | 2002-08-05 | Hisamitsu Pharmaceutical Co | 3-/-menthoxypropan-1,2-diol som solubiliseringsmiddel og præparat til udvortes brug, der indeholder samme |
| JPH0789853A (ja) * | 1993-09-24 | 1995-04-04 | Shiseido Co Ltd | 貼付剤 |
| JP3054009B2 (ja) | 1993-12-14 | 2000-06-19 | 帝人株式会社 | プラスター |
| JP3782834B2 (ja) | 1994-10-26 | 2006-06-07 | 株式会社トクホン | 鎮痛抗炎症貼付剤 |
| JP3693696B2 (ja) | 1994-12-15 | 2005-09-07 | 久光製薬株式会社 | ケトチフェン含有経皮投与製剤 |
| JPH08319234A (ja) | 1995-05-24 | 1996-12-03 | Yuutoku Yakuhin Kogyo Kk | 経皮吸収型消炎鎮痛貼付剤 |
| WO1997028794A1 (fr) * | 1996-02-07 | 1997-08-14 | Tsumura & Co. | Solution aqueuse transparente de diclofenac sodique, compositions medicinales, et utilisations |
| JPH09208463A (ja) | 1996-02-07 | 1997-08-12 | Tsumura & Co | 経皮吸収性に優れた消炎鎮痛組成物 |
| JPH10147521A (ja) | 1996-09-18 | 1998-06-02 | Yuutoku Yakuhin Kogyo Kk | 持続性疼痛緩和用貼付剤 |
-
1997
- 1997-07-18 JP JP19375997A patent/JP4181232B2/ja not_active Expired - Lifetime
-
1998
- 1998-07-14 DK DK98931077T patent/DK0950408T3/da active
- 1998-07-14 ES ES98931077T patent/ES2167910T3/es not_active Expired - Lifetime
- 1998-07-14 AU AU81295/98A patent/AU708584B2/en not_active Ceased
- 1998-07-14 US US09/254,925 patent/US6262121B1/en not_active Expired - Lifetime
- 1998-07-14 KR KR1019997002263A patent/KR100540821B1/ko not_active Expired - Fee Related
- 1998-07-14 CA CA002265893A patent/CA2265893C/en not_active Expired - Lifetime
- 1998-07-14 DE DE69801893T patent/DE69801893T2/de not_active Expired - Lifetime
- 1998-07-14 EP EP98931077A patent/EP0950408B1/en not_active Expired - Lifetime
- 1998-07-14 WO PCT/JP1998/003135 patent/WO1999003461A1/ja active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP0950408A1 (en) | 1999-10-20 |
| DK0950408T3 (da) | 2002-01-28 |
| DE69801893D1 (de) | 2001-11-08 |
| ES2167910T3 (es) | 2002-05-16 |
| HK1020675A1 (en) | 2000-05-19 |
| DE69801893T2 (de) | 2002-04-25 |
| AU8129598A (en) | 1999-02-10 |
| EP0950408A4 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1999-12-01 |
| KR20000068581A (ko) | 2000-11-25 |
| US6262121B1 (en) | 2001-07-17 |
| WO1999003461A1 (fr) | 1999-01-28 |
| CA2265893A1 (en) | 1999-01-28 |
| CA2265893C (en) | 2008-02-19 |
| KR100540821B1 (ko) | 2006-01-12 |
| JPH1135458A (ja) | 1999-02-09 |
| AU708584B2 (en) | 1999-08-05 |
| EP0950408B1 (en) | 2001-10-04 |
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