JP4099234B2 - 抗ウイルス活性を有する新規化合物 - Google Patents

抗ウイルス活性を有する新規化合物 Download PDF

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Publication number
JP4099234B2
JP4099234B2 JP54074697A JP54074697A JP4099234B2 JP 4099234 B2 JP4099234 B2 JP 4099234B2 JP 54074697 A JP54074697 A JP 54074697A JP 54074697 A JP54074697 A JP 54074697A JP 4099234 B2 JP4099234 B2 JP 4099234B2
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Japan
Prior art keywords
compound
salt
glycero
galacto
dideoxy
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Expired - Fee Related
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JP54074697A
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English (en)
Japanese (ja)
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JPWO1997043296A1 (ja
Inventor
秀治 藤田
昌明 沼田
和夫 鈴木
茂樹 布村
守 杉本
正樹 寺田
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Nissin Food Products Co Ltd
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Nissin Food Products Co Ltd
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Publication of JPWO1997043296A1 publication Critical patent/JPWO1997043296A1/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/06—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical being a hydroxyalkyl group esterified by a fatty acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP54074697A 1996-05-16 1997-05-16 抗ウイルス活性を有する新規化合物 Expired - Fee Related JP4099234B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP12202596 1996-05-16
JP8-122025 1996-05-16
PCT/JP1997/001654 WO1997043296A1 (en) 1996-05-16 1997-05-16 Novel compounds having antiviral activity

Publications (2)

Publication Number Publication Date
JPWO1997043296A1 JPWO1997043296A1 (ja) 1999-06-22
JP4099234B2 true JP4099234B2 (ja) 2008-06-11

Family

ID=14825732

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54074697A Expired - Fee Related JP4099234B2 (ja) 1996-05-16 1997-05-16 抗ウイルス活性を有する新規化合物

Country Status (8)

Country Link
US (3) US6337390B1 (enExample)
EP (1) EP0957107B1 (enExample)
JP (1) JP4099234B2 (enExample)
AT (1) ATE271560T1 (enExample)
AU (1) AU737680C (enExample)
CA (1) CA2255070C (enExample)
DE (1) DE69729958T2 (enExample)
WO (1) WO1997043296A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2255070C (en) * 1996-05-16 2006-08-15 Nissin Food Products Co., Ltd. Novel compounds having antiviral activity
WO1999043689A1 (fr) * 1998-02-27 1999-09-02 Meiji Milk Products Co., Ltd. Nouveaux derives de kdn et medicaments les contenant sous forme de principes actifs
DE60007074T2 (de) 1999-01-15 2004-09-16 The Board Of Trustees For The University Of Illinois, Urbana Sulfatierte phosphatidylinositole, ihre herstellung und verwendung
WO2003049672A2 (en) * 2001-10-30 2003-06-19 Microbiotix, Inc. Methods and compositions for treating flavivirus-mediated disease
JP2008074720A (ja) * 2006-09-19 2008-04-03 Noguchi Inst Ｇｍ３糖鎖プローブ
US8877917B2 (en) 2007-04-23 2014-11-04 Alnylam Pharmaceuticals, Inc. Glycoconjugates of RNA interference agents
WO2009082607A2 (en) 2007-12-04 2009-07-02 Alnylam Pharmaceuticals, Inc. Targeting lipids
AU2014277867B2 (en) * 2007-12-04 2016-11-03 Arbutus Biopharma Corporation Targeting lipids
CA2708171C (en) 2007-12-04 2018-02-27 Alnylam Pharmaceuticals, Inc. Folate conjugates
US8575123B2 (en) 2008-04-11 2013-11-05 Tekmira Pharmaceuticals Corporation Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
JP5327839B2 (ja) * 2008-06-09 2013-10-30 国立大学法人埼玉大学 シアル酸誘導体の製造方法とインフルエンザウィルス阻害剤としての利用
MY155507A (en) * 2009-07-07 2015-10-30 Adenovir Pharma Ab Antiviral compounds
JOP20200092A1 (ar) 2014-11-10 2017-06-16 Alnylam Pharmaceuticals Inc تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها
WO2017027980A1 (en) * 2015-08-19 2017-02-23 National Research Council Canada Treatment and prevention of neisseria gonorrhoeae infection using cmp-activated nonulosonate analog compounds
US11324820B2 (en) 2017-04-18 2022-05-10 Alnylam Pharmaceuticals, Inc. Methods for the treatment of subjects having a hepatitis b virus (HBV) infection
BR112021001613A2 (pt) 2018-08-13 2021-05-04 Alnylam Pharmaceuticals, Inc. agentes de ácido ribonucleico de fita dupla, célula, composições farmacêuticas, métodos de inibição da expressão gênica, de inibição da replicação e de tratar um sujeito, métodos para reduzir o nível de um antígeno e para reduzir a carga viral e uso de um agente de dsrna
JP2024542305A (ja) * 2021-10-14 2024-11-14 アウルストーン・メディカル・リミテッド Ｅｖｏｃプローブを合成するための方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59164798A (ja) 1983-03-09 1984-09-17 Rikagaku Kenkyusho シアル酸含有糖脂質誘導体
JPH064671B2 (ja) 1985-04-02 1994-01-19 メクト株式会社 シアル酸誘導体及びその製造方法
JPS62212335A (ja) 1986-03-14 1987-09-18 Mitsui Toatsu Chem Inc ２−アリ−ル−２−メチルプロピルエ−テル誘導体およびそれを有効成分として含有する殺虫剤
JPS6345223A (ja) 1986-04-04 1988-02-26 Ueno Seiyaku Oyo Kenkyusho:Kk ひと免疫不全ウイルス性疾患処置剤
JPS63264493A (ja) 1986-12-29 1988-11-01 Mect Corp 活性カルボニル基を持つシアル酸誘導体
JPS6452794A (en) 1987-05-29 1989-02-28 Kanto Ishi Pharma Co Ltd Sialic acid-containing thioglycerolipid derivative and production thereof
JPH01125394A (ja) 1987-11-10 1989-05-17 Mect Corp シアロシルグリセロリピッド類及びその製造方法
JPH02304025A (ja) 1989-05-18 1990-12-17 Tanabe Seiyaku Co Ltd 抗レトロウィルス薬
JPH0317020A (ja) 1989-06-14 1991-01-25 Nippon Koutai Kenkyusho:Kk 抗ｈｉｖ剤
JPH03246297A (ja) 1990-02-22 1991-11-01 Nippon Koutai Kenkyusho:Kk ガングリオシド誘導体及びこれを含有する抗ｈｉｖ剤
JPH04136001A (ja) 1990-09-27 1992-05-11 Tanabe Seiyaku Co Ltd β―シクロデキストリン・スルホンアミド誘導体のポリ硫酸エステル及びその製法
ZA936452B (en) 1992-09-02 1994-03-25 Virostat Na N V Sulphated glycoside
US5344417A (en) 1992-09-11 1994-09-06 Becton, Dickinson And Company Universal fitting for inoculation receptacles
JPH06256373A (ja) 1993-01-11 1994-09-13 Dainippon Ink & Chem Inc 硫酸化オリゴ糖配糖体アシル化物およびこれを有効成分とする抗ウイルス剤
JP3062906B2 (ja) * 1993-01-29 2000-07-12 丸金醤油株式会社 Ｎ−アセチルノイラミン酸ホモポリマーの硫酸エステル
US5663151A (en) 1994-03-04 1997-09-02 Bristol-Myers Squibb Company Sulfated α-glycolipid derivatives as cell adhesion inhibitors
JPH09183789A (ja) * 1995-10-31 1997-07-15 Sanwa Kagaku Kenkyusho Co Ltd 新規な硫酸化及び燐酸化糖誘導体、その製法及び用途
CA2255070C (en) * 1996-05-16 2006-08-15 Nissin Food Products Co., Ltd. Novel compounds having antiviral activity

Also Published As

Publication number Publication date
US6541461B2 (en) 2003-04-01
US6337390B1 (en) 2002-01-08
DE69729958T2 (de) 2005-07-28
DE69729958D1 (de) 2004-08-26
EP0957107B1 (en) 2004-07-21
EP0957107A4 (enExample) 1999-11-17
US20020077472A1 (en) 2002-06-20
AU737680B2 (en) 2001-08-30
WO1997043296A1 (en) 1997-11-20
AU737680C (en) 2002-05-02
US20030073664A1 (en) 2003-04-17
ATE271560T1 (de) 2004-08-15
AU2789597A (en) 1997-12-05
CA2255070A1 (en) 1997-11-20
US6835720B2 (en) 2004-12-28
CA2255070C (en) 2006-08-15
EP0957107A1 (en) 1999-11-17

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