JP4067562B2 - 進行性グリコシル化最終生成物の生成を阻止し、反転するためのチアゾリウム化合物の使用 - Google Patents

進行性グリコシル化最終生成物の生成を阻止し、反転するためのチアゾリウム化合物の使用 Download PDF

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JP4067562B2
JP4067562B2 JP52237996A JP52237996A JP4067562B2 JP 4067562 B2 JP4067562 B2 JP 4067562B2 JP 52237996 A JP52237996 A JP 52237996A JP 52237996 A JP52237996 A JP 52237996A JP 4067562 B2 JP4067562 B2 JP 4067562B2
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oxoethyl
bromide
group
thiazolium
methyl
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Expired - Fee Related
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JPH10512864A (ja
Inventor
アントニー セラミ
ピーター シー ウルリック
ディリップ アール ワーグル
サン バオ ワン
サラ ヴァーサン
ジョン ジェイ イーガン
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アルテオン インコーポレイテッド
ザ ピコワー インスティテュート フォア メディカル リサーチ
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

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  • General Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
JP52237996A 1995-01-18 1996-01-18 進行性グリコシル化最終生成物の生成を阻止し、反転するためのチアゾリウム化合物の使用 Expired - Fee Related JP4067562B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/375,155 US5656261A (en) 1995-01-18 1995-01-18 Preventing and reversing advanced glycosylation endproducts
US08/375,155 1995-01-18
US08/588,249 US5853703A (en) 1995-01-18 1996-01-18 Preventing and reversing the formation of advanced glycosylation endproducts
PCT/US1996/000663 WO1996022095A2 (fr) 1995-01-18 1996-01-18 Utilisation de composes de thiazolium pour empecher et inverser la formation de produits finis de glycosylation avancee
US08/588,249 1996-01-18

Publications (2)

Publication Number Publication Date
JPH10512864A JPH10512864A (ja) 1998-12-08
JP4067562B2 true JP4067562B2 (ja) 2008-03-26

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JP52237996A Expired - Fee Related JP4067562B2 (ja) 1995-01-18 1996-01-18 進行性グリコシル化最終生成物の生成を阻止し、反転するためのチアゾリウム化合物の使用

Country Status (14)

Country Link
US (1) US5853703A (fr)
EP (2) EP1327887A3 (fr)
JP (1) JP4067562B2 (fr)
CN (1) CN1142778C (fr)
AT (1) ATE245420T1 (fr)
BR (1) BR9607598B1 (fr)
CA (1) CA2210684C (fr)
DE (1) DE69629176T2 (fr)
DK (1) DK0808163T3 (fr)
ES (1) ES2203677T3 (fr)
MX (1) MX9705449A (fr)
NZ (1) NZ302027A (fr)
PT (1) PT808163E (fr)
WO (1) WO1996022095A2 (fr)

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EP0877943A1 (fr) * 1995-12-26 1998-11-18 The Picower Institute For Medical Research Procede de mesure et de traitement fondes sur la presence de produits terminaux de glycosylation poussee dans le tabac et dans ses sous-produits de combustion
US20040198795A1 (en) * 1996-05-08 2004-10-07 Wagle Dilip R Substituted imidazoliums and methods of use therefor
US6119701A (en) * 1998-02-13 2000-09-19 Cerami Consulting Corp. Methods, agents and devices for removing nucleophilic toxins from tobacco and tobacco smoke
US6121300A (en) * 1998-11-10 2000-09-19 Wagle; Dilip R. Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium salts
US6608094B2 (en) 1999-10-06 2003-08-19 Torrent Pharmaceuticals Ltd. Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof
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US20020103228A1 (en) * 1999-10-06 2002-08-01 Torrent Pharmaceuticals Ltd. Composition and method for use of pyridinium derivatives in cosmetic and therapeutic applications
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JP2003523388A (ja) * 2000-02-23 2003-08-05 アルテオン インコーポレーテッド チアゾリウム化合物及びタンパク質老化に関連する障害の治療
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US7439330B2 (en) * 2000-05-08 2008-10-21 President And Fellows Of Harvard College Anti-glycated CD59 antibodies and uses thereof
US6835545B2 (en) 2000-05-08 2004-12-28 President And Fellows Of Harvard College Methods, products and treatments for diabetes
JP2004504389A (ja) * 2000-07-13 2004-02-12 アルテオン　インコーポレーテッド シアノメチル置換化チアゾリウム及びイミダゾリウム、並びにタンパク質老化と関連する疾患の治療
EP1353669B1 (fr) * 2000-12-29 2007-08-15 Alteon, Inc. Methode de traitement du glaucome
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AU2002243636A1 (en) * 2001-01-22 2002-07-30 Farrington Pharmaceuticals, Llc Method and composition for rejuvenating hair, nails, tissues, cells and organs by ex-vivo or immersive treatment
CZ303214B6 (cs) * 2001-03-21 2012-05-30 Torrent Pharmaceuticals Ltd Pyridiniová sloucenina, zpusob její výroby, její použití, farmaceutický prostredek ji obsahující, zpusob jeho výroby a jeho použití
ATE299496T1 (de) * 2001-03-21 2005-07-15 Torrent Pharmaceuticals Ltd Pyridiniumverbindungen zur behandlung von age- relatierten krankheiten
AU766824B2 (en) * 2001-03-28 2003-10-23 Torrent Pharmaceuticals Ltd Novel compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses
ES2231685T3 (es) * 2001-04-05 2005-05-16 Torrent Pharmaceuticals Ltd Compuestos heterociclicos para complicaciones vasculares diabeticas y relacionadas con la edad.
EP1406611A2 (fr) * 2001-05-30 2004-04-14 Alteon, Inc. Methode de traitement de maladies fibreuses ou d'autres indications
US6806268B2 (en) * 2001-05-30 2004-10-19 Alteon, Inc. Method for treating glaucoma V
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WO2003099241A2 (fr) * 2002-05-23 2003-12-04 Tony Maniscalco Compositions antisolaires et leurs procedes d'utilisation
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US20060172972A1 (en) * 2002-12-20 2006-08-03 Chakshu Research Inc Formulation and method for administration of ophthalmologically active agents
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JPH10512864A (ja) 1998-12-08
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DE69629176T2 (de) 2004-06-03
EP1327887A2 (fr) 2003-07-16
DE69629176D1 (de) 2003-08-28
EP0808163A2 (fr) 1997-11-26
CA2210684A1 (fr) 1996-07-25
EP0808163B1 (fr) 2003-07-23
CA2210684C (fr) 2008-01-15
WO1996022095A2 (fr) 1996-07-25
NZ302027A (en) 2001-04-27
US5853703A (en) 1998-12-29
EP1327887A3 (fr) 2008-12-10
DK0808163T3 (da) 2003-11-10
WO1996022095A3 (fr) 1997-02-27
MX9705449A (es) 1998-02-28
BR9607598B1 (pt) 2009-05-05
ES2203677T3 (es) 2004-04-16
CN1185736A (zh) 1998-06-24
PT808163E (pt) 2003-12-31
ATE245420T1 (de) 2003-08-15

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