PT808163E - Uso de compostos de tiazolio para prevencao e inversao da formacao de produtos finais com glicosilacao avancada - Google Patents
Uso de compostos de tiazolio para prevencao e inversao da formacao de produtos finais com glicosilacao avancadaInfo
- Publication number
- PT808163E PT808163E PT96903540T PT96903540T PT808163E PT 808163 E PT808163 E PT 808163E PT 96903540 T PT96903540 T PT 96903540T PT 96903540 T PT96903540 T PT 96903540T PT 808163 E PT808163 E PT 808163E
- Authority
- PT
- Portugal
- Prior art keywords
- reversal
- formation
- advanced
- advanced glycosylation
- protein
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/375,155 US5656261A (en) | 1995-01-18 | 1995-01-18 | Preventing and reversing advanced glycosylation endproducts |
US08/588,249 US5853703A (en) | 1995-01-18 | 1996-01-18 | Preventing and reversing the formation of advanced glycosylation endproducts |
Publications (1)
Publication Number | Publication Date |
---|---|
PT808163E true PT808163E (pt) | 2003-12-31 |
Family
ID=27006923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT96903540T PT808163E (pt) | 1995-01-18 | 1996-01-18 | Uso de compostos de tiazolio para prevencao e inversao da formacao de produtos finais com glicosilacao avancada |
Country Status (14)
Country | Link |
---|---|
US (1) | US5853703A (pt) |
EP (2) | EP1327887A3 (pt) |
JP (1) | JP4067562B2 (pt) |
CN (1) | CN1142778C (pt) |
AT (1) | ATE245420T1 (pt) |
BR (1) | BR9607598B1 (pt) |
CA (1) | CA2210684C (pt) |
DE (1) | DE69629176T2 (pt) |
DK (1) | DK0808163T3 (pt) |
ES (1) | ES2203677T3 (pt) |
MX (1) | MX9705449A (pt) |
NZ (1) | NZ302027A (pt) |
PT (1) | PT808163E (pt) |
WO (1) | WO1996022095A2 (pt) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO315930B1 (no) * | 1995-01-18 | 2003-11-17 | Picower Inst For Medical Res T | Anvendelse av tiazoliumforbindelser ved fremstilling av farmasöytiske preparater, preparater som inneholder forbindelsene, samt nyetiazoliumforbindelser |
US5656261A (en) | 1995-01-18 | 1997-08-12 | The Picower Institute For Medical Research | Preventing and reversing advanced glycosylation endproducts |
CN1211321A (zh) * | 1995-12-26 | 1999-03-17 | 皮考瓦医疗研究院 | 基于烟草及其燃烧副产物中存在的高级糖基化终产物的测定和处理方法 |
US20040198795A1 (en) * | 1996-05-08 | 2004-10-07 | Wagle Dilip R | Substituted imidazoliums and methods of use therefor |
US6119701A (en) * | 1998-02-13 | 2000-09-19 | Cerami Consulting Corp. | Methods, agents and devices for removing nucleophilic toxins from tobacco and tobacco smoke |
US6121300A (en) * | 1998-11-10 | 2000-09-19 | Wagle; Dilip R. | Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium salts |
US6608094B2 (en) | 1999-10-06 | 2003-08-19 | Torrent Pharmaceuticals Ltd. | Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof |
DK1222171T3 (da) | 1999-10-06 | 2004-07-05 | Torrent Pharmaceuticals Ltd | Pyridiniumderivater, til regulering af aldersrelaterede og diabetesvaskulære komplikationer, fremgangsmåde til fremstilling af disse samt terapeutiske anvendelser deraf |
US20020103228A1 (en) * | 1999-10-06 | 2002-08-01 | Torrent Pharmaceuticals Ltd. | Composition and method for use of pyridinium derivatives in cosmetic and therapeutic applications |
WO2001025209A1 (en) * | 1999-10-06 | 2001-04-12 | Torrent Pharmaceuticals Ltd | Pyridinium derivatives for the treatment of diabetic and aging-related vascular complications |
KR100766158B1 (ko) * | 2000-01-19 | 2007-10-10 | 알테온 인크. | 티아졸, 이미다졸 및 옥사졸 화합물, 및 단백질 노화와관련된 장애의 치료 |
MXPA02008276A (es) * | 2000-02-23 | 2004-04-05 | Alteon Inc | Compuestos de tiazolio y tratamientos de trastornos asociados con el envejecimiento proteinico. |
WO2001072724A1 (en) * | 2000-03-29 | 2001-10-04 | Alteon, Inc. | Synthesis of thiazolium compounds |
US7439330B2 (en) * | 2000-05-08 | 2008-10-21 | President And Fellows Of Harvard College | Anti-glycated CD59 antibodies and uses thereof |
US6835545B2 (en) * | 2000-05-08 | 2004-12-28 | President And Fellows Of Harvard College | Methods, products and treatments for diabetes |
ES2251500T3 (es) * | 2000-07-13 | 2006-05-01 | Alteon, Inc. | Tiazolios e imidazolios sustituidos por cianometilo y tratamientos de desordenes asociados al envejecimiento proteinico. |
EP1353676A4 (en) * | 2000-12-29 | 2006-05-31 | Alteon Inc | METHOD FOR THE TREATMENT OF FIBROUS OR OTHER INDICATIONS |
MXPA03005922A (es) * | 2000-12-29 | 2004-05-04 | Alteon Inc | Metodo para tratar glaucoma ib. |
WO2002067851A2 (en) * | 2000-12-29 | 2002-09-06 | Alteon, Inc. | Method for treating fibrotic diseases or other indications iiic |
WO2002056836A2 (en) * | 2001-01-22 | 2002-07-25 | Farrington Pharmaceuticals, Llc | Method and composition for rejuvenating hair, nails, tissues, cells and organs by ex-vivo or immersive treatment |
ES2243389T3 (es) * | 2001-03-21 | 2005-12-01 | Torrent Pharmaceuticals Ltd | Compuestos de piridinio utiles para el tratamiento de enfermedades relacionadas con los age. |
CZ303214B6 (cs) * | 2001-03-21 | 2012-05-30 | Torrent Pharmaceuticals Ltd | Pyridiniová sloucenina, zpusob její výroby, její použití, farmaceutický prostredek ji obsahující, zpusob jeho výroby a jeho použití |
AU766824B2 (en) * | 2001-03-28 | 2003-10-23 | Torrent Pharmaceuticals Ltd | Novel compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses |
AU2002253432B2 (en) | 2001-04-05 | 2005-03-24 | Torrent Pharmaceuticals Ltd. | Heterocyclic compounds for aging-related and diabetic vascular complications |
CA2448317A1 (en) * | 2001-05-30 | 2002-12-05 | Alteon Inc. | Method for treating glaucoma v |
CA2448294A1 (en) * | 2001-05-30 | 2002-12-05 | Alteon Inc. | Method for treating fibrotic diseases or other indications vi |
CA2448306A1 (en) * | 2001-05-30 | 2002-12-05 | Alteon Inc. | Method for treating fibrotic diseases or other indications |
US7144570B2 (en) * | 2002-05-23 | 2006-12-05 | Alteon, Inc. | Sunscreen compositions and methods of use thereof |
AU2003239868A1 (en) * | 2002-05-23 | 2003-12-12 | Tony Maniscalco | Sunscreen compositions and methods of use thereof |
DE10225537A1 (de) * | 2002-06-10 | 2003-12-18 | Bayer Ag | N-alkylierte Thiazoliumsalze und Verfahren zu deren Herstellung |
JP2006512900A (ja) * | 2002-08-16 | 2006-04-20 | ワイス | Rage関連疾患の治療用組成物及び方法 |
US6991488B2 (en) | 2002-09-25 | 2006-01-31 | Anthony Freakes | Electrical connector devices and methods for employing same |
US20060177430A1 (en) * | 2002-12-20 | 2006-08-10 | Chakshu Research Inc | Treatment of ocular disorders with ophthalmic formulations containing methylsulfonylmethane as a transport enhancer |
US20060166879A1 (en) * | 2002-12-20 | 2006-07-27 | Chakshu Research Inc | Treatment of conditions associated with the presence of macromolecular aggregates, particularly ophthalmic disorders |
US20060172972A1 (en) * | 2002-12-20 | 2006-08-03 | Chakshu Research Inc | Formulation and method for administration of ophthalmologically active agents |
AU2003297511B2 (en) * | 2002-12-20 | 2010-01-21 | Chakshu Research, Inc. | Ophthalmic formulation for the prevention and treatment of ocular conditions |
CN1324019C (zh) * | 2003-04-02 | 2007-07-04 | 深圳市东阳光实业发展有限公司 | 氮杂双环盐类化合物及其治疗蛋白老化疾病的用途 |
US20050014747A1 (en) * | 2003-04-18 | 2005-01-20 | Emily Reinhard | Dihydrothiazine prodrugs of thiazolium agents |
US7416756B2 (en) | 2003-09-10 | 2008-08-26 | Eastman Chemical Company | Process for the recovery of a phytolipid composition |
US20050137239A1 (en) * | 2003-12-17 | 2005-06-23 | Hines Michelle D. | Thiazole derivatives |
US8119651B2 (en) * | 2004-01-30 | 2012-02-21 | Biotie Therapies Corp. | Compositions useful especially for treatment or prevention of metabolic syndrome |
FI20060768A0 (fi) * | 2006-08-28 | 2006-08-28 | Faron Pharmaceuticals Oy | Erityisesti metabolia-oireyhtymän hoitoon tai ehkäisyyn soveltuvia koostumuksia |
US20090047258A1 (en) * | 2004-08-02 | 2009-02-19 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for reversing age-related changes in extracellular matrix proteins |
UA92154C2 (ru) * | 2004-08-03 | 2010-10-11 | Транстек Фарма, Инк. | Rage-слитые белки и способы их применения |
JP5188804B2 (ja) | 2004-08-03 | 2013-04-24 | トランステック ファーマ,インコーポレイティド | Rage融合タンパク質及びその使用方法 |
WO2006032165A1 (fr) * | 2004-09-23 | 2006-03-30 | Beijing Molecule Science And Technology Co., Ltd | Nouveaux composés n-hétérocycliques substitués à cinq chaînons, et utilisation desdits composés dans le traitement des maladies liées au vieillissement des protéines |
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-
1996
- 1996-01-18 CA CA002210684A patent/CA2210684C/en not_active Expired - Fee Related
- 1996-01-18 EP EP03075955A patent/EP1327887A3/en not_active Withdrawn
- 1996-01-18 AT AT96903540T patent/ATE245420T1/de not_active IP Right Cessation
- 1996-01-18 WO PCT/US1996/000663 patent/WO1996022095A2/en active IP Right Grant
- 1996-01-18 PT PT96903540T patent/PT808163E/pt unknown
- 1996-01-18 NZ NZ302027A patent/NZ302027A/en not_active IP Right Cessation
- 1996-01-18 DE DE69629176T patent/DE69629176T2/de not_active Expired - Fee Related
- 1996-01-18 US US08/588,249 patent/US5853703A/en not_active Expired - Fee Related
- 1996-01-18 CN CNB961923938A patent/CN1142778C/zh not_active Expired - Fee Related
- 1996-01-18 ES ES96903540T patent/ES2203677T3/es not_active Expired - Lifetime
- 1996-01-18 BR BRPI9607598-8A patent/BR9607598B1/pt not_active IP Right Cessation
- 1996-01-18 JP JP52237996A patent/JP4067562B2/ja not_active Expired - Fee Related
- 1996-01-18 DK DK96903540T patent/DK0808163T3/da active
- 1996-01-18 EP EP96903540A patent/EP0808163B1/en not_active Expired - Lifetime
- 1996-01-18 MX MX9705449A patent/MX9705449A/es not_active IP Right Cessation
Also Published As
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DE69629176D1 (de) | 2003-08-28 |
CN1185736A (zh) | 1998-06-24 |
DE69629176T2 (de) | 2004-06-03 |
WO1996022095A3 (en) | 1997-02-27 |
EP1327887A2 (en) | 2003-07-16 |
EP1327887A3 (en) | 2008-12-10 |
JPH10512864A (ja) | 1998-12-08 |
EP0808163B1 (en) | 2003-07-23 |
BR9607598A (pt) | 1999-11-30 |
BR9607598B1 (pt) | 2009-05-05 |
CA2210684C (en) | 2008-01-15 |
NZ302027A (en) | 2001-04-27 |
MX9705449A (es) | 1998-02-28 |
ES2203677T3 (es) | 2004-04-16 |
ATE245420T1 (de) | 2003-08-15 |
CA2210684A1 (en) | 1996-07-25 |
JP4067562B2 (ja) | 2008-03-26 |
DK0808163T3 (da) | 2003-11-10 |
WO1996022095A2 (en) | 1996-07-25 |
CN1142778C (zh) | 2004-03-24 |
US5853703A (en) | 1998-12-29 |
EP0808163A2 (en) | 1997-11-26 |
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