JP4038337B2 - ガルドスチャンネル拮抗物質 - Google Patents

ガルドスチャンネル拮抗物質 Download PDF

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Publication number
JP4038337B2
JP4038337B2 JP2000600638A JP2000600638A JP4038337B2 JP 4038337 B2 JP4038337 B2 JP 4038337B2 JP 2000600638 A JP2000600638 A JP 2000600638A JP 2000600638 A JP2000600638 A JP 2000600638A JP 4038337 B2 JP4038337 B2 JP 4038337B2
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Japan
Prior art keywords
substituent
compound
ring
acetamide
para
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Expired - Fee Related
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JP2000600638A
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English (en)
Japanese (ja)
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JP2002537331A5 (enExample
JP2002537331A (ja
Inventor
マクノートン−スミス，グラント，アンドリュー
リグドン，グレゴリー，クックセイ
ストッカー，ジョナサン，ウォルター
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アイカゲン，インコーポレイティッド
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Publication of JP2002537331A5 publication Critical patent/JP2002537331A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2000600638A 1999-02-23 2000-02-10 ガルドスチャンネル拮抗物質 Expired - Fee Related JP4038337B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13551199P 1999-02-23 1999-02-23
US60/135,511 1999-02-23
US09/386,601 1999-08-31
US09/386,601 US6288122B1 (en) 1999-02-23 1999-08-31 Gardos channel antagonists
PCT/US2000/003663 WO2000050026A1 (en) 1999-02-23 2000-02-10 Gardos channel antagonists

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007121967A Division JP2007262075A (ja) 1999-02-23 2007-05-02 ガルドスチャンネル拮抗物質

Publications (3)

Publication Number Publication Date
JP2002537331A JP2002537331A (ja) 2002-11-05
JP2002537331A5 JP2002537331A5 (enExample) 2005-06-30
JP4038337B2 true JP4038337B2 (ja) 2008-01-23

Family

ID=26833406

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000600638A Expired - Fee Related JP4038337B2 (ja) 1999-02-23 2000-02-10 ガルドスチャンネル拮抗物質
JP2007121967A Pending JP2007262075A (ja) 1999-02-23 2007-05-02 ガルドスチャンネル拮抗物質

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2007121967A Pending JP2007262075A (ja) 1999-02-23 2007-05-02 ガルドスチャンネル拮抗物質

Country Status (16)

Country Link
US (1) US6288122B1 (enExample)
EP (1) EP1158971B1 (enExample)
JP (2) JP4038337B2 (enExample)
KR (1) KR100705726B1 (enExample)
CN (1) CN1193748C (enExample)
AP (1) AP1465A (enExample)
AT (1) ATE370728T1 (enExample)
AU (1) AU762039B2 (enExample)
BR (1) BR0008416A (enExample)
CA (1) CA2371857C (enExample)
DE (1) DE60036093T2 (enExample)
ES (1) ES2291191T3 (enExample)
HK (1) HK1045262B (enExample)
IL (2) IL145012A0 (enExample)
OA (1) OA11838A (enExample)
WO (1) WO2000050026A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003004010A1 (en) * 2001-07-06 2003-01-16 Poseidon Pharmaceuticals A/S Carbonylamino derivatives useful for obtaining immune regulation
EP1465863B1 (en) 2002-01-04 2008-07-09 NeuroSearch A/S Potassium channel modulators
AU2003217810C9 (en) * 2002-02-28 2008-06-12 Icagen, Inc. Methods for treating diseases related to intraocular pressure
EP1644332A1 (en) * 2003-07-03 2006-04-12 Poseidon Pharmaceuticals A/S Diarylmethyl derivatives as potassium channel modulators
WO2005003143A1 (en) * 2003-07-03 2005-01-13 Poseidon Pharmaceuticals A/S Novel potassium channel modulators
WO2006084031A1 (en) * 2005-02-01 2006-08-10 Icagen, Inc. Imines as ion channel modulators
US20100056637A1 (en) * 2005-12-20 2010-03-04 Icagen, Inc. Treatment methods using triaryl methane compounds
CA2633805A1 (en) * 2005-12-20 2007-07-05 Icagen, Inc. Treatment methods using triaryl methane compounds
WO2009027292A1 (en) * 2007-08-24 2009-03-05 Neurosearch A/S Carbonylamino derivatives useful for the treatment of certain inflammatory disorders
US20090076157A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched senicapoc
KR101896430B1 (ko) * 2008-04-09 2018-09-10 세루스 코포레이션 적혈구 병원체 불활성화를 위한 개선된 퀀칭 방법
CN102272152B (zh) 2008-11-10 2014-05-28 贝林格尔.英格海姆国际有限公司 通过中电导钙激活钾通道调控细胞-细胞融合的组合物及方法
WO2016134353A1 (en) * 2015-02-20 2016-08-25 Children's Medical Center Corporation Methods for treating malaria using potassium channel inhibitors
EP3106155A1 (en) * 2015-06-15 2016-12-21 Universite d'Aix Marseille Treatment and diagnosis of hereditary xerocytosis
CN110177548A (zh) * 2016-10-25 2019-08-27 罗兰·斯塔尔 Senicapoc用于治疗神经性疼痛的用途
WO2018162426A1 (en) 2017-03-06 2018-09-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Treatment and diagnosis of hereditary xerocytosis
CN112020353A (zh) 2019-03-29 2020-12-01 深圳仁泰医药科技有限公司 2,2-双(4-氟苯基)-2-苯乙酰胺的晶型a及其制备方法和应用
US12186286B2 (en) * 2019-07-29 2025-01-07 Paracelsus Neuroscience Llc Use of senicapoc for treatment of stroke
CN115943138A (zh) * 2020-07-14 2023-04-07 阿迪玛生物有限责任公司 包含gardos通道拮抗剂的组合物及其用途
US20240024335A1 (en) * 2020-12-11 2024-01-25 Sanquin IP B.V. Treatment and prevention of anaemia of inflammation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5273992A (en) 1992-11-02 1993-12-28 Beth Israel Hospital Assoc. Inc. Method for reducing sickle erythrocyte dehydration and delaying the occurrence of erythrocyte sickling in-situ
ATE314060T1 (de) 1996-03-20 2006-01-15 Harvard College Triarylmethanverbindungen zur behandlung von krebs, aktinischer keratose und kaposisarkom

Also Published As

Publication number Publication date
AU2880700A (en) 2000-09-14
HK1045262B (zh) 2005-07-29
AP1465A (en) 2005-09-22
AU762039B2 (en) 2003-06-19
CA2371857A1 (en) 2000-08-31
KR20020002393A (ko) 2002-01-09
JP2007262075A (ja) 2007-10-11
OA11838A (en) 2005-08-22
CA2371857C (en) 2008-07-29
IL145012A0 (en) 2002-06-30
KR100705726B1 (ko) 2007-04-11
ATE370728T1 (de) 2007-09-15
EP1158971A1 (en) 2001-12-05
WO2000050026A1 (en) 2000-08-31
CN1344158A (zh) 2002-04-10
BR0008416A (pt) 2002-01-29
AP2001002268A0 (en) 2001-09-30
DE60036093D1 (de) 2007-10-04
ES2291191T3 (es) 2008-03-01
DE60036093T2 (de) 2008-05-15
US6288122B1 (en) 2001-09-11
EP1158971B1 (en) 2007-08-22
HK1045262A1 (en) 2002-11-22
IL145012A (en) 2006-12-10
JP2002537331A (ja) 2002-11-05
CN1193748C (zh) 2005-03-23
EP1158971A4 (en) 2003-04-16

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