CA2371857C - Gardos channel antagonists - Google Patents
Gardos channel antagonists Download PDFInfo
- Publication number
- CA2371857C CA2371857C CA002371857A CA2371857A CA2371857C CA 2371857 C CA2371857 C CA 2371857C CA 002371857 A CA002371857 A CA 002371857A CA 2371857 A CA2371857 A CA 2371857A CA 2371857 C CA2371857 C CA 2371857C
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- Prior art keywords
- compounds
- compound
- substituent
- gardos channel
- ring
- Prior art date
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- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13551199P | 1999-02-23 | 1999-02-23 | |
| US09/386,601 US6288122B1 (en) | 1999-02-23 | 1999-08-31 | Gardos channel antagonists |
| US09/386,601 | 1999-08-31 | ||
| US60/135,511 | 1999-08-31 | ||
| PCT/US2000/003663 WO2000050026A1 (en) | 1999-02-23 | 2000-02-10 | Gardos channel antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2371857A1 CA2371857A1 (en) | 2000-08-31 |
| CA2371857C true CA2371857C (en) | 2008-07-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002371857A Expired - Fee Related CA2371857C (en) | 1999-02-23 | 2000-02-10 | Gardos channel antagonists |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6288122B1 (enExample) |
| EP (1) | EP1158971B1 (enExample) |
| JP (2) | JP4038337B2 (enExample) |
| KR (1) | KR100705726B1 (enExample) |
| CN (1) | CN1193748C (enExample) |
| AP (1) | AP1465A (enExample) |
| AT (1) | ATE370728T1 (enExample) |
| AU (1) | AU762039B2 (enExample) |
| BR (1) | BR0008416A (enExample) |
| CA (1) | CA2371857C (enExample) |
| DE (1) | DE60036093T2 (enExample) |
| ES (1) | ES2291191T3 (enExample) |
| HK (1) | HK1045262B (enExample) |
| IL (2) | IL145012A0 (enExample) |
| OA (1) | OA11838A (enExample) |
| WO (1) | WO2000050026A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003004010A1 (en) * | 2001-07-06 | 2003-01-16 | Poseidon Pharmaceuticals A/S | Carbonylamino derivatives useful for obtaining immune regulation |
| ATE400551T1 (de) | 2002-01-04 | 2008-07-15 | Neurosearch As | Kaliumkanal-modulatoren |
| WO2003074038A1 (en) * | 2002-02-28 | 2003-09-12 | Icagen, Inc. | Methods for treating diseases related to intraocular pressure |
| WO2005003143A1 (en) * | 2003-07-03 | 2005-01-13 | Poseidon Pharmaceuticals A/S | Novel potassium channel modulators |
| WO2005003094A1 (en) * | 2003-07-03 | 2005-01-13 | Poseidon Pharmaceuticals A/S | Diarylmethyl derivatives as potassium channel modulators |
| US7709533B2 (en) * | 2005-02-01 | 2010-05-04 | Icagen, Inc. | Imines as ion channel modulators |
| CN101437403A (zh) * | 2005-12-20 | 2009-05-20 | Icagen公司 | 使用三芳基甲烷化合物的治疗方法 |
| US20100056637A1 (en) * | 2005-12-20 | 2010-03-04 | Icagen, Inc. | Treatment methods using triaryl methane compounds |
| JP2010536827A (ja) | 2007-08-24 | 2010-12-02 | ノイロサーチ アクティーゼルスカブ | ある種の炎症性障害の治療に有用なカルボニルアミノ誘導体 |
| US20090076157A1 (en) * | 2007-09-15 | 2009-03-19 | Protia, Llc | Deuterium-enriched senicapoc |
| KR101896430B1 (ko) | 2008-04-09 | 2018-09-10 | 세루스 코포레이션 | 적혈구 병원체 불활성화를 위한 개선된 퀀칭 방법 |
| US9428568B2 (en) | 2008-11-10 | 2016-08-30 | Boehringer Ingelheim International Gmbh | Compositions and methods for modulating cell-cell fusion via intermediate-conductance calcium-activated potassium channels |
| US10179115B2 (en) | 2015-02-20 | 2019-01-15 | The Children's Medical Center Corporation | Methods for treating malaria using potassium channel inhibitors |
| EP3106155A1 (en) | 2015-06-15 | 2016-12-21 | Universite d'Aix Marseille | Treatment and diagnosis of hereditary xerocytosis |
| US11439607B2 (en) * | 2016-10-25 | 2022-09-13 | Paracelsus Neuroscience I, LLC | Use of senicapoc for treatment of neuropathic pain |
| WO2018162426A1 (en) | 2017-03-06 | 2018-09-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Treatment and diagnosis of hereditary xerocytosis |
| WO2020198939A1 (zh) * | 2019-03-29 | 2020-10-08 | 深圳仁泰医药科技有限公司 | 2,2-双(4-氟苯基)-2-苯乙酰胺的晶型a及其制备方法和应用 |
| US12186286B2 (en) * | 2019-07-29 | 2025-01-07 | Paracelsus Neuroscience Llc | Use of senicapoc for treatment of stroke |
| EP4181908A4 (en) * | 2020-07-14 | 2024-03-06 | Adimabio LLC | COMPOSITIONS COMPRISING GARDOS CHANNEL ANTAGONISTS AND THEIR USES |
| CN116847838A (zh) | 2020-12-11 | 2023-10-03 | 桑昆专利有限公司 | 炎症性贫血的治疗和预防 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5273992A (en) | 1992-11-02 | 1993-12-28 | Beth Israel Hospital Assoc. Inc. | Method for reducing sickle erythrocyte dehydration and delaying the occurrence of erythrocyte sickling in-situ |
| WO1997034589A1 (en) | 1996-03-20 | 1997-09-25 | President And Fellows Of Harvard College | Triaryl methane compounds for sickle cell disease |
-
1999
- 1999-08-31 US US09/386,601 patent/US6288122B1/en not_active Expired - Lifetime
-
2000
- 2000-02-10 OA OA1200100220A patent/OA11838A/en unknown
- 2000-02-10 KR KR1020017010707A patent/KR100705726B1/ko not_active Expired - Fee Related
- 2000-02-10 AU AU28807/00A patent/AU762039B2/en not_active Ceased
- 2000-02-10 JP JP2000600638A patent/JP4038337B2/ja not_active Expired - Fee Related
- 2000-02-10 AT AT00907283T patent/ATE370728T1/de active
- 2000-02-10 AP APAP/P/2001/002268A patent/AP1465A/en active
- 2000-02-10 IL IL14501200A patent/IL145012A0/xx active IP Right Grant
- 2000-02-10 HK HK02106773.8A patent/HK1045262B/zh not_active IP Right Cessation
- 2000-02-10 BR BR0008416-6A patent/BR0008416A/pt not_active IP Right Cessation
- 2000-02-10 ES ES00907283T patent/ES2291191T3/es not_active Expired - Lifetime
- 2000-02-10 EP EP00907283A patent/EP1158971B1/en not_active Expired - Lifetime
- 2000-02-10 CN CNB008054525A patent/CN1193748C/zh not_active Expired - Fee Related
- 2000-02-10 CA CA002371857A patent/CA2371857C/en not_active Expired - Fee Related
- 2000-02-10 WO PCT/US2000/003663 patent/WO2000050026A1/en not_active Ceased
- 2000-02-10 DE DE60036093T patent/DE60036093T2/de not_active Expired - Lifetime
-
2001
- 2001-08-21 IL IL145012A patent/IL145012A/en not_active IP Right Cessation
-
2007
- 2007-05-02 JP JP2007121967A patent/JP2007262075A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL145012A0 (en) | 2002-06-30 |
| CN1344158A (zh) | 2002-04-10 |
| HK1045262B (zh) | 2005-07-29 |
| JP4038337B2 (ja) | 2008-01-23 |
| KR20020002393A (ko) | 2002-01-09 |
| CA2371857A1 (en) | 2000-08-31 |
| DE60036093T2 (de) | 2008-05-15 |
| US6288122B1 (en) | 2001-09-11 |
| AU2880700A (en) | 2000-09-14 |
| IL145012A (en) | 2006-12-10 |
| EP1158971A1 (en) | 2001-12-05 |
| CN1193748C (zh) | 2005-03-23 |
| EP1158971B1 (en) | 2007-08-22 |
| HK1045262A1 (en) | 2002-11-22 |
| KR100705726B1 (ko) | 2007-04-11 |
| WO2000050026A1 (en) | 2000-08-31 |
| AP2001002268A0 (en) | 2001-09-30 |
| AP1465A (en) | 2005-09-22 |
| EP1158971A4 (en) | 2003-04-16 |
| OA11838A (en) | 2005-08-22 |
| JP2007262075A (ja) | 2007-10-11 |
| ES2291191T3 (es) | 2008-03-01 |
| JP2002537331A (ja) | 2002-11-05 |
| AU762039B2 (en) | 2003-06-19 |
| DE60036093D1 (de) | 2007-10-04 |
| ATE370728T1 (de) | 2007-09-15 |
| BR0008416A (pt) | 2002-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20150210 |