BR0008416A - Composto, formulação e composição farmacêuticas, métodos para inibir o fluxo de potássio de uma célula, para o tratamento ou prevenção de um evento de doença falciforme, e, para melhorar a resistência à degradação em um meio biológico de um inibidor de canal de potássio compreendendo uma porção fenila - Google Patents
Composto, formulação e composição farmacêuticas, métodos para inibir o fluxo de potássio de uma célula, para o tratamento ou prevenção de um evento de doença falciforme, e, para melhorar a resistência à degradação em um meio biológico de um inibidor de canal de potássio compreendendo uma porção fenilaInfo
- Publication number
- BR0008416A BR0008416A BR0008416-6A BR0008416A BR0008416A BR 0008416 A BR0008416 A BR 0008416A BR 0008416 A BR0008416 A BR 0008416A BR 0008416 A BR0008416 A BR 0008416A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- methods
- potassium
- resistance
- cell
- Prior art date
Links
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 title abstract 4
- 229910052700 potassium Inorganic materials 0.000 title abstract 4
- 239000011591 potassium Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000015556 catabolic process Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000006731 degradation reaction Methods 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 208000007056 sickle cell anemia Diseases 0.000 title abstract 2
- 102000004257 Potassium Channel Human genes 0.000 title 1
- 229940125400 channel inhibitor Drugs 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
- 108020001213 potassium channel Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 206010025482 malaise Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13551199P | 1999-02-23 | 1999-02-23 | |
| US09/386,601 US6288122B1 (en) | 1999-02-23 | 1999-08-31 | Gardos channel antagonists |
| PCT/US2000/003663 WO2000050026A1 (en) | 1999-02-23 | 2000-02-10 | Gardos channel antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0008416A true BR0008416A (pt) | 2002-01-29 |
Family
ID=26833406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0008416-6A BR0008416A (pt) | 1999-02-23 | 2000-02-10 | Composto, formulação e composição farmacêuticas, métodos para inibir o fluxo de potássio de uma célula, para o tratamento ou prevenção de um evento de doença falciforme, e, para melhorar a resistência à degradação em um meio biológico de um inibidor de canal de potássio compreendendo uma porção fenila |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6288122B1 (enExample) |
| EP (1) | EP1158971B1 (enExample) |
| JP (2) | JP4038337B2 (enExample) |
| KR (1) | KR100705726B1 (enExample) |
| CN (1) | CN1193748C (enExample) |
| AP (1) | AP1465A (enExample) |
| AT (1) | ATE370728T1 (enExample) |
| AU (1) | AU762039B2 (enExample) |
| BR (1) | BR0008416A (enExample) |
| CA (1) | CA2371857C (enExample) |
| DE (1) | DE60036093T2 (enExample) |
| ES (1) | ES2291191T3 (enExample) |
| HK (1) | HK1045262B (enExample) |
| IL (2) | IL145012A0 (enExample) |
| OA (1) | OA11838A (enExample) |
| WO (1) | WO2000050026A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003004010A1 (en) * | 2001-07-06 | 2003-01-16 | Poseidon Pharmaceuticals A/S | Carbonylamino derivatives useful for obtaining immune regulation |
| EP1465863B1 (en) | 2002-01-04 | 2008-07-09 | NeuroSearch A/S | Potassium channel modulators |
| AU2003217810C9 (en) * | 2002-02-28 | 2008-06-12 | Icagen, Inc. | Methods for treating diseases related to intraocular pressure |
| EP1644332A1 (en) * | 2003-07-03 | 2006-04-12 | Poseidon Pharmaceuticals A/S | Diarylmethyl derivatives as potassium channel modulators |
| WO2005003143A1 (en) * | 2003-07-03 | 2005-01-13 | Poseidon Pharmaceuticals A/S | Novel potassium channel modulators |
| WO2006084031A1 (en) * | 2005-02-01 | 2006-08-10 | Icagen, Inc. | Imines as ion channel modulators |
| US20100056637A1 (en) * | 2005-12-20 | 2010-03-04 | Icagen, Inc. | Treatment methods using triaryl methane compounds |
| CA2633805A1 (en) * | 2005-12-20 | 2007-07-05 | Icagen, Inc. | Treatment methods using triaryl methane compounds |
| WO2009027292A1 (en) * | 2007-08-24 | 2009-03-05 | Neurosearch A/S | Carbonylamino derivatives useful for the treatment of certain inflammatory disorders |
| US20090076157A1 (en) * | 2007-09-15 | 2009-03-19 | Protia, Llc | Deuterium-enriched senicapoc |
| KR101896430B1 (ko) * | 2008-04-09 | 2018-09-10 | 세루스 코포레이션 | 적혈구 병원체 불활성화를 위한 개선된 퀀칭 방법 |
| CN102272152B (zh) | 2008-11-10 | 2014-05-28 | 贝林格尔.英格海姆国际有限公司 | 通过中电导钙激活钾通道调控细胞-细胞融合的组合物及方法 |
| WO2016134353A1 (en) * | 2015-02-20 | 2016-08-25 | Children's Medical Center Corporation | Methods for treating malaria using potassium channel inhibitors |
| EP3106155A1 (en) * | 2015-06-15 | 2016-12-21 | Universite d'Aix Marseille | Treatment and diagnosis of hereditary xerocytosis |
| CN110177548A (zh) * | 2016-10-25 | 2019-08-27 | 罗兰·斯塔尔 | Senicapoc用于治疗神经性疼痛的用途 |
| WO2018162426A1 (en) | 2017-03-06 | 2018-09-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Treatment and diagnosis of hereditary xerocytosis |
| CN112020353A (zh) | 2019-03-29 | 2020-12-01 | 深圳仁泰医药科技有限公司 | 2,2-双(4-氟苯基)-2-苯乙酰胺的晶型a及其制备方法和应用 |
| US12186286B2 (en) * | 2019-07-29 | 2025-01-07 | Paracelsus Neuroscience Llc | Use of senicapoc for treatment of stroke |
| CN115943138A (zh) * | 2020-07-14 | 2023-04-07 | 阿迪玛生物有限责任公司 | 包含gardos通道拮抗剂的组合物及其用途 |
| US20240024335A1 (en) * | 2020-12-11 | 2024-01-25 | Sanquin IP B.V. | Treatment and prevention of anaemia of inflammation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5273992A (en) | 1992-11-02 | 1993-12-28 | Beth Israel Hospital Assoc. Inc. | Method for reducing sickle erythrocyte dehydration and delaying the occurrence of erythrocyte sickling in-situ |
| ATE314060T1 (de) | 1996-03-20 | 2006-01-15 | Harvard College | Triarylmethanverbindungen zur behandlung von krebs, aktinischer keratose und kaposisarkom |
-
1999
- 1999-08-31 US US09/386,601 patent/US6288122B1/en not_active Expired - Lifetime
-
2000
- 2000-02-10 JP JP2000600638A patent/JP4038337B2/ja not_active Expired - Fee Related
- 2000-02-10 OA OA1200100220A patent/OA11838A/en unknown
- 2000-02-10 IL IL14501200A patent/IL145012A0/xx active IP Right Grant
- 2000-02-10 AU AU28807/00A patent/AU762039B2/en not_active Ceased
- 2000-02-10 AP APAP/P/2001/002268A patent/AP1465A/en active
- 2000-02-10 EP EP00907283A patent/EP1158971B1/en not_active Expired - Lifetime
- 2000-02-10 HK HK02106773.8A patent/HK1045262B/zh not_active IP Right Cessation
- 2000-02-10 CN CNB008054525A patent/CN1193748C/zh not_active Expired - Fee Related
- 2000-02-10 BR BR0008416-6A patent/BR0008416A/pt not_active IP Right Cessation
- 2000-02-10 WO PCT/US2000/003663 patent/WO2000050026A1/en not_active Ceased
- 2000-02-10 KR KR1020017010707A patent/KR100705726B1/ko not_active Expired - Fee Related
- 2000-02-10 ES ES00907283T patent/ES2291191T3/es not_active Expired - Lifetime
- 2000-02-10 DE DE60036093T patent/DE60036093T2/de not_active Expired - Lifetime
- 2000-02-10 AT AT00907283T patent/ATE370728T1/de active
- 2000-02-10 CA CA002371857A patent/CA2371857C/en not_active Expired - Fee Related
-
2001
- 2001-08-21 IL IL145012A patent/IL145012A/en not_active IP Right Cessation
-
2007
- 2007-05-02 JP JP2007121967A patent/JP2007262075A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2880700A (en) | 2000-09-14 |
| HK1045262B (zh) | 2005-07-29 |
| AP1465A (en) | 2005-09-22 |
| AU762039B2 (en) | 2003-06-19 |
| JP4038337B2 (ja) | 2008-01-23 |
| CA2371857A1 (en) | 2000-08-31 |
| KR20020002393A (ko) | 2002-01-09 |
| JP2007262075A (ja) | 2007-10-11 |
| OA11838A (en) | 2005-08-22 |
| CA2371857C (en) | 2008-07-29 |
| IL145012A0 (en) | 2002-06-30 |
| KR100705726B1 (ko) | 2007-04-11 |
| ATE370728T1 (de) | 2007-09-15 |
| EP1158971A1 (en) | 2001-12-05 |
| WO2000050026A1 (en) | 2000-08-31 |
| CN1344158A (zh) | 2002-04-10 |
| AP2001002268A0 (en) | 2001-09-30 |
| DE60036093D1 (de) | 2007-10-04 |
| ES2291191T3 (es) | 2008-03-01 |
| DE60036093T2 (de) | 2008-05-15 |
| US6288122B1 (en) | 2001-09-11 |
| EP1158971B1 (en) | 2007-08-22 |
| HK1045262A1 (en) | 2002-11-22 |
| IL145012A (en) | 2006-12-10 |
| JP2002537331A (ja) | 2002-11-05 |
| CN1193748C (zh) | 2005-03-23 |
| EP1158971A4 (en) | 2003-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B07C | Technical examination (opinion): republication [chapter 7.3 patent gazette] |
Free format text: REFERENTE AO DESPACHO 7.7 PUBLICADO NA RPI 2244 DE 07/01/2014 |
|
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 15A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2308 DE 31/03/2015. |