BR0215777A - Composto, método para preparar o mesmo, composição farmacêutica para prevenir e tratar cardioisquemia, cerebroisquemia, oclusão arterial cerebral e para melhorar microcirculação do cérebro, e uso do composto - Google Patents

Composto, método para preparar o mesmo, composição farmacêutica para prevenir e tratar cardioisquemia, cerebroisquemia, oclusão arterial cerebral e para melhorar microcirculação do cérebro, e uso do composto

Info

Publication number
BR0215777A
BR0215777A BR0215777-2A BR0215777A BR0215777A BR 0215777 A BR0215777 A BR 0215777A BR 0215777 A BR0215777 A BR 0215777A BR 0215777 A BR0215777 A BR 0215777A
Authority
BR
Brazil
Prior art keywords
compound
cerebroischemia
cardioischemia
treating
preventing
Prior art date
Application number
BR0215777-2A
Other languages
English (en)
Other versions
BR0215777B1 (pt
Inventor
Jinghua Yang
Xiaoliang Wang
Ying Peng
Zhibin Xu
Original Assignee
Inst Materia Medica Cams
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Materia Medica Cams filed Critical Inst Materia Medica Cams
Publication of BR0215777A publication Critical patent/BR0215777A/pt
Publication of BR0215777B1 publication Critical patent/BR0215777B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic System
    • C07F1/06—Potassium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic System
    • C07F1/04—Sodium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic System
    • C07F3/04—Calcium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic System
    • C07F3/06—Zinc compounds

Abstract

"COMPOSTO, MéTODO PARA PREPARAR O MESMO, COMPOSIçãO FARMACêUTICA PARA PREVENIR E TRATAR CARDIOISQUEMIA, CEREBROISQUEMIA, OCLUSãO ARTERIAL CEREBRAL E PARA MELHORAR MICROCIRCULAçãO DO CéREBRO, E USO DO COMPOSTO". A invenção refere-se a novos 2-(<244>-hidroxipentil) benzoatos sintéticos, à sua preparação e as composições farmacêuticas contendo estes sais como ingredientes ativos. A invenção também se refere ao uso dos compostos para prevenir e tratar cardioisquemia, cerebroisquemia e oclusão arterial cardíaca ou cerebral (obstrução) e semelhantes.
BRPI0215777A 2002-05-09 2002-05-09 Composition, method for preparing the same, pharmaceutical composition for preventing and treating cardioischemia, cerebrosis, cerebral arterial oclusion and for improving micro-circulation of the brain, and use of compound BR0215777B1 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2002/000320 WO2003095412A1 (fr) 2002-05-09 2002-05-09 2-($g(a)-hydroxypentyl) benzoate,sa preparation et son utilisation

Publications (2)

Publication Number Publication Date
BR0215777A true BR0215777A (pt) 2005-03-01
BR0215777B1 BR0215777B1 (pt) 2017-10-24

Family

ID=33569588

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0215777A BR0215777B1 (pt) 2002-05-09 2002-05-09 Composition, method for preparing the same, pharmaceutical composition for preventing and treating cardioischemia, cerebrosis, cerebral arterial oclusion and for improving micro-circulation of the brain, and use of compound

Country Status (11)

Country Link
US (2) US7550507B2 (pt)
EP (2) EP1508561B1 (pt)
JP (1) JP5058439B2 (pt)
KR (1) KR100756470B1 (pt)
CN (1) CN1243541C (pt)
AU (1) AU2002252949A1 (pt)
BR (1) BR0215777B1 (pt)
CA (1) CA2485479C (pt)
DE (1) DE60233825D1 (pt)
IL (1) IL164845A (pt)
WO (1) WO2003095412A1 (pt)

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CN1243541C (zh) 2002-05-09 2006-03-01 中国医学科学院药物研究所 2－(α－羟基戊基)苯甲酸盐及其制法和用途
CN100422133C (zh) * 2003-09-01 2008-10-01 北京天衡药物研究院 2-（α-羟基戊基）苯甲酸盐及其制法和用途
CN100422134C (zh) 2004-03-12 2008-10-01 北京天衡药物研究院 新的2-（α-正戊酮基）苯甲酸盐及其制法和用途
US20070203233A1 (en) * 2004-06-04 2007-08-30 Team Academy Of Pharmaceutical Science NOVEL 2-(alpha-N-PENTANONYL)BENZOATES, THEIR PREPARATION AND USE
CN100540523C (zh) * 2004-06-17 2009-09-16 北京天衡药物研究院 L-2-（α-羟基戊基）苯甲酸盐及其制法和用途
JP2011527290A (ja) 2008-07-08 2011-10-27 インスティトゥート オブ マタリア メディカ，チャイニーズ アカデミー オブ メディカル サイエンシズ ２−（α−ヒドロキシ−ペンチル）安息香酸カリウムを用いたアルツハイマー病の予防と／またおよび／または治療においての役割への適用
CN102397272B (zh) * 2010-09-17 2013-08-14 石药集团恩必普药业有限公司 丁基苯酞及其衍生物在制备预防和治疗als的药物中的应用
NZ610853A (en) * 2010-10-27 2015-05-29 Prometic Biosciences Inc Phenylketone carboxylate compounds and pharmaceutical uses thereof
CN103830200A (zh) * 2012-11-21 2014-06-04 石药集团中奇制药技术（石家庄）有限公司 一种3-正丁基苯酞衍生物的组合物及其制备方法
CN103113210A (zh) * 2013-02-19 2013-05-22 石药集团中奇制药技术（石家庄）有限公司 羟戊基苯甲酸钾晶体及其制备方法
CN105616375B (zh) * 2013-03-06 2018-08-28 贵州贵安新区协生元医药科技有限公司 消旋2-(α-羟基戊基)苯甲酸盐片及其制备方法
CN103142513B (zh) * 2013-03-25 2016-01-20 石家庄鸯星科技有限公司 一种注射用消旋2-(α-羟基戊基)苯甲酸盐冻干粉针及其制备方法
CN104086399B (zh) 2013-07-17 2016-08-24 浙江奥翔药业股份有限公司 5-溴-2-（α-羟基戊基）苯甲酸钠盐的不同晶型及其制备方法
CN104414981A (zh) * 2013-08-28 2015-03-18 云南昊邦制药有限公司 羟戊基苯甲酸盐的注射用冻干制剂及其制备方法
CN104546827B (zh) * 2013-10-09 2019-12-27 石药集团恩必普药业有限公司 丁基苯酞或其衍生物在制备治疗或预防糖尿病的药物中的应用
CN104546828B (zh) * 2013-10-09 2017-11-14 石药集团恩必普药业有限公司 丁基苯酞或其衍生物在制备治疗或预防糖尿病并发症的药物中的应用
CN103896763B (zh) * 2014-03-27 2015-11-18 云南昊邦制药有限公司 一种2-（α-羟基戊基）苯甲酸钾多晶型及其制备方法、制剂与应用
CN103989651A (zh) * 2014-03-27 2014-08-20 云南昊邦制药有限公司 一种2-（α-羟基戊基）苯甲酸盐控释片及其制备方法
CN104510720A (zh) * 2014-12-25 2015-04-15 云南昊邦制药有限公司 一种2-(α-羟基戊基)苯甲酸盐分散片及其制备方法
CN104510721A (zh) * 2014-12-25 2015-04-15 云南昊邦制药有限公司 一种2-(α-羟基戊基)苯甲酸盐滴丸及其制备方法
CN106146297A (zh) * 2015-04-03 2016-11-23 米文君 一种新的化合物及其用途
CN105130934B (zh) * 2015-08-15 2018-11-23 石药集团恩必普药业有限公司 一种丁苯酞原料药产品及其制备方法
CN105859670B (zh) * 2016-04-19 2019-04-05 丽珠医药集团股份有限公司 一种高纯度丁苯酞的制备方法
CN108283633A (zh) * 2017-01-06 2018-07-17 郑州大学 5-溴-2-（α-羟基戊基）苯甲酸钠在治疗心血管疾病药物中的应用
ES2927538T3 (es) * 2018-03-19 2022-11-08 Henan Genuine Biotech Co Ltd Compuestos de ácido benzoico y método de preparación de los mismos y aplicaciones de los mismos
CN108715579B (zh) 2018-05-17 2020-03-24 四川大学 一种2-（α羟基戊基）苯甲酸的有机胺酯衍生物药物
CN109223749A (zh) * 2018-11-14 2019-01-18 郑州大学 5- 溴-2-（α- 羟基戊基）苯甲酸钠盐在治疗心肌肥厚和心力衰竭中的药物用途
CN109678715B (zh) * 2018-11-28 2019-11-12 中国药科大学 2-(1-酰氧正戊基)苯甲酸与碱性氨基酸或氨基胍形成的盐、其制备方法及用途
CN111943898A (zh) * 2019-05-17 2020-11-17 浙江大学 苯联四氮唑类衍生物、制备、含其的药物组合物及其应用
KR20220156597A (ko) 2020-03-20 2022-11-25 씨에스피씨 엔비피 파머슈티컬 캄파니 리미티드 부틸프탈라이드 및 이의 유도체의 용도
CN112457265A (zh) * 2020-11-06 2021-03-09 浙江大学 四氮唑类衍生物、制备、含其的药物组合物及其应用

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CN1136209C (zh) * 1999-07-05 2004-01-28 中国医学科学院药物研究所 制备光学活性3-正丁苯酞的方法
CN1243541C (zh) 2002-05-09 2006-03-01 中国医学科学院药物研究所 2－(α－羟基戊基)苯甲酸盐及其制法和用途

Also Published As

Publication number Publication date
CA2485479C (en) 2010-06-22
KR20040106457A (ko) 2004-12-17
US7550507B2 (en) 2009-06-23
EP2186792A1 (en) 2010-05-19
US20050288263A1 (en) 2005-12-29
CN1243541C (zh) 2006-03-01
IL164845A0 (en) 2005-12-18
IL164845A (en) 2011-08-31
JP5058439B2 (ja) 2012-10-24
US20090227809A1 (en) 2009-09-10
EP2186792A8 (en) 2010-08-04
EP1508561A4 (en) 2006-07-19
DE60233825D1 (de) 2009-11-05
WO2003095412A1 (fr) 2003-11-20
KR100756470B1 (ko) 2007-09-07
AU2002252949A1 (en) 2003-11-11
CN1382682A (zh) 2002-12-04
BR0215777B1 (pt) 2017-10-24
EP2186792B1 (en) 2015-11-25
JP2005524715A (ja) 2005-08-18
CA2485479A1 (en) 2003-11-20
EP1508561A1 (en) 2005-02-23
EP1508561B1 (en) 2009-09-23

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
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Free format text: NAO CONHECIMENTO DA PETICAO DE NO020120004887 DE 19/01/2012, EM VIRTUDE DO DISPOSTO NO ARTIGO 218, INCISO I DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 19A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2622 DE 06-04-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.