ATE314060T1 - Triarylmethanverbindungen zur behandlung von krebs, aktinischer keratose und kaposisarkom - Google Patents

Triarylmethanverbindungen zur behandlung von krebs, aktinischer keratose und kaposisarkom

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Publication number
ATE314060T1
ATE314060T1 AT97916889T AT97916889T ATE314060T1 AT E314060 T1 ATE314060 T1 AT E314060T1 AT 97916889 T AT97916889 T AT 97916889T AT 97916889 T AT97916889 T AT 97916889T AT E314060 T1 ATE314060 T1 AT E314060T1
Authority
AT
Austria
Prior art keywords
compounds
treatment
replaced
kaposiarcoma
cancer
Prior art date
Application number
AT97916889T
Other languages
English (en)
Inventor
Carlo Brugnara
Jose Halperin
Emile M Bellot Jr
Mark Froimowitz
Richard J Lombardy
John J Clifford
Ying-Duo Gao
Reem M Haidar
Eugene W Kelleher
Falguni M Kher
Adel M Moussa
Yesh P Sachdeva
Minghua Sun
Heather N Taft
Original Assignee
Harvard College
Childrens Medical Center
Nuchem Pharmaceuticals Inc
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Publication date
Application filed by Harvard College, Childrens Medical Center, Nuchem Pharmaceuticals Inc filed Critical Harvard College
Application granted granted Critical
Publication of ATE314060T1 publication Critical patent/ATE314060T1/de

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    • A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
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    • A61K31/075—Ethers or acetals
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
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    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
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    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/535—Organo-phosphoranes
    • C07F9/5352—Phosphoranes containing the structure P=C-
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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AT97916889T 1996-03-20 1997-03-19 Triarylmethanverbindungen zur behandlung von krebs, aktinischer keratose und kaposisarkom ATE314060T1 (de)

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US61876296A 1996-03-20 1996-03-20
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PCT/US1997/004551 WO1997034589A1 (en) 1996-03-20 1997-03-19 Triaryl methane compounds for sickle cell disease

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AU732881B2 (en) 2001-05-03
DE69734983D1 (de) 2006-02-02
JP2001521485A (ja) 2001-11-06
DE69734983T2 (de) 2006-09-07
JP4376970B2 (ja) 2009-12-02
NZ332103A (en) 2000-08-25
BR9708230A (pt) 2000-01-04
EP0918514A4 (de) 2001-05-09
AU732881C (en) 2002-11-07
US6331564B1 (en) 2001-12-18
CA2250092C (en) 2001-10-02
CA2250092A1 (en) 1997-09-25
US20020119953A1 (en) 2002-08-29
EP0918514B1 (de) 2005-12-28
AU2538897A (en) 1997-10-10
EP0918514B9 (de) 2006-07-05
WO1997034589A1 (en) 1997-09-25
EP0918514A1 (de) 1999-06-02

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