ATE258379T1 - Nukleinsäure, die für einen tumor abstossungsantigenvorläufer kodiert - Google Patents

Nukleinsäure, die für einen tumor abstossungsantigenvorläufer kodiert

Info

Publication number
ATE258379T1
ATE258379T1 AT94911498T AT94911498T ATE258379T1 AT E258379 T1 ATE258379 T1 AT E258379T1 AT 94911498 T AT94911498 T AT 94911498T AT 94911498 T AT94911498 T AT 94911498T AT E258379 T1 ATE258379 T1 AT E258379T1
Authority
AT
Austria
Prior art keywords
tumor rejection
rejection antigen
nucleic acid
antigen precursor
acid coding
Prior art date
Application number
AT94911498T
Other languages
English (en)
Inventor
Vincent Brichard
Pel Aline Van
Catia Traversari
Thomas Wolfel
Thierry Boon-Falleur
Plaen Etienne De
Original Assignee
Ludwig Inst Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ludwig Inst Cancer Res filed Critical Ludwig Inst Cancer Res
Application granted granted Critical
Publication of ATE258379T1 publication Critical patent/ATE258379T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT94911498T 1993-03-18 1994-03-09 Nukleinsäure, die für einen tumor abstossungsantigenvorläufer kodiert ATE258379T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/032,978 US5620886A (en) 1993-03-18 1993-03-18 Isolated nucleic acid sequence coding for a tumor rejection antigen precursor processed to at least one tumor rejection antigen presented by HLA-A2
PCT/US1994/002487 WO1994021126A1 (en) 1993-03-18 1994-03-09 Nucleic acid coding for a tumor rejection antigen precursor

Publications (1)

Publication Number Publication Date
ATE258379T1 true ATE258379T1 (de) 2004-02-15

Family

ID=21867896

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94911498T ATE258379T1 (de) 1993-03-18 1994-03-09 Nukleinsäure, die für einen tumor abstossungsantigenvorläufer kodiert

Country Status (17)

Country Link
US (2) US5620886A (de)
EP (1) EP0690675B1 (de)
JP (1) JP3433322B2 (de)
CN (1) CN1072719C (de)
AT (1) ATE258379T1 (de)
AU (1) AU675707B2 (de)
CA (1) CA2158446C (de)
DE (2) DE69433518T4 (de)
DK (1) DK0690675T5 (de)
ES (1) ES2210252T3 (de)
FI (1) FI954360A0 (de)
NO (1) NO953601L (de)
NZ (1) NZ263348A (de)
PT (1) PT690675E (de)
TW (1) TW442568B (de)
WO (1) WO1994021126A1 (de)
ZA (1) ZA941812B (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856091A (en) * 1993-03-18 1999-01-05 Ludwig Institute For Cancer Research Isolated nucleic acid sequence coding for a tumor rejection antigen precursor processed to at least one tumor rejection antigen presented by HLA-A2
US5874560A (en) 1994-04-22 1999-02-23 The United States Of America As Represented By The Department Of Health And Human Services Melanoma antigens and their use in diagnostic and therapeutic methods
EP0756604A1 (de) * 1994-04-22 1997-02-05 THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services Melanoma antigene
US5997870A (en) * 1994-06-03 1999-12-07 Ludwig Institute For Cancer Research Isolated peptides which bind to HLA-B44 Molecules
US5821122A (en) * 1995-06-07 1998-10-13 Inserm (Institute Nat'l De La Sante Et De La Recherche . .) Isolated nucleic acid molecules, peptides which form complexes with MHC molecule HLA-A2 and uses thereof
UA68327C2 (en) * 1995-07-04 2004-08-16 Gsf Forschungszentrum Fur Unwe A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals
US6096313A (en) * 1996-02-09 2000-08-01 Ludwig Institute For Cancer Research Compositions containing immunogenic molecules and granulocyte-macrophage colony stimulating factor, as an adjuvant
FR2746110B1 (fr) * 1996-03-14 1998-04-17 Methode de traitement par therapie genique des tumeurs humaines et virus recombinants correspondants
US5674749A (en) * 1996-03-26 1997-10-07 Ludwig Institute For Cancer Research Monoclonal antibodies which bind to tumor rejection antigen precursor melan-A, and uses thereof
JP2001503966A (ja) * 1996-06-25 2001-03-27 ザ ルードヴィッヒ インスティテュート フォー キャンサー リサーチ 脳グリコーゲンホスホリラーゼ癌抗原
EP1961820B1 (de) 1997-01-27 2012-11-28 Ludwig Institute for Cancer Research Ltd Impfstoffzusammensetzung welche LAGE-1-Tumor-assoziierte Nukleinsäuren oder LAGE-1 Polypeptide enthält
US5879892A (en) 1997-04-25 1999-03-09 Ludwig Institute For Cancer Research Leukemia associated genes
EP1051507A4 (de) * 1998-01-26 2003-02-05 Genzyme Corp Antigen-spezifische zellen, verfahren zu deren herstellung und deren verwendungen
US7001999B1 (en) 1998-04-15 2006-02-21 Ludwig Institute For Cancer Research Tumor associated nucleic acids and uses therefor
US6245525B1 (en) 1998-07-27 2001-06-12 Ludwig Institute For Cancer Research Tumor associated nucleic acids and uses therefor
US6770456B1 (en) 1998-07-29 2004-08-03 Ludwig Institute For Cancer Research Endogenous retrovirus tumor associated nucleic acids and antigens
DE19913707A1 (de) * 1999-03-26 2000-10-05 Privates Inst Bioserv Gmbh Immunadsorber zur Sepsistherapie
CN1402782A (zh) 1999-10-19 2003-03-12 路德维哥癌症研究院 Mage－a12抗原肽及其应用
US20030113919A1 (en) * 2001-08-17 2003-06-19 Aventis Pasteur, Ltd. Immunogenic targets for melanoma
EP1467759A4 (de) 2002-01-30 2006-05-31 Brigham & Womens Hospital Zusammensetzungen und verfahren im zusammenhang mit tim-3, a th1-spezifischem zelloberflächenmolekül
US7311914B2 (en) * 2002-08-13 2007-12-25 Ludwig Institute For Cancer Research MAGE-A4 antigenic peptides and uses thereof
US7178491B2 (en) * 2003-06-05 2007-02-20 Caterpillar Inc Control system and method for engine valve actuator
US20060008468A1 (en) * 2004-06-17 2006-01-12 Chih-Sheng Chiang Combinations of tumor-associated antigens in diagnostics for various types of cancers
US20060159689A1 (en) * 2004-06-17 2006-07-20 Chih-Sheng Chiang Combinations of tumor-associated antigens in diagnostics for various types of cancers
CA2571168A1 (en) * 2004-06-17 2006-01-26 Mannkind Corporation Mhc i-binding ssx-241-49 variants
US8188243B2 (en) 2004-06-23 2012-05-29 Board Of Regents Of The University Of Texas System Methods and compositions for the detection of biological molecules using a two particle complex
AU2005321898B2 (en) 2004-12-29 2012-07-19 Mannkind Corporation Use of compositions comprising various tumor-associated antigens as anti-cancer vaccines
EP1901774B1 (de) 2005-06-17 2014-04-09 MannKind Corporation Multivalente entrain-und-amplify immuntherapeutika für karzinome
AU2006259307B2 (en) 2005-06-17 2012-12-20 Mannkind Corporation Epitope analogues
ES2413079T3 (es) 2005-06-17 2013-07-15 Mannkind Corporation Métodos y composiciones para desencadenar respuestas inmunitarias multivalentes contra epítopos dominantes y subdominantes expresados en células cancerosas y estroma tumoral
WO2008039818A2 (en) * 2006-09-26 2008-04-03 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Modified t cell receptors and related materials and methods
JP2010528591A (ja) * 2007-05-23 2010-08-26 マンカインド コーポレイション マルチシストロン性ベクター及びそれらの設計方法
ES2445755T3 (es) 2007-11-07 2014-03-05 Celldex Therapeutics, Inc. Anticuerpos que se unen a células dendríticas y epiteliales humanas 205 (DEC-205)
CA2778707A1 (en) 2009-10-23 2011-04-28 Mannkind Corporation Cancer immunotherapy and method of treatment
CA2796571C (en) 2010-04-13 2019-10-29 Celldex Therapeutics Inc. Antibodies that bind human cd27 and uses thereof
ES2755395T3 (es) 2014-06-06 2020-04-22 Bristol Myers Squibb Co Anticuerpos contra el receptor del factor de necrosis tumoral inducido por glucocorticoides (GITR) y usos de los mismos
EP3268037B1 (de) 2015-03-09 2022-08-31 Celldex Therapeutics, Inc. Cd27 agonists
SG10202008304TA (en) 2015-05-29 2020-10-29 Bristol Myers Squibb Co Antibodies against ox40 and uses thereof
SG11201803817PA (en) 2015-11-19 2018-06-28 Bristol Myers Squibb Co Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof
WO2017184619A2 (en) 2016-04-18 2017-10-26 Celldex Therapeutics, Inc. Agonistic antibodies that bind human cd40 and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5342774A (en) * 1991-05-23 1994-08-30 Ludwig Institute For Cancer Research Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1
US5487974A (en) * 1992-12-22 1996-01-30 Ludwig Institute For Cancer-Research Method for detecting complexes containing human leukocyte antigen A2 (HLA-A2) molecules and a tyrosinase drived peptide on abnormal cells

Also Published As

Publication number Publication date
JP3433322B2 (ja) 2003-08-04
NO953601D0 (no) 1995-09-13
CN1093406A (zh) 1994-10-12
AU675707B2 (en) 1997-02-13
EP0690675A1 (de) 1996-01-10
DK0690675T3 (da) 2004-06-01
FI954360A (fi) 1995-09-15
PT690675E (pt) 2004-06-30
DE69433518T4 (de) 2009-07-23
EP0690675A4 (de) 1998-12-23
WO1994021126A1 (en) 1994-09-29
DE69433518D1 (de) 2004-03-04
AU6399394A (en) 1994-10-11
NZ263348A (en) 1996-06-25
EP0690675B1 (de) 2004-01-28
JPH08507693A (ja) 1996-08-20
CA2158446C (en) 2009-01-06
US5854203A (en) 1998-12-29
NO953601L (no) 1995-10-31
ES2210252T3 (es) 2004-07-01
DK0690675T5 (da) 2008-11-17
ZA941812B (en) 1994-10-13
US5620886A (en) 1997-04-15
CA2158446A1 (en) 1994-09-29
FI954360A0 (fi) 1995-09-15
TW442568B (en) 2001-06-23
DE69433518T2 (de) 2004-06-24
CN1072719C (zh) 2001-10-10

Similar Documents

Publication Publication Date Title
ATE258379T1 (de) Nukleinsäure, die für einen tumor abstossungsantigenvorläufer kodiert
ATE267254T1 (de) Isolierte peptide, die mit mhc mulekül hla-c-klon 10 komplexe bilden und ihre verwendungen
DE69013313T2 (de) Mehrstufenverfahren zur Herstellung von Hexafluorpropylen.
PT845032E (pt) Moleculas isoladas de acidos nucleicos peptidos que formam complexos com a molecula a2-alh do cph e suas aplicacoes
FI960268A (fi) Menetelmä sairauden diagnosoimiseksi määrittämällä GAGE-tuumorihyljintäantigeenin prekursorien ilmentymistä
EA200200565A1 (ru) Применение клеток, трансфицированных днк, кодирующей лиганд мнс класса ii, и способ получения таких клеток
DE69008326T2 (de) Mehrstufenverfahren zur Herstellung von Hexafluoropropylen.
DE69604560T2 (de) Die herstellung von fluorinierten organischen verbindungen
DE69010171D1 (de) Mehrstufenverfahren zur Herstellung von Hexafluoropropylen.
ATE234858T1 (de) Isolierte und verkürzte nukleinsäuremoleküle kodierend für gage-tumorabstossungsantigen
NO970030L (no) Isolert nukleinsyresekvens som koder for et tumor-rejeksjonsantigen presentert av HLA-A2
FR2357517A1 (fr) Procede de production d'halogenophenols
ES2058067T3 (es) Proceso para la produccion de 2,6-didesoxi-2-fluoro-l-talopiranosa y sus derivados.
DK1404844T3 (da) Fremgangsmåde til fremstilling af 2,4-dideoxyhexoser og 2,4,6-trideoxyhyxoser
ES2148891T3 (es) Procedimiento para la fabricacion de 2-metil-2,4-diaminopentano.
DE3780665D1 (de) Mehrstufiges reduktionsverfahren zur herstellung von ferromagnetischem chromdioxid.
ATE265418T1 (de) Neue substituierte 3-phenoxy- und 3- phenylalkyloxy-2-phenyl-propylamine
DE69617255D1 (de) Durch hla-b44 moleküle präsentierte tumor-abstossungsantigene und ihre verwendung
EA200000705A1 (ru) Промежуточные соединения и способ синтеза 17-замещенных 16.бета.-арилокси 4-азастероидов
DE68914551D1 (de) Verfahren zur Produktion von O-silyl O,N-Keten-Acetalen.
TW372973B (en) Isolated, truncated nucleic acid molecules which code for gage tumor rejection antigen, the tumor rejection antigen, and uses thereof
ES2194745T3 (es) Procedimiento para la obtencion de 4,6-dicloropirimidi-na.
DE3577315D1 (de) Verfahren zur ringoeffnung von gem-dicyanoepoxyden und verbindungen, die durch dieses verfahren erhalten werden.
DE69118192D1 (de) CVD-Verfahren zur Herstellung von Wolfram
IT8125953A0 (it) Processo per la produzione di cianoacetilidrazoni di 2-formilchinossalin-1, 4-diossidi.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0690675

Country of ref document: EP