DE69534632T2 - Clotrimazol-Metaboliten bei der Behandlung von Sichelzellenkrankheit - Google Patents
Clotrimazol-Metaboliten bei der Behandlung von Sichelzellenkrankheit Download PDFInfo
- Publication number
- DE69534632T2 DE69534632T2 DE69534632T DE69534632T DE69534632T2 DE 69534632 T2 DE69534632 T2 DE 69534632T2 DE 69534632 T DE69534632 T DE 69534632T DE 69534632 T DE69534632 T DE 69534632T DE 69534632 T2 DE69534632 T2 DE 69534632T2
- Authority
- DE
- Germany
- Prior art keywords
- clotrimazole
- metabolites
- treatment
- sickle cell
- cell disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
- A61K31/025—Halogenated hydrocarbons carbocyclic
- A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30787494A | 1994-09-16 | 1994-09-16 | |
PCT/US1995/011822 WO1996008242A2 (en) | 1994-09-16 | 1995-09-15 | Clotrimazole metabolites in the treatment of sickle cell disease |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69534632D1 DE69534632D1 (de) | 2005-12-29 |
DE69534632T2 true DE69534632T2 (de) | 2006-06-14 |
Family
ID=23191532
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69534632T Expired - Fee Related DE69534632T2 (de) | 1994-09-16 | 1995-09-15 | Clotrimazol-Metaboliten bei der Behandlung von Sichelzellenkrankheit |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0781128B1 (de) |
DE (1) | DE69534632T2 (de) |
WO (1) | WO1996008242A2 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7531573B2 (en) * | 1994-09-16 | 2009-05-12 | Children's Medical Center Corporation | Use of triaryl methane compounds for inhibiting unwanted cellular proliferation associated with inflammatory disease |
US6028103A (en) * | 1994-09-16 | 2000-02-22 | Children's Medical Center Corporation | Triaryl methane compounds and analogues thereof useful for the treatment or prevention of sickle cell disease or diseases characterized by abnormal cell proliferation |
AU732881C (en) * | 1994-09-16 | 2002-11-07 | Children's Medical Center Corporation | Triaryl and diaryl compounds, their analogues and uses thereof |
US5889038A (en) * | 1996-03-20 | 1999-03-30 | Children's Hospital | Methods and products for treating diarrhea and scours: use of clotrimazole and related aromatic compounds |
WO1997045111A1 (de) * | 1996-05-24 | 1997-12-04 | Neurosearch A/S | Phenyl derivatives useful as blockers of chloride channels |
JP4073489B2 (ja) | 1996-05-24 | 2008-04-09 | ニューロサーチ・アクティーゼルスカブ | 酸性基を有するフエニル誘導体、その製造方法及びそれをクロライドチャンネル遮断剤として使用する方法 |
EP1052990A2 (de) | 1997-11-14 | 2000-11-22 | Neurosearch A/S | Chemische verbindungen mit ionenkanalblockierender aktivität zur behandlung von dysfunktionen des immunsystems |
US6291449B1 (en) | 1998-09-23 | 2001-09-18 | Children's Medical Center Corporation | Use of 11-phenyl-dibenzazepine compounds to treat diarrhea or scours |
US6992079B2 (en) | 1997-11-20 | 2006-01-31 | President Fellows of Harvard College | Substituted 11-phenyl-dibenzazepine compounds useful for the treatment or prevention of diseases characterized by abnormal cell proliferation |
US6800658B2 (en) | 1997-11-20 | 2004-10-05 | Children's Medical Center Corporation | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation |
IL136208A0 (en) * | 1997-11-20 | 2001-05-20 | Childrens Medical Center | Use of substituted diphenyl indanone, indane and indole compounds for the treatment or prevention of sickle cell disease, inflammatory diseases characterized by abnormal cell proliferation, diarrhea and scours |
CA2310773A1 (en) * | 1997-11-20 | 1999-06-03 | Carlo Brugnara | Use of substituted 11-phenyl-dibenzazepine compounds for the treatment or prevention of sickle cell disease, inflammatory diseases characterized by abnormal cell proliferation, diarrhea and scour |
MXPA00005035A (es) | 1997-11-20 | 2002-10-11 | Harvard College | Compuestos de 11-difenil-dibenzazepina substituidos utiles para el tratamiento o prevencion de enfermedades caracterizadas por proliferacion celular anormal. |
CN103102284A (zh) * | 2011-11-09 | 2013-05-15 | 南京大学 | 4-三氟甲基-2,6-二硝基苯水杨醛肟类衍生物的制备及其在抗癌治疗药物中的应用 |
US20240024335A1 (en) | 2020-12-11 | 2024-01-25 | Sanquin IP B.V. | Treatment and prevention of anaemia of inflammation |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56110615A (en) * | 1980-02-06 | 1981-09-01 | Yutaka Idota | Treating and preventing agent against disease of respiratory organ of chicken |
US5273992A (en) * | 1992-11-02 | 1993-12-28 | Beth Israel Hospital Assoc. Inc. | Method for reducing sickle erythrocyte dehydration and delaying the occurrence of erythrocyte sickling in-situ |
-
1995
- 1995-09-15 EP EP95933842A patent/EP0781128B1/de not_active Expired - Lifetime
- 1995-09-15 WO PCT/US1995/011822 patent/WO1996008242A2/en active IP Right Grant
- 1995-09-15 DE DE69534632T patent/DE69534632T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1996008242A2 (en) | 1996-03-21 |
WO1996008242A3 (en) | 1996-05-09 |
EP0781128A2 (de) | 1997-07-02 |
DE69534632D1 (de) | 2005-12-29 |
EP0781128B1 (de) | 2005-11-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |